=========================================
Tpl2 kinase activity is increased irt IL1
=========================================

Irak1--  ???

  *** Tpl2[Ab]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** reqs: Irak1 [KO]
    *** source: 19754427-Fig-1b
  *** xTpl2[tAb]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** does not req: Irak1 [KO]
    *** source: 19754427-Fig-2a

Tpl2 features

  *** xTpl2[tAb]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** partially inhibited by: xTpl2(S62A) [substitution]
    *** inhibited by: xTpl2(T290A) [substitution]
    *** unaffected by: xTpl2(S400A) [substitution]
    *** inhibited by: xTpl2(S62A/S400A) [substitution]
    *** source: 19754427-Fig-8a
  *** xTpl2(30-397)[tAb]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTpl2(30-397)> in BMLS
    *** times: 0 15++ 30+ min
    *** partially inhibited by: xTpl2(30-397/S62A) [substitution]
    *** inhibited by: xTpl2(30-397/T290A) [substitution]
    *** source: 16806191-Fig-3

chemicals

  *** Tpl2[Ab]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** inhibited by: PP2 [addition]
    *** source: 19754427-Fig-3a
  *** Tpl2[Ab]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** inhibited by: PS1145 [addition]
    *** source: 19754427-Fig-1b
  *** xTpl2[tAb]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** unaffected by: PS1145 [addition]
    *** source: 19754427-Fig-2a
  *** xTpl2[tAb]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** inhibited by: PP2 [addition]
    *** source: 19754427-Fig-4a
  *** xTpl2(30-397)[tAb]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** inhibited by: PP2 [addition]
    *** source: 19754427-Fig-4a
  *** xTpl2(30-467)[tAb]IP IVKA(Mek1,Erk2,MBP)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** inhibited by: PP2 [addition]
    *** source: 19754427-Fig-4a

no extras

  *** Tpl2[Ab]IP IVKA(snr)[32P-ATP] is increased irt IL1 (15 min)
    *** cells: HELA in BMS
    *** source: 16371247-Fig-1a
  *** Tpl2[Ab]IP IVKA(snr)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** source: 18180283-Fig-6b

======================
Phosphorylation on S62
======================

  *** xTpl2[tAb]IP phos(S62)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** inhibited by: xTpl2(D270A) [substitution]
    *** inhibited by: xTpl2(K167R) [substitution]
    *** inhibited by: xTpl2((30-397)/D270A) [substitution]
    *** inhibited by: xTpl2((30-397)/K167R) [substitution]
    *** source: 19754427-Fig-6
  *** xTpl2[tAb]IP phos(S62)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** unaffected by: xTpl2(30-467) [substitution]
    *** unaffected by: xTpl2(30-397) [substitution]
    *** source: 19754427-Fig-5
  *** xTpl2[tAb]IP phos(S62)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** unaffected by: xTpl2(T290A) [substitution]
    *** unaffected by: xTpl2(S400A) [substitution]
    *** source: 19754427-Fig-8b
  *** xTpl2[tAb]IP phos(S62)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null><xTnip2> in BMLS
    *** inhibited by: xTpl2(D270A) [substitution]
    *** unaffected by: xTpl2(T290A) [substitution]
    *** source: 19754427-Fig-9a
  *** xTpl2(30-397)[tAb]IP phos(S62)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTpl2(30-397)> in BMS
    *** times: 0 15+ 30++ min
    *** inhibited by: xTpl2(30-397/S62A) [substitution]
    *** inhibited by: xTpl2(30-397/T290A) [substitution]
    *** source: 16806191-Fig-4a
  *** xTpl2(30-397)[tAb]IP phos(S62)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTpl2(30-397)> in BMS
    *** times: 0 15+ 30++ min
    *** source: 16806191-Fig-4a

=======================
Phosphorylation on T290
=======================

  *** xTpl2[tAb]IP phos(T290)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** inhibited by: xTpl2(D270A) [substitution]
    *** inhibited by: xTpl2(K167R) [substitution]
    *** inhibited by: xTpl2((30-397)/D270A) [substitution]
    *** inhibited by: xTpl2((30-397)/K167R) [substitution]
    *** source: 19754427-Fig-6
  *** xTpl2[tAb]IP phos(T290)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** unaffected by: xTpl2(30-467) [substitution]
    *** unaffected by: xTpl2(30-397) [substitution]
    *** source: 19754427-Fig-5
  *** xTpl2[tAb]IP phos(T290)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** unaffected by: xTpl2(S62A) [substitution]
    *** partially inhibited by: xTpl2(S400A) [substitution]
    *** inhibited by: xTpl2(S62A/S400A) [substitution]
    *** source: 19754427-Fig-8b
  *** xTpl2[tAb]IP phos(T290)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null><xTnip2> in BMLS
    *** inhibited by: Compound-1 [addition]
    *** source: 19754427-Fig-9a
  *** xTpl2[tAb]IP phos(T290)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null><xTnip2> in BMLS
    *** inhibited by: xTpl2(D270A) [substitution]
    *** source: 19754427-Fig-9a
  *** xTpl2(30-397)[tAb]IP phos(T290)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTpl2(30-397)> in BMS
    *** times: 0 15+ 30++ min
    *** source: 16806191-Fig-4a
  *** xTpl2(30-397/S62A)[tAb]IP phos(T290)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><xTpl2(30-397/S62A)> in BMS
    *** unaffected by: PS1145 [pretreatment]
    *** source: 16806191-Fig-5
  *** xTpl2(30-397/S62A)[tAb]IP phos(T290)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTpl2(30-397/S62A)> in BMS
    *** times: 0 15+ 30++ min
    *** source: 16806191-Fig-4b

=======================
Phosphorylation on S400
=======================

  *** xTpl2[tAb]IP phos(S400)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** inhibited by: xTpl2(D270A) [substitution]
    *** inhibited by: xTpl2(K167R) [substitution]
    *** inhibited by: xTpl2((30-397)/D270A) [substitution]
    *** inhibited by: xTpl2((30-397)/K167R) [substitution]
    *** source: 19754427-Fig-6
  *** xTpl2[tAb]IP phos(S400)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** unaffected by: xTpl2(30-467) [substitution]
    *** source: 19754427-Fig-5
  *** xTpl2[tAb]IP phos(S400)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** unaffected by: xTpl2(S62A) [substitution]
    *** unaffected by: xTpl2(T290A) [substitution]
    *** source: 19754427-Fig-8b
  *** xTpl2[tAb]IP phos(S400)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null><xTnip2> in BMLS
    *** inhibited by: Compound-1 [addition]
    *** source: 19754427-Fig-9a
  *** xTpl2[tAb]IP phos(S400)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null><xTnip2> in BMLS
    *** inhibited by: xTpl2(D270A) [substitution]
    *** partially inhibited by: xTpl2(T290A) [substitution]
    *** source: 19754427-Fig-9a

