Tak1 is capable of autophos so act rule is placed before phos rule

=================
Required Proteins
=================

Irak1-- ???

  *** Tak1[Ab] phos[WBMS] is unchanged irt IL1 (30 min)
    *** cells: HEK293I1A<Irak1~null> in BMS
    *** source: 17197697-Fig-4b

Tab1--

  *** Tak1[Ab]IP phos(T187)[phosAb] is increased irt IL1a (times)
    *** cells: mEFs in BMLS
    *** times: 0 5++ 10+ min
    *** partially reqs: Tab1 [KO]
    *** source: 18021073-Fig-7b

Tab2-- and/or Tab3--

  *** Tak1[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: mEFs in BMLS
    *** times: 0 5+ 10++ 20++ 30+ min
    *** reqs: Tab2 [KO]
    *** source: 15836773(D)
  *** Tak1[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30++ min
    *** reqs: Tab2 [KO]
    *** source: 12556483-Fig-5
  *** Tak1[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: HELA in BMS
    *** times: 0 3+ 10++ min
    *** partially reqs: Tab2 [RNAi]
    *** does not req: Tab3 [RNAi]
    *** reqs: Tab2 and/or Tab3 [DRNAi]
    *** source: 14633987-Fig-7a

Mekk3-- ???

  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Mekk3~null> in BMS
    *** times: 0 5++ 15+ min
    *** comment: inhibited by xMekk3(mnr)"KD" [substitution] at 5 min only
    *** comment: reqs xMekk3 [omission] at 5 min only
    *** source: 19843958-Fig-3b

not Nemo--

  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Nemo~null><xNemo> in BMS
    *** times: 0 5++ 20+ min
    *** does not req: xNemo [omission]
    *** unaffected by: xNemo(K285R) [substitution]
    *** source: 19112497-Fig-6a

Traf6--

  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5++ 15+ min
    *** inhibited by: xTraf6(C162A/C165A)"T6mZ2" [substitution]
    *** inhibited by: xTraf6(C189A/C192A)"T6mZ3" [substitution]
    *** unaffected by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-S12c
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5+ 10+ min
    *** reqs: xTraf6 [omission]
    *** bkg inhibited by: xTraf6(C70A) [substitution]
    *** unaffected by: xTraf6(mnr)"K32-518R" [substitution]
    *** source: 19112497-Fig-3d
  *** Tak1[phosAb] phos(T187/S192)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTraf6> in BMLS
    *** times: 0+ 5++ 10++ min
    *** partially inhibited by: xTraf6(C70A)"E3-mutant" [substitution]
    *** source: 22069318-Fig-2b

Ubc13--

  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15+ min
    *** comment: increased at 15 min by removal of Ubc13 [KO]
    *** source: 19843958-Fig-S8a
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15++ min
    *** reqs: Ubc13 [KO]
    *** source: 19843958-Fig-4c

========================
Tak1 required attributes
========================

kinase activity

  *** xTak1[Ab]IP phos[WBMS] is increased irt IL1 (10 min)
    *** cells: HEK293<xIL1R1><xTak1><xTak1> in BMS
    *** inhibited by: xTak1(K63W)"KD" [substitution]
    *** source: 10702308-Fig-3a

phos sites

  *** xTak1[Ab]IP phos[WBMS] is increased irt IL1 (10 min)
    *** cells: HEK293<xIL1R1><xTak1><xTak1> in BMS
    *** inhibited by: xTak1(S192A) [substitution]
    *** source: 10702308-Fig-3a

ubiq sites

  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5+ 10++ 15++ 30++ min
    *** inhibited by: xTak1(K158R) [addition]
    *** source: 20038579-Fig-7b
  *** xTak1[phosAb] phos(T187)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Tak1~null> in BMS
    *** times: 0 5++ 15+ min
    *** unaffected by: xTak1(K172R) [substitution]
    *** partially inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-2a

=========
Chemicals
=========

  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 1+ 1++ 2+ 5+ min
    *** unaffected by: Tautomycin [addition]
    *** unaffected by: CsA [addition]
    *** inhibited by: Okadaic-acid [addition]
    *** inhibited by: CalyculinA [addition]
    *** inhibited by: xPpp6c [addition]
    *** unaffected by: xPpp6c(D84N)"DN" [addition]
    *** source: 17079228(D)

=========
no extras
=========

  *** Tak1[Ab] phos[WBMS] is increased irt IL1 (30 min)
    *** cells: HEK293 in BMS
    *** source: 17197697-Fig-4b
  *** Tak1[Ab] phos[WBMS] is increased irt IL1b (30 min)
    *** cells: HEK293 in BMS
    *** source: 11518704-Fig-6b
  *** Tak1[Ab] phos[WBMS-PPase] is increased irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0 10+ 30++ 60++ min
    *** source: 17197697-Fig-4c
  *** Tak1[Ab] upshift[WBMS] is increased irt IL1b (times)
    *** cells: HEK293<xTLR8> in BMS
    *** times: 0 5+ 15+ 30+ min
    *** source: 16737960-Fig-2e
  *** Tak1[Ab]IP upshift[WBMS] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3+ 15++ min
    *** source: 14633987-Fig-5a
  *** Tak1[Ab]IP phos[WBMS-PPase] is increased irt IL1 (10 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** source: 10702308-Fig-1
  *** xTak1[tAb]IP phos(T178/T184)[phosAb] is increased irt IL1b (5 min)
    *** cells: HELA<xTak1> in BMS
    *** source: 18617512-Fig-4a
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMLS "Tab1 IP"
    *** times: 0 2+ 5++ 10++ 20+ 30+ 40+ 50+ 60+ min
    *** source: 18180283-Fig-5b
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10++ 20++ 30 min
    *** source: 19843958-Fig-3c
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10++ 20++ 30+ min
    *** source: 19843958-Fig-3d
  *** xTak1[tAb]IP phos(T187)[phosAb] is increased irt IL1b (times)
    *** cells: HELA<xTak1> in BMS
    *** times: 0 2+ 5+ 15+ min
    *** source: 20038579-Fig-6c
  *** xTak1[phosAb] phos(T187/S192)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTak1><xUbiq> in BMLS
    *** times: 0+ 5++ 10+ 20++ min
    *** source: 22069318-Fig-1d


