Azi2--

  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293T in BMS
    *** partially reqs: Azi2 [RNAi]
    *** source: 14560022-Fig-7b

not Casp1--

  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: U373 in BMS
    *** unaffected by: Ac-YVAD-CMK [addition]
    *** source: 17360653(D)

inhibited by Cyld--

  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: HEK293T in BMS
    *** inhibited by: xCyld [addition]
    *** source: 12917691-Fig-4a
  *** Nfkb-reporter[Luc] is increased irt IL1b (tnr)
    *** cells: HEK293T in BMS
    *** inhibited by: xCyld [addition]
    *** source: 19675569-Fig-S12a
  *** Nfkb-reporter[Luc] is increased irt IL1b (tnr)
    *** cells: HEK293T in BMS
    *** inhibited by: xCyld [addition]
    *** source: 19675569-Fig-S12b

Erc1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: HELA in BMS
    *** times: 0 30+ 60+ min
    *** partially reqs: Erc1 [RNAi]
    *** source: 15218148-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt IL1 (4 hr)
    *** cells: HELA in BMS
    *** reqs: Erc1 [RNAi]
    *** source: 15218148-Fig-3c

Ikba-- phos -> degradation

  *** Nfkb-reporter[Luc] is increased irt IL1b (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** inhibited by: xIkba(S32A/S36A)"SR" [addition]
    *** source: 17360530-Fig-5b

Ikk1--

  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: mEFs in BMS
    *** reqs: Ikk1 [KO]
    *** source: 17244613-Fig-2d
  --------------------------------------------------------------
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: HELA in BMS
    *** times: 0 2 5 10+ 20++ 60+++ min
    *** partially reqs: Ikk1 [RNAi]
    *** source: 12547194(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** times: 0 15++ 30+ 60 min
    *** partially reqs: Ikk1 [KO]
    *** source: 17244613-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: mEFs in BMS
    *** bkg reqs: Ikk1 [KO]
    *** source: 11733537-Fig-1b
  --------------------------------------------------------------
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (20 min)
    *** cells: mEFs in BMS
    *** does not req: Ikk1 [KO]
    *** source: 11733537-Fig-3b
  --------------------------------------------------------------
  *** Nfkb-reporter[Luc] is increased irt IL1 (4 hr)
    *** cells: HELA in BMS
    *** inhibited by: xIkk1 [addition]
    *** unaffected by: xIkk1(mnr)"KD" [addition]
    *** source: 11864612-Fig-1a

Ikk2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: HELA in BMS
    *** times: 0 2 5 10+ 20++ 60+++ min
    *** partially reqs: Ikk2 [RNAi]
    *** source: 12547194(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (20 min)
    *** cells: mEFs in BMS
    *** partially reqs: Ikk2 [KO]
    *** source: 11733537-Fig-3b
  --------------------------------------------------------------
  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: mEFs in BMS
    *** bkg reqs: Ikk2 [KO]
    *** source: 11733537-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt IL1 (4 hr)
    *** cells: HELA in BMS
    *** unaffected by: xIkk2 [addition]
    *** bkg inhibited by: xIkk2(mnr)"KD" [addition]
    *** source: 11864612-Fig-1a
  --------------------------------------------------------------
  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: mEFs in BMS
    *** does not req: Ikk2 [KO]
    *** source: 17244613-Fig-3d
  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: mEFs in BMS
    *** does not req: Ikk2 [KO]
    *** source: 17244613-Fig-2d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** times: 0 15++ 30+ 60 min
    *** does not req: Ikk2 [KO]
    *** source: 17244613-Fig-2a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** times: 0 15++ 60 min
    *** does not req: Ikk2 [KO]
    *** source: 17244613-Fig-3c

Ikk1 and/or Ikk2

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: HELA in BMS
    *** times: 0 2 5 10+ 20++ 60+++ min
    *** partially reqs: Ikk1 and/or Ikk2 [RNAi]
    *** source: 12547194(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 60+ min
    *** reqs: Ikk1 and/or Ikk2 [DKO]
    *** source: 10898787-Fig-2a

IL1R1-- and IL1Rap-- and IL1a--

  *** Nfkb-reporter[Luc] is increased irt IL1a (6 hr)
    *** cells: JURKAT-E6.1<xIL1R1><xIL1Rap> in BMS
    *** source: 11046021-Table-1
  *** Nfkb-reporter[Luc] is increased irt IL1a (6 hr)
    *** cells: JURKAT-E6.1<xIL1R1><xIL1Rap> in BMS
    *** source: 11046021-Fig-1a

IL1R1-- and IL1Rap-- and IL1b--

  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: JURKAT-E6.1<xIL1R1><xIL1Rap> in BMS
    *** source: 11046021-Table-1
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: JURKAT-E6.1<xIL1R1><xIL1Rap> in BMS
    *** source: 11046021-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt IL1b (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** reqs: IL1R1 [RNAi]
    *** source: 17360530-Fig-5b

Irak1--

  *** Nfkb-reporter[Luc] is increased irt IL1b (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** reqs: Irak1 [RNAi]
    *** source: 17360530-Fig-1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (15 min)
    *** cells: HEK293 in BMS
    *** reqs: Irak1 [null-mut]
    *** source: 10373513-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: HEK293 in BMS
    *** reqs: Irak1 [null-mut]
    *** source: 10373513-Fig-3b
  *** Nfkb-reporter[Luc] is increased irt IL1b (5 hr)
    *** cells: mEFs<Irak1~null> in BMS
    *** bkg reqs: Irak1 [KO]
    *** source: 18347055-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt IL1b (20 hr)
    *** cells: EL4 in BMS
    *** enhanced by: xIrak1 [addition]
    *** enhanced by: xIrak1(K239S)"KD" [addition]
    *** source: 10217414-Fig-2
  --------------------------------------------------------------------
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null><xIrak1(K239A)"KD"> in BMS
    *** times: 0 10+ 30+ 60+ min
    *** reqs: xIrak1(K239A)"KD" [omission]
    *** unaffected by: xIrak1(K239A/S131A/S137A/S138A/S140A/T141A/S144A) [substitution]
    *** unaffected by: xIrak1(K239A/K32R/K134R/K179R) [substitution]
    *** source: 17197697-Fig-3b

Irak1--

  *** Nfkb-reporter[Luc] is increased itpo (xIL1R1 + xIL1Rap)
    *** cells: HEK293T in BMS
    *** inhibited by: xIrak2(97-590)"DN" [addition]
    *** source: 9374458-Fig-2b,4a,4c

Irak4--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30++ min
    *** unaffected by: xIrak4(K213M/K214M)"KD" [addition]
    *** source: 17470642-Fig-6f
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs<Irak4~null><xIrak4> in BMS
    *** times: 0 10+ 30+ 60 min
    *** inhibited by: xIrak4(mnr)"KD" [substitution]
    *** source: 15292196(D)
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: mEFs<Irak4~null><xIrak4> in BMS
    *** inhibited by: xIrak4(mnr)"KD" [substitution]
    *** source: 15292196(D)
  *** Nfkb-reporter[Luc] is increased irt IL1b (8 hr)
    *** cells: mEFs in BMS
    *** inhibited by: kIrak4(K213A/K214A)"KD" [substitution]
    *** source: 17337443-Fig-4a

not Ksr1--

  *** Nfkb-reporter[Luc] is increased irt IL1b (16 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xKsr2 [addition]
    *** source: 16039990-Fig-3b

not Mekk1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mESCs in BMS
    *** times: 0 10 30+ 60+ min
    *** enhanced by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 10805784-Fig-3b

Mekk2-- req at > 60 min

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0 15+ 60+ 120+ min
    *** comment: reqs Mekk2 [RNAi] at 60,120 min
    *** source: 14636585-Fig-6b

Mekk3-- ???

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** does not req: Mekk3 [KO]
    *** source: 17197697-Fig-5d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10 20 40+ 60+ min
    *** reqs: Mekk3 [KO]
    *** source: 14661019-Fig-3g
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs<xTLR8> in BMS
    *** times: 0 15+ 30+ min
    *** does not req: Mekk3 [KO]
    *** source: 16737960-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs<Mekk2~null> in BMS "on gelatin"
    *** times: 0 15+ 60 120 min
    *** reqs: Mekk3 [KO]
    *** source: 14636585-Fig-6b
  *** Nfkb-reporter[Luc] is increased irt IL1b (12 hr)
    *** cells: mEFs in BMS
    *** inhibited by: xMekk3(mnr)"DN" [addition]
    *** source: 14661019-Fig-3d
  *** Nfkb-reporter[Luc] is increased irt IL1 (12 hr)
    *** cells: mEFs in BMS
    *** reqs: Mekk3 [KO]
    *** source: 11429546-Fig-S1
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** times: 0 15++ 30+ 60+ min
    *** reqs: Mekk3 [KO]
    *** source: 19843958-Fig-S11

Myd88--

  *** Nfkb-reporter[Luc] is increased irt IL1b (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** reqs: Myd88 [RNAi]
    *** source: 17360530-Fig-1a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (15 min)
    *** cells: HEK293 in BMS
    *** reqs: Myd88 [null-mut]
    *** source: 10373513-Fig-3a
  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: HEK293 in BMS
    *** reqs: Myd88 [null-mut]
    *** source: 10373513-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (45 min)
    *** cells: hMDMacs in BMS
    *** inhibited by: xMyd88(F56N/del(1-53))"DN" [addition]
    *** source: 14630816(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (45 min)
    *** cells: hSNFs in BMS
    *** inhibited by: xMyd88(F56N/del(1-53))"DN" [addition]
    *** source: 14630816(D)
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293<xTLR4> in BMS
    *** partially inhibited by: xMyd88(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xMyd88(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293<xIL1R1> in BMS
    *** inhibited by: xMyd88(del(1-151))"DN" [addition]
    *** inhibited by: xMyd88(F56N)"DN" [addition]
    *** source: 9575168(D)
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293<xIL1R1> in BMS
    *** inhibited by: xMyd88(mnr)"TIR" [addition]
    *** source: 10854325-Fig-5a
  *** Nfkb-reporter[Luc] is increased itpo (xIL1R1 + xIL1Rap)
    *** cells: HEK293T in BMS
    *** inhibited by: xMyd88(152-296)"DN" [addition]
    *** source: 9374458-Fig-2b,4a,4c

Nemo--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** times: 0 15++ 30+ 60 min
    *** reqs: Nemo [KO]
    *** source: 17244613-Fig-2a
  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: mEFs in BMS
    *** reqs: Nemo [KO]
    *** source: 17244613-Fig-2d
  *** Nfkb-reporter[Luc] is increased irt IL1b (5 hr)
    *** cells: mEFs<Nemo~null><xNemo> in BMS
    *** reqs: xNemo [omission]
    *** inhibited by: xNemo(L329P)"impaired-K63-Ubiq-binding-mut" [substitution]
    *** source: 18347055-Fig-2e
  *** Nfkb-reporter[Luc] is increased irt IL1b (16 hr)
    *** cells: mEFs in BMS
    *** bkg reqs: Nemo [KO]
    *** source: 18180283-Fig-2
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (15 min)
    *** cells: mEFs<Ikk2~null> in BMS "nuclear-extracts"
    *** comment: inhibited by pretreatment with a "Nemo-binding-domain" peptide
    *** source: 17244613-Fig-6b

not Nfkbiz--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 30++ 60+ 120+ 180+ 240+ min
    *** does not req: Nfkbiz [KO]
    *** source: 15241416-Fig-S3a

not Nik--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15++ 30++ 60+ min
    *** does not req: Nik [KO]
    *** source: 11251123-Fig-1b
  *** Nfkb-reporter[Luc] is increased itpo (xIL1R1 + xIL1Rap)
    *** cells: HEK293T in BMS
    *** partially inhibited by: xNik(K429A/K430A)"DN" [addition]
    *** source: 9374458-Fig-2b,4a,4c


Peli1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0 2+ 4++ 8+++ hr
    *** partially reqs: Peli1 [RNAi]
    *** source: 12496252-Fig-3a

Pin1--

  *** Nfkb-reporter[Luc] is increased irt IL1b (tnr)
    *** cells: mEFs in BMS
    *** reqs: Pin1 [KO]
    *** source: 14690596-Fig-5a,5b

not Pkca--

  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: HEPG2 in BMS
    *** unaffected by: xPkca(mnr)"DN" [addition]
    *** source: 10747026-Fig-1

Pkcz--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (30 min)
    *** cells: mEFs in BMS
    *** reqs: Pkcz [KO]
    *** source: 11684013-Fig-3c
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: mEFs in BMS
    *** reqs: Pkcz [KO]
    *** source: 11684013-Fig-2b

Rela--

  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: HEK293<xIL1R1> in BMS
    *** enhanced by: xRela [addition]
    *** source: 15489227(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (10 min)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** unaffected by: xRela(S276A) [substitution]
    *** source: 12559944-Fig-3b
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** reqs: xRela [omission]
    *** enhanced by: xRela(S468A) [substitution]
    *** source: 16046471-Fig-5b

not Ripk1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30+ 60 min
    *** does not req: Ripk1 [KO]
    *** source: 12654725-Fig-2d
  *** Nfkb-reporter[Luc] is increased irt IL1b (12 hr)
    *** cells: mEFs in BMS
    *** does not req: Ripk1 [KO]
    *** source: 12654725-Fig-7a

not Smad2--

  *** Nfkb-reporter[Luc] is increased irt IL1b (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** does not req: Smad2 [RNAi]
    *** source: 17360530-Fig-5b

not Socs1--

  *** Nfkb-reporter[Luc] is increased irt IL1b (tnr)
    *** cells: NotReported in BMS
    *** inhibited by: xSocs1 [addition]
    *** source: 14690596-Fig-7d

Sqstm1--

  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: HEPG2 in BMS
    *** reqs: Sqstm1 [AntiSense]
    *** source: 10747026-Fig-1

not Tab1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40+ min
    *** does not req: Tab1 [KO]
    *** source: 16260493(D)

Tab2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ min
    *** does not req: Tab2 [KO]
    *** source: 12556483-Fig-4a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40+ min
    *** does not req: Tab2 [KO]
    *** source: 16260493(D)

Tab3--

  *** Nfkb-reporter[Luc] is increased irt IL1b (21 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTab3(1-392)"Nterm" [substitution]
    *** inhibited by: xTab3(393-712)"Cterm" [substitution]
    *** source: 14633987-Fig-3b

Tak1--  protein expression

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: HELA in BMS
    *** times: 0 2 5 10+ 20++ 60+++ min
    *** reqs: Tak1 [RNAi]
    *** source: 12547194(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs<xTLR8> in BMS
    *** times: 0 15+ 30+ min
    *** partially reqs: Tak1 [KO]
    *** source: 16737960-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40+ min
    *** partially reqs: Tak1 [KO]
    *** source: 16260493(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ 60+ min
    *** comment: reqs Tak1 [KO] at 10 min only
    *** source: 17197697-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** reqs: xTak1 [omission]
    *** source: 20038579-Fig-7d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS "nuclear-extracts"
    *** times: 0 15+ 30++ 60++ min
    *** comment: reqs xTak1 [omission] at 15-30 min
    *** source: 19843958-Fig-S13b

Tak1--  kinase activity

  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: HELA in BMS
    *** inhibited by: xTak1(K63W)"KD" [addition] no-bkg-control
    *** source: 11050078-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt IL1 (tnr)
    *** cells: HEK293 in BMS
    *** partially inhibited by: xTak1(K63W) [addition] no-bkg-control
    *** source: 10094049-Fig-2b
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293<xIL1R1> in BMLS
    *** unaffected by: xTak1(K63W) [addition]
    *** source: 22069318-Fig-5a
  *** Nfkb-reporter[Luc] is increased irt IL1b (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** partially inhibited by: Tak1(mnr)"DN" [addition]
    *** inhibited by: Traf6(mnr)"DN" [addition]
    *** source: 17360530-Fig-1b

Tak1-- phos site T178

  *** Nfkb-reporter[Luc] is increased irt IL1b (12 hr)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** partially inhibited by: xTak1(T178A) [substitution]
    *** unaffected by: xTak1(T184A) [substitution]
    *** inhibited by: xTak1(T178A/T184A) [substitution]
    *** unaffected by: xTak1(T178E/T184E) [substitution]
    *** source: 18617512-Fig-4b

Tak1-- ubiq site K34

  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293<xIL1R1> in BMLS
    *** inhibited by: xTak1(K34R) [addition]
    *** source: 22069318-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293<xIL1R1> in BMLS
    *** inhibited by: xTak1(K34R) [addition]
    *** source: 22069318-Fig-5a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS "nuclear-extracts"
    *** times: 0 15+ 30++ 60+ min
    *** unaffected by: xTak1(K34R) [substitution]
    *** source: 19843958-Fig-2g

Tak1-- other sites

  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** inhibited by: xTak1(K158R) [substitution]
    *** source: 20038579-Fig-7d
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** unaffected by: xTak1(K34R) [substitution]
    *** unaffected by: xTak1(K52R/K54R) [substitution]
    *** unaffected by: xTak1(K58R) [substitution]
    *** inhibited by: xTak1(K63R) [substitution]
    *** unaffected by: xTak1(K72R) [substitution]
    *** unaffected by: xTak1(K91R) [substitution]
    *** unaffected by: xTak1(K150R) [substitution]
    *** inhibited by: xTak1(K158R) [substitution]
    *** unaffected by: xTak1(K172R) [substitution]
    *** unaffected by: xTak1(K190R) [substitution]
    *** unaffected by: xTak1(K209R) [substitution]
    *** unaffected by: xTak1(K227R) [substitution]
    *** unaffected by: xTak1(K253R) [substitution]
    *** unaffected by: xTak1(K257R) [substitution]
    *** unaffected by: xTak1(K269R) [substitution]
    *** unaffected by: xTak1(K282R) [substitution]
    *** source: 20038579-Fig-4d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS "nuclear-extracts"
    *** times: 0 15+ 30+ 60+ min
    *** comment: reqs xTak1 [omission] at 15 min only
    *** unaffected by: xTak1(K172R) [substitution]
    *** comment: inhibited by xTak1(K209R) [substitution] at 15 min only
    *** source: 19843958-Fig-2a

not Tbk1--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 1+ 3+ 9+ 27+ 90+ min
    *** does not req: Tbk1 [KO]
    *** source: 10990461-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: HEK293<xIL1R1> in BMS
    *** enhanced by: xTbk1 [addition]
    *** source: 15489227(D)
  *** Nfkb-reporter[Luc] is increased irt IL1 (5 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTbk1(K38A) [addition]
    *** source: 10581243-Fig-9a

not TgfbR1--  or TgfbR2--

  *** Nfkb-reporter[Luc] is increased irt IL1b (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** does not req: TgfbR1 [RNAi]
    *** does not req: TgfbR2 [RNAi]
    *** source: 17360530-Fig-5b

not Ticam2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+++ 30++ 60+ min
    *** does not req: Ticam2 [KO]
    *** source: 14556004(D)
  *** Nfkb-reporter[Luc] is increased irt IL1b (8 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTicam2(C113H)"DN" [addition]
    *** source: 14517278-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xTicam2(78-171)"DN" [addition]
    *** source: 12721283-Fig-5b

Tifa--

  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEPG2 in BMS
    *** inhibited by: xTifa(G50E/S66A) [addition]
    *** source: 12566447-Fig-6a

Tirap--  ???

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (45 min)
    *** cells: hSNFs in BMS
    *** partially inhibited by: xTirap(P125H)"DN" [addition]
    *** source: 14630816(D)
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293<xTLR4> in BMS
    *** unaffected by: xTirap(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: RAW2647 in BMS
    *** unaffected by: xTirap(mnr)"TIR-domain" [addition]
    *** source: 11544529-Fig-4c
  *** Nfkb-reporter[Luc] is increased itpo (xIL1R1 + xIL1Rap)
    *** cells: HEK293T in BMS
    *** unaffected by: xTirap(P125H)"DN" [addition]
    *** source: 11526399(D)

not Tollip--

  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: mEFs in BMS
    *** does not req: Tollip [KO]
    *** source: 16428431(D)
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293<xIL1R1> in BMS
    *** partially inhibited by: xTollip [addition]
    *** repressed by: Tollip [AntiSense]
    *** source: 10854325-Fig-5a

not TLR1--

  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTLR1 [addition]
    *** source: 17360530-Fig-4


not TLR2--

  *** Nfkb-reporter[Luc] is increased irt IL1b (5 hr)
    *** cells: HEK293 in BMS "containing Md2 conditioned medium"
    *** unaffected by: xTLR2 [addition]
    *** source: 12324469(D)
  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTLR2 [addition]
    *** source: 17360530-Fig-4

not TLR4--

  *** Nfkb-reporter[Luc] is increased irt IL1b (5 hr)
    *** cells: HEK293 in BMS "containing Md2 conditioned medium"
    *** unaffected by: xTLR4 [addition]
    *** source: 12324469(D)

not TLR5--

  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTLR5 [addition]
    *** source: 17360530-Fig-4

not TLR6--

  *** Nfkb-reporter[Luc] is increased irt IL1b (4 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTLR6 [addition]
    *** source: 17360530-Fig-4


not Tpl2--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mBMMs in BMS
    *** times: 0 15++ 30+ 60+ min
    *** does not req: Tpl2 [KO]
    *** source: 15833743-Fig-1b

not Traf2-- or Traf5--

  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTraf2(87-501)"DN" [addition]
    *** source: 8565075-Fig-6b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ min
    *** does not req: Traf2 [KO]
    *** does not req: Traf5 [KO]
    *** does not req: Traf2 or Traf5 [DKO]
    *** source: 11479302-Fig-1a
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTraf2(289-522)"DN" [addition]
    *** source: 8837778-Fig-3b

Traf6--

  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ 90 hr
    *** reqs: Traf6 [KO]
    *** source: 10215628-Fig-5a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 7+ 15+ min
    *** reqs: xTraf6 [omission]
    *** inhibited by: xTraf6(C70A)"E3-mut" [substitution]
    *** source: 18347055-Fig-3f
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xTraf6(87-502)"DN" [addition]
    *** source: 8837778-Fig-3b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 15+ 30++ 60++ min
    *** comment: inhibited by xTraf6(110-522)"T6dR" [substitution] at 15 min only
    *** comment: inhibited by xTraf6(C242A/C249A)"T6mZ5" [substitution] at 60 min only
    *** source: 19843958-Fig-5a
  *** Nfkb-reporter[Luc] is increased itpo (xIL1R1 + xIL1Rap)
    *** cells: HEK293T in BMS
    *** inhibited by: xTraf6(289-522)"DN" [addition]
    *** unaffected by: xTraf2(87-501)"DN" [addition]
    *** source: 9374458-Fig-2b,4a,4c


Ubc13--

  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xUbc13(C87A)"DN" [addition]
    *** source: 11057907(D)

inhibited by Usp5--

  *** Nfkb-reporter[Luc] is increased irt IL1b (tnr)
    *** cells: HEK293T in BMS
    *** inhibited by: xUsp5 [addition]
    *** source: 19675569-Fig-S12a
  *** Nfkb-reporter[Luc] is increased irt IL1b (tnr)
    *** cells: HEK293T in BMS
    *** inhibited by: xUsp5 [addition]
    *** source: 19675569-Fig-S12b

not Usp21--

  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HELA in BMS
    *** unaffected by: xUsp21 [addition]
    *** unaffected by: xUsp21(C221A)"CIA" [addition]
    *** source: 19910467-Fig-S3

not Zfand5--

  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xZfand5 [addition]
    *** source: 14754897-Fig-4a

chemicals

  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293<xIL1R1> in BMLS
    *** inhibited by: Cl-Radicicol-A [pretreatment]
    *** source: 22069318-Fig-5c
  *** Nfkb-reporter[Luc] is increased irt IL1 (tnr)
    *** cells: HELA in BMS
    *** inhibited by: Geldanamycin [addition]
    *** source: 11864612-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: BD-FMK [addition]
    *** source: 10753878-Fig-4c
  *** Nfkb-reporter[Luc] is increased irt IL1b (5 hr)
    *** cells: HEK293 in BMS "containing Md2 conditioned medium"
    *** unaffected by: Brefeldin-A [addition]
    *** source: 12324469(D)
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293T in BMS
    *** bkg inhibited by: Curcumin [addition]
    *** unaffected by: SB203580 [addition]
    *** source: 18456659-Fig-7a
  *** Nfkb-reporter[Luc] is increased itpo (xIL1b + xIL1R1)
    *** cells: HEK293T in BMS
    *** partially inhibited by: xMyd88(1-109)"DN" [addition]
    *** unaffected by: Lps (16 hr) [stim]
    *** source: 11058605-Fig-1b

no extras

  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-3a
  *** Nfkb[RE] oligo-binding[EMSA] is unchanged irt IL1 (45 min)
    *** cells: mPECs in BMS
    *** source: 14630816(D)
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293 in BMS
    *** source: 10346818-Fig-2e
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTLR8> in BMS
    *** times: 0 5+ 15+ 30+ min
    *** source: 16737960-Fig-1b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ min
    *** source: 16186825(D)
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (times)
    *** cells: mKidneyCells in BMS
    *** times: 0 15+ 30+ min
    *** source: 16737960-Fig-1d
  *** Nfkb-reporter[Luc] is increased irt IL1 (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xTnfaip3 [addition]
    *** source: 8692885-Fig-5
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1b (1 hr)
    *** cells: HEK293<xIL1R1> in BMS
    *** source: 9371760-Fig-1b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0 10+ 30+ 60 min
    *** source: 17197697-Fig-3b
  *** Nfkb-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: xBtrc(mnr)"F-box-deletion-mutant" [addition]
    *** source: 9990853-Fig-3b
  *** Nfkb-reporter[SAP] is increased irt IL1b (16 hr)
    *** cells: NIH3T3 in BMS
    *** source: 10191251-Fig-2a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6(C242A/C249A)"T6mZ5"> in BMS "nuclear-extracts"
    *** times: 0 6 12 24+ hr
    *** source: 19843958-Fig-S15b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6(C242A/C249A)"T6mZ5"> in BMS "nuclear-extracts"
    *** times: 0 30++ 60+ 90++ 120++ 150++ 180 210++ 240+ 270+ 300+ 330+ min
    *** source: 19843958-Fig-S15a
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS "nuclear-extracts"
    *** times: 0 6++ 12+ 24+ hr
    *** source: 19843958-Fig-S15b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS "nuclear-extracts"
    *** times: 0 30+++ 60++ 90+ 120++ 150++ 180++ 210+ 240+ 270+ 300+ 330+ min
    *** source: 19843958-Fig-S15a







