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Coprecipitation with other proteins in IL1R1 complex
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not Ikk2--  does not require kinase activity or phos sites

  *** Mekk3[Ab] copptby[WB] xIkk2[tAb] is increased irt IL1a (5 min)
    *** cells: mEFs<Ikk2~null><xIkk2> in BMS "on gelatin"
    *** unaffected by: xIkk2(K44M)"KD" [substitution]
    *** source: 14636585-Fig-4b
  *** Mekk3[Ab] copptby[WB] xIkk2[tAb] is increased irt IL1a (5 min)
    *** cells: mEFs<Ikk2~null><xIkk2> in BMS "on gelatin"
    *** unaffected by: xIkk2(K44M)"KD" [substitution]
    *** unaffected by: xIkk2(K44M/S177A/S181A) [substitution]
    *** unaffected by: xIkk2(S177E/S181E) [substitution]
    *** source: 14636585-Fig-4c

requirement for Tak1 K209R K63 ubiq site

  *** Mekk3[Ab] copptby[WB] xTak1[Ab] is increased irt IL1 (times)
    *** cells: mEFs<Tak1~null> in BMS
    *** times: 0 10+ 20 min
    *** inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-3h

reqs Traf6--  ???

  *** Mekk3[Ab] copptby[WB] Tak1[Ab] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 10+ 20+ min
    *** bkg reqs: xTraf6 [omission]
    *** source: 19843958-Fig-3e
  *** Mekk3[Ab] copptby[WB] Traf6[Ab] is increased irt IL1 (10 min)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** reqs: xTak1 [omission]
    *** inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-3g

no extras

  *** Mekk3[Ab] copptby[WB] Tak1[Ab] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10+ 20 30 min
    *** source: 19843958-Fig-3d
  *** Mekk3[Ab] copptby[WB] Ikk1[Ab] is increased irt IL1a (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** reqs: Ikba [KO]
    *** source: 14636585-Fig-2f
  *** Mekk3[Ab] copptby[WB] Ikk1[Ab] is increased irt IL1a (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** reqs: Ikk2 [KO]
    *** source: 14636585-Fig-2f
  *** Mekk3[Ab] copptby[WB] Ikk2[Ab] is increased irt IL1a (5 min)
    *** cells: mEFs in BMS "on gelatin"
    *** reqs: Ikba [KO]
    *** source: 14636585-Fig-2e
  *** Mekk3[Ab] copptby[WB] Ikk2[Ab] is increased irt IL1a (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0 5+ 60 min
    *** source: 14636585-Fig-3b
  *** Mekk3[Ab] copptby[WB] Traf6[Ab] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 5 10+ 20++ 40 min
    *** source: 14661019-Fig-3i

reqs Ubc13 at later times

  *** Mekk3[Ab] copptby[WB] Tak1[Ab] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20++ min
    *** comment: reqs Ubc13 [KO] at 20 min only
    *** source: 19843958-Fig-4d



