=======================
needs location evidence
=======================

Irak4--

  *** Jun[phosAb] phos(S63/S73)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ min
    *** reqs: Irak4 [KO]
    *** source: 11923871(D)

Jnk1-- and/or Jnk2--

  *** Jun[phosAb] phos(S63)[phosAb] is increased irt IL1a (2 hr)
    *** cells: mEFs in BMLS
    *** reqs: Jnk1 and/or Jnk2 [KO]
    *** inhibited by: kJun(S63A/S73A) [substitution]
    *** source: 18443042-Fig-1b

Tak1--

  *** Jun[phosAb] phos(S63/S73)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40+ min
    *** reqs: Tak1 [KO]
    *** source: 16260493(D)

other

  *** Jun[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (times)
    *** cells: 3T3L1 in BMS "differentiated into adipocytes"
    *** times: 0 5 10+ 15+ 30+ 60 120 360 720 min
    *** source: 17500068-Fig-5b
  *** Jun[phosAb] phos(S63)[phosAb] is increased irt IL1a (2 hr)
    *** cells: MRC5 in BMS
    *** inhibited by: SP600125 [addition]
    *** source: 18443042-Fig-4b
  *** Jun[phosAb] phos(S63)[phosAb] is increased irt IL1a (times)
    *** cells: MRC5 in BMS
    *** times: 0 30++ 60+ 120++ 180++ 240+ 360 min
    *** source: 18443042-Fig-4a
  *** Jun[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (15 min)
    *** cells: MRC5 in BMS
    *** source: 19181383-Fig-7a
  *** Jun[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (15 min)
    *** cells: MRC5 in BMS
    *** source: 19181383-Fig-7b
  *** Jun[phosAb] phos(S63)[phosAb] is increased irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** unaffected by: Gefitinib [cotreatment]
    *** unaffected by: BMS345541 [cotreatment]
    *** unaffected by: PD325901 [cotreatment]
    *** unaffected by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1

==========================
evidence of Jun activation
==========================

  *** Jun[Ab] boundto(CcL2-gene)[ChIP] is increased irt IL1a (2 hr)
    *** cells: mEFs in BMLS
    *** source: 18443042-Fig-3c
  *** Jun[Ab] boundto(CcL2-gene)[ChIP] is increased irt IL1a (2 hr)
    *** cells: MRC5 in BMS
    *** comment: bound Jun is phosed on S73 irt IL1a stim but is not req for binding
    *** source: 18443042-Fig-4a

==================================================================
Jun is already bound to CcL2-promo in cells growing in 10% serum
and is not increased irt IL1a
==================================================================

  *** Jun[Ab] boundto(CcL2-gene)[ChIP] is unchanged irt IL1a (2 hr)
    *** cells: mEFs in BMS
    *** source: 18443042-Fig-3c
