not Ikk1--

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** does not req: Ikk1 [KO]
    *** source: 17197697-Fig-7c

not Ikk2--

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** does not req: Ikk2 [KO]
    *** source: 17197697-Fig-7b
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs<Ikk2~null><xIkk2> in BMS
    *** does not req: xIkk2 [omission]
    *** unaffected by: xIkk2(mnr)"KD" [substitution]
    *** source: 17197697-Fig-7b

not Ikk1 or Ikk2

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15++ min
    *** does not req: Ikk1 or Ikk2 [DKO]
    *** source: 16737960-Fig-4f
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15+ min
    *** does not req: Ikk1 or Ikk2 [DKO]
    *** source: 17197697-Fig-7d

Irak1--

  protein expression

  *** Jnk1[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (10 min)
    *** cells: mEFs in BMLS
    *** reqs: Irak1 [KO]
    *** source: 9625767(D)
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (tnr)
    *** cells: HEK293 in BMS
    *** reqs: Irak1 [null-mut]
    *** source: 10373513-Fig-7b
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (tnr)
    *** cells: HEK293I1A<Irak1~null><xIrak1> in BMS
    *** reqs: xIrak1 [omission]
    *** source: 10373513-Fig-7a

  kinase domain

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt IL1a (30 min)
    *** cells: HEK293 in BMS
    *** inhibited by: xIrak1(del(218-507))"DN" [addition]
    *** source: 10346818-Fig-1a

  not kinase activity ???

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (tnr)
    *** cells: HEK293I1A<Irak1~null><xIrak1> in BMS
    *** unaffected by: xIrak1(K239A)"KD" [substitution]
    *** source: 10373513-Fig-7a
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (15 min)
    *** cells: EL4 in BMS
    *** enhanced by: xIrak1 [addition]
    *** enhanced by: xIrak1(K239S)"KD" [addition]
    *** source: 10217414-Fig-3a
  -----------------------------------------------------------------------
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null> in BMS
    *** times: 0 10+ 30+ 120+ min
    *** source: 17197697-Fig-3e
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null><xIrak1(K239A)"KD"> in BMS
    *** times: 0 10+ 30++ 60+ min
    *** source: 17197697-Fig-3e
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null><xIrak1(K239A/S131A/S137A/S138A/S140A/T141A/S144A)> in BMS
    *** times: 0 10++ 30+ 60+ min
    *** source: 17197697-Fig-3e
  *** Jnks[phosAb] phos(TPY)[phosAb] is unchanged irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null><xIrak1(K239A/K32R/K134R/K179R)> in BMS
    *** times: 0 10 30 60 min
    *** source: 17197697-Fig-3e


Irak4--

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (times)
    *** cells: mEFs<Irak4~null><xIrak4> in BMS
    *** times: 0 10+++ 30++ 60 min
    *** inhibited by: xIrak4(mnr)"KD" [substitution]
    *** source: 15292196(D)
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ min
    *** reqs: Irak4 [KO]
    *** source: 11923871(D)
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ min
    *** inhibited by: xIrak4(K213M/K214M) [addition]
    *** source: 17337443-Fig-3a
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: hFibros<Irak4~null> in BMS
    *** times: 0  10+ 20+ min
    *** reqs: Irak4 [KO]
    *** unaffected by: xIrak4(K213A/K214A) [addition]
    *** source: 15084582(D)
  ---------------------------------------------------------------
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30+ min
    *** unaffected by: xIrak4(K213M/K214M) [addition]
    *** source: 17470642-Fig-6e

Mekk1--

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: mESCs in BMS
    *** times: 0 10+ 30+ 60 min
    *** inhibited by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 10805784-Fig-2

not Mekk3--  ????

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1a (times)
    *** cells: mEFs in BMLS
    *** times: 0 10++ 15++ 30+ min
    *** does not req: Mekk3 [KO]
    *** source: 18021073-Fig-8b
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ 40 60 min
    *** reqs: Mekk3 [KO]
    *** source: 14661019(D)
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** does not req: Mekk3 [KO]
    *** source: 17197697-Fig-5d

Mkk4/Mkk7--

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10++ 15++ 30+ 60 min
    *** bkg reqs: Mkk4 [KO]
    *** reqs: Mkk7 [KO]
    *** reqs: Mkk4 and/or Mkk7 [DKO]
    *** source: 11390361-Fig-5b

not Mlk3--

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5 8+ 10++ 12++ 15++ 30+ 60 min
    *** does not req: Mlk3 [KO]
    *** source: 15831472(D)

Myd88--

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (tnr)
    *** cells: HEK293 in BMS
    *** reqs: Myd88 [null-mut]
    *** source: 10373513-Fig-7b
  *** xJnk?[phosAb] phos(TPY)[phosAb] is increased irt IL1b (tnr)
    *** cells: HEK293<xIL1R1> in BMS
    *** inhibited by: xMyd88(mnr)"TIR" [addition]
    *** source: 10854325-Fig-5a


not Nik--

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (10 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** unaffected by: xNik(K429A/K430A) [addition]
    *** source: 10094049-Fig-2c


not Nfkbiz--

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30+ 60 min
    *** does not req: Nfkbiz [KO]
    *** source: 15241416-Fig-S3b

not Ripk1--

  *** Jnks[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ 90+ min
    *** does not req: Ripk1 [KO]
    *** source: 9529147-Fig-6b
  *** Jnk1[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10+ 15++ min
    *** does not req: Ripk1 [KO]
    *** source: 12776182-Fig-1c
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30 min
    *** does not req: Ripk1 [KO]
    *** source: 15833743-Fig-3b
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 30 min
    *** does not req: Ripk1 [KO]
    *** source: 15064760-Fig-5b

not Tab1--

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30+ 60 120 240 min
    *** does not req: Tab1 [KO]
    *** source: 16260493(D)

Tab2-- or Tab3--

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30+ 60 120 240 min
    *** does not req: Tab2 [KO]
    *** source: 16260493(D)
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 20+ min
    *** does not req: Tab2 [KO]
    *** source: 12556483-Fig-4b
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 20+ min
    *** does not req: Tab2 [KO]
    *** source: 12556483-Fig-4b
  *** Jnk1[Ab] phos[WBMS] is increased irt IL1b (10 min)
    *** cells: HELA in BMS
    *** partially reqs: Tab2 [RNAi]
    *** partially reqs: Tab3 [RNAi]
    *** reqs: Tab2 and/or Tab3 [DRNAi]
    *** source: 14633987-Fig-7c

Tak1--

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30+ 60 120 240 min
    *** reqs: Tak1 [KO]
    *** source: 16260493(D)
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 20++ 30+ min
    *** reqs: Tak1 [KO]
    *** source: 16186825(D)
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30++ 60 min
    *** reqs: Tak1 [KO]
    *** source: 17197697-Fig-5a
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Tak1~null> in BMS
    *** times: 0+ 5++ 10++ 15++ 30+ min
    *** enhanced by: xTak1 [addition]
    *** partially inhibited by: xTak1(K158R) [addition]
    *** source: 20038579-Fig-7b

  requires Tak1 kinase activity

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (30 min)
    *** cells: HELA in BMS
    *** inhibited by: xTak1(K63W) [addition]
    *** source: 11050078-Fig-5b
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (10 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** inhibited by: xTak1(K63W)"KD" [addition]
    *** source: 10094049-Fig-2c
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** inhibited by: 5Z7Oxozeaenol [addition]
    *** source: 17197697-Fig-7c

  requires Tak1 T187

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5+ 20+ min
    *** bkg reqs: xTak1 [omission]
    *** inhibited by: xTak1(T187A) [substitution]
    *** source: 19112497-Fig-S2

  requires Tak1 T178 T184

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5+ 10++ 15++ 30+ min
    *** partially reqs: xTak1 [omission]
    *** partially inhibited by: xTak1(T178A/T184A) [substitution]
    *** source: 18617512-Fig-4d

not Ticam2

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 20+ 30 min
    *** does not req: Ticam2 [KO]
    *** source: 14556004(D)

not Tollip

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15+++ 30++ 60+ 180++ min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)
  *** xJnk?[phosAb] phos(TPY)[phosAb] is increased irt IL1b (tnr)
    *** cells: HEK293<xIL1R1> in BMS
    *** inhibited by: xTollip [addition]
    *** source: 10854325-Fig-5a

not Tpl2

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ 30+ 45 60 min
    *** does not req: Tpl2 [KO]
    *** source: 15833743-Fig-1c

not Traf2--
not Traf5--

  *** Jnk1[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ min
    *** does not req: Traf2 [KO]
    *** does not req: Traf5 [KO]
    *** does not req: Traf2 or Traf5 [DKO]
    *** source: 11479302-Fig-2
  *** Jnk1[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10+ 15++ min
    *** does not req: Traf2 [KO]
    *** source: 12776182-Fig-1c
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (20 min)
    *** cells: EJ in BMS
    *** does not req: Traf2 [RNAi]
    *** source: 16260598-Fig-3e
  *** Jnk1[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (20 min)
    *** cells: mEFs in BMS
    *** does not req: Traf2 [RNAi]
    *** source: 16260598-Fig-4b

Traf6--

  *** Jnks[Ab]IP IVKA(snr)[32P-ATP] is increased irt IL1 (times)
    *** cells: mEFs in BMLS
    *** times: 0 10+ 30+ 90 min
    *** reqs: Traf6 [KO]
    *** source: 10215628-Fig-5d
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5+ 20+ min
    *** reqs: xTraf6 [omission]
    *** inhibited by: xTraf6(C70A) [substitution]
    *** unaffected by: xTraf6(mnr)"K32-518R" [substitution]
    *** source: 19112497-Fig-3e
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5+ 20+ min
    *** reqs: xTraf6 [omission]
    *** inhibited by: xTraf6(C70A) [substitution]
    *** unaffected by: xTraf6(mnr)"K32-518R" [substitution]
    *** unaffected by: xTraf6(K124R) [substitution]
    *** source: 19112497-Fig-S3
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt RankL (times)
    *** cells: mBMMs<Traf6~null><xTraf6> in BMS
    *** times: 0 5+ 20 min
    *** reqs: xTraf6 [omission]
    *** inhibited by: xTraf6(C70A) [substitution]
    *** unaffected by: xTraf6(mnr)"K32-518R" [substitution]
    *** source: 19112497-Fig-4a
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt IL1a (30 min)
    *** cells: HEK293 in BMS
    *** inhibited by: xTraf6(289-522)"DN" [addition]
    *** source: 10346818-Fig-1a
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5+ 15++ 30++ min
    *** inhibited by: xTraf6(110-522)"T6dR" [substitution]
    *** unaffected by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-S12e
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 30+ 60 360 720 1440 min
    *** unaffected by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-S12e

Ubc13--

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15+ min
    *** comment: reqs Ubc13 [KO] at 5 min only
    *** source: 19843958-Fig-S8a
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15++ min
    *** reqs: Ubc13 [KO]
    *** source: 19843958-Fig-4c

=========
Chemicals
=========

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** unaffected by: PP2 [addition]
    *** source: 19754427-Fig-3b
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** unaffected by: PS1145 [addition]
    *** source: 19754427-Fig-1c
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1a (20 min)
    *** cells: KB in BMS
    *** enhanced by: SB203580 [addition] no-bkg-control
    *** unaffected by: PD184352 [addition] no-bkg-control
    *** source: 14592977-Fig-10
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (20 min)
    *** cells: HELA in BMS
    *** unaffected by: PP1 [addition]
    *** source: 16371247-Fig-5a
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** unaffected by: Gefitinib [cotreatment]
    *** unaffected by: BMS345541 [cotreatment]
    *** unaffected by: PD325901 [cotreatment]
    *** unaffected by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1

=========
No extras
=========

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt IL1a (10 min)
    *** cells: HEK293 in BMS
    *** source: 10346818-Fig-2c
  *** Jnks[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: 3T3L1 in BMS "differentiated into adipocytes"
    *** times: 0 5+ 10++ 15+++ 30++ 60 120 360 720 min
    *** source: 17500068-Fig-4c,4d
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (30 min)
    *** cells: HEK293 in BMS
    *** source: 10882101(D)
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTLR8> in BMS
    *** times: 0 15+ 30+ min
    *** source: 16737960-Fig-1c
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1b (times)
    *** cells: mKidneyCells in BMS
    *** times: 0 15+ 30+ min
    *** source: 16737960-Fig-1d
  *** Jnk1[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt IL1a (times)
    *** cells: HELA in BMS
    *** times: 0+ 15++ 30++ 60+ 120+ min
    *** source: 7535770-Fig-6
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (1 hr)
    *** cells: COS1 in BMS
    *** source: 7499279-Fig-2
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0 10++ 30+ 120+ min
    *** source: 17197697-Fig-3e
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (times)
    *** cells: CHO in BMLS
    *** times: 0 15+++ 30++ 60+ min
    *** source: 9111305-Fig-5c
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt IL1 (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 15++ 30+ 60+ min
    *** source: 9111305-Fig-6c
