Ikk1--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** does not req: Ikk1 [KO]
    *** source: 17197697-Fig-7c

Ikk2--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15+ 30+ 60+ min
    *** partially reqs: Ikk2 [KO]
    *** source: 17197697-Fig-7a
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Ikk2~null><xIkk2> in BMS
    *** times: 0 5+ 15+ 30+ 60+ min
    *** partially reqs: xIkk2 [omission]
    *** source: 17197697-Fig-7a
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** comment: phos band is lower in Ikk2-null cells
    *** source: 17197697-Fig-7b
  -------------------------------------------------------------------
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 5++ 15+ min
    *** does not req: Ikk2 [KO]
    *** source: 17244613-Fig-1d

Ikk1 and/or Ikk2--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1 (times)
    *** cells: HELA in BMS
    *** times: 0 2 5++ 10++ 20 60+ min
    *** partially reqs: Ikk1 [RNAi]
    *** partially reqs: Ikk2 [RNAi]
    *** partially reqs: Ikk1 and/or Ikk2 [RNAi]
    *** source: 12547194(D)
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1a (10 min)
    *** cells: HELA in BMS
    *** partially reqs: Ikk1 [RNAi]
    *** partially reqs: Ikk2 [RNAi]
    *** source: 15489227(D)
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15 min
    *** reqs: Ikk1 and/or Ikk2 [DKO]
    *** source: 16737960-Fig-4f
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 15+ min
    *** reqs: Ikk1 and/or Ikk2 [DKO]
    *** source: 17197697-Fig-7d

reqs Irak1--

  *** Ikba[phosAb] phos[WBMS] is unchanged irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null> in BMS
    *** times: 0 10 30 120 min
    *** source: 17197697-Fig-3c
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null><xIrak1(K239A)"KD"> in BMS
    *** times: 0 5++ 60+ min
    *** unaffected by: xIrak1(K239A/S131A/S137A/S138A/S140A/T141A/S144A) [substitution]
    *** unaffected by: xIrak1(K239A/K32R/K134R/K179R) [substitution]
    *** source: 17197697-Fig-3c
  *** Ikba[Ab] phos[WBMS] is unchanged irt IL1b (5 min)
    *** cells: HEK293I1A<Irak1~null><xIL1R1> in BMS
    *** source: 19675569-Fig-S5b

not Mekk3--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<xTLR8> in BMS
    *** times: 0 15+ 30+ min
    *** does not req: Mekk3 [KO]
    *** source: 16737960-Fig-4b
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** does not req: Mekk3 [KO]
    *** source: 17197697-Fig-5d
  ---  effects of Traf6 mutants on Mekk3 requirement ----------------
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6(110-522)"T6dR"> in BMS
    *** times: 0 5+ 15 30 min
    *** reqs: Mekk3 [RNAi]
    *** source: 19843958-Fig-S10b
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (5 min)
    *** cells: mEFs<Traf6~null><xTraf6(C242A/C249A)"T6mZ5"> in BMS
    *** reqs: Mekk3 [RNAi]
    *** source: 19843958-Fig-S12d
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6(C242A/C249A)"T6mZ5"> in BMS "treated with MG132"
    *** times: 0 5 15+ 30++ min
    *** partially reqs: Mekk3 [RNAi]
    *** source: 19843958-Fig-5c
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6(D57K)> in BMS "treated with MG132"
    *** times: 0 5+ 15+ 30++ min
    *** comment: reqs Mekk3[RNAi] at 5 min only
    *** source: 19843958-Fig-5d


Nemo--

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Nemo~null><xNemo> in BMS
    *** reqs: xNemo [omission]
    *** unaffected by: xNemo(K285R) [substitution]
    *** source: 19112497-Fig-6a

not Ripk1--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1b (10 min)
    *** cells: mEFs in BMS
    *** does not req: Ripk1 [KO]
    *** source: 16115877-Fig-1a,1b,1c
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs in BMS
    *** does not req: Ripk1 [KO]
    *** source: 15064760-Fig-5b
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1b (30 min)
    *** cells: mEFs in BMS
    *** reqs: Ripk1 [KO]
    *** source: 15064760-Fig-5b

reqs Tab2 or Tab3--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1b (times)
    *** cells: HELA in BMS
    *** times: 0 2+ 6+ min
    *** does not req: Tab2 [RNAi]
    *** does not req: Tab3 [RNAi]
    *** reqs: Tab2 and/or Tab3 [DRNAi]
    *** source: 14633987-Fig-7a

Tak1--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1 (times)
    *** cells: HELA in BMS
    *** times: 0 2 5++ 10++ 20 60+ min
    *** partially reqs: Tak1 [RNAi]
    *** source: 12547194(D)
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** partially reqs: xTak1 [omission]
    *** partially inhibited by: xTak1(T187A) [substitution]
    *** source: 19112497-Fig-S2
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ 60+ min
    *** does not req: Tak1 [KO]
    *** source: 17197697-Fig-5a
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** reqs: xTak1 [omission]
    *** partially inhibited by: xTak1(K158R) [addition]
    *** source: 20038579-Fig-7b

  --- requirement for xTak1 at early times only --------------------

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS "treated with MG132"
    *** times: 0 5+ 15++ 30+ min
    *** comment: reqs xTak1 [omission] at 5-15 min
    *** source: 19843958-Fig-S13a

  --- does not req xTak1 K34 K209 K172  --------------------

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (5 min)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** partially reqs: xTak1 [omission]
    *** unaffected by: xTak1(K34R) [substitution]
    *** source: 19843958-Fig-2f
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (5 min)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** partially reqs: xTak1 [omission]
    *** unaffected by: xTak1(K172R) [substitution]
    *** unaffected by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-2a

  ---  effects of Traf6 mutants on Tak1 requirement ----------------

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (5 min)
    *** cells: mEFs<Traf6~null><xTraf6(C242A/C249A)"T6mZ5"> in BMS
    *** reqs: Tak1 [RNAi]
    *** source: 19843958-Fig-S12d
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6(110-522)"T6dR"> in BMS
    *** times: 0 5+++ 15+ 30++ min
    *** comment: reqs Tak1 [RNAi] at 30 min only
    *** source: 19843958-Fig-S10b
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6(C242A/C249A)"T6mZ5"> in BMS "treated with MG132"
    *** times: 0 5 15+ 30++ min
    *** does not req: Tak1 [RNAi]
    *** source: 19843958-Fig-5c
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6(D57K)> in BMS "treated with MG132"
    *** times: 0 5+ 15+ 30++ min
    *** comment: partially reqs Tak1[RNAi] at 30 min only
    *** source: 19843958-Fig-5d



not Tbk1--

  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 1+ 3+ 9 27+ 90+ min
    *** does not req: Tbk1 [KO]
    *** source: 10990461-Fig-5a

not Tollip--

  *** Ikba[phosAb] phos(S23)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 30+ 60+ 180+ min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)

Traf6--   ubiq-E3-ligase-activity (C70)

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** reqs: xTraf6 [omission]
    *** source: 19112497-Fig-3e
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** reqs: xTraf6 [omission]
    *** source: 19112497-Fig-S3

  --- requirement for Traf6 C70 -------------------------------------

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMLS
    *** times: 0 2++ 5++ 10+ min
    *** inhibited by: xTraf6(C70A)"E3-mut" [substitution]
    *** source: 17135271-Fig-7b
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6(110-522)"T6dR"> in BMS "treated with MG132"
    *** times: 0 5+ 15++ 30++ min
    *** inhibited by: xTraf6(C70A) [substitution]
    *** source: 19843958-Fig-S14a
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** inhibited by: xTraf6(C70A) [substitution]
    *** source: 19112497-Fig-3e
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** inhibited by: xTraf6(C70A) [substitution]
    *** source: 19112497-Fig-S3

  --- requirement for Traf6 K124R ubiq site ??? ---------------------

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMLS
    *** times: 0 2++ 5++ 10+ min
    *** inhibited by: xTraf6(K124R) [substitution]
    *** source: 17135271-Fig-7b
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** unaffected by: xTraf6(K124R) [substitution]
    *** source: 19112497-Fig-S3

  --- requirement for Traf6 other sites --------------------------

  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** unaffected by: xTraf6(mnr)"K32-518R" [substitution]
    *** source: 19112497-Fig-3e
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** unaffected by: xTraf6(mnr)"K32-518R" [substitution]
    *** source: 19112497-Fig-S3
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5+ 15 30+ min
    *** comment: inhibited by xTraf6(110-522)"T6dR" [substitution] at 30 min only
    *** inhibited by: xTraf6(260-522)"T6dRZ" [substitution]
    *** source: 19843958-Fig-S9a
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5++ 15+ min
    *** inhibited by: xTraf6(C134A/C139A)"T6mZ1" [substitution]
    *** unaffected by: xTraf6(C162A/C165A)"T6mZ2" [substitution]
    *** unaffected by: xTraf6(C189A/C192A)"T6mZ3" [substitution]
    *** inhibited by: xTraf6(C215A/C218A)"T6mZ4" [substitution]
    *** unaffected by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-S12b
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS "treated with MG132"
    *** times: 0 5+ 15+ 30+ min
    *** inhibited by: xTraf6(mnr)"T6mZ5/ligase-deficient-mutant" [substitution]
    *** comment: inhibited by xTraf6(D57K) [substitution] at 5,15 min only
    *** inhibited by: xTraf6(mnr)"T6D57K-T6mZ5" [substitution]
    *** source: 19843958-Fig-5d
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS "treated with MG132"
    *** times: 0 5+ 15++ 30++ min
    *** comment: inhibited by xTraf6(110-522)"T6dR" [substitution] at 5,15 min only
    *** comment: inhibited by xTraf6(C242A/C249A)"T6mZ5" [substitution] at 30 min only
    *** source: 19843958-Fig-5b

not Ube1--

  *** Ikba[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 10+ min
    *** does not req: Ube1 [RNAi]
    *** source: 19854138-Fig-S3c

not Ube2ds--

  *** Ikba[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 15+ min
    *** does not req: Ube2ds [RNAi]
    *** source: 19854138-Fig-4a

Ubc13--

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (5 min)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15 min
    *** partially reqs: Ubc13 [KO]
    *** source: 19843958-Fig-4c
  *** Ikba[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: U2OS in BMS
    *** times: 0 10+ 20+ min
    *** reqs: Ubc13 [RNAi]
    *** source: 19854138-Fig-3a,3b
  *** Ikba[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: U2OS<Ubc13~null><xUbc13> in BMS
    *** times: 0 5+ 15+ min
    *** inhibited by: xUbc13(C87A) [substitution]
    *** source: 19854138-Fig-3b

Ubiq--  K63 linked

  *** Ikba[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 15+ min
    *** reqs: Ubiq [RNAi]
    *** source: 19854138-Fig-2a,2b
  *** Ikba[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: U2OS<Ubiq~null><xUbiq> in BMS
    *** times: 0 5+ 15+ min
    *** inhibited by: xUbiq(K63R) [substitution]
    *** source: 19854138-Fig-2b
  *** Ikba[phosAb] phos(sitenr)[phosAb] is unchanged irt IL1b (5 min)
    *** cells: U2OS<Ubiq~null><xUbiq(K6R/K63R)> in BMS
    *** source: 19854138-Fig-S7
  *** Ikba[phosAb] phos(sitenr)[phosAb] is unchanged irt IL1b (5 min)
    *** cells: U2OS<Ubiq~null><xUbiq(K11R/K63R)> in BMS
    *** source: 19854138-Fig-S7

=========
Chemicals
=========

  *** Ikba[Ab] phos[WBMS] is increased irt IL1b (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 10+ min
    *** unaffected by: SmacMimetic [addition]
    *** source: 19854138-Fig-7a
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** unaffected by: Gefitinib [cotreatment]
    *** inhibited by: BMS345541 [cotreatment]
    *** unaffected by: PD325901 [cotreatment]
    *** unaffected by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** unaffected by: 5Z7Oxozeaenol [addition]
    *** source: 17197697-Fig-5d
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** unaffected by: 5Z7Oxozeaenol [addition]
    *** source: 17197697-Fig-7c
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0 10+ 30++ 60++ min
    *** partially inhibited by: 5Z7Oxozeaenol [addition]
    *** comment: Ikba phos shift is not inhibited by 5Z7Oxozeaenol
    *** source: 17197697-Fig-5c

=========
no extras
=========

  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 15 30++ min
    *** source: 17197697-Fig-9a
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Lps (times)
    *** cells: mCECs in BMS
    *** times: 0 10+ 30++ min
    *** source: 17197697-Fig-9b
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 15 30++ min
    *** source: 17197697-Fig-9a
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is unchanged irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0 10+ 30+ 120+ min
    *** source: 17197697-Fig-3c
  *** Ikba[phosAb] phos[WBMS] is increased irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0 10+ 30+ 120+ min
    *** source: 17197697-Fig-3c
  *** Ikba[Ab] phos[WBMS] is increased irt IL1b (5 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** source: 19675569-Fig-S5b
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 1 2++ 5+ 15 30 min
    *** source: 11259596-Fig-8a
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTLR8> in BMS
    *** times: 0 15+ 30+ min
    *** source: 16737960-Fig-1c
  *** Ikba[phosAb] phos(S32)[phosAb] is increased irt IL1b (times)
    *** cells: mKidneyCells in BMS
    *** times: 0 15+ 30 min
    *** source: 16737960-Fig-1d
  *** Ikba[phosAb] phos(S32/S36)[phosAb] is increased irt IL1 (times)
    *** cells: mCECs in BMS
    *** times: 0 15+ 30++ min
    *** source: 17197697-Fig-9b
  *** Ikba[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (5 min)
    *** cells: U2OS in BMS
    *** source: 19854138-Fig-S7
  *** Ikba[Ab]IP phos(S32)[phosAb] is increased irt IL1a (times)
    *** cells: HELA in BMS "pretreated with MG132"
    *** times: 0 5 15+ 30++ 60+ 120+ min
    *** source: 11297557-Fig-5b
