===================
Recruitment to EgfR
===================

  *** xSos1[tAb] copptby[WB] EgfR[Ab] is increased irt Egf (times)
    *** cells: COS<xSos1> in BMLS
    *** times: 0 2+ 10+ min
    *** unaffected by: xAbi1 [addition]
    *** source: 11003655-Fig-3b
  *** xSos1[tAb] copptby[WB] EgfR[Ab] is increased irt Egf (3 min)
    *** cells: COS7<xSos1> in BMLS
    *** inhibited by: xAbi1 [addition]
    *** source: 11777939-Fig-4a
  *** Sos1[Ab] copptby[WB] EgfR[Ab] is increased irt Egf (times)
    *** cells: RAT1 in BMS
    *** times: 0 2+ 10+ min
    *** source: 8490966-Fig-4
  *** EgfR[Ab] copptby[WB] xSos1[tAb] is increased irt Egf (5 min)
    *** cells: NIH3T3 in BMLS
    *** source: 9447973-Fig-9a
  *** EgfR[Ab] copptby[WB] Sos1[Ab] is increased irt Egf (5 min)
    *** cells: NIH3T3 in BMLS
    *** source: 9447973-Fig-9a

Grb2--

  *** xSos1[Ab] copptby[WB] xEgfR[Ab] is increased irt Egf (2 min)
    *** cells: HEK293<xEgfR><xSos1><xGrb2> in BMS
    *** reqs: xGrb2 [omission]
    *** source: 8479541-Fig-1b

in membrane fraction

  *** Sos1[Ab] infraction(membrane)[WB] is increased irt Egf (5 min)
    *** cells: VERO in BMLS
    *** inhibited by: Wortmannin [addition] no-bkg-control
    *** inhibited by: LY294002 [addition] no-bkg-control
    *** source: 11134009-Fig-4c

===========================================
Tyrosine phosphorylation in response to Egf
===========================================

Yphos

  *** Sos1[Ab]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: COS7 in BMLS
    *** source: 15039778-Fig-1a
  *** xSos1[tAb]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: COS7 in BMLS
    *** source: 15039778-Fig-1b
  *** xSos1[tAb]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: mEFs<Abl1~null><Abl2~null><xAbi1> in BMLS
    *** partially reqs: xAbl1 [omission]
    *** source: 15039778-Fig-1d
 *** Sos1[Ab]IP Yphos[pYab] is increased irt Egf (5 min)
   *** B82L<EgfR~null><xEgfR(1-1046)"delCterm">
   *** inhibited by: Imatinib [pretreatment]
   *** comment: also ppts something EgfR-sized that is Yphosed and not inhib by Imatinib
   *** source: 15039778-Fig-1c

total phos

  *** Sos1[Ab]IP phos[WBMS] is increased irt Egf (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0 1 10++ 30++ 60+ 120 min
    *** inhibited by: PD98059 [addition]
    *** source: 7592690-Fig-3a
  *** Sos1[Ab] phos[WBMS] is increased irt Egf (15 min)
    *** cells: CHO<xInsR><xEgfR> in BMS
    *** source: 8626525-Fig-1b
  *** Sos1[Ab] phos[WBMS] is increased irt Egf (15 min)
    *** cells: NIH3T3<xEgfR> in BMS
    *** unaffected by: xEgfR(Y1016F/Y1092F/Y1110F/Y1172F/Y1197F) [substitution]
    *** source: 8626525-Fig-3b
  *** Sos1[Ab] phos[WBMS] is increased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0 2++ 5+++ 15++ 30 60 min
    *** source: 11278445-Fig-4a

==================================================
Coprecipitation with other EgfR binding proteins
==================================================

Pik3c2b--

  *** Sos1[Ab] copptby[WB] xPik3c2b[tAb] is increased irt Egf (10 min)
    *** cells: A431 in BMLS "Triton-Soluble fraction"
    *** source: 16775008-Fig-2d

Grb2--  ????

  *** Sos1[Ab] copptby[WB] Grb2[Ab] is detectable-but unchanged irt Egf (2 min)
    *** cells: HER14 in BMS
    *** source: 8493579-Fig-4c
  *** Sos1[Ab] copptby[WB] Grb2[Ab] is detectable-but unchanged irt Egf (times)
    *** cells: CHO<xEgfR><xInsR> in BMS
    *** times: 0+ 2+ 5+ 15+ min
    *** source: 15192046-Fig-4b
  *** Sos1[Ab] copptby[WB] Grb2[Ab] is detectable-but unchanged irt Egf (times)
    *** cells: CHO<xEgfR><xInsR> in BMS
    *** times: 0+ 5+ min
    *** comment: this might be an increase under a lower exposure
    *** source: 15192046-Fig-4a
  *** Grb2[Ab] copptby[WB] Sos1[Ab] is unchanged irt Egf (times)
    *** cells: mEFs<xEgfR> in BMLS
    *** times: 0+ 10+ 90+ 360+ min
    *** comment: this might be an increase 0++ 10+++ 90++ under a lower exposure
    *** source: 10675333-Fig-8a
  *** Sos1[Ab] copptby[WB] xGrb2[GST] is unchanged irt Egf (times)
    *** cells: COS<xUsp6nl> in BMLS
    *** times: 0+ 5+ 15+ min
    *** source: 12399475-Fig-3b
  ------ what is going on here? ---
  *** Sos1[Ab] copptby[WB] Grb2[Ab] is detectable-but unchanged irt Egf (15 min)
    *** cells: NIH3T3<xEgfR> in BMS
    *** inhibited by: xEgfR(Y1016F/Y1092F/Y1110F/Y1172F/Y1197F) [substitution]
    *** source: 8626525-Fig-3c
  --------- cell fractions ------------------------------------
  *** Sos1[Ab] copptby[WB] Grb2[Ab] is unchanged irt Egf (times)
    *** cells: A431<xPik3c2b> in BMLS "Triton-insoluble fraction"
    *** times: 0+ 5+ 30+ 120+ 240+ min
    *** source: 16775008-Fig-3a
  -----------------------------------------------------------------
  *** Sos1[Ab] copptby[WB] Grb2[Ab] is decreased irt Egf (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0++ 1++ 10 30+ 60++ 120++ min
    *** inhibited by: PD98059 [addition]
    *** source: 7592690-Fig-3b
  -----------------------------------------------------------------
  *** xGrb2[tAb] copptby[WB] Sos1[Ab] is increased irt Egf (5 min)
    *** cells: RAT1<xGrb2> in BMS
    *** source: 8490966-Fig-7
  *** Sos1[Ab] copptby[WB] Grb2[Ab] is increased irt Egf (30 min)
    *** cells: CHO<xInsR><xEgfR> in BMLS
    *** source: 8663461-Fig-1a
  *** Sos1[Ab] copptby[WB] Grb2[Ab] is increased irt Egf (15 min)
    *** cells: CHO<xInsR><xEgfR> in BMS
    *** source: 8626525-Fig-1c
  *** Sos1[Ab] copptby[WB] xGrb2[tAb] is increased irt Egf (15 min)
    *** cells: CHO<xInsR><xEgfR> in BMS
    *** inhibited by: xGrb2(R86K)"SH2-domain-mut" [substitution]
    *** source: 8626525-Fig-5a
  *** xSos1[Ab] copptby[WB] xGrb2[Ab] is increased irt Egf (2 min)
    *** cells: HEK293<xEgfR><xSos1><xGrb2> in BMS
    *** source: 8479541-Fig-1b

Shc1--

  *** Sos1[Ab] copptby[WB] Shc1[Ab] is increased irt Egf (times)
    *** cells: mEFs<xEgfR> in BMS
    *** times: 0 10++ 90+ 360 min
    *** source: 10675333-Fig-9a
  *** Sos1[Ab] copptby[WB] Shc1[Ab] is increased irt Egf (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0 1+ 10 30 60 120 min
    *** comment: unaffected by PD98059 [addition] at 1 min
    *** comment: inhibited by PD98059 [addition] at 10-30 min
    *** source: 7592690-Fig-3c
  *** Sos1[Ab] copptby[WB] Shc1[Ab] is increased irt Egf (times)
    *** cells: NIH3T3<xEgfR> in BMS
    *** times: 0 1+ 15 30 min
    *** source: 8626525-Fig-2a


