===============
Kinase Activity
===============

requires Mek1--

  *** xRsk2[tAb]IP IVKA(peptide)[32P-ATP] is increased irt Egf (15 min)
    *** cells: COS7<xRsk2> in BMLS
    *** inhibited by: xMek1(S218A) [substitution]
    *** unaffected by: xMek1(S218E/S222E) [substitution]
    *** source: 8939914-Fig-2

not Msk1--

  *** Rsk2[Ab]IP IVKA(Crosstide)[32P-ATP] is increased irt Egf (times)
    *** cells: mESCs in BMLS
    *** times: 0 10+ 20 30 min
    *** does not req: Msk1 [KO]
    *** source: 11018520-Fig-4c

Chemicals--

  *** xRsk2[tAb]IP IVKA(peptide)[32P-ATP] is increased irt Egf (15 min)
    *** cells: COS7<xRsk2> in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 8939914-Fig-3b
  *** Rsk2[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt Egf (15 min)
    *** cells: HEK293E in BMLS
    *** partially inhibited by: FMK [pretreatment]
    *** source: 17360704-Fig-4b
  *** Rsk2[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Egf (5 min)
    *** cells: mEFs in BMLS
    *** inhibited by: PD184352 [addition] no-bkg-control
    *** source: 11909979-Fig-3b

No extras

  *** xRsk2[tAb]IP IVKA(Rps6)[32P-ATP] is increased irt Egf (10 min)
    *** cells: HEK293<xRsk2> in BMLS
    *** source: 12832467-Fig-6c
  *** xRsk2[tAb]IP IVKA(Rps6)[32P-ATP] is increased irt Egf (times)
    *** cells: HEK293<xRsk2> in BMLS
    *** times: 0 10+++ 30++ 60+ 90+ 120+ min
    *** source: 12832467-Fig-7a
  *** xRsk2[tAb]IP IVKA(peptide)[32P-ATP] is increased irt Egf (15 min)
    *** cells: COS7<xRsk2> in BMLS
    *** source: 8939914-Fig-1b

===============
Phosphorylation
===============

phos(S386)  reqs T570

  *** xRsk2[tAb]IP phos(S386)[phosAb] is increased irt Egf (times)
    *** cells: HELA<xRsk2> in BMS
    *** times: 0 5+ 10+ min
    *** does not req: IL17Rd [RNAi]
    *** source: 15239952-Fig-6f
  *** Rsk2[Ab]IP phos(S386)[phosAb] is increased irt Egf (5 min)
    *** cells: HEK293T in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 18156174-Fig-1
  *** Rsk2[Ab]IP phos(S386)[phosAb] is increased irt Egf (5 min)
    *** cells: HEK293T in BMLS
    *** partially inhibited by: PP2 [pretreatment]
    *** source: 18156174-Fig-5

phos(Y529)

  *** Rsk2[Ab] phos(Y529)[phosAb] is increased irt Egf (5 min)
    *** cells: HEK293T in BMLS
    *** unaffected by: U0126 [pretreatment]
    *** source: 18156174-Fig-1
  *** Rsk2[Ab] phos(Y529)[phosAb] is increased irt Egf (5 min)
    *** cells: HEK293T in BMLS
    *** inhibited by: PP2 [pretreatment]
    *** source: 18156174-Fig-5



