============
GTP binding
============

  *** xRap1a[tAb] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: COS7 in BMLS
    *** times: 0+ 5++ 10++ 20+ 30 min
    *** source: 11395506-Fig-9
  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: RAT1 in BMLS
    *** times: 0 1+ 2+ 5+ 20+ min
    *** source: 9774335-Fig-1a
  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0+ 2++ 5+ 7+ 20 50+ min
    *** source: 9774335-Fig-5
  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (1 min)
    *** cells: NIH3T3<xEgfR><xAbi1> in BMLS
    *** source: 16182283-Fig-4a,5a
  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (1 min)
    *** cells: NIH3T3<xEgfR> in BMLS
    *** source: 16182283-Fig-4b,5a
  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (5 min)
    *** cells: COS1 in BMLS
    *** source: 12574122(D)
  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0 2++ 5+ 15 30 60 min
    *** comment: the pattern is the same using the Braf1-RBD or Raf1-RBD
    *** source: 11278445-Fig-3a
  --------------------------------------------------------------
  *** xRap1a[tAb]IP GTP-association[TLC] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** source: 9774335-Fig-1d

  contradictions ------------------------------------------------

  *** xRap1a[tAb]IP GTP-association[TLC] is unchanged irt Egf (5 min)
    *** cells: PC12 in BMLS
    *** source: 9094716-Fig-6b
  *** Rap1s[Ab] GTP-association[BDPD] is unchanged irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0 2 5 10 30 60 120 180 min
    *** source: 11466412-Fig-1c

===================
Requirement for Cbl
===================

  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (5 min)
    *** cells: COS1 in BMLS
    *** inhibited by: xCbl(G306E)"DN" [addition]
    *** inhibited by: xCbl(mnr)"DN" [addition]
    *** source: 12574122(D)

================
Chemical Effects
================

  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (5 min)
    *** cells: COS1 in BMLS
    *** inhibited by: Monodansylcadaverine [addition]
    *** source: 12574122(D)
  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (1 min)
    *** cells: NIH3T3<xEgfR><xAbi1> in BMLS
    *** bkg inhibited by: PP1 [addition]
    *** unaffected by: STI571 [addition]
    *** source: 16182283-Fig-4a,5a
  *** Rap1s[Ab] GTP-association[BDPD] is increased irt Egf (1 min)
    *** cells: NIH3T3<xEgfR> in BMLS
    *** unaffected by: PP1 [addition]
    *** unaffected by: STI571 [addition]
    *** source: 16182283-Fig-4b,5a

============================
missing evidence:
Rap1a{GTP} requires a RapGef
============================
