==================
Kinase Activation
==================

Mek12s--  chemicals only

  *** Msk1[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Egf (times)
    *** cells: RAT2 in BMS
    *** times: 0 2+ 5++ 10++ 20+ 40 min
    *** inhibited by: PD184352 [addition]
    *** source: 11297520-Fig-5b
  *** Msk1[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Egf (5 min)
    *** cells: mEFs in BMLS
    *** inhibited by: PD184352 [addition]
    *** source: 11909979-Fig-3b

not Msk2--

  *** Msk1[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Egf (5 min)
    *** cells: mEFs in BMLS
    *** reqs: Msk1 [KO]
    *** does not req: Msk2 [KO]
    *** reqs: Msk1 and/or Msk2 [DKO]
    *** source: 11909979-Fig-4b

P38s-- chemicals only

  *** Msk1[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Egf (5 min)
    *** cells: mEFs in BMLS
    *** partially inhibited by: SB203580 [addition]
    *** source: 11909979-Fig-3b

Msk1 features

  *** xMsk1[tAb]IP IVKA(Crebtide)[32P-ATP] is increased irt Egf (20 min)
    *** cells: COS7<xMsk1> in BMLS
    *** inhibited by: xMsk1(R102A) [substitution]
    *** source: 12374740-Fig-8a
  *** xMsk1[tAb]IP phos(S376)[phosAb] is increased irt Egf (20 min)
    *** cells: COS7<xMsk1> in BMLS
    *** inhibited by: xMsk1(R102A) [substitution]
    *** source: 12374740-Fig-8b

chemicals

  *** Msk1[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Egf (10 min)
    *** cells: RAT2 in BMS
    *** unaffected by: H89 [addition]
    *** source: 11297520-Fig-7c
  *** Msk1[Ab]IP IVKA(Crosstide)[32P-ATP] is increased irt Egf (10 min)
    *** cells: HEK293 in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** unaffected by: SB203580 [pretreatment]
    *** source: 9687510-Fig-5a
  *** Msk1[Ab]IP IVKA(Creb1)[32P-ATP] is increased irt Egf (10 min)
    *** cells: mESCs in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 11018520-Fig-2b

no extras

  *** xMsk1[tAb]IP IVKA(peptide)[32P-ATP] is increased irt Egf (20 min)
    *** cells: COS7<xMsk1> in BMLS
    *** source: 10856237-Fig-11b
  *** Msk1[Ab]IP IVKA(Creb1)[32P-ATP] is increased irt Egf (times)
    *** cells: mESCs in BMLS
    *** times: 0 5++ 10+ 20+ min
    *** source: 11018520-Fig-3a
  *** xMsk1[tAb]IP IVKA(Crebtide)[32P-ATP] is increased irt Egf (10 min)
    *** cells: HEK293<xMsk1> in BMS
    *** inhibited by: xMsk1(mnr)"DN" [substitution]
    *** source: 12234923-Fig-7


