===========================
Phosphorylation on Tyrosine
===========================

  *** Gab2[Ab]IP Yphos[pYAb] is increased irt Egf (1 min)
    *** cells: rHepatocytes in BMLS
    *** inhibited by: PP1 [addition] no-bkg-control
    *** source: 12464621-Fig-1a
  *** xGab2[Ab]IP Yphos[pYAb] is increased irt Egf (1 min)
    *** cells: rHepatocytes in BMLS
    *** inhibited by: xGab2(del(348-355)) [substitution]
    *** source: 12464621-Fig-5
  *** xGab2[Ab]IP Yphos[pYAb] is increased irt Egf (1 min)
    *** cells: rHepatocytes in BMLS
    *** unaffected by: xGab2(Y603F/Y632F) [substitution]
    *** source: 12464621-Fig-7b
  *** Gab2[Ab]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: T47D in BMLS
    *** source: 15952937(D)
  *** xGab2[tAb]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0 3+ 20++ 60+ min
    *** unaffected by: xGab2(S210A) [substitution]
    *** unaffected by: xGab2(S391A) [substitution]
    *** unaffected by: xGab2(S210A/S391A) [substitution]
    *** unaffected by: xGab2(S159A/S210A/S391A/S668A) [substitution]
    *** source: 19172738-Fig-4a
  *** xGab2[tAb]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0 3++ 20+ min
    *** source: 19172738-Fig-1b

==================================
Phosphorylation on Serine/Tyrosine
==================================

  *** xGab2[phosAb] phos(S210)[phosAb] is increased irt Egf (3 min)
    *** cells: COS<xGab2> in BMLS
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 19172738-Fig-3e
  *** xGab2[phosAb] phos(S210)[phosAb] is increased irt Egf (3 min)
    *** cells: COS<xGab2> in BMLS
    *** inhibited by: xGab2(R30C) [substitution]
    *** source: 19172738-Fig-3e
  *** xGab2[phosAb] phos(S210)[phosAb] is increased irt Egf (3 min)
    *** cells: MCF10A<xGab2> in BMLS
    *** partially inhibited by: AktI12 [pretreatment]
    *** partially inhibited by: Wortmannin [pretreatment]
    *** enhanced by: Rapamycin [pretreatment]
    *** source: 19172738-Fig-3c
  *** xGab2[phosAb] phos(S210)[phosAb] is increased irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0+ 3++ 5++ 10++ 20+ 60+ min
    *** source: 19172738-Fig-3a
  *** xGab2[phosAb] phos(T391)[phosAb] is increased irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0+ 3++ 5++ 10++ 20+ 60+ min
    *** source: 19172738-Fig-3a
  *** xGab2[phosAb] phos(T391)[phosAb] is increased irt Egf (3 min)
    *** cells: COS<xGab2> in BMLS
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 19172738-Fig-3e
  *** xGab2[phosAb] phos(T391)[phosAb] is increased irt Egf (3 min)
    *** cells: COS<xGab2> in BMLS
    *** inhibited by: xGab2(R30C) [substitution]
    *** source: 19172738-Fig-3e


===============================================
Association with other proteins in EgfR Complex
===============================================

CrkL--

  *** Gab2[Ab] copptby[WB] CrkL[Ab] is decreased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0+ 5 10 min
    *** source: 11466412-Fig-4c

Grb2--  constitutive

  *** Grb2[Ab] copptby[WB] xGab2[tAb] is detectable-but unchanged irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0+ 3+ 20+ 60+ min
    *** source: 19172738-Fig-4a

Pi3k--

  *** Gab2[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Egf (1 min)
    *** cells: rHepatocytes in BMLS
    *** inhibited by: PP1 [addition] no-bkg-control
    *** source: 12464621-Fig-3a
  *** xGab2[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Egf (1 min)
    *** cells: rHepatocytes in BMLS
    *** enhanced by: xGab2(Y603F/Y632F) [substitution]
    *** source: 12464621-Fig-8a
  *** xGab2[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Egf (1 min)
    *** cells: rHepatocytes in BMLS
    *** partially inhibited by: xGab2(del(348-355)) [substitution]
    *** source: 12464621-Fig-6a
  *** Pik3rs[Ab] copptby[WB] xGab2[tAb] is detectable-but unchanged irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0+ 3+ 20+ 60+ min
    *** source: 19172738-Fig-4b

Shc1--

  *** Shc1[Ab] copptby[WB] xGab2[tAb] is increased irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0 3++ 20++ 60+ min
    *** enhanced by: xGab2(S391A) [substitution]
    *** enhanced by: xGab2(S210A/S391A) [substitution]
    *** enhanced by: xGab2(S159A/S210A/S391A/S668A) [substitution]
    *** source: 19172738-Fig-4a

Shp2--

  *** Shp2[Ab] copptby[WB] xGab2[tAb] is increased irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0 3++ 20++ 60+ min
    *** enhanced by: xGab2(S210A) [substitution]
    *** enhanced by: xGab2(S391A) [substitution]
    *** enhanced by: xGab2(S210A/S391A) [substitution]
    *** enhanced by: xGab2(S159A/S210A/S391A/S668A) [substitution]
    *** source: 19172738-Fig-4a

Ywhas--

  *** xGab2[tAb]IP boundby[FarWestern] rYwhab[GST] is increased irt Egf (3 min)
    *** cells: MCF10A<xGab2> in BMLS
    *** unaffected by: xGab2(S159A) [substitution]
    *** unaffected by: xGab2(S210A) [substitution]
    *** partially inhibited by: xGab2(S391A) [substitution]
    *** unaffected by: xGab2(S668A) [substitution]
    *** inhibited by: xGab2(S210A/S391A) [substitution]
    *** inhibited by: xGab2(S159A/S210A/S391A/S668A) [substitution]
    *** source: 19172738-Fig-2c
  *** xGab2[tAb]IP boundby[FarWestern] rYwhab[GST] is increased irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0+ 3++ 20++ min
    *** source: 19172738-Fig-S1d
  *** Ywhas[Ab] copptby[WB] xGab2[tAb] is increased irt Egf (3 min)
    *** cells: MCF10A<xGab2> in BMLS
    *** unaffected by: xGab2(S159A) [substitution]
    *** inhibited by: xGab2(S210A) [substitution]
    *** inhibited by: xGab2(S391A) [substitution]
    *** unaffected by: xGab2(S668A) [substitution]
    *** inhibited by: xGab2(S210A/S391A) [substitution]
    *** inhibited by: xGab2(S159A/S210A/S391A/S668A) [substitution]
    *** source: 19172738-Fig-2b
  *** Ywhas[Ab] copptby[WB] xGab2[tAb] is increased irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0 3++ 20+ min
    *** inhibited by: xGab2(S210A/S391A) [substitution]
    *** enhanced by: xGab2(mnr)"2XR18" [substitution]
    *** inhibited by: xGab2(mnr)"2XKK" [substitution]
    *** source: 19172738-Fig-6d
  *** Ywhas[Ab] copptby[WB] xGab2[tAb] is increased irt Egf (times)
    *** cells: MCF10A<xGab2> in BMLS
    *** times: 0 3++ 20+ min
    *** source: 19172738-Fig-1b
