Tab2 is not a kinase - assume IVKA comes from Tak1

=====================================
Tak1 Tab2 Associated Kinase Activity
=====================================

Atm--

  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** reqs: Atm [RNAi]
    *** source: 20932476-Fig-2a
  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: mEFs in BMS
    *** reqs: Atm [KO]
    *** source: 20932476-Fig-2b

not Cyld--  Deubiquitinating activity

  *** Tab2[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** partially inhibited by: xCyld [addition]
    *** unaffected by: xCyld(mnr)"CIA" [addition]
    *** source: 20932476-Fig-5e

Nemo--

  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** reqs: xNemo [omission]
    *** source: 20932476-Fig-2e
  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(F312A) [substitution]
    *** unaffected by: xNemo(Y308S) [substitution]
    *** unaffected by: xNemo(L329P) [substitution]
    *** source: 20932476-Fig-5h
  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** reqs: Nemo [RNAi]
    *** source: 20932476-Fig-2f
  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Etoposide (90 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** partially reqs: xNemo [omission]
    *** inhibited by: xNemo(S85A) [substitution]
    *** source: 20932476-Fig-2g

Erc1--

  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** reqs: Erc1 [RNAi]
    *** source: 20932476-Fig-3a
  *** Tab2[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** reqs: Erc1 [RNAi]
    *** source: 20932476-Fig-3a

Ubc13--

  *** Tab2[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** reqs: Ubc13 [RNAi]
    *** source: 20932476-Fig-5c

chemicals

  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** partially inhibited by: KU55933 [pretreatment]
    *** source: 20932476-Fig-2c

no extras

  *** Tab2[Ab]IP IVKA(Ikk2)[32P-ATP] is increased irt Etoposide (times)
    *** cells: HEK293 in BMS
    *** times: 0 30++ 60++ 90++ 120+ min
    *** source: 20932476-Fig-1a

=======================
Tak1 - Erc1 association
=======================

Atm--

  *** xErc1[tAb] copptby[WB] xTak1[tAb] is increased irt Etoposide (2 hr)
    *** cells: HEK293<xErc1><xTak1> in BMS
    *** reqs: Atm [RNAi]
    *** source: 20932476-Fig-4e

not Ubc13--

  *** xTak1[tAb] copptby[WB] Erc1[Ab] is increased irt Etoposide (2 hr)
    *** cells: HEK293<xTak1> in BMS
    *** does not req: Ubc13 [RNAi]
    *** source: 20932476-Fig-5b

Tab2-- and/or Tab3--

  *** xTak1[tAb] copptby[WB] Erc1[Ab] is increased irt Etoposide (2 hr)
    *** cells: HEK293<xTak1> in BMS
    *** reqs: Tab2 and/or Tab3 [RNAi]
    *** source: 20932476-Fig-5a

chemicals

  *** xTak1[tAb] copptby[WB] Erc1[Ab] is increased irt Etoposide (2 hr)
    *** cells: HEK293<xTak1> in BMS
    *** inhibited by: KU55933 [pretreatment]
    *** source: 20932476-Fig-S4
  *** Erc1[Ab] copptby[WB] Tak1[Ab] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** inhibited by: KU55933 [pretreatment]
    *** source: 20932476-Fig-4d
  *** xErc1[tAb] copptby[WB] xTak1[tAb] is increased irt Etoposide (2 hr)
    *** cells: HEK293<xErc1><xTak1> in BMS
    *** inhibited by: KU55933 [pretreatment]
    *** source: 20932476-Fig-4c

no extras

  *** xErc1[tAb] copptby[WB] xTak1[tAb] is increased irt Etoposide (2 hr)
    *** cells: HEK293<xErc1><xTak1> in BMS
    *** source: 20932476-Fig-S4

=======================
Nemo - Erc1 association
=======================

  *** xNemo[tAb] copptby[WB] xErc1[Ab] is increased irt Etoposide (2 hr)
    *** cells: HEK293<xNemo><xErc1> in BMS
    *** inhibited by: xNemo(F312A) [substitution]
    *** inhibited by: xNemo(Y308S) [substitution]
    *** inhibited by: xNemo(L329P) [substitution]
    *** source: 20932476-Fig-5i
