==================
Protein Expression
==================

  *** Mdm4[Ab] prot-exp[WB] is decreased irt NCS (5 hr)
    *** cells: U2OS in BMS
    *** inhibited by: MG132 [pretreatment]
    *** source: 15788536-Fig-6b
  *** Mdm4[Ab] prot-exp[WB] is decreased irt NCS (times)
    *** cells: C3ABR in BMS
    *** times: 0++ 90+ 150+ 210+ min
    *** source: 15788536-Fig-1a
  *** Mdm4[Ab] prot-exp[WB] is decreased irt NCS (times)
    *** cells: L3AT<Atm~fmut> in BMS
    *** times: 0++ 90+ 150+ 210+ min
    *** comment: decrease is less than seen in C3ABR
    *** source: 15788536-Fig-1a
  *** Mdm4[Ab] prot-exp[WB] is decreased irt NCS (times)
    *** cells: MCF7 in BMS
    *** times: 0++ 1+ 2+ 3+ 5+ hr
    *** reversed by: KU55933 [pretreatment]
    *** source: 15788536-Fig-1c
  *** xMdm4[tAb] prot-exp[WB] is decreased irt NCS (5 hr)
    *** cells: MCF7<xMdm4><xMdm2> in BMS
    *** reqs: xMdm2 [omission]
    *** source: 15788536-Fig-4b
  *** xMdm4[tAb] prot-exp[WB] is decreased irt NCS (5 hr)
    *** cells: MCF7<xMdm4><xMdm2> in BMS
    *** reversed by: xMdm4(S367A) [substitution]
    *** reversed by: xMdm4(S403A) [substitution]
    *** reversed by: xMdm4(S367A/S403A) [substitution]
    *** reversed by: xMdm4(S342A) [substitution]
    *** reversed by: xMdm4(S342A/S403A) [substitution]
    *** unaffected by: xMdm4(T365A) [substitution]
    *** reversed by: xMdm4(T365A/S367A) [substitution]
    *** source: 15788536-Fig-4c
  *** xMdm4[tAb] prot-exp[WB] is decreased irt NCS (5 hr)
    *** cells: MCF7<xMdm4><xMdm2> in BMS
    *** reversed by: xMdm4(S403A) [substitution]
    *** source: 15788536-Fig-4b
  *** xMdm4[tAb] prot-exp[WB] is decreased irt NCS (times)
    *** cells: MCF7<xMdm4> in BMS
    *** times: 0++ 5+ 7+ hr
    *** source: 15788536-Fig-1b
  *** xMdm4[tAb] prot-exp[WB] is unchanged irt NCS (5 hr)
    *** cells: MCF7<xMdm4> in BMS
    *** source: 15788536-Fig-4b

=================
Protein Stability
=================

  *** Mdm4[Ab] prot-stability[CHX-WB] is decreased irt NCS (3 hr)
    *** cells: MCF7 in BMS
    *** source: 15788536-Fig-6a

