========================
Phosphorylation on S1981
========================

requires Atm kinase activity

  *** xAtm[Ab]IP phos(S1981)[phosAb] is increased irt Bleomycin (30 min)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** inhibited by: xAtm(D2870A/N2875K/D2889A)"KD" [substitution]
    *** source: 17923702-Fig-4b

requires Tip60--

  *** Atm[Ab]IP phos(S1981)[phosAb] is increased irt Bleomycin (30 min)
    *** cells: HEK293T in BMS
    *** reqs: Tip60 [RNAi]
    *** source: 17923702-Fig-1b

requires the FATC domain

  *** xAtm[Ab]IP phos(S1981)[phosAb] is increased irt Bleomycin (tnr)
    *** cells: GM5849<Atm~fmut> in BMS
    *** inhibited by: xAtm(1-3032)"dFATC" [substitution]
    *** unaffected by: xAtm(chimera)"AtrFATC" [substitution]
    *** unaffected by: xAtm(chimera)"PrkdcFATC" [substitution]
    *** unaffected by: xAtm(chimera)"TrrapFATC" [substitution]
    *** source: 16603769-Fig-1b

requires K3016 acetylation site

  *** xAtm[Ab]IP phos(S1981)[phosAb] is increased irt Bleomycin (30 min)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** inhibited by: xAtm(K3016A) [substitution]
    *** unaffected by: xAtm(K3018A) [substitution]
    *** source: 17923702-Fig-1d
  *** xAtm[Ab]IP phos(S1981)[phosAb] is increased irt Bleomycin (30 min)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** inhibited by: xAtm(K3016T) [substitution]
    *** inhibited by: xAtm(K3016Q) [substitution]
    *** inhibited by: xAtm(K3016E) [substitution]
    *** inhibited by: xAtm(K3016A) [substitution]
    *** source: 17923702-Fig-1e
  *** xAtm[Ab]IP phos(S1981)[phosAb] is increased irt Bleomycin (times)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** times: 0 5+ 40+ 120+ min
    *** inhibited by: xAtm(K3016A) [substitution]
    *** source: 17923702-Fig-2b

===============
Kinase Activity
===============

  *** xAtm[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Bleomycin (30 min)
    *** cells: GM5849<Atm~fmut> in BMS
    *** inhibited by: xAtm(1-3032)"dFATC" [substitution]
    *** unaffected by: xAtm(chimera)"AtrFATC" [substitution]
    *** unaffected by: xAtm(chimera)"PrkdcFATC" [substitution]
    *** unaffected by: xAtm(chimera)"TrrapFATC" [substitution]
    *** source: 16603769-Fig-2a

  *** xAtm[Ab]IP IVKA(Tp53)[32P-ATP] is increased irt Bleomycin (30 min)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** inhibited by: xAtm(K3016R) [substitution]
    *** source: 17923702-Fig-3b

===============
Oligomerization
===============

  *** xAtm[tAb] oligomerization[2TagPpt] is decreased irt Bleomycin (30 min)
    *** cells: GM5849<Atm~fmut><xAtm> in BMS
    *** reversed by: xAtm(K3016R) [substitution]
    *** reversed by: xAtm(D2870A/N2875K/D2889A)"KD" [substitution]
    *** source: 17923702-Fig-4c

