======================
Direct phosphorylation
======================

S15--

  *** rTp53[phosAb] phos(S15)[phosAb] is increased by rChek1
    *** cells: none
    *** inhibited by: rTp53(del(334-356)) [substitution]
    *** source: 10673501-Fig-3b
  *** rTp53[phosAb] phos(S15)[phosAb] is increased by rChek1
    *** cells: none
    *** source: 10673501-Fig-2a
  *** rTp53[phosAb] phos(S15)[phosAb] is increased by rChek1
    *** cells: none
    *** unaffected by: rTp53(1-363) [substitution]
    *** partially inhibited by: rTp53(1-307) [substitution]
    *** source: 10673501-Fig-3a

  contradiction
  *** rTp53[phosAb] phos(S15)[phosAb] is unchanged by rChek1
    *** cells: none
    *** source: 16163388-Fig-8a



S20--

  *** rTp53[phosAb] phos(S20)[phosAb] is increased by rChek1
    *** cells: none
    *** inhibited by: rTp53(del(334-356)) [substitution]
    *** source: 10673501-Fig-3b
  *** rTp53[phosAb] phos(S20)[phosAb] is increased by rChek1
    *** cells: none
    *** partially inhibited by: rTp53(1-363) [substitution]
    *** inhibited by: rTp53(1-307) [substitution]
    *** source: 10673501-Fig-3a
  *** rTp53[phosAb] phos(S20)[phosAb] is increased by rChek1
    *** cells: none
    *** source: 10673501-Fig-2a
  *** rTp53[phosAb] phos(S20)[phosAb] is increased by rChek1
    *** cells: none
    *** unaffected by: Wortmannin [cotreatment]
    *** comment: unaffected by addition of DNA to the kinase reaction
    *** source: 10673501-Fig-2b

not S33--

  *** rTp53[phosAb] phos(S33)[phosAb] is unchanged by rChek1
    *** cells: none
    *** source: 10673501-Fig-2c

S37--

  *** rTp53[phosAb] phos(S37)[phosAb] is increased by rChek1
    *** cells: none
    *** source: 10673501-Fig-2c

not S392--

  *** rTp53[phosAb] phos(S392)[phosAb] is unchanged by rChek1
    *** cells: none
    *** source: 10673501-Fig-2c

total phosphorylation


  *** rTp53[32P] phos[32P-ATP] is increased by rChek1
    *** cells: none
    *** inhibited by: rChek1(D130A)"KD" [substitution]
    *** source: 10673501-Fig-2b
  *** rTp53[32P] phos[32P-ATP] is increased by rChek1
    *** cells: none
    *** partially inhibited by: rTp53(1-363) [substitution]
    *** partially inhibited by: rTp53(1-307) [substitution]
    *** source: 10673501-Fig-3a
  *** rTp53[32P] phos[32P-ATP] is increased by rChek1
    *** cells: none
    *** partially inhibited by: rTp53(del(334-356)) [substitution]
    *** source: 10673501-Fig-3b
  *** rTp53[32P] phos[32P-ATP] is increased by rChek1
    *** cells: none
    *** partially inhibited by: xTp53(97-393) [substitution]
    *** partially inhibited by: xTp53(97-363) [substitution]
    *** inhibited by: xTp53(97-305) [substitution]
    *** source: 10673501-Fig-5a

============================================================
Phosphorylation by Chek1 does not affect Tp53 stabilization
============================================================

  *** xTp53[Ab] prot-exp[WB] is unchanged itpo xChek1
    *** cells: H1299<Tp53~null><xTp53> in BMS
    *** source: 10673501-Fig-4a
  *** xTp53[Ab] prot-exp[WB] is increased itpo xChek1
    *** cells: MCF7<xTp53> in BMS
    *** unaffected by: xChek1(mnr)"kinase-domain" [substitution]
    *** source: 10673501-Fig-4b
  *** xTp53[Ab] prot-exp[WB] is detectable
    *** cells: H1299<Tp53~null><xTp53> in BMS
    *** unaffected by: xChek1 [addition]
    *** unaffected by: xChek1(D130A) [addition]
    *** comment: partially inhibited by addtion of Chek1 anti-sense DNA
    *** source: 10673501-Fig-4a
