========================================================
direct phosphorylation on S15 by immunoprecipitated Atm
========================================================

S15--

  *** rTp53(1-47)[phosAb] phos(S15)[phosAb] is increased by Atm[Ab]IP
    *** cells: none
    *** IPfrom: L40 in BMS
    *** source: 9733514-Fig-2c
  *** rTp53(1-101)[32P] phos[32P-ATP] is increased by xAtm[tAb]IP
    *** cells: none
    *** IPfrom: HEK293T in BMS
    *** unaffected by: rTp53((1-101)/S6A) [substitution]
    *** unaffected by: rTp53((1-101)/S9A) [substitution]
    *** inhibited by: rTp53((1-101)/S15A) [substitution]
    *** source: 9733515-Fig-1b
  *** rTp53[32P] phos[32P-ATP] is increased by Atm[Ab]IP
    *** cells: none
    *** IPfrom: L40 in BMS
    *** inhibited by: rTp53(31-393) [substitution] 
    *** inhibited by: rTp53(42-393) [substitution] 
    *** inhibited by: rTp53(97-393) [substitution] 
    *** inhibited by: rTp53(97-305) [substitution] 
    *** inhibited by: rTp53(S15A/S37A) [substitution] 
    *** source: 9733514-Fig-2b
  *** rTp53[phosAb] phos(S15)[phosAb] is increased by xAtm[Ab]IP
    *** cells: none
    *** IPfrom: HEK293T<xAtm> in BMS
    *** inhibited by: xAtm(mnr)"KD" [substitution]
    *** source: 16163388-Fig-8a
  *** rTp53[32P] phos[32P-ATP] is increased by xAtm[tAb]IP
    *** cells: none
    *** IPfrom: GM9607<Atm~fmut><xAtm> in BMS
    *** inhibited by: rTp53(S15A/S37A) [substitution]
    *** source: 12556884-Fig-3a
  *** rTp53(9-22)[32P] phos[32P-ATP] is increased by xAtm[tAb]IP
    *** cells: none
    *** IPfrom: HEK293T<xAtm> in BMS
    *** inhibited by: xAtr(D2870A/N2875K)"KD" [substitution]
    *** source: 10766245-Fig-3b
  *** rTp53(1-102)[phosAb] phos(S15)[phosAb] is increased by (xAtm{dimer}[tAb]IP + rRad50 + rMre11 + rNbs1 + dsDNA)
    *** cells: none
    *** IPfrom: HEK293T<xAtm{dimer}> in BMS
    *** source: 15790808-Fig-1g
  *** rTp53(1-102)[phosAb] phos(S15)[phosAb] is increased by xAtm[tAb]IP
    *** cells: none
    *** IPfrom: HEK293T<xAtm> in BMS
    *** enhanced by: rMre11 + rRad50 + rNbs1 [addition]
    *** source: 15064416-Fig-2b
  *** rTp53[phosAb] phos(S15)[phosAb] is increased by (xAtm{dimer}[tAb]IP + rRad50 + rMre11 + rNbs1 + dsDNA)
    *** cells: none
    *** IPfrom: HEK293T<xAtm{dimer}> in BMS
    *** reqs: dsDNA [omission]
    *** source: 15790808-Fig-S2a
  *** rTp53[phosAb] phos(S15)[phosAb] is increased by (xAtm{dimer}[tAb]IP + rRad50 + rMre11 + rNbs1 + dsDNA)
    *** cells: none
    *** IPfrom: HEK293T<xAtm{dimer}> in BMS
    *** unaffected by: xAtm(S1981A) [substitution]
    *** source: 15790808-Fig-S2a
  *** rTp53(1-66)[32P] phos[32P-ATP] is increased by Atm[Ab]IP
    *** cells: none
    *** IPfrom: HELA in BMS "nuclear-extracts"
    *** inhibited by: KU55933 [addition]
    *** source: 18006705-Fig-1d

not S33--

  *** rTp53(1-47)[phosAb] phos(S33)[phosAb] is unchanged by Atm[Ab]IP
    *** cells: none
    *** IPfrom: L40 in BMS
    *** source: 9733514-Fig-2c

not S37--

  *** rTp53(1-47)[phosAb] phos(S37)[phosAb] is unchanged by Atm[Ab]IP
    *** cells: none
    *** IPfrom: L40 in BMS
    *** source: 9733514-Fig-2c

total

  *** rTp53(1-47)[32P] phos[32P-ATP] is increased by Atm[Ab]IP
    *** cells: none
    *** IPfrom: L40 in BMS
    *** comment: inhibited by pretreatment of IP with wortmannin
    *** source: 9733514-Fig-1d
  *** rTp53[32P] phos[32P-ATP] is increased by Atm[Ab]IP
    *** cells: none
    *** IPfrom: L40 in BMS
    *** unaffected by: rTp53(1-80) [substitution]
    *** unaffected by: rTp53(1-47) [substitution]
    *** source: 9733514-Fig-2a
  *** rTp53(1-47)[32P] phos[32P-ATP] is increased by Atm[Ab]IP
    *** cells: none
    *** IPfrom: L39 in BMS
    *** source: 10611322-Fig-4a
  ***  rTp53[32P] phos[32P-ATP] is increased by xAtm[tAb]IP
    *** cells: none
    *** IPfrom: HEK293T<xAtm> in BMS
    *** source: 11331603-Fig-3a
  *** rTp53(9-21)[32P] phos[32P-ATP] is increased by xAtm[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xAtm> in BMS
    *** source: 11877376-Fig-2a

===================
Protein Association
===================

  *** rTp53(1-102)[tAb] boundby[WB] xAtm[tAb]IP is increased by (rMre11 + rRad50 + rNbs1)
    *** cells: none
    *** IPfrom: HEK293T<xAtm> in BMS
    *** source: 15064416-Fig-4c
