===================
dephos of Smad3(T8)
===================

  *** rSmad3{phos}[phosAb] phos(T8)[phosAb] is decreased by rCtdsp1
    *** cells: none
    *** comment: rSmad3 was phosphorylated by rErk2{act}
    *** inhibited by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4d

  *** xSmad3[tAb]IP phos(T8)[phosAb] is decreased by rCtdsp1
    *** cells: none
    *** IPfrom: HEK293T<xSmad2> in BMS
    *** inhibited by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4b
  *** xSmad3[tAb]IP phos(T8)[phosAb] is decreased by xCtdsp1[tAb]IP
    *** cells: none
    *** IP1from: HEK293T<xSmad2> in BMS
    *** IP2from: HEK293T in BMS
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA"[tAb]IP [substitution]
    *** source: 17035229-Fig-4a
  -----------------------------------------------------------------
  *** xSmad3[tAb]IP phos(T8)[phosAb] is decreased itpo xCtdsp1
    *** cells: HACAT in BMS
    *** source: 17035229-Fig-7d
  *** xSmad3[tAb]IP phos(T8)[phosAb] is decreased itpo xCtdsp1
    *** cells: HEK293T in BMS
    *** enhanced by: Egf (90 min) [stim]
    *** enhanced by: Tgfb1 (90 min) [stim]
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-7b
  *** xSmad3[tAb]IP phos(T8)[phosAb] is decreased itpo xCtdsp1
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-2b
  *** xSmad3[tAb]IP phos(T8)[phosAb] is decreased by xCtdsp1[tAb]IP
    *** cells: none
    *** IP1from: HEK293T<xSmad2> in BMS
    *** IP2from: HEK293T in BMS
    *** unaffected by: Egf (90 min) [stim]
    *** unaffected by: Tgfb1 (90 min) [stim]
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA"[tAb]IP [substitution]
    *** source: 17035229-Fig-7c
  -----------------------------------------------------------------
  *** xSmad3[tAb]IP phos(T8)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-5b
  *** xSmad3[tAb]IP phos(T8)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1 [addition]
    *** unaffected by: xCtdsp1(D96E/D98N)"CIA" [addition]
    *** source: 17035229-Fig-5a
  *** xSmad3[tAb]IP phos(T8)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-2a
  *** xSmad3[tAb]IP phos(T8)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-1c

========================
no dephos of Smad3(T179)
========================

  *** rSmad3{phos}[phosAb] phos(T179)[phosAb] is unchanged by rCtdsp1
    *** cells: none
    *** comment: rSmad3 was phosphorylated by rErk2{act}
    *** unaffected by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4d
  *** xSmad3[tAb]IP phos(T179)[phosAb] is unchanged by rCtdsp1
    *** cells: none
    *** IPfrom: HEK293T<xSmad2> in BMS
    *** unaffected by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4b
  *** xSmad3[tAb]IP phos(T179)[phosAb] is unchanged by xCtdsp1[tAb]IP
    *** cells: none
    *** IP1from: HEK293T<xSmad2> in BMS
    *** IP2from: HEK293T in BMS
    *** unaffected by: Egf (90 min) [stim]
    *** unaffected by: Tgfb1 (90 min) [stim]
    *** unaffected by: xCtdsp1(D96E/D98N)"CIA"[tAb]IP [substitution]
    *** source: 17035229-Fig-7c
  *** xSmad3[tAb]IP phos(T179)[phosAb] is unchanged by xCtdsp1[tAb]IP
    *** cells: none
    *** IP1from: HEK293T<xSmad2> in BMS
    *** IP2from: HEK293T in BMS
    *** unaffected by: xCtdsp1(D96E/D98N)"CIA"[tAb]IP [substitution]
    *** source: 17035229-Fig-4a
  -----------------------------------------------------------------
  *** xSmad3[tAb]IP phos(T179)[phosAb] is unchanged itpo xCtdsp1
    *** cells: HEK293T<xSmad2> in BMS
    *** unaffected by: xCtdsp1(D96E/D98N)"CIA"[tAb]IP [substitution]
    *** source: 17035229-Fig-2b
  -----------------------------------------------------------------
  *** xSmad3[tAb]IP phos(T179)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** unaffected by: xCtdsp1(D96E/D98N)"CIA" [addition]
    *** source: 17035229-Fig-5a
  *** xSmad3[tAb]IP phos(T179)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** unaffected by: xCtdsp1 [addition]
    *** source: 17035229-Fig-2a
  *** xSmad3[tAb]IP phos(T179)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** unaffected by: xCtdsp1 [addition]
    *** source: 17035229-Fig-5b
  *** xSmad3[tAb]IP phos(T179)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** unaffected by: xCtdsp1 [addition]
    *** source: 17035229-Fig-1c


=====================
dephos of Smad3(S204)
=====================

  *** rSmad3{phos}[phosAb] phos(S204)[phosAb] is decreased by rCtdsp1
    *** cells: none
    *** comment: rSmad3 was phosphorylated by rErk2{act}
    *** inhibited by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4d
  *** xSmad3[tAb]IP phos(S204)[phosAb] is decreased by rCtdsp1
    *** cells: none
    *** IPfrom: HEK293T<xSmad2> in BMS
    *** inhibited by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4b
  *** xSmad3[tAb]IP phos(S204)[phosAb] is decreased itpo xCtdsp1
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-2b
  -----------------------------------------------------------------
  *** xSmad3[tAb]IP phos(S204)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-5b
  *** xSmad3[tAb]IP phos(S204)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** unaffected by: xCtdsp1(D96E/D98N)"CIA" [addition]
    *** source: 17035229-Fig-5a
  *** xSmad3[tAb]IP phos(S204)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-2a
  *** xSmad3[tAb]IP phos(S204)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-1c

=====================
dephos of Smad3(S208)
=====================

  *** rSmad3{phos}[phosAb] phos(S208)[phosAb] is decreased by rCtdsp1
    *** cells: none
    *** comment: rSmad3 was phosphorylated by rErk2{act}
    *** inhibited by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4d
  *** xSmad3[tAb]IP phos(S208)[phosAb] is decreased by rCtdsp1
    *** cells: none
    *** IPfrom: HEK293T<xSmad2> in BMS
    *** inhibited by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4b
  *** xSmad3[tAb]IP phos(S208)[phosAb] is decreased by xCtdsp1[tAb]IP
    *** cells: none
    *** IP1from: HEK293T<xSmad2> in BMS
    *** IP2from: HEK293T in BMS
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA"[tAb]IP [substitution]
    *** source: 17035229-Fig-4a
  --------------------------------------------------------------------
  *** xSmad3[tAb]IP phos(S208)[phosAb] is decreased by xCtdsp1[tAb]IP
    *** cells: none
    *** IP1from: HEK293T<xSmad2> in BMS
    *** IP2from: HEK293T in BMS
    *** unaffected by: Egf (90 min) [stim]
    *** unaffected by: Tgfb1 (90 min) [stim]
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA"[tAb]IP [substitution]
    *** source: 17035229-Fig-7c
  *** xSmad3[tAb]IP phos(S208)[phosAb] is decreased itpo xCtdsp1
    *** cells: HEK293T in BMS
    *** unaffected by: Egf (90 min) [stim]
    *** unaffected by: Tgfb1 (90 min) [stim]
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-7b
  *** xSmad3[tAb]IP phos(S208)[phosAb] is decreased itpo xCtdsp1
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-2b
  --------------------------------------------------------------------
  *** xSmad3[tAb]IP phos(S208)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-5b
  *** xSmad3[tAb]IP phos(S208)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** unaffected by: xCtdsp1(D96E/D98N)"CIA" [addition]
    *** source: 17035229-Fig-5a
  *** xSmad3[tAb]IP phos(S208)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-2a
  *** xSmad3[tAb]IP phos(S208)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-1c
  --------------------------------------------------------------------
  *** Smad3[tAb]IP phos(S208)[phosAb] is unchanged itpo xCtdsp1
    *** cells: HACAT in BMS
    *** source: 17035229-Fig-7d

=====================
dephos of Smad3(S213)
=====================

  *** rSmad3{phos}[phosAb] phos(S213)[phosAb] is decreased by rCtdsp1
    *** cells: none
    *** comment: rSmad3 was phosphorylated by rErk2{act}
    *** inhibited by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4d
  *** xSmad3[tAb]IP phos(S213)[phosAb] is decreased by rCtdsp1
    *** cells: none
    *** IPfrom: HEK293T<xSmad2> in BMS
    *** inhibited by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-4b
  *** xSmad3[tAb]IP phos(S213)[phosAb] is decreased by xCtdsp1[tAb]IP
    *** cells: none
    *** IP1from: HEK293T<xSmad2> in BMS
    *** IP2from: HEK293T in BMS
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA"[tAb]IP [substitution]
    *** source: 17035229-Fig-4a
  *** xSmad3[tAb]IP phos(S213)[phosAb] is decreased by xCtdsp1[tAb]IP
    *** cells: none
    *** IP1from: HEK293T<xSmad2> in BMS
    *** IP2from: HEK293T in BMS
    *** unaffected by: Egf (90 min) [stim]
    *** unaffected by: Tgfb1 (90 min) [stim]
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA"[tAb]IP [substitution]
    *** source: 17035229-Fig-7c
  --------------------------------------------------------------------
  *** xSmad3[tAb]IP phos(S213)[phosAb] is decreased itpo xCtdsp1
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-2b
  --------------------------------------------------------------------
  *** xSmad3[tAb]IP phos(S213)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-5a
  *** xSmad3[tAb]IP phos(S213)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-2a
  *** xSmad3[tAb]IP phos(S213)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-1c

==========================
dephos of Smad3(S423/S425)  ???
==========================

  *** xSmad3[tAb]IP phos(S423/S425)[phosAb] is detectable
    *** cells: HEK293T<xSmad2> in BMS
    *** partially inhibited by: xCtdsp1 [addition]
    *** source: 17035229-Fig-2a

=================
coppt with Ctdsp1
=================

  *** Smad3[Ab] snaggedby[WB] rCtdsp1[GST] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: rCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-3a
  *** xSmad3[Ab] copptby[WB] xCtdsp1[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: xCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-3b
  *** xSmad3[tAb] copptby[WB] xCtdsp1[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: Egf (90 min) [stim]
    *** unaffected by: Tgfb1 (90 min) [stim]
    *** unaffected by: xCtdsp1(D96E/D98N)"CIA" [substitution]
    *** source: 17035229-Fig-7a

