============================
Vav2-Yphos is a Gef for Rac1
============================

  *** xVav2[tAb] snaggedby[WB] rRac1(G15N)"NucFree"[GST] is detectable
    *** cells: NIH3T3 in BMS
    *** source: 12376551-Fig-1

  *** rRac1{GDP} GTP-association[35S-GTPgS] is increased by xVav2{phos}[His]IP
    *** cells: none
    *** IPfrom: SF9 in BMS
    *** comment: Vav2-IP was phosphorylated by rLck
    *** inhibited by: xVav2[His]IP [substitution]
    *** source: 9822605-Fig-4a

  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xVav2
    *** cells: NIH3T3 in BMS
    *** source: 10744696-Fig-8
  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xVav2
    *** cells: HEK293 in BMS
    *** bkg inhibited by: xVav2(L342R/L343S)"DH-domain-mut" [substitution]
    *** source: 11448999-Fig-5a
  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xVav2
    *** cells: HEK293 in BMS
    *** inhibited by: xVav2(R425G)"PH-domain-mut" [substitution]
    *** source: 11448999-Fig-4a
  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xVav2
    *** cells: HEK293 in BMS
    *** source: 11448999-Fig-1b
  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xVav2
    *** cells: HEK293 in BMS
    *** unaffected by: Wortmannin [addition]
    *** source: 11448999-Fig-4a
  *** xRac1[tAb] GTP-association[BDPD] is increased itpo xVav2
    *** cells: NIH3T3 in BMS
    *** source: 11448999-Fig-1a

=======================================================
Requirement for Src kinase activity
evidence that Vav2 requires Yphos for Rac1Gef activity
Does the kinase matter?
=======================================================

  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xVav2
    *** cells: HEK293 in BMS
    *** inhibited by: xSrc(mnr)"KD" [addition]
    *** source: 11448999-Fig-3a
  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xVav2
    *** cells: HEK293 in BMS
    *** enhanced by: xSrc(Y530F)"CA" [addition]
    *** source: 12810717(D)

================================================================
Increase in Rac1{GTP} by "oncogenic" Vav2 does not req Vav2-Yphos
================================================================

  *** rRac1{GDP} GTP-association[35S-GTPgS] is increased by xVav2(mnr)"oncoprotein"{phos}[His]IP
    *** cells: none
    *** IPfrom: SF9 in BMS
    *** comment: Vav2-IP was phosphorylated by rLck
    *** unaffected by: xVav2(mnr)"oncoprotein"[His]IP [substitution]
    *** source: 9822605-Fig-5b
