===============
Direct response
===============

  *** rRac1 GDP-dissociation[3H-GDP] is increased by rRasGrf1{Yphos}
    *** cells: none
    *** comment: rRasGrf1 is phosed by rSrc
    *** inhibited by: rRasGrf1(WT) [substitution]
    *** source: 10681520-Fig-6b

===================
SemiDirect Response
===================

requires Src coexpression or RasGrf1 Cterm deletion

  *** rRac1{GDP} GDP-dissociation[3H-GDP] is increased by xRasGrf1[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xRasGrf1><xSrc(Y530F)> in BMLS
    *** reqs: xSrc(Y530F) [omission]
    *** source: 16481401-Fig-5b
  *** rRac1{GDP} GDP-dissociation[3H-GDP] is increased by xRasGrf1(1-631)"delC"[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xRasGrf1(1-631)"delC"><xSrc(Y530F)> in BMLS
    *** does not req: xSrc(Y530F) [omission]
    *** source: 16481401-Fig-5c

==============================
GTP binding in the presence of
==============================

enhanced by Src-CA

  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xRasGrf1
    *** cells: HEK293 in BMS
    *** enhanced by: xSrc(mnr)"vSrc" [addition]
    *** source: 10681520-Fig-2c
  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xRasGrf1
    *** cells: HEK293 in BMS
    *** enhanced by: xRasGrf1(1-631)"delC" [substitution]
    *** inhibited by: xRasGrf1(632-1262)"delN" [substitution]
    *** source: 16481401-Fig-5a
  *** Rac1[Ab] GTP-association[BDPD] is increased itpo xRasGrf1
    *** cells: HEK293 in BMS
    *** enhanced by: xSrc(Y530F)"CA" [addition]
    *** source: 16481401-Fig-5a
