===========================
Gain of Tgfa in supernatant
===========================

  *** xTgfa[Ab] secretion[ELISA] is increased itpo xAdam17
    *** cells: M2<Adam17~fmut><xProTgfa> in BMLS
    *** unaffected by: xAdam17(S819A) [substitution]
    *** unaffected by: xAdam17(S791A) [substitution]
    *** inhibited by: xAdam17(T735A) [substitution]
    *** source: 20188673-Fig-5b
  *** xTgfa[Ab] secretion[ELISA] is increased itpo xAdam17
    *** cells: CHO<xProTgfa> in BMLS
    *** inhibited by: xAdam17(T735A) [substitution]
    *** source: 20188673-Fig-5d
  *** xTgfa[AP] secretion[AP] is detectable
    *** cells: mEFs<xProTgfa> in BMS
    *** partially reqs: Adam17 [KO]
    *** does not req: Adam10 [KO]
    *** source: 19158376-Fig-2
  *** xTgfa[AP] secretion[AP] is increased itpo xAdam17
    *** cells: mEFs<Adam17~null><xProTgfa> in BMS
    *** source: 19158376-Fig-2g
  *** xTgfa[AP] secretion[AP] is increased itpo xAdam17
    *** cells: mEFs<Adam17~null><Adam10~null><xProTgfa> in BMS
    *** source: 19158376-Fig-3b

======================
Loss from cell surface
======================

  *** xProTgfa[Ab] prot-exp[WB] is decreased itpo xAdam17
    *** cells: M2<Adam17~fmut><xProTgfa> in BMLS
    *** comment: all three bands are gone
    *** reversed by: xAdam17(E406A) [substitution]
    *** source: 20188673-Fig-3d
  *** xProTgfa[Ab] prot-exp[WB] is increased itao Adam17 [RNAi]
    *** cells: CHO<xProTgfa> in BMLS
    *** source: 20188673-Fig-5c

=================
Indirect Evidence
=================

  *** EgfR[Ab]IP Yphos[pYAb] is decreased itao Adam17 [RNAi]
    *** cells: T42 in BMLS
    *** source: 20188673-Fig-7g




