direct interactions

  *** rMras{GTP}[Ab] boundby[WB] (rShoc2[GST] + rPpp1cs[GST]) is detectable
    *** cells: none
    *** reqs: rPpp1cs [omission]
    *** inhibited by: rMras{GDP} [substitution]
    *** source: 16630891-Fig-1g
  *** rPpp1cs[Ab] boundby[WB] (rShoc2[GST] + rMras{GTP}[GST]) is detectable
    *** cells: none
    *** inhibited by: rMras{GDP} [substitution]
    *** source: 16630891-Fig-1g

Ppp1cs - Mras complex reqs Shoc2 Mras{GTP}

  *** Ppp1cs[Ab] copptby[WB] xMras[GST] is detectable
    *** cells: HEK293T in BMS
    *** enhanced by: xMras(H81L)"CA" [substitution]
    *** source: 16630891-Fig-1b
  *** Ppp1cs[Ab] copptby[WB] xMras(H81L)[GST] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Shoc2 [RNAi]
    *** source: 16630891-Fig-1f
  *** Ppp1cs[Ab] copptby[WB] xMras(H81L)[GST] is detectable
    *** cells: HEK293T in BMS
    *** enhanced by: xShoc2 [addition]
    *** unaffected by: xRaf1 [addition]
    *** unaffected by: xAraf [addition]
    *** inhibited by: xBraf [addition]
    *** source: 16630891-Fig-3a
  *** Ppp1cs[Ab] copptby[WB] xMras(H81L)[GST] is detectable
    *** cells: HEK293T<xShoc2> in BMS
    *** unaffected by: xRaf1 [addition]
    *** inhibited by: xAraf [addition]
    *** unaffected by: xBraf [addition]
    *** source: 16630891(D)
  *** Ppp1ca[MS] copptby[WB] xMras(H81L)[GST] is detectable
    *** cells: HEK293 in BMS
    *** source: 16630891-Fig-1a
  *** Ppp1cs[Ab] copptby[WB] xMras(H81L)[GST] is detectable
    *** cells: HEK293T in BMS
    *** enhanced by: xShoc2 [addition]
    *** unaffected by: xKsr1 [addition]
    *** unaffected by: xCnksr1 [addition]
    *** source: 16630891-Fig-3d
  *** Ppp1cs[Ab] copptby[WB] xMras(H81L)[GST] is increased itpo xShoc2
    *** cells: HEK293T in BMS
    *** unaffected by: xRaf1 [addition]
    *** source: 16630891-Fig-3a
  *** Ppp1cs[Ab] copptby[WB] xMras(H81L)[GST] is increased itpo xShoc2
    *** cells: HEK293T<xRaf1> in BMS
    *** source: 16630891-Fig-3b,3d
  *** Ppp1cs[Ab] copptby[WB] xMras(H81L)[GST] is increased itpo xShoc2
    *** cells: HEK293T<xRaf1> in BMS
    *** inhibited by: xShoc2(D175N) [substitution]
    *** partially inhibited by: xShoc2(E457K) [substitution]
    *** unaffected by: xShoc2(C260Y) [substitution]
    *** unaffected by: xShoc2(P510L) [substitution]
    *** source: 16630891-Fig-3c
  *** Ppp1cs[Ab] copptby[WB] xMras(H81L)[GST] is increased itpo xShoc2
    *** cells: HEK293T<xRaf1> in BMS
    *** source: 16630891-Fig-3d

Shoc2 - Mras complex reqs Mras{GTP}

  *** Shoc2[Ab] copptby[WB] xMras[GST] is detectable
    *** cells: HEK293T in BMS
    *** enhanced by: xMras(H81L)"CA" [substitution]
    *** source: 16630891-Fig-1b,1f
  *** xShoc2[tAb] copptby[WB] xMras[tAb] is detectable
    *** cells: HEK293T in BMS
    *** enhanced by: xMras(H81L)"CA" [substitution]
    *** unaffected by: xRaf1 [addition]
    *** unaffected by: xBraf [addition]
    *** source: 16630891-Fig-3a
  *** Shoc2[MS] copptby[WB] xMras(H81L)[GST] is detectable
    *** cells: HEK293 in BMS
    *** source: 16630891-Fig-1a
  *** Shoc2[Ab] copptby[WB] xMras(H81L)[GST] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xMras(H81L/D48A) [substitution]
    *** source: 16630891-Fig-1c
  *** xShoc2[tAb] copptby[WB] xMras(H81L)[GST] is detectable
    *** cells: HEK293T<xRaf1> in BMS
    *** source: 16630891-Fig-3b
  *** xShoc2[tAb] copptby[WB] xMras(H81L)[GST] is detectable
    *** cells: HEK293T<xRaf1> in BMS
    *** inhibited by: xShoc2(D175N) [substitution]
    *** partially inhibited by: xShoc2(E457K) [substitution]
    *** unaffected by: xShoc2(C260Y) [substitution]
    *** unaffected by: xShoc2(P510L) [substitution]
    *** source: 16630891-Fig-3c
  *** xMras[tAb] copptby[WB] xShoc2[GST] is detectable
    *** cells: HEK293T in BMS
    *** enhanced by: xMras(H81L) [substitution]
    *** unaffected by: xRaf1 [addition]
    *** source: 16630891-Fig-1d
  *** xMras(H81L)[tAb] copptby[WB] xShoc2[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: xRaf1 [addition]
    *** source: 16630891-Fig-1d

Shoc2

  *** Ppp1cs[Ab] copptby[WB] Shoc2[Ab] is detectable
    *** cells: HELA in BMLS
    *** unaffected by: Egf (5 min) [stim]
    *** source: 16630891-Fig-1e

