=====================================================
Myc is phosphorylated on T358, S373, and T400 by Pak2
=====================================================

Direct Phosphorylation

  *** rMyc(353-439)"CT"[32P] phos[32P-ATP] is increased by rPak2{act}
    *** cells: none
    *** comment: rPak2 was activated with Cdc42{GTPgS}
    *** inhibited by: rMyc((353-439)/T358A/S373A/T400A) [substitution]
    *** partially inhibited by: rMyc((353-439)/S373A/T400A) [substitution]
    *** partially inhibited by: rMyc((353-439)/T358A/T400A) [substitution]
    *** partially inhibited by: rMyc((353-439)/T358A/S373A) [substitution]
    *** source: 14749374-Fig-2b
  *** xMyc(353-439)"CT"[Ab]IP phos[32Pi] is increased itpo xPak2
    *** cells: HEK293T<xMyc(353-439)> in BMS
    *** inhibited by: xMyc((353-439)/T358A/S373A/T400A) [substitution]
    *** source: 14749374-Fig-3a
  *** rMyc[32P] phos[32P-ATP] is increased by rPak2{act}
    *** cells: none
    *** comment: rPak2 was activated with Cdc42{GTPgS}
    *** comment: phosphorylation occurs on Ser and Thr
    *** inhibited by: rMyc(1-352)"NT" [substitution]
    *** source: 14749374-Fig-2a

Indirect Phosphorylation

  *** xMyc[Ab]IP phos[32Pi] is increased itpo xPak2
    *** cells: HEK293T<xMyc> in BMS
    *** inhibited by: xMyc(T358A/S373A/T400A) [substitution]
    *** source: 14749374-Fig-3a
  *** Myc[Ab]IP phos[32Pi] is increased itpo xPak2
    *** cells: HEK293T in BMS
    *** source: 14749374-Fig-3a

===================================================================
Myc DNA binding is decreased in response to phosphorylation by Pak2
===================================================================

  *** xMyc[Ab] snaggedby[WB] oligo[biotin] is decreased itpo xPak2
    *** cells: HEK293T<xMyc> in BMS
    *** reversed by: xMyc(T358A/S373A/T400A) [substitution] 
    *** source: 14749374-Fig-5a
  *** xMyc[Ab] snaggedby[WB] oligo[biotin] is detectable
    *** cells: HEK293T<xMyc> in BMS
    *** unaffected by: xMyc(T358A/S373A/T400A) [substitution]
    *** inhibited by: xMyc(T358D/S373D/T400D) [substitution]
    *** partially inhibited by: xMyc(T358D) [substitution]
    *** partially inhibited by: xMyc(S373D) [substitution]
    *** unaffected by: xMyc(T400D) [substitution]
    *** inhibited by: xMyc(S373D/T400D) [substitution]
    *** partially inhibited by: xMyc(T358D/S373D) [substitution]
    *** partially inhibited by: xMyc(T358D/T400D) [substitution]
    *** source: 14749374-Fig-5a

=======================================================================
Myc binding to Max is decreased in response to phosphorylation by Pak2
=======================================================================

  *** rMyc[tAb] boundby[WB] rMax[GST] is detectable
    *** cells: none
    *** inhibited by: rMyc{phos} [substitution]
    *** comment: rMyc was phosed by rPak2{act}
    *** source: 14749374-Fig-4a
  *** rMyc(353-439)"CT"[tAb] boundby[WB] rMax[GST] is detectable
    *** cells: none
    *** inhibited by: rMyc(353-439){phos} [substitution]
    *** comment: rMyc(353-439) was phosed by rPak2{act}
    *** source: 14749374-Fig-4a

