  *** Mre11[Ab] copptby[WB] Nbs1[Ab] is detectable
    *** cells: GM637 in BMS
    *** source: 16478990-Fig-6a
  *** Mre11[Ab] copptby[WB] Nbs1[Ab] is detectable
    *** cells: HELA in BMS
    *** source: 16431910-Fig-S1
  *** Mre11[Ab] copptby[WB] Nbs1[Ab] is detectable
    *** cells: HELA in BMS "nuclear-extracts"
    *** source: 12607003-Fig-1c
  *** Mre11[Ab] copptby[WB] Rad50[Ab] is detectable
    *** cells: HELA in BMS "nuclear-extracts"
    *** source: 12607003-Fig-1c

===========================================
Nbs1 features required for binding to Mre11
===========================================

  *** Mre11[Ab] copptby[WB] xNbs1[Ab] is detectable
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** inhibited by: xNbs1(1-652) [substitution]
    *** unaffected by: xNbs1(401-754) [substitution]
    *** unaffected by: xNbs1(S278A/S343A) [substitution]
    *** source: 15234984-Fig-1b
  *** Mre11[Ab] copptby[WB] xNbs1[Ab] is detectable
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** unaffected by: xNbs1(1-735)"dAtm" [substitution]
    *** unaffected by: xNbs1(454-754)"NbFR5" [substitution]
    *** unaffected by: xNbs1(454-735)"NbFR5sAtm" [substitution]
    *** source: 16478990-Fig-6a
  *** Mre11[Ab] copptby[WB] xNbs1[tAb] is detectable
    *** cells: NotReported<xAtm><xNbs1> in BMS
    *** unaffected by: xNbs1(1-734) [substitution]
    *** source: 15758953-Fig-1d
  *** Mre11[Ab] snaggedby[WB] rNbs1(675-697)[biotin] is detectable
    *** cells: HELA in BMS "nuclear-extract"
    *** inhibited by: rNbs1(734-754) [substitution]
    *** source: 15758953-Fig-1b
  *** Mre11[Ab] snaggedby[WB] rNbs1(675-697)[biotin] is detectable
    *** cells: HELA in BMS "nuclear-extract"
    *** inhibited by: rNbs1(734-754) [substitution]
    *** source: 15758953-Fig-S4a
  *** Mre11[tAb] copptby[WB] xNbs1[tAb] is detectable
    *** cells: NotReported<xAtm><xNbs1> in BMS
    *** unaffected by: xNbs1(1-734)"delC" [substitution]
    *** inhibited by: xNbs1(N684A/F685A/K686A/K687A)"dMIR" [substitution]
    *** source: 15758953-Fig-1e
  *** xNbs1[tAb] copptby[WB] xMre11[tAb] is detectable
    *** cells: HEK293T<xNbs1><xMre11> in BMS
    *** unaffected by: xNbs1(S343A) [substitution]
    *** source: 10766245-Fig-5a

==========================================
Mre11 requires Nbs1 to relocate to nucleus
==========================================
is it recruited by Nbs1 or does it bind in cyto first?
=======================================================

  *** Mre11[Ab] locatedin(nucleus)[IHC] is increased itpo xNbs1
    *** cells: NBS1LBI<Nbs1~fmut> in BMS
    *** unaffected by: xNbs1(1-734)"delC" [substitution]
    *** source: 15758953-Fig-S2
  *** xMre11[Ab] locatedin(nucleus)[IHC] is detectable
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1><xMre11> in BMS
    *** reqs: xNbs1 [omission]
    *** comment: req for xNbs1 can be overcome by fusing NLS to xMre11-Cterm
    *** source: 16478990-Fig-2b

=============================
Rad50 binds to Mre11 via Nbs1
=============================

  *** Rad50[Ab] copptby[WB] Mre11[Ab] is detectable
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** partially reqs: xNbs1 [omission]
    *** source: 16478990-Fig-1b

============================================
Rad50 features required for binding to Nbs1
============================================

  *** Rad50[Ab] copptby[WB] xNbs1[Ab] is detectable
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** inhibited by: xNbs1(1-652) [substitution]
    *** unaffected by: xNbs1(401-754) [substitution]
    *** unaffected by: xNbs1(S278A/S343A) [substitution]
    *** source: 15234984-Fig-1b
  *** Rad50[Ab] copptby[WB] xNbs1[Ab] is detectable
    *** cells: NBS1LBI<Nbs1~fmut><xNbs1> in BMS
    *** unaffected by: xNbs1(1-735)"dAtm" [substitution]
    *** unaffected by: xNbs1(454-754)"NbFR5" [substitution]
    *** unaffected by: xNbs1(454-735)"NbFR5sAtm" [substitution]
    *** source: 16478990-Fig-6a
  *** Rad50[Ab] copptby[WB] xNbs1[tAb] is detectable
    *** cells: NotReported<xAtm><xNbs1> in BMS
    *** unaffected by: xNbs1(1-734) [substitution]
    *** source: 15758953-Fig-1d

  *** Nbs1[Ab] copptby[WB] Mre11[Ab] is detectable
    *** cells: HELA in BMS
    *** source: 16431910-Fig-S1
  *** Nbs1[Ab] copptby[WB] Mre11[Ab] is detectable
    *** cells: HELA in BMS "nuclear-extracts"
    *** source: 12607003-Fig-1c
  *** Nbs1[Ab] copptby[WB] Rad50[Ab] is detectable
    *** cells: HELA in BMS "nuclear-extracts"
    *** source: 12607003-Fig-1c
  *** Rad50[Ab] copptby[WB] Mre11[Ab] is detectable
    *** cells: GM637 in BMS
    *** source: 16478990-Fig-1b
  *** Rad50[Ab] copptby[WB] Mre11[Ab] is detectable
    *** cells: HELA in BMS
    *** source: 16431910-Fig-S1
  *** Rad50[Ab] copptby[WB] Mre11[Ab] is detectable
    *** cells: HELA in BMS "nuclear-extracts"
    *** source: 12607003-Fig-1c
  *** Rad50[Ab] copptby[WB] Nbs1[Ab] is detectable
    *** cells: HELA in BMS
    *** source: 16431910-Fig-S1
  *** Rad50[Ab] copptby[WB] Nbs1[Ab] is detectable
    *** cells: HELA in BMS "nuclear-extracts"
    *** source: 12607003-Fig-1c


================================================================
KD of one MRN component causes a decrease in prot-exp of others
================================================================

  *** Mre11[Ab] prot-exp[WB] is decreased itao Nbs1 [RNAi]
    *** cells: HT1080<xAtm> in BMS
    *** source: 20026654-Fig-S1d
  *** Mre11[Ab] prot-exp[WB] is decreased itao Rad50 [RNAi]
    *** cells: HT1080<xAtm> in BMS
    *** source: 20026654-Fig-S1d
  *** Nbs1[Ab] prot-exp[WB] is decreased itao Mre11 [RNAi]
    *** cells: HT1080<xAtm> in BMS
    *** source: 20026654-Fig-S1d
  *** Nbs1[Ab] prot-exp[WB] is decreased itao Rad50 [RNAi]
    *** cells: HT1080<xAtm> in BMS
    *** source: 20026654-Fig-S1d
  *** Rad50[Ab] prot-exp[WB] is decreased itao Mre11 [RNAi]
    *** cells: HT1080<xAtm> in BMS
    *** source: 20026654-Fig-S1d
  *** Rad50[Ab] prot-exp[WB] is decreased itao Nbs1 [RNAi]
    *** cells: HT1080<xAtm> in BMS
    *** source: 20026654-Fig-S1d

