========================
semi-direct phos by Mlk3
========================

  *** rMkk4(K167R)[32P] phos[32P-ATP] is increased by xMlk3[tAb]IP
    *** cells: none
    *** comment: xMlk3 IP is from HEK293 cells
    *** inhibited by: xMlk3(K144A)"KD" [substitution]
    *** source: 10232608-Fig-5b
  *** rMkk4(K131R)[32P] phos[32P-ATP] is increased by xMlk3[tAb]IP
    *** cells: COS in BMS
    *** comment: xMlk3[tAb]IP was from COS cells
    *** inhibited by: rMkk4(S257A/T261L) [substitution]
    *** source: 8702571-Fig-3a

==============================
semi-direct activation by Mlk3
==============================

  *** rMkk4[GST] IVKA(Jnk?,Jun)[32P-ATP] is increased by xMlk3[tAb]IP
    *** cells: COS in BMS
    *** comment: xMlk3[tAb]IP was from COS cells
    *** source: 8702571-Fig-3a

  *** rJnk2[32P] phos[32P-ATP] is increased by xMlk3[tAb]IP
    *** cells: none
    *** comment: rMkk4 is present in the reaction mix
    *** comment: xMlk3 IP is from HEK293 cells
    *** inhibited by: xMlk3(K144A)"KD" [substitution]
    *** source: 10232608-Fig-5d





====
IVKA
====

  *** xMkk4[tAb]IP IVKA(Jnk1,Jun)[32P-ATP] is increased itpo xMlk3
    *** cells: COS7 in BMS
    *** source: 9891090-Fig-7
  *** xMkk4[tAb]IP IVKA(Jnk2)[32P-ATP] is increased itpo xMlk3
    *** cells: COS in BMS
    *** source: 8702571-Fig-2a

====
phos
====

  *** xMkk4[tAb]IP phos[32Pi] is increased itpo xMlk3
    *** cells: HELA in BMS
    *** source: 9003778-Fig-1b
  *** Mkk4[phosAb] phos(T261)[phosAb] is increased itpo xMlk3
    *** cells: HEK293 in BMS
    *** inhibited by: xMlk3(L410P)"oligo-mut" [substitution]
    *** enhanced by: xCdc42(G12V)"CA" [addition]
    *** source: 10862766(D)
  *** xMkk4[phosAb] phos(T261)[phosAb] is increased itpo xMlk3
    *** cells: HELA in BMS
    *** inhibited by: xMlk3(T277A) [substitution]
    *** unaffected by: xMlk3(T278A) [substitution]
    *** inhibited by: xMlk3(S281A) [substitution]
    *** source: 11053428-Fig-2b

====================
physical interaction
====================

  *** xMlk3[Ab] snaggedby[WB] rMkk4[GST] is detectable
    *** cells: HEK293 in BMS
    *** partially inhibited by: xMlk3(L410P) [substitution]
    *** source: 10862766(D)

