======================
Direct Phosphorylation
======================

  *** rMek1[32P] phos[32P-ATP] is increased by rTpl2
    *** cells: none
    *** comment: partially inhibited by treatment of rTpl2 with PPase
    *** source: 15466476-Fig-1b
  *** rMek1[32P] phos[32P-ATP] is increased by rTpl2(30-398)
    *** cells: none
    *** comment: partially inhibited by treatment of rTpl2(30-398) with PPase
    *** source: 15466476-Fig-1a

===========================
Semi-Direct Phosphorylation
===========================

  *** rMek1[phosAb] phos(S218)[phosAb] is increased by xTpl2[tAb]IP
    *** cells: none
    *** IPfrom: HEK293T<xTpl2> in BMS
    *** inhibited by: xTpl2(K167R)"KD" [substitution]
    *** inhibited by: xTpl2(T290A) [substitution]
    *** inhibited by: xTpl2(T290D) [substitution]
    *** inhibited by: xTpl2(T290E) [substitution]
    *** source: 15466476-Fig-4a

==================================================
Phosphorylation in response to Tpl2 overexpression
==================================================

  *** Mek12s[phosAb] phos(SMANS)[phosAb] is increased itpo xTpl2
    *** cells: HEK293T in BMS
    *** inhibited by: xTpl2(K167R)"KD" [substitution]
    *** inhibited by: xTpl2(T290A) [substitution]
    *** partially inhibited by: xTpl2(T290D) [substitution]
    *** inhibited by: xTpl2(T290E) [substitution]
    *** source: 15466476-Fig-3
  *** xMek1[tAb]IP phos(sitenr)[phosAb] is increased itpo xTpl2
    *** cells: NIH3T3 in BMS
    *** source: 10669751-Fig-6
  *** Mek12s[phosAb] phos(SMANS)[phosAb] is increased itpo xTpl2
    *** cells: mEFs in BMS
    *** inhibited by: xNfkb1 [addition]
    *** source: 12832462-Fig-9a

=================
Downstream events
=================

  *** Erks[phosAb] phos(TEY)[phosAb] is increased itpo xTpl2
    *** cells: HEK293T in BMS
    *** inhibited by: xTpl2(K167R)"KD" [substitution]
    *** partially inhibited by: xTpl2(T290A) [substitution]
    *** partially inhibited by: xTpl2(T290D) [substitution]
    *** inhibited by: xTpl2(T290E) [substitution]
    *** source: 15466476-Fig-3
  *** xErk1[phosAb] phos(TEY)[phosAb] is increased itpo xTpl2
    *** cells: HEK293 in BMS
    *** source: 16291755-Fig-3d
  *** Erk2[Ab]IP IVKA(Elk1)[32P-ATP] is increased itpo xTpl2
    *** cells: HEK293 in BMS
    *** source: 16291755-Fig-3a
  *** Erk2[Ab]IP IVKA(Elk1)[32P-ATP] is increased itpo xTpl2
    *** cells: HEK293 in BMS
    *** source: 16291755-Fig-3c
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased itpo xTpl2
    *** cells: NIH3T3 in BMS
    *** source: 10669751-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased itpo xTpl2
    *** cells: HEK293 in BMS
    *** inhibited by: xTpl2(K167M)"KD" [substitution]
    *** inhibited by: xTpl2(S274A) [substitution]
    *** inhibited by: xTpl2(Y282A) [substitution]
    *** inhibited by: xTpl2(Y282D) [substitution]
    *** inhibited by: xTpl2(T290A) [substitution]
    *** partially inhibited by: xTpl2(T290D) [substitution]
    *** unaffected by: xTpl2(T278A) [substitution]
    *** unaffected by: xTpl2(T278D) [substitution]
    *** source: 15778223-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased itpo xTpl2
    *** cells: HEK293 in BMS
    *** inhibited by: xTpl2(K167M)"KD" [substitution]
    *** inhibited by: xTpl2(T290A) [substitution]
    *** partially inhibited by: xTpl2(T290D) [substitution]
    *** source: 15778223-Fig-2d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased itpo xTpl2
    *** cells: HEK293 in BMS
    *** source: 16371247-Fig-2a
