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phosphorylation of Mek1 on S218/S222 by Pak2 requires Mek1 kinase activity
===========================================================================

  *** rMek1[phosAb] phos(S218/S222)[phosAb] is increased by rPak2
    *** cells: none
    *** comment: rxn also contains rErk2-KD
    *** inhibited by: rMek1(K97A)"KD" [substitution]
    *** inhibited by: rMek1(S298A) [substitution]
    *** unaffected by: rMek1(T292A) [substitution]
    *** source: 17314031-Fig-4b

  *** rMek1[phosAb] phos(S218/S222)[phosAb] is increased by rPak2
    *** cells: none
    *** partially inhibited by: U0126 [addition] no-bkg-control
    *** source: 17314031-Fig-5a

  *** rMek1[phosAb] phos(S218/S222)[phosAb] is increased by rPak2
    *** cells: none
    *** comment: rxn also contains rErk2-KD
    *** inhibited by: rMek1(K97A)"KD" [substitution]
    *** inhibited by: rMek1(S298A) [substitution]
    *** inhibited by: rMek1(S281A/S222A) [substitution]
    *** source: 17314031-Fig-5b

=======================================
phosphorylation of Mek1 on S298 by Pak2
=======================================

  *** rMek1[phosAb] phos(S298)[phosAb] is increased by rPak2
    *** cells: none
    *** comment: rxn also contains rErk2-KD
    *** unaffected by: rMek1(K97A)"KD" [substitution]
    *** inhibited by: rMek1(S298A) [substitution]
    *** unaffected by: rMek1(T292A) [substitution]
    *** source: 17314031-Fig-4b

  *** rMek1[phosAb] phos(S298)[phosAb] is increased by rPak2
    *** cells: none
    *** unaffected by: U0126 [addition]
    *** source: 17314031-Fig-5a

  *** rMek1[phosAb] phos(S298)[phosAb] is increased by rPak2
    *** cells: none
    *** comment: rxn also contains rErk2-KD
    *** unaffected by: rMek1(K97A)"KD" [substitution]
    *** inhibited by: rMek1(S298A) [substitution]
    *** unaffected by: rMek1(S281A/S222A) [substitution]
    *** source: 17314031-Fig-5b
