=================
Direct Activation
=================

  *** rMek1 IVKA(Erk?,MBP)[32P-ATP] is increased by rBraf
    *** cells: none
    *** enhanced by: rLamtor3 [addition]
    *** source: 9733512-Fig-2b

  *** rErk2(K52M)"KD"[phosAb] phos(TEY)[phosAb] is increased by (rBraf + rMek1)
    *** cells: none
    *** inhibited by: rMek1(K97A)"KD" [substitution]
    *** unaffected by: rMek1(S298A) [substitution]
    *** partially inhibited by: rMek1(S281A/S222A) [substitution]
    *** comment: no controls for rMek1 alone
    *** source: 17314031-Fig-5b

======================
Direct phosphorylation
======================

  *** rMek1[phosAb] phos(S218/S222)[phosAb] is increased by (rBraf + rErk2(mnr)"KD")
    *** cells: none
    *** partially inhibited by: rMek1(K97A)"KD" [substitution]
    *** unaffected by: rMek1(S298A) [substitution]
    *** source: 17314031-Fig-5b
  *** rMek1[phosAb] phos(S298)[phosAb] is unchanged by (rBraf + rErk2(mnr)"KD")
    *** cells: none
    *** source: 17314031-Fig-5b
  *** rMek1[32P] phos[32P-ATP] is increased by rBraf
    *** cells: none
    *** enhanced by: rLamtor3 [addition]
    *** source: 9733512-Fig-2a

====================
physical interaction
====================

  *** Mek12s[Ab] copptby[WB] xBraf[tAb] is detectable
    *** cells: COS1 in BMS
    *** unaffected by: xBraf(T599A) [substitution]
    *** unaffected by: xBraf(S602A) [substitution]
    *** unaffected by: xBraf(T599A/S602A) [substitution]
    *** source: 11032810-Fig-3

