requirement for (Nae1 : Uba3) Ube2m from the neddylation of Tp53 in 15242646
assumes that neddylation works similarly to ubiquitination

  *** Mdm2[Ab] nedd[NdAb-ppt] is detectable
    *** cells: H1299 in BMS
    *** source: 15242646-Fig-3f
  *** Mdm2[Ab] nedd[NdAb-ppt] is detectable
    *** cells: SJSA in BMS
    *** source: 15242646-Fig-3f
  *** xMdm2[Ab] nedd[tNdAb-ppt] is detectable
    *** cells: H1299<Tp53~null><xMdm2><xNedd8> in BMS
    *** inhibited by: xMdm2(C464A) [substitution]
    *** inhibited by: xMdm2(1-342) [substitution]
    *** inhibited by: xMdm2(1-272) [substitution]
    *** inhibited by: xMdm2(1-152) [substitution]
    *** source: 15242646-Fig-1b
  *** Mdm2[Ab]IP nedd[NdAb] is detectable
    *** cells: H1299 in BMS
    *** source: 15242646-Fig-3f
  *** Mdm2[Ab]IP nedd[NdAb] is detectable
    *** cells: SJSA in BMS
    *** source: 15242646-Fig-3f

