  *** rMdm2[32P] phos[32P-ATP] is increased by rAkt1(mnr)"CA"
    *** cells: none
    *** inhibited by: rMdm2(S166A/S186A) [substitution]
    *** comment: rMdm2 was phosed on S166 and S186 [MS]
    *** source: 11504915-Fig-1b

  *** rMdm2[32P] phos[32P-ATP] is increased by xAkt1(mnr)"CA"
    *** cells: none
    *** IPfrom: HEK293T<xAkt1(mnr)"CA"> in BMS
    *** unaffected by: rMdm2(S166D) [substitution]
    *** unaffected by: rMdm2(S166D) [substitution]
    *** inhibited by: rMdm2(S166D/S186D) [substitution]
    *** source: 11715018-Fig-3e

===================
Protein Association
===================

  *** xAkt1(mnr)"CA"[Ab] copptby[WB] Mdm2[Ab] is detectable
    *** cells: NIH3T3<xAkt1(mnr)"CA"> in BMS
    *** unaffected by: xAkt1(mnr)"DN" [substitution]
    *** source: 11715018-Fig-3d
  *** xAkt1(mnr)"DN"[Ab] copptby[WB] Mdm2[Ab] is detectable
    *** cells: NIH3T3<xAkt1(mnr)"DN"> in BMS
    *** unaffected by: Etoposide [addition]
    *** source: 11715018-Fig-3c
  *** Akt1[Ab] copptby[WB] Mdm2[Ab] is detectable
    *** cells: NIH3T3<xErbb2> in BMS
    *** unaffected by: Etoposide [addition]
    *** source: 11715018-Fig-3c

  *** Mdm2[Ab] copptby[WB] xAkt1(mnr)"CA"[Ab] is detectable
    *** cells: NIH3T3<xAkt1(mnr)"CA"> in BMS
    *** enhanced by: xAkt1(mnr)"DN" [substitution]
    *** source: 11715018-Fig-3d
  *** Mdm2[Ab] copptby[WB] xAkt1(mnr)"CA"[tAb] is detectable
    *** cells: NIH3T3<xAkt1(mnr)"CA"> in BMS
    *** unaffected by: xAkt1(mnr)"DN" [substitution]
    *** source: 11715018-Fig-3d


=================
Downstream Events
=================

  *** Mdm2[Ab] prot-exp[WB] is increased itpo xAkt1(mnr)"DN"
    *** cells: NIH3T3 in BMS
    *** source: 11715018-Fig-2d
