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Transcription
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  *** Mdm2-gene mRNA[Northern] is increased itpo xTp53(A138V)
    *** cells: DP161 in BMS
    *** source: 12654245-Fig-1b

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Translation
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  *** Mdm2[Ab] prot-exp[WB] is increased itpo xTp53
    *** cells: H1299<Tp53~null> in BMS
    *** unaffected by: xTp53(S46A) [substitution]
    *** unaffected by: xTp53(del(46-46)) [substitution]
    *** inhibited by: xTp53(S121F) [substitution]
    *** source: 11030628-Fig-8a
  *** Mdm2[Ab] prot-exp[WB] is increased itpo xTp53
    *** cells: H1299<Tp53~null> in BMS
    *** unaffected by: xTp53(K120R/K164R/K370R/K372R/K373R/K381R/K382R/K386R)"8KR" [substitution]
    *** source: 18485870-Fig-3c
  *** Mdm2[Ab] prot-exp[WB] is increased itpo xTp53
    *** cells: H1299<Tp53~null> in BMS
    *** unaffected by: xTp53(K120R/K164R) [substitution]
    *** unaffected by: xTp53(K120R/K370R/K372R/K373R/K381R/K382R/K386R)"K120R/6KR" [substitution]
    *** unaffected by: xTp53(K120R/K164R/K370R/K372R/K373R/K381R/K382R/K386R)"8KR" [substitution]
    *** source: 18485870-Fig-2c
  *** Mdm2[Ab] prot-exp[WB] is increased itpo xTp53
    *** cells: H1299<Tp53~null> in BMS
    *** unaffected by: xTp53(K120R) [substitution]
    *** source: 18485870-Fig-S2b
  *** Mdm2[Ab] prot-exp[WB] is increased itpo xTp53
    *** cells: H1299<Tp53~null> in BMS
    *** unaffected by: xTp53(K120R/K164R/K370R/K372R/K373R/K381R/K382R/K386R)"8KR" [substitution]
    *** source: 18485870-Fig-7a
  *** Mdm2[Ab] prot-exp[WB] is increased itpo xTp53
    *** cells: H1299<Tp53~null> in BMS
    *** unaffected by: xTp53(K164R) [substitution]
    *** unaffected by: xTp53(K370R/K372R/K373R/K381R/K382R/K386R)"6KR" [substitution]
    *** unaffected by: xTp53(K164R/K370R/K372R/K373R/K381R/K382R/K386R)"7KR" [substitution]
    *** unaffected by: xTp53(K120R/K164R/K370R/K372R/K373R/K381R/K382R/K386R)"8KR" [substitution]
    *** source: 18485870-Fig-2b

================
Promoter Binding
================

  *** Tp53[Ab] boundto(Mdm2-gene)[ChIP] is detectable
    *** cells: mEFs in BMS "treated with Adriamycin for 8 hr"
    *** partially reqs: Pin1 [KO]
    *** source: 12397361-Fig-3e
  *** Tp53[Ab] boundto(Mdm2-gene)[ChIP] is detectable
    *** cells: mEFs in BMS "treated with ActinomycinD for 12 hr"
    *** partially reqs: Pin1 [KO]
    *** source: 12397361-Fig-3e
  *** xTp53(A138V)[Ab] boundto(Mdm2-gene)[ChIP] is detectable
    *** cells: DP161<xTp53(A138V)> in BMS
    *** source: 12654245-Fig-2c


  *** xTp53[Ab] boundto(Mdm2-gene)[ChIP] is detectable
    *** cells: H1299<Tp53~null><xTp53> in BMS
    *** unaffected by: xMdm2 [addition]
    *** unaffected by: xCbp + xTip60 + xMdm2 [addition]
    *** source: 18485870-Fig-4c
  *** xTp53[Ab] boundto(Mdm2-gene)[ChIP] is detectable
    *** cells: H1299<Tp53~null><xTp53> in BMS
    *** unaffected by: xTp53(K120R/K164R/K370R/K372R/K373R/K381R/K382R/K386R)"8KR" [substitution]
    *** source: 18485870-Fig-4c

