=====================================
Activation of Jun-gene promo-reporter
=====================================

  *** Jun-gene promo-reporter[Luc] is increased itpo xJun
    *** cells: HCT116 in BMS
    *** inhibited by: xJun(T63A/T73A/T91A/T93A) [substitution]
    *** source: 16007074-Fig-S4b
  *** Jun-gene promo-reporter[Luc] is increased itpo xJun
    *** cells: NIH3T3 in BMS
    *** inhibited by: xJun(T63A/T73A/T91A/T93A) [substitution]
    *** source: 16007074-Fig-S4a
  *** Jun-gene promo-reporter[Luc] is increased itpo xJun
    *** cells: SW480 in BMS
    *** inhibited by: xJun(T63A/T73A/T91A/T93A) [substitution]
    *** source: 16007074-Fig-S5a
  *** Jun-gene promo-reporter[Luc] is increased itpo xJun
    *** cells: HCT116 in BMS
    *** enhanced by: xTcf7l2 [addition]
    *** source: 16007074-Fig-S4b
  *** Jun-gene promo-reporter[Luc] is increased itpo xJun
    *** cells: SW480 in BMS
    *** enhanced by: xTcf7l2 [addition]
    *** source: 16007074-Fig-S5a
  *** Jun-gene promo-reporter[Luc] is increased itpo xJun
    *** cells: SW480 in BMS
    *** enhanced by: xTcf7l2 [addition]
    *** source: 16007074-Fig-S5b
  *** Jun-gene promo-reporter[Luc] is increased itpo xJun
    *** cells: HCT116 in BMS
    *** enhanced by: xTcf7l2 [addition]
    *** source: 16007074-Fig-2e
  *** Jun-gene promo-reporter[Luc] is increased itpo xJun
    *** cells: HCT116 in BMS
    *** enhanced by: xTcf7l2 [addition]
    *** source: 16007074-Fig-2f

  *** Jun-gene promo-reporter[Luc] is increased itpo xTcf7l2
    *** cells: HCT116<xJun> in BMS
    *** reqs: Ctnnb1 [RNAi]
    *** source: 16007074-Fig-2e

  *** Jun-gene promo-reporter[Luc] is increased itpo xTcf7l2
    *** cells: HCT116 in BMS
    *** enhanced by: xJun [addition]
    *** partially inhibited by: xJun(T63A/T73A/T91A/T93A) [addition]
    *** source: 16007074-Fig-S4b
  *** Jun-gene promo-reporter[Luc] is increased itpo xTcf7l2
    *** cells: HCT116 in BMS
    *** enhanced by: xJun [addition]
    *** source: 16007074-Fig-2e
  *** Jun-gene promo-reporter[Luc] is increased itpo xTcf7l2
    *** cells: HCT116 in BMS
    *** enhanced by: xJun [addition]
    *** source: 16007074-Fig-2f
  *** Jun-gene promo-reporter[Luc] is increased itpo xTcf7l2
    *** cells: SW480 in BMS
    *** enhanced by: xJun [addition]
    *** partially inhibited by: xJun(T63A/T73A/T91A/T93A) [addition]
    *** source: 16007074-Fig-S5a
  *** Jun-gene promo-reporter[Luc] is increased itpo xTcf7l2
    *** cells: SW480 in BMS
    *** enhanced by: xJun [addition]
    *** source: 16007074-Fig-S5b

===============================================
Binding to Jun-gene in Anisomycin treated cells
===============================================

  *** Ctnnb1[Ab] boundto(Jun-gene)[ChIP] is detectable
    *** cells: HCT116 in BMS "treated with Anisomycin"
    *** source: 16007074-Fig-2d
  *** xJun[tAb] boundto(Jun-gene)[ChIP] is detectable
    *** cells: HCT116<xJun> in BMS "treated with Anisomycin"
    *** inhibited by: xJun(T63A/T73A/T91A/T93A) [substitution]
    *** source: 16007074-Fig-2c
  *** Tcf7l2[Ab] boundto(Jun-gene)[ChIP] is detectable
    *** cells: HCT116 in BMS "treated with Anisomycin"
    *** source: 16007074-Fig-2b

========================
Jun-Tcfl2-Ctnnb1 complex
========================

  *** xCtnnb1[Ab] copptby[WB] xJun[Ab] is detectable
    *** cells: HEK293T<xCtnnb1><xJun> in BMS "treated with Anisomycin"
    *** reqs: Tcf7l2 [RNAi]
    *** source: 16007074-Fig-1d
  *** Tcf7l2[Ab] copptby[WB] Jun[Ab] is detectable
    *** cells: HCT116 in BMS "treated with Anisomycin"
    *** source: 16007074-Fig-1a
  *** xTcf7l2[tAb] copptby[WB] Ctnnb1[Ab] is detectable
    *** cells: HEK293T<xTcf7l2> in BMS "treated with Anisomycin"
    *** inhibited by: xTcf7l2(mnr)"del-Nterm" [substitution]
    *** source: 16007074-Fig-1e
  *** xTcf7l2[tAb] copptby[WB] Jun[Ab] is detectable
    *** cells: HEK293T<xTcf7l2> in BMS "treated with Anisomycin"
    *** unaffected by: xTcf7l2(mnr)"del-Nterm" [substitution]
    *** source: 16007074-Fig-1c
  *** xTcf7l2[tAb] copptby[WB] xJun[tAb] is detectable
    *** cells: HEK293T<xTcf7l2><xJun> in BMS "treated with Anisomycin"
    *** inhibited by: xJun(T63A/T73A/T91A/T93A) [substitution]
    *** inhibited by: xJun(T63A/T73A) [substitution]
    *** unaffected by: xJun(T91A/T93A) [substitution]
    *** source: 16007074-Fig-S1
  *** xTcf7l2[tAb] copptby[WB] xJun[tAb] is detectable
    *** cells: HEK293T<xTcf7l2><xJun> in BMS "treated with Anisomycin"
    *** inhibited by: xJun(T63A/T73A/T91A/T93A) [substitution]
    *** source: 16007074-Fig-1b

===============================
What happens in NIH3T3 cells??
===============================

  *** Jun-gene promo-reporter[Luc] is unchanged itpo xTcf7l2
    *** cells: NIH3T3 in BMS
    *** source: 16007074-Fig-S4a
  *** Jun-gene promo-reporter[Luc] is increased itpo xJun
    *** cells: NIH3T3 in BMS
    *** unaffected by: xTcf7l2 [addition]
    *** source: 16007074-Fig-S4a

