===========================
Semi-direct Phosphorylation
===========================

phos(T32)

  *** rFoxo3[phosAb] phos(T32)[phosAb] is increased by xSgk1(S422D)"CA"[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xSgk1(S422D)"CA"> in BMS
    *** source: 11154281-Fig-1c
  *** rFoxo3[32P] phos[32P-ATP] is increased by xSgk1(S422D)"CA"[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xSgk1(S422D)"CA"> in BMS
    *** partially inhibited by: rFoxo3(T32A) [substitution]
    *** partially inhibited by: rFoxo3(T32A/T253A) [substitution]
    *** inhibited by: rFoxo3(T32A/S315A) [substitution]
    *** inhibited by: rFoxo3(T32A/T253A/S315A) [substitution]
    *** source: 11154281-Fig-1b

phos(S253)

  *** rFoxo3[phosAb] phos(S253)[phosAb] is unchanged by xSgk1(S422D)"CA"[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xSgk1(S422D)"CA"> in BMS
    *** source: 11154281-Fig-1c
  *** rFoxo3[32P] phos[32P-ATP] is increased by xSgk1(S422D)"CA"[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xSgk1(S422D)"CA"> in BMS
    *** partially inhibited by: rFoxo3(T253A) [substitution]
    *** partially inhibited by: rFoxo3(T32A/T253A) [substitution]
    *** partially inhibited by: rFoxo3(T253A/S315A) [substitution]
    *** inhibited by: rFoxo3(T32A/T253A/S315A) [substitution]
    *** source: 11154281-Fig-1b

phos(S315)

  *** rFoxo3[phosAb] phos(S315)[phosAb] is increased by xSgk1(S422D)"CA"[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xSgk1(S422D)"CA"> in BMS
    *** source: 11154281-Fig-1c
  *** rFoxo3[32P] phos[32P-ATP] is increased by xSgk1(S422D)"CA"[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xSgk1(S422D)"CA"> in BMS
    *** partially inhibited by: rFoxo3(S315A) [substitution]
    *** inhibited by: rFoxo3(T32A/S315A) [substitution]
    *** partially inhibited by: rFoxo3(T253A/S315A) [substitution]
    *** inhibited by: rFoxo3(T32A/T253A/S315A) [substitution]
    *** source: 11154281-Fig-1b

total phos

  *** rFoxo3[32P] phos[32P-ATP] is increased by xSgk1[tAb]IP
    *** cells: none
    *** IPfrom: HEK293<xSgk1> in BMLS
    *** inhibited by: xSgk1(K127Q)"KD" [substitution]
    *** enhanced by: xSgk1(S422D)"CA" [substitution]
    *** source: 11154281-Fig-1a

=====================
Basal Phosphorylation
=====================

phos(T32)

  *** Foxo3[phosAb] phos(T32)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xSgk1(T256A/S422A)"KN" [addition]
    *** source: 11154281-Fig-4

phos(S253)

  *** Foxo3[phosAb] phos(S253)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xSgk1(T256A/S422A)"KN" [addition]
    *** source: 11154281-Fig-4

phos(S315)

  *** Foxo3[phosAb] phos(S315)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xSgk1(T256A/S422A)"KN" [addition]
    *** source: 11154281-Fig-4


======================
Sgk1-CA Overexpression
======================

phos(T32)

  *** xFoxo3[phosAb] phos(T32)[phosAb] is increased itpo xSgk1(S422D)"CA"
    *** cells: HEK293T<xFoxo3> in BMS
    *** source: 11154281-Fig-2a
  *** xFoxo3[phosAb] phos(T32)[phosAb] is increased itpo xSgk1(S422D)"CA"
    *** cells: CCL39<xFoxo3> in BMS
    *** source: 11154281-Fig-2a
  *** xFoxo3[phosAb] phos(T32)[phosAb] is increased itpo xSgk1(S422D)"CA"
    *** cells: CCL39<xFoxo3> in BMS
    *** source: 11154281-Fig-3

phos(S253)

  *** xFoxo3[phosAb] phos(S253)[phosAb] is unchanged itpo xSgk1(S422D)"CA"
    *** cells: HEK293T<xFoxo3> in BMS
    *** source: 11154281-Fig-2a
  *** xFoxo3[phosAb] phos(S253)[phosAb] is unchanged itpo xSgk1(S422D)"CA"
    *** cells: CCL39<xFoxo3> in BMS
    *** source: 11154281-Fig-2a
  *** xFoxo3[phosAb] phos(S253)[phosAb] is increased itpo xSgk1(S422D)"CA"
    *** cells: CCL39<xFoxo3> in BMS
    *** source: 11154281-Fig-3

phos(S315)

  *** xFoxo3[phosAb] phos(S315)[phosAb] is increased itpo xSgk1(S422D)"CA"
    *** cells: CCL39<xFoxo3> in BMS
    *** source: 11154281-Fig-2a
  *** xFoxo3[phosAb] phos(S315)[phosAb] is increased itpo xSgk1(S422D)"CA"
    *** cells: HEK293T<xFoxo3> in BMS
    *** source: 11154281-Fig-2a
