==================
Direct Association
==================

  *** rAxin1(298-506)[tAb] boundby[WB] rCtnnb1(1-423)[GST] is detectable
    *** cells: none
    *** inhibited by: rCtnnb1(1-131) [substitution]
    *** unaffected by: rCtnnb1(132-423) [substitution]
    *** unaffected by: rCtnnb1(175-423) [substitution]
    *** inhibited by: rCtnnb1(423-781) [substitution]
    *** source: 9482734-Fig-6d
  *** rAxin1(298-506)[tAb] boundby[WB] rCtnnb1[GST] is detectable
    *** cells: none
    *** comment: unaffected by ATP in the binding buffer
    *** source: 9482734-Fig-7a
  *** rAxin1(298-506)[tAb] boundby[WB] rCtnnb1[GST] is detectable
    *** cells: none
    *** inhibited by: rAxin1(353-437) [substitution]
    *** unaffected by: rAxin1(437-506) [substitution]
    *** comment: numbering refers to rat Axin1
    *** source: 9482734-Fig-8b
  *** rAxin1[tAb] boundby[WB] rCtnnb1[Ab] is detectable
    *** cells: none
    *** comment: unaffected by rBtrc in reaction mix
    *** source: 10228155-Fig-1c
  *** rCtnnb1[35S] boundby[WB] rAxin1[GST] is detectable
    *** cells: none
    *** unaffected by: rCtnnb1{phos} [substitution]
    *** comment: rCtnnb1 was phosed with rCsnk1d and rGsk3b
    *** source: 14600025-Fig-5
  *** rAxin1[35S] boundby[WB] rCtnnb1(133-665)"Arm"[GST] is detectable
    *** cells: none
    *** inhibited by: rAxin1(L471A/D472A) [substitution]
    *** inhibited by: rAxin1(H476A) [substitution]
    *** source: 14600025-Fig-3

inhibited by: Apc(1362-1540){phos}

  *** rAxin1[35S] boundby[WB] rCtnnb1(133-665)"Arm"[GST] is detectable
    *** cells: none
    *** unaffected by: rApc(1133-1189)"B,C" [addition]
    *** unaffected by: rApc(1133-1189)"B,C"{phos} [addition]
    *** unaffected by: rApc(1362-1540)"2,3" [addition]
    *** inhibited by: rApc(1362-1540)"2,3"{phos} [addition]
    *** comment: Apc fragments were phosed with rCsnk1d
    *** source: 14600025-Fig-4c

unaffected by Dvl1--

  *** rCtnnb1[GST] boundby[WB] rAxin1[MalBP] is detectable
    *** cells: none
    *** unaffected by: rDvl1 [addition]
    *** source: 10330181-Fig-5d

==========================
Coprecipitation with Axin1
==========================

Axin1 required features

  *** Ctnnb1[Ab] copptby[WB] xAxin1[tAb] is detectable
    *** cells: COS<xAxin1> in BMS
    *** unaffected by: xAxin1(298-832) [substitution]
    *** inhibited by: xAxin1(508-832) [substitution]
    *** inhibited by: xAxin1(713-832) [substitution]
    *** inhibited by: xAxin1(1-229) [substitution]
    *** unaffected by: xAxin1(1-713) [substitution]
    *** unaffected by: xAxin1(298-713) [substitution]
    *** unaffected by: xAxin1(298-506) [substitution]
    *** comment: numbering refers to rat Axin1
    *** source: 9482734-Fig-6c
  *** Ctnnb1[Ab] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293<xAxin1><xMyc> in BMS
    *** unaffected by: xAxin1(1-594)"Ex2-6" [substitution]
    *** unaffected by: xAxin1(1-651)"Ex2-7" [substitution]
    *** unaffected by: xAxin1(1-728)"Ex2-8" [substitution]
    *** unaffected by: xAxin1(1-764)"Ex2-9" [substitution]
    *** source: 19131971-Fig-6c
  *** Ctnnb1[Ab] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293<xAxin1> in BMS
    *** partially inhibited by: xAxin1(284-500) [substitution]
    *** partially inhibited by: xAxin1(284-712) [substitution]
    *** inhibited by: xAxin1(475-676) [substitution]
    *** inhibited by: xAxin1(712-827) [substitution]
    *** source: 11487578-Fig-6a
  *** Ctnnb1[Ab] copptby[WB] xAxin1[tAb] is detectable
    *** cells: SW480 in BMS
    *** unaffected by: xAxin1(L396P) [substitution]
    *** source: 11487578-Fig-3a

Ctnnb1 required features

  *** xAxin1[tAb] snaggedby[WB] rCtnnb1[GST] is detectable
    *** cells: COS<xAxin1> in BMS
    *** unaffected by: rCtnnb1(1-423) [substitution]
    *** unaffected by: rCtnnb1(423-781) [substitution]
    *** source: 9482734-Fig-6b

does not require Mekk1--

  *** xCtnnb1(mnr)"delN"[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCtnnb1(mnr)"delN"> in BMS
    *** unaffected by: xMekk1(mnr)"C" [addition]
    *** source: 11408485-Fig-4b
  *** xCtnnb1(mnr)"delN"[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293T<xAxin1><xApc><xCtnnb1(mnr)"delN"> in BMS
    *** unaffected by: xMekk1(mnr)"C" [addition]
    *** source: 11408485-Fig-5c
  *** xAxin1[tAb] copptby[WB] xCtnnb1(mnr)"delN"[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCtnnb1(mnr)"delN"> in BMS
    *** unaffected by: xMekk1(mnr)"C" [addition]
    *** source: 11408485-Fig-4b
  *** xAxin1[tAb] copptby[WB] xCtnnb1(mnr)"delN"[tAb] is detectable
    *** cells: HEK293T<xAxin1><xApc><xCtnnb1(mnr)"delN"> in BMS
    *** unaffected by: xMekk1(mnr)"C" [addition]
    *** source: 11408485-Fig-5c

No extras

  *** Ctnnb1[Ab] copptby[WB] xAxin1[tAb] is detectable
    *** cells: COS<xAxin1> in BMS
    *** source: 9482734-Fig-6a
  *** xAxin1[tAb] snaggedby[WB] rCtnnb1[GST] is detectable
    *** cells: COS<xAxin1> in BMS
    *** comment: ppt also contains Gsk3b [Ab]
    *** source: 9482734-Fig-8b
  *** Ctnnb1[Ab] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293T<xBtrc><xAxin1> in BMS
    *** source: 10228155-Fig-1b
  *** xAxin1[tAb] copptby[WB] Ctnnb1[Ab] is detectable
    *** cells: HEK293T<xBtrc><xAxin1> in BMS
    *** source: 10228155-Fig-1b
  *** Ctnnb1[Ab] copptby[WB] xAxin1[tAb] is undetectable
    *** cells: HEK293T<xFbxw2><xAxin1> in BMS
    *** source: 10228155-Fig-1b
  *** xAxin1[tAb] copptby[WB] Ctnnb1[Ab] is undetectable
    *** cells: HEK293T<xFbxw2><xAxin1> in BMS
    *** source: 10228155-Fig-1b

======================================================
Coprecipitation with other members of the Axin complex
======================================================

Apc--

  *** Ctnnb1[Ab] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xApc> in BMS
    *** unaffected by: xAxin1 [addition]
    *** unaffected by: xAxin1 + Csnk1e [addition]
    *** unaffected by: xAxin1 + Csnk1e + Dvl1 [addition]
    *** source: 11425858-Fig-7
  *** Ctnnb1[Ab] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xApc> in BMS
    *** unaffected by: xCsnk1e [addition]
    *** unaffected by: xCsnk1e(mnr)"KD" [addition]
    *** source: 11425858-Fig-7
  *** Ctnnb1[Ab] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xApc><xCsnk1e> in BMS
    *** unaffected by: xDvl1 [addition]
    *** source: 11425858-Fig-7

Btrc--

  *** Ctnnb1[Ab] copptby[WB] Btrc[Ab] is detectable
    *** cells: HEK293 in BMS
    *** source: 10074433-Fig-2d
  *** Ctnnb1[Ab] copptby[WB] Btrc[Ab] is detectable
    *** cells: NEURO2A in BMS
    *** source: 10074433-Fig-2d
  *** Ctnnb1[Ab] copptby[WB] xBtrc[tAb] is detectable
    *** cells: HEK293 in BMS "treated with ALLN for 4 hr"
    *** partially inhibited by: xBtrc(241-569)"WD1-7" [substitution]
    *** inhibited by: xBtrc(291-569)"WD2-7" [substitution]
    *** inhibited by: xBtrc(1-247)"Fbox" [substitution]
    *** inhibited by: xBtrc(1-306)"FWD1" [substitution]
    *** source: 10074433-Fig-2c
  *** Ctnnb1[Ab] copptby[WB] xBtrc[tAb] is detectable
    *** cells: HEK293 in BMS "treated with ALLN for 4 hr"
    *** source: 10074433-Fig-2a
  *** Ctnnb1[Ab] copptby[WB] xBtrc[tAb] is detectable
    *** cells: HEK293T<xBtrc> in BMS
    *** enhanced by: xAxin1 [addition]
    *** source: 10228155-Fig-1a
  *** Ctnnb1[Ab] copptby[WB] xBtrc[tAb] is detectable
    *** cells: HEK293T<xBtrc><xAxin1> in BMS
    *** inhibited by: xBtrc(1-140)"delF/WD" [substitution]
    *** inhibited by: xBtrc(1-214)"delWD" [substitution]
    *** inhibited by: xBtrc(194-569)"delN/F" [substitution]
    *** unaffected by: xBtrc(del(140-194))"delFbox" [substitution]
    *** source: 10228155-Fig-2b
  *** Ctnnb1[Ab] copptby[WB] xBtrc[tAb] is detectable
    *** cells: NEURO2A in BMS "treated with ALLN for 4 hr"
    *** source: 10074433-Fig-2b
  *** Ctnnb1[Ab] copptby[WB] xBtrc[tAb] is detectable
    *** cells: SW480 in BMS "treated with ALLN for 4 hr"
    *** source: 10074433-Fig-2b

Gsk3b--

  *** Ctnnb1[Ab] copptby[WB] xGsk3b[tAb] is detectable
    *** cells: COS<xAxin1><xGsk3b> in BMS
    *** reqs: xAxin1 [omission]
    *** source: 9482734-Fig-8a
  *** Ctnnb1[Ab] copptby[WB] xGsk3b[tAb] is detectable
    *** cells: HEK293T<xBtrc><xAxin1> in BMS
    *** reqs: xBtrc [omission]
    *** source: 10228155-Fig-3a
  *** Ctnnb1[Ab] copptby[WB] xGsk3b[tAb] is undetectable
    *** cells: HEK293T<xFbxw2><xAxin1> in BMS
    *** source: 10228155-Fig-3a
  *** Ctnnb1[Ab] copptby[WB] xGsk3b[tAb] is detectable
    *** cells: SW480<xGsk3b> in BMS
    *** source: 8638126-Fig-1



