=======================
Direct Phosphorylation
=======================

  *** rAmpka1[32P] phos[32P-ATP] is increased by rLkb1
    *** cells: none
    *** comment: reaction also contains rAmpkb1 and rAmpkg1
    *** enhanced by: rPkcz [addition]
    *** source: 19414597-Fig-1d

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Ampka activity is increased itpo xLkb1
======================================

requires Lkb1 kinase activity

  *** Ampk[Ab]IP IVKA(peptide)[32P-ATP] is increased itpo xLkb1
    *** cells: A549 in BMS
    *** inhibited by: xLkb1(D194A)"KD" [substitution]
    *** source: 19414597-Fig-4a

does not require Lkb1 phos(S307) or phos(S428)

  *** Ampk[Ab]IP IVKA(peptide)[32P-ATP] is increased itpo xLkb1
    *** cells: A549 in BMS
    *** unaffected by: xLkb1(S307A) [substitution]
    *** unaffected by: xLkb1(S428A) [substitution]
    *** unaffected by: xLkb1(S307A/S428A) [substitution]
    *** source: 19414597-Fig-4a

does not require Pkcz

  *** Ampk[Ab]IP IVKA(peptide)[32P-ATP] is increased itpo xLkb1
    *** cells: A549 in BMS
    *** unaffected by: PKCzPS [addition]
    *** source: 19414597-Fig-4a

===============================================================
Ampka phos(T172) is increased itpo Lkb1(S325A/S428A) > Lkb1(WT)
===============================================================

  *** Ampkas[phosAb] phos(T172)[phosAb] is detectable
    *** cells: mEFs<Lkb1~null> in BMS
    *** unaffected by: xLkb1 [addition]
    *** source: 19187764-Fig-5a
  *** Ampkas[phosAb] phos(T172)[phosAb] is detectable
    *** cells: mEFs<Lkb1~null><xLkb1> in BMS
    *** enhanced by: xLkb1(S428A) [substitution]
    *** enhanced by: xLkb1(S325A) [substitution]
    *** enhanced by: xLkb1(S325A/S428A) [substitution]
    *** source: 19187764-Fig-5a
  *** Ampkas[phosAb] phos(T172)[phosAb] is detectable
    *** cells: SKMEL28<xLkb1> in BMS
    *** enhanced by: xLkb1(S428A) [substitution]
    *** enhanced by: xLkb1(S325A) [substitution]
    *** enhanced by: xLkb1(S325A/S428A) [substitution]
    *** source: 19187764-Fig-5b
  *** Ampkas[phosAb] phos(T172)[phosAb] is increased itpo xLkb1
    *** cells: HELA in BMS
    *** enhanced by: xLkb1(S428A) [substitution]
    *** enhanced by: xLkb1(S325A) [substitution]
    *** enhanced by: xLkb1(S325A/S428A) [substitution]
    *** source: 19187764-Fig-S10
  *** Ampkas[phosAb] phos(T172)[phosAb] is increased itpo xLkb1
    *** cells: UACC257 in BMS
    *** enhanced by: xLkb1(S325A/S428A) [addition]
    *** source: 19187764-Fig-S11
  *** Ampkas[phosAb] phos(T172)[phosAb] is increased itpo xLkb1
    *** cells: CHO in BMS
    *** enhanced by: xLkb1(S325A/S428A) [addition]
    *** source: 19187764-Fig-S11

==========================================
Ampk binds to Lkb1(S325A/S428A) > Lkb1(WT)
==========================================

  *** Ampk[Ab] copptby[WB] xLkb1[tAb] is detectable
    *** cells: SKMEL28 in BMS
    *** enhanced by: xLkb1(S325A/S428A) [substitution]
    *** source: 19187764-Fig-5d
  *** xLkb1[tAb] copptby[WB] xAmpka1[GST] is detectable
    *** cells: HEK293<xStrada><xCab39> in BMS
    *** enhanced by: xLkb1(S325A/S428A) [substitution]
    *** source: 19187764-Fig-5c
  *** xAmpka1[GST] copptby[WB] xLkb1[tAb] is detectable
    *** cells: HEK293<xStrada><xCab39> in BMS
    *** enhanced by: xLkb1(S325A/S428A) [substitution]
    *** source: 19187764-Fig-5c
  ------- contradiction -----------------------------








