direct phos

  *** rAkt1[phosAb] phos(S473)[phosAb] is increased by rIlk
    *** cells: none
    *** inhibited by: KPSD1 [addition]
    *** unaffected by: PD98059 [addition]
    *** source: 11313365-Fig-2b
  *** rAkt1[phosAb] phos(S473)[phosAb] is increased by rIlk
    *** cells: none
    *** partially inhibited by: rIlk(E359K) [substitution]
    *** inhibited by: rIlk(S343A) [substitution]
    *** source: 11313365-Fig-4

============================
Akt1 phos(S473) requires Ilk
============================

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MCF7 in BMS
    *** reqs: Ilk [RNAi]
    *** source: 18339839-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mBMMs in BMS "immortalized"
    *** reqs: Ilk [RNAi]
    *** source: 12686550-Fig-3b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MDAMB231 in BMS
    *** reqs: Ilk [RNAi]
    *** source: 18339839-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MDAMB231 in BMS
    *** reqs: Ilk [RNAi]
    *** source: 18339839-Fig-2d
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: PC3 in BMS
    *** reqs: Ilk [RNAi]
    *** source: 18339839-Fig-2a

required Ilk attributes

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: PC3 in BMLS
    *** inhibited by: xIlk(E359K) [addition]
    *** inhibited by: xIlk(E359K/S343A) [addition]
    *** inhibited by: xIlk(E359K/S343D) [addition]
    *** source: 11313365-Fig-7
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mBMMs<Ilk~null><xIlk> in BMS "immortalized"
    *** inhibited by: xIlk(S343A) [substitution]
    *** source: 12686550-Fig-3b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mBMMs<Ilk~null><xIlk> in BMS "immortalized"
    *** unaffected by: xIlk(S343D) [substitution]
    *** source: 12686550-Fig-3b

Akt1 phos(S473) is enhanced itpo Ilk

  *** Akt1[phosAb] phos(S473)[phosAb] is increased itpo xIlk
    *** cells: DU145 in BMLS
    *** inhibited by: xIlk(R211A) [substitution]
    *** unaffected by: xIlk(S343D) [substitution]
    *** source: 11313365-Fig-5a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased itpo xIlk(S343D)
    *** cells: DU145 in BMLS
    *** inhibited by: Wortmannin [addition]
    *** inhibited by: LY294002 [addition]
    *** source: 11313365-Fig-6a

====================================
Akt1 phos(T308) does not require Ilk
====================================

  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** does not req: Ilk [RNAi]
    *** source: 12686550-Fig-2a
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: mBMMs in BMS "immortalized"
    *** does not req: Ilk [RNAi]
    *** source: 12686550-Fig-3b
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: MDAMB231 in BMS
    *** does not req: Ilk [RNAi]
    *** source: 18339839-Fig-2a



  *** Akt1[Ab]IP IVKA(Gsk3b)(S9)[phosAb] is detectable
    *** cells: mBMMs in BMS "immortalized"
    *** partially reqs: Ilk [RNAi]
    *** source: 12686550-Fig-3c

  *** Akt1[Ab] copptby[WB] Ilk[Ab] is detectable
    *** cells: DU145 in BMLS
    *** source: 11313365-Fig-8a

====================
Physical interaction
====================

  *** Akt1[Ab] copptby[WB] Ilk[Ab] is detectable
    *** cells: MDAMB231 in BMS
    *** does not req: Mtor [RNAi]
    *** does not req: Rictor [RNAi]
    *** comment: coppt is not affected by Akt1(S473) phos state
    *** source: 18339839-Fig-4

