======================
Direct Phosphorylation
======================

  *** rAdam17[32P] phos[32P-ATP] is increased by rP38a{act}
    *** cells: none
    *** comment: rP38a was activated by rMkk6(S151E/T211E)
    *** inhibited by: rAdam17(T735A) [substitution]
    *** inhibited by: xP38a(T180A/Y182F) [substitution]
    *** source: 20188673-Fig-4b

===========================
Semi-Direct Phosphorylation
===========================

  *** xAdam17[tAb]IP phos[32P-ATP] is increased by xP38a[tAb]IP
    *** cells: none
    *** IP1from: CHO<xProTgfa><xAdam17> in BMS
    *** IP2from: CHO<xProTgfa><xP38a> in BMS
    *** comment: xMkk6(S151E/T211E)[tAb]IP from CHO<xProTgfa> was included in kinase reaction
    *** inhibited by: SB203580 [addition]
    *** inhibited by: xP38a(T180A/Y182F) [substitution]
    *** source: 20188673-Fig-4c
  *** xAdam17[tAb]IP phos[32P-ATP] is increased by xP38a[tAb]IP
    *** cells: none
    *** IP1from: CHO<xProTgfa><xAdam17> in BMS
    *** IP2from: CHO<xProTgfa><xP38a> in BMS "treated with Anisomycin for 30 min"
    *** reqs: Anisomycin [omission]
    *** source: 20188673-Fig-4d
  *** xAdam17[tAb]IP phos[32P-ATP] is increased by xP38a[tAb]IP
    *** cells: none
    *** IP1from: CHO<xProTgfa><xAdam17> in BMS
    *** IP2from: CHO<xProTgfa><xP38a><xMkk6(S151E/T211E)> in BMS
    *** reqs: xMkk6(S151E/T211E) [omission]
    *** source: 20188673-Fig-4d
  *** xAdam17[tAb]IP phos[32P-ATP] is increased by xP38a[tAb]IP
    *** cells: none
    *** IP1from: CHO<xProTgfa><xAdam17> in BMS
    *** IP2from: CHO<xProTgfa><xP38a><xMkk6(S151E/T211E)> in BMS
    *** unaffected by: xAdam17(S819A) [substitution]
    *** unaffected by: xAdam17(S791A) [substitution]
    *** partially inhibited by: xAdam17(T735A) [substitution]
    *** partially inhibited by: xAdam17(T735A/S819A) [substitution]
    *** partially inhibited by: xAdam17(T735A/S791A) [substitution]
    *** source: 20188673-Fig-5a
  *** xAdam17[tAb]IP phos[32P-ATP] is increased by xP38a[tAb]IP
    *** cells: none
    *** IP1from: CHO<xProTgfa><xAdam17> in BMS
    *** IP2from: CHO<xProTgfa><xP38a><xMkk6(S151E/T211E)> in BMS
    *** unaffected by: xAdam17(S819A) [substitution]
    *** unaffected by: xAdam17(S791A) [substitution]
    *** partially inhibited by: xAdam17(T735A) [substitution]
    *** partially inhibited by: xAdam17(T735A/S819A) [substitution]
    *** partially inhibited by: xAdam17(T735A/S791A) [substitution]
    *** source: 20188673-Fig-S4
  *** xAdam17[tAb]IP Tphos[pTPAb] is increased by xP38a[tAb]IP
    *** cells: none
    *** IP1from: CHO<xProTgfa><xAdam17> in BMS
    *** IP2from: CHO<xProTgfa><xP38a><xMkk6(S151E/T211E)> in BMS
    *** partially inhibited by: xAdam17(S819A) [substitution]
    *** unaffected by: xAdam17(S791A) [substitution]
    *** inhibited by: xAdam17(T735A) [substitution]
    *** inhibited by: xAdam17(T735A/S819A) [substitution]
    *** inhibited by: xAdam17(T735A/S791A) [substitution]
    *** source: 20188673-Fig-5a
  *** xAdam17[tAb]IP Tphos[pTPAb] is increased by xP38a[tAb]IP
    *** cells: none
    *** IP1from: CHO<xProTgfa><xAdam17> in BMS
    *** IP2from: CHO<xProTgfa><xP38a><xMkk6(S151E/T211E)> in BMS
    *** partially inhibited by: xAdam17(S819A) [substitution]
    *** unaffected by: xAdam17(S791A) [substitution]
    *** inhibited by: xAdam17(T735A) [substitution]
    *** inhibited by: xAdam17(T735A/S819A) [substitution]
    *** inhibited by: xAdam17(T735A/S791A) [substitution]
    *** source: 20188673-Fig-S4

==================
Indirect Evidence
==================

  *** Adam17[Ab]IP Tphos[pTPAb] is detectable
    *** cells: T42 in BMLS
    *** reqs: P38a [RNAi]
    *** source: 20188673-Fig-4f

===================
Protein Association
===================

  *** xP38a[tAb] copptby[WB] xAdam17[tAb] is detectable
    *** cells: CHO<xProTgfa><xP38a><xAdam17> in BMLS
    *** inhibited by: xP38a(T180A/Y182F) [substitution]
    *** source: 20188673-Fig-4a







