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Tak1 phosphorylated on T184/T187 irt Cd40L
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Ciap1-- and/or Ciap2--

  *** Tak1[Ab]IP phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS "S100-fraction"
    *** times: 0 10+ 30+ min
    *** inhibited by: SmacMimetic [addition]
    *** source: 18635759-Fig-6d
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 10+ 30+ min
    *** inhibited by: SmacMimetic [addition]
    *** source: 18635759-Fig-6a
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 2 5+ 10++ 30+ min
    *** partially inhibited by: SmacMimetic [addition]
    *** source: 18635759-Fig-S11

Nemo--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: 70Z3 in BMS
    *** times: 0 5+ 10+ 30++ 60++ min
    *** reqs: Nemo [KO]
    *** source: 18635759-Fig-2b

not Traf3--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: A20 in BMS
    *** times: 0 2 5+ 10++ 30++ min
    *** does not req: Traf3 [RNAi]
    *** comment: signal is enhanced at 5 min in Traf3-KO cells
    *** source: 18635759-Fig-1b

not Traf2--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: A20 in BMS
    *** times: 0 2 5+ 10++ 30++ min
    *** reqs: Traf2 [RNAi]
    *** source: 18635759-Fig-1b
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5+ 10++ 30++ 60++ min
    *** does not req: Traf2 [KO]
    *** source: 18635759-Fig-1a

not Traf3--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5+ 10++ 30++ 60++ min
    *** does not req: Traf3 [KO]
    *** comment: signal is enhanced at 5 min in Traf3-KO cells
    *** source: 18635759-Fig-1a

Traf6--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: A20 in BMS
    *** times: 0 2 5+ 10++ 30++ min
    *** reqs: Traf6 [RNAi]
    *** source: 18635759-Fig-1b
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5+ 10++ 30++ 60++ min
    *** partially reqs: Traf6 [KO]
    *** source: 18635759-Fig-1a

===================
Proteasome Activity
===================

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 10+ 30+ min
    *** inhibited by: MG132 [addition]
    *** source: 18635759-Fig-6b


