=================
Required Proteins
=================

Ciap1-- and/or Ciap2--

  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (10 min)
    *** cells: KMS28BM<Ciap1~null><Ciap2~null><xCiap2> in BMS
    *** reqs: xCiap2 [omission]
    *** inhibited by: xCiap2(mnr)"E3-ligase-inactive" [substitution]
    *** source: 18635759-Fig-7a
  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: A20<Traf3~null> in BMS
    *** times: 0 10+ 30+ min
    *** unaffected by: SmacMimetic [addition]
    *** source: 18635759-Fig-7b
  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: KMS28BM in BMS
    *** times: 0 5+ 10+ 30+ 60 min
    *** partially reqs: Ciap1 and/or Ciap2 [null-mut]
    *** source: 18635759-Fig-S8
  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 10++ 30+ min
    *** inhibited by: SmacMimetic [addition]
    *** source: 18635759-Fig-6a
  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 2 5+ 10++ 30+ min
    *** inhibited by: SmacMimetic [addition]
    *** source: 18635759-Fig-S11
  *** Mekk1[Ab]IP phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS "S100-fraction"
    *** times: 0 2 5+ 10++ min
    *** inhibited by: SmacMimetic [addition]
    *** source: 18635759-Fig-S9

Nemo--

  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: 70Z3 in BMS
    *** times: 0 5+ 10+ 30++ 60++ min
    *** reqs: Nemo [KO]
    *** source: 18635759-Fig-2b

Traf2--

  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: A20 in BMS
    *** times: 0 2 5+ 10++ 30+ min
    *** reqs: Traf2 [RNAi]
    *** source: 18635759-Fig-1b
  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5+ 10++ 30++ 60+++ min
    *** reqs: Traf2 [KO]
    *** source: 18635759-Fig-1a
  *** Mekk1[Ab]IP IVKA(Mkk4)[32P-ATP] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5 10+ 30+ 60+ min
    *** reqs: Traf2 [KO]
    *** source: 18635759-Fig-S1a

not Traf3--

  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: A20 in BMS
    *** times: 0 2 5+ 10++ 30+ min
    *** does not req: Traf3 [RNAi]
    *** comment: signal is enhanced at 5 min in Traf3-KO cells
    *** source: 18635759-Fig-1b
  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5+ 10++ 30++ 60+++ min
    *** does not req: Traf3 [KO]
    *** comment: signal is enhanced at 5 min in Traf3-KO cells
    *** source: 18635759-Fig-1a
  *** Mekk1[Ab]IP IVKA(Mkk4)[32P-ATP] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5 10+ 30+ 60+ min
    *** does not req: Traf3 [KO]
    *** comment: signal is enhanced at 5 min in Traf3-KO cells
    *** source: 18635759-Fig-S1a

not Traf6--

  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: A20 in BMS
    *** times: 0 2 5+ 10++ 30+ min
    *** does not req: Traf6 [RNAi]
    *** source: 18635759-Fig-1b
  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5+ 10++ 30++ 60+++ min
    *** does not req: Traf6 [KO]
    *** source: 18635759-Fig-1a
  *** Mekk1[Ab]IP IVKA(Mkk4)[32P-ATP] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5 10+ 30+ 60+ min
    *** does not req: Traf6 [KO]
    *** source: 18635759-Fig-S1a

Ubc13--

  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: A20 in BMS
    *** times: 0 5++ 10++ 30+ 60+ min
    *** reqs: Ubc13 [RNAi]
    *** source: 18635759-Fig-2a

============================
Requires Proteasome Activity
============================

  *** Mekk1[phosAb] phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 10+ 30+ min
    *** inhibited by: MG132 [addition]
    *** source: 18635759-Fig-6b

=========
no extras
=========

  *** Mekk1[Ab]IP phos(T1381)[phosAb] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS "S100-fraction"
    *** times: 0 10+ 30+ min
    *** source: 18635759-Fig-6c
  *** Mekk1[Ab]IP IVKA(auto)[32P-ATP] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5+ 10++ 30+ 60 min
    *** source: 17143273-Fig-4a
  *** Mekk1[Ab]IP IVKA(Mkk4)[32P-ATP] is increased irt anti-Cd40 (times)
    *** cells: mSpBCs in BMS
    *** times: 0 5+ 10++ 30+ 60 min
    *** source: 17143273-Fig-4a

