=======================
Phosphorylation on T735
=======================

  *** Adam17[Ab]IP Tphos[pTPAb] is increased irt Anisomycin (45 min)
    *** cells: T42 in BMLS
    *** inhibited by: SB203580 [cotreatment]
    *** source: 20188673-Fig-S3
  *** Adam17[Ab]IP Tphos[pTPAb] is increased irt Anisomycin (45 min)
    *** cells: T42 in BMLS
    *** source: 20188673-Fig-4f

The only TP site in Adam17 is T735 - Uniprot, PhosoSite

==================
Surface Expression
==================

  *** xAdam17[biotin]IP surface-exp[biotin-labeling] is increased irt Anisomycin (30 min)
    *** cells: CHO<xProTgfa><xAdam17> in BMS
    *** inhibited by: SB203580 [pretreatment]
    *** source: 22550340-Fig-4b
  *** Adam17[biotin]IP surface-exp[biotin-labeling] is increased irt Anisomycin (30 min)
    *** cells: T42 in BMS
    *** inhibited by: SB203580 [pretreatment]
    *** source: 22550340-Fig-4c

=======================
Total Protein Expresson
=======================

  *** xAdam17[tAb]IP prot-exp[WB] is detectable-but unchanged irt Anisomycin (30 min)
    *** cells: HEPG2<xAdam17> in BMS
    *** source: 22550340-Fig-S3b


===============
Oligomerization
===============

  *** xAdam17[tAb] oligomerization[NativeWB] is decreased irt Anisomycin (30 min)
    *** cells: HEK293T<xAdam17> in BMS
    *** reversed by: SB203580 [pretreatment]
    *** source: 22550340-Fig-4d
  *** xAdam17[tAb] oligomerization[2TagPpt] is decreased irt Anisomycin (30 min)
    *** cells: CHO<xProTgfa><xAdam17> in BMS
    *** reversed by: SB203580 [pretreatment]
    *** source: 22550340-Fig-4a
  *** xAdam17[tAb] oligomerization[2TagPpt] is decreased irt Anisomycin (30 min)
    *** cells: HEPG2<xAdam17> in BMS
    *** reversed by: SB203580 [pretreatment]
    *** source: 22550340-Fig-S3b

=================
Protease Activity
=================

  *** Adam17[Ab]IP IVProteaseAct(peptide)[FRET] is unchanged irt Anisomycin (times)
    *** cells: MDAMB231 in BMS
    *** times: 0+ 15+ 30+ 60+ min
    *** source: 23720309-Fig-S4a
  *** Adam17[Ab]IP IVProteaseAct(peptide)[FRET] is increased irt Anisomycin (60 min)
    *** cells: T42 in BMLS
    *** inhibited by: SB203580 [cotreatment]
    *** comment: activation is slight
    *** source: 20188673-Fig-3e


=====================
Association with P38s
=====================

  *** P38s[Ab] copptby[WB] Adam17[Ab] is increased irt Anisomycin (15 min)
    *** cells: T42 in BMLS
    *** source: 20188673-Fig-4g

