============================
Phosphorylatiion on Tyrosine
============================

IL4R--

  *** Irs2[Ab]IP Yphos[pYAb] is increased irt IL4 (5 min)
    *** cells: mSpBCs in BMS
    *** inhibited by: kIL4R(Y500F) [knockin]
    *** source: 14557412-Fig-2e
  *** Irs2[Ab]IP Yphos[pYAb] is increased irt IL4 (10 min)
    *** cells: mSpCs in BMS "blasted with anti-TcRb/IL2"
    *** inhibited by: kIL4R(Y500F) [knockin]
    *** source: 14557412-Fig-2b

Fes--

  *** Irs2[Ab]IP Yphos[pYAb] is increased irt IL4 (15 min)
    *** cells: M1241 in BMS
    *** inhibited by: xFes(K590E)"KD" [addition]
    *** source: 11160325-Fig-3a
  *** Irs2[Ab]IP Yphos[pYAb] is increased irt IL4 (15 min)
    *** cells: M1241<xFes> in BMS
    *** inhibited by: xFes(K590E)"KD" [substitution]
    *** source: 11160325-Fig-3a

Ikba-- ???

  *** Irs2[Ab]IP Yphos[pYAb] is increased irt IL4 (30 min)
    *** cells: mThyCs in BMS "treated with PMA + Ionomycin for 20 hr, followed by 4 hr medium alone"
    *** unaffected by: xIkba(mnr)"del-Nterm" [addition]
    *** source: 11160275-Fig-3b

No extras

  *** Irs2[Ab]IP Yphos[pYAb] is increased irt IL4 (10 min)
    *** cells: FD5 in BMS
    *** source: 8995447-Fig-1
  *** Irs2[Ab]IP Yphos[pYAb] is increased irt IL4 (10 min)
    *** cells: FD5 in BMS
    *** source: 8995447-Fig-3
  *** Irs2[Ab]IP Yphos[pYAb] is increased irt IL4 (15 min)
    *** cells: hPHAblasts in BMLS
    *** source: 7499365-Fig-1b

Contradiction

  *** Irs2[Ab]IP Yphos[pYAb] is detectable-but unchanged irt IL4 (30 min)
    *** cells: mThyCs in BMS "treated with PMA + Ionomycin for 20 hr"
    *** unaffected by: xIkba(mnr)"del-Nterm" [addition]
    *** source: 11160275-Fig-3a


===============
Coppt with IL4R
===============

  *** Irs2[Ab] copptby[WB] IL4R[Ab] is increased irt IL4 (tnr)
    *** cells: mSpCs<Cd4~neg><Cd45~neg><Cd8~pos> in BMS "treated with anti-Cd3,anti-Cd28/IL2"
    *** source: 17200144-Fig-2a

============================================
Coppt with other members of the IL4R complex
============================================

  *** Irs2[Ab] copptby[WB] Pik3rs[Ab] is increased irt IL4 (15 min)
    *** cells: M1241 in BMS
    *** inhibited by: xFes(K590E)"KD" [addition]
    *** source: 11160325-Fig-4b
  *** Irs2[Ab] copptby[WB] Pik3rs[Ab] is increased irt IL4 (15 min)
    *** cells: M1241<xFes> in BMS
    *** inhibited by: xFes(K590E)"KD" [substitution]
    *** source: 11160325-Fig-4b

