===========================
Phosphorylation on Tyrosine
===========================

requires adherence

  *** xPxn[Ab]IP Yphos[pYAb] is detectable
    *** cells: cECs<xPxn> in BMS
    *** comment: Yphos is not detectable when cells are held in suspension
    *** comment: Yphos is decreased when cells are replated on Fn1 for 1 hr
    *** source: 11695992-Fig-4a
  *** Pxn[Ab]IP Yphos[pYAb] is detectable
    *** cells: hMesangialCells in BMS
    *** comment: Yphos is not detectable when cells are held in suspension
    *** source: 10092539-Fig-1

  *** xPxn[Ab]IP Yphos[pYAb] is detectable
    *** cells: cECs<xPxn> in BMS
    *** inhibited by: xPxn(Y31F/Y40F/Y88F/Y118F) [substitution]
    *** partially inhibited by: xPxn(Y40F/Y88F/Y118F) [substitution]
    *** partially inhibited by: xPxn(Y31F/Y40F/Y118F) [substitution]
    *** partially inhibited by: xPxn(Y31F/Y40F/Y88F) [substitution]
    *** source: 11695992-Fig-3b
  *** xPxn[Ab]IP Yphos[pYAb] is detectable
    *** cells: cECs<xPxn> in BMS
    *** partially inhibited by: xPxn(Y31F) [substitution]
    *** unaffected by: xPxn(Y40F) [substitution]
    *** partially inhibited by: xPxn(Y88F) [substitution]
    *** partially inhibited by: xPxn(Y118F) [substitution]
    *** partially inhibited by: xPxn(Y31F/Y40F) [substitution]
    *** partially inhibited by: xPxn(Y31F/Y118F) [substitution]
    *** inhibited by: xPxn(Y31F/Y40F/Y88F/Y118F) [substitution]
    *** source: 11695992-Fig-3a
  *** xPxn[Ab]IP Yphos[pYAb] is detectable
    *** cells: cECs<xPxn> in BMS "treated with pervanadate before lysis"
    *** inhibited by: xPxn(Y31F/Y40F/Y88F/Y118F) [substitution]
    *** partially inhibited by: xPxn(Y31F) [substitution]
    *** unaffected by: xPxn(Y118F) [substitution]
    *** partially inhibited by: xPxn(Y40F/Y88F/Y118F) [substitution]
    *** partially inhibited by: xPxn(Y31F/Y40F/Y88F) [substitution]
    *** source: 11695992-Fig-5a

======================
Phosphorylation on Y31
======================

  *** xPxn[Ab]IP phos(Y31)[phosAb] is detectable
    *** cells: cECs<xPxn> in BMS "treated with pervanadate before lysis"
    *** inhibited by: xPxn(Y31F/Y40F/Y88F/Y118F) [substitution]
    *** inhibited by: xPxn(Y31F) [substitution]
    *** unaffected by: xPxn(Y118F) [substitution]
    *** partially inhibited by: xPxn(Y40F/Y88F/Y118F) [substitution]
    *** inhibited by: xPxn(Y31F/Y40F/Y88F) [substitution]
    *** source: 11695992-Fig-5b

=======================
Phosphorylation on Y118
=======================

  *** xPxn[Ab]IP phos(Y118)[phosAb] is detectable
    *** cells: cECs<xPxn> in BMS "treated with pervanadate before lysis"
    *** inhibited by: xPxn(Y31F/Y40F/Y88F/Y118F) [substitution]
    *** partially inhibited by: xPxn(Y31F) [substitution]
    *** inhibited by: xPxn(Y118F) [substitution]
    *** inhibited by: xPxn(Y40F/Y88F/Y118F) [substitution]
    *** partially inhibited by: xPxn(Y31F/Y40F/Y88F) [substitution]
    *** source: 11695992-Fig-5b

====================
Protein Interactions
====================

ArhGap5--

  *** Pxn[Ab] copptby[WB] ArhGap5[Ab] is detectable
    *** cells: hMesangialCells in BMS
    *** comment: coppt is not detectable when cells are held in suspension
    *** source: 10092539-Fig-3

Asap2--

  *** Pxn[Ab] copptby[WB] Asap2[Ab] is detectable
    *** cells: U937 in BMS "treated with PMA for 3 days"
    *** source: 10749932-Fig-1g
  *** Pxn[Ab] copptby[WB] xAsap2[GST] is detectable
    *** cells: COS7 in BMS
    *** source: 10749932-Fig-1f
  *** Pxn[Ab] snaggedby[WB] rAsap2[GST] is detectable
    *** cells: SF9 in BMS
    *** source: 10749932-Fig-1c
  *** Pxn[Ab] snaggedby[WB] rAsap2[GST] is detectable
    *** cells: U937 in BMS
    *** source: 10749932-Fig-2c
  *** Pxn[Ab] snaggedby[WB] rAsap2[GST] is detectable
    *** cells: U937 in BMS "treated with PMA for 3 days"
    *** source: 10749932-Fig-2c

Crk--

  *** Pxn[Ab] copptby[WB] xCrk[Ab] is detectable
    *** cells: COS7<xCrk> in BMLS
    *** enhanced by: xCrk(Y221F) [substitution]
    *** comment: differences in Pxn prot-exp itpo xCrk WTvsY221F were not investigated
    *** source: 12198159-Fig-2a

CrkL--

  *** Pxn[Ab] copptby[WB] CrkL[Ab] is detectable
    *** cells: K562 in BMS
    *** source: 7493940-Fig-4a
  *** Pxn[Ab] copptby[WB] CrkL[Ab] is undetectable
    *** cells: 32D in BMS
    *** unaffected by: IL3 (10 min) [stim]
    *** source: 7493940-Fig-4a
  *** Pxn[Ab] copptby[WB] CrkL[Ab] is undetectable
    *** cells: hNeut in BMS
    *** source: 7493940-Fig-5

Fak1--

  *** Pxn[Ab] copptby[WB] Fak1[Ab] is undetectable
    *** cells: AB1 in BMS
    *** unaffected by: anti-Cd3 (20 min) [stim]
    *** source: 9488700-Fig-7

Fak2--

  *** Pxn[Ab] copptby[WB] Fak2[Ab] is detectable
    *** cells: PC12 in BMS
    *** source: 16199135-Fig-2c

Git1--

  *** Pxn[Ab] copptby[WB] xGit1[tAb] is detectable
    *** cells: COS7<xGit1> in BMS
    *** source: 10896954-Fig-10

Git2-short--

  *** Pxn[Ab] copptby[WB] xGit2-short[tAb] is undetectable
    *** cells: COS7<xGit2-short> in BMS
    *** source: 10896954-Fig-10

Git2--

  *** Pxn[Ab] copptby[WB] xGit2[tAb] is undetectable
    *** cells: COS7<xGit2> in BMS
    *** source: 10896954-Fig-10

Ilk--

  *** Pxn[Ab] copptby[WB] Ilk[Ab] is detectable
    *** cells: rSMCs in BMS
    *** comment: unaffected by cell suspension
    *** source: 11304546-Fig-6

Limk1--

  *** Pxn[Ab] copptby[WB] Limk1[Ab] is detectable
    *** cells: NIH3T3 in BMS
    *** source: 15023529-Fig-3b
  *** Pxn[Ab] copptby[WB] Limk1[Ab] is detectable
    *** cells: OLF442 in BMS
    *** source: 15023529-Fig-3b

Itgb3--

  *** Pxn[Ab] copptby[WB] Itgb3[Ab] is detectable
    *** cells: mOLCs in BMS
    *** source: 16600665-Fig-3a

Pak1--

  *** Pxn[Ab] snaggedby[WB] rPak1[GST] is detectable
    *** cells: 3Y1 in BMS
    *** source: 11096073-Fig-1a

Pak3--

  *** rPxn[Ab] boundby[WB] xPak3[tAb]IP is detectable
    *** cells: none
    *** inhibited by: rArhGef7 [addition]
    *** source: 11096073-Fig-4a
  *** rPxn[Ab] boundby[WB] xPak3[tAb]IP is detectable
    *** cells: none
    *** source: 11096073-Fig-2b
  *** xPxn[Ab] copptby[WB] xPak3[GST] is detectable
    *** cells: COS7 in BMS
    *** inhibited by: xNck1 [addition]
    *** source: 11096073-Fig-4c
  *** Pxn[Ab] snaggedby[WB] rPak3[GST] is detectable
    *** cells: 3Y1 in BMS
    *** source: 11096073-Fig-1a

Ptprh--

  *** Pxn[Ab] copptby[WB] xPtprh(D988A)"CIA"[tAb] is detectable
    *** cells: PANC1<xPtprh(D988A)"CIA"> in BMS "treated with pervanadate for 30 min"
    *** inhibited by: xPtprh(C1022S)"CIA" [substitution]
    *** inhibited by: xPtprh [substitution]
    *** source: 11278335-Fig-1d
  *** xPxn[tAb]IP Yphos[pYAb] is decreased itpo xPtprh
    *** cells: HEK293 in BMS
    *** reversed by: rPtprh(C1022S)"CIA" [substitution]
    *** reversed by: rPtprh(D988A)"CIA" [substitution]
    *** source: 11278335-Fig-3a

Sorbs1--

  *** Pxn[Ab] copptby[WB] Sorbs1[Ab] is detectable
    *** cells: CV1 in BMS
    *** source: 17082770-Fig-2a
  *** Pxn[Ab] snaggedby[WB] rSorbs1[GST] is detectable
    *** cells: CV1 in BMS
    *** unaffected by: rSorbs1(mnr)"SH3A" [substitution]
    *** unaffected by: rSorbs1(mnr)"SH3B" [substitution]
    *** inhibited by: rSorbs1(mnr)"SH3C" [substitution]
    *** source: 17082770-Fig-2c
  *** xPxn[tAb] copptby[WB] xSorbs1[tAb] is detectable
    *** cells: COS1<xPxn><xSorbs1> in BMS
    *** partially inhibited by: xSorbs1(W536F) [substitution]
    *** partially inhibited by: xSorbs1(W601F) [substitution]
    *** unaffected by: xSorbs1(W716F) [substitution]
    *** unaffected by: xSorbs1(W536F/W601F) [substitution]
    *** source: 17082770-Fig-2d
  *** xPxn[tAb] copptby[WB] xSorbs1[tAb] is detectable
    *** cells: CV1<xPxn><xSorbs1> in BMS
    *** unaffected by: xPxn(mnr)"delLIM" [substitution]
    *** inhibited by: xPxn(mnr)"delPro" [substitution]
    *** source: 17082770-Fig-2b

Tubas--

  *** Pxn[Ab] copptby[WB] Tubas[Ab] is detectable
    *** cells: hPHAblasts in BMS
    *** source: 10840040-Fig-2

Tubgs--

  *** Pxn[Ab] copptby[WB] Tubgs[Ab] is detectable
    *** cells: hPHAblasts in BMS
    *** source: 10840040-Fig-2

