===============
Kinase Activity
===============

Atm--

  *** Abl1[Ab]IP IVKA(Polr2a)[32P-ATP] is increased irt IR (1 hr)
    *** cells: mEFs in BMS
    *** reqs: Atm [KO]
    *** source: 9168116-Fig-1a
  *** Abl1[Ab]IP IVKA(Polr2a)[32P-ATP] is increased irt IR (1 hr)
    *** cells: GM5849<Atm~fmut><xAtm(2711-2962)> in BMS "nuclear-extracts"
    *** reqs: xAtm [omission]
    *** source: 9168116-Fig-4a
  *** Abl1[Ab]IP IVKA(Polr2a)[32P-ATP] is unchanged irt IR (1 hr)
    *** cells: GM1526<Atm~fmut> in BMS "nuclear-extracts"
    *** source: 9168116-Fig-4a

not Tp53--

  *** Abl1[Ab]IP IVKA(Polr2a)[32P-ATP] is increased irt IR (1 hr)
    *** cells: mEFs in BMS
    *** does not req: Tp53 [KO]
    *** source: 9168116-Fig-1a

Abl1 features

  *** xAbl1[tAb]IP IVKA(Polr2a)[32P-ATP] is increased irt IR (1 hr)
    *** cells: mEFs<Abl1~null><xAbl1> in BMS
    *** inhibited by: xAbl1(S446A) [substitution]
    *** source: 9168116-Fig-3c

===============================================================
Location in nucleus because activity found in nuclear extracts
===============================================================

  *** Abl1[Ab]IP IVKA(Polr2a)[32P-ATP] is increased irt IR (1 hr)
    *** cells: GM2184 in BMS "nuclear-extracts"
    *** source: 9168116-Fig-4a

===================
Autophosphorylation
===================

  *** xAtm[tAb]IP phos[32Pi] is increased irt IR (30 min)
    *** cells: HEK293T<xAtm><xNbs1> in BMS
    *** inhibited by: xAtr(D2870A/N2875K)"KD" [substitution]
    *** source: 10766245-Fig-3d



