===================
Recruitment to EgfR
===================

ArhGef7 required attributes

  *** xArhGef7[tAb] copptby[WB] EgfR[Ab] is increased irt Egf (10 min)
    *** cells: NIH3T3 in BMLS
    *** inhibited by: xArhGef7(Y619F) [substitution]
    *** source: 16892055-Fig-4a
  *** xArhGef7[tAb] copptby[WB] EgfR[Ab] is detectable
    *** cells: NIH3T3<xSrc(mnr)"vSrc"> in BMLS
    *** inhibited by: xArhGef7(Y619F) [substitution]
    *** inhibited by: xArhGef7(mnr)"SH3-mutant" [substitution]
    *** source: 16892055-Fig-4c

===========================
Phosphorylation on Tyrosine
===========================

Fak1--

  *** xArhGef7[tAb]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: mEFs in BMLS
    *** bkg reqs: Fak1 [KO]
    *** source: 16892055-Fig-2c
  *** xArhGef7[tAb]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: mEFs<Fak1~null><xFak1><xEgfR> in BMLS
    *** reqs: xFak1 [omission]
    *** source: 16892055-Fig-2c

Src--

  *** xArhGef7[tAb]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: mEFs in BMLS
    *** partially reqs: Src and/or Yes1 and/or Fyn [KO]
    *** source: 16892055-Fig-2c
  *** xArhGef7[tAb]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: mEFs<Src~null><Yes1~null><Fyn~null><xSrc><xEgfR> in BMLS
    *** reqs: xSrc [omission]
    *** source: 16892055-Fig-2c
  ---------------------------------------------------------------------
  *** ArhGef7[Ab]IP Yphos[pYAb] is detectable-but unchanged irt Egf (times)
    *** cells: NIH3T3<xSrc(mnr)"vSrc"> in BMLS
    *** times: 0+ 15+ 45+ 90+ min
    *** source: 20375009-Fig-3b
  *** xArhGef7[tAb]IP Yphos[pYAb] is detectable-but unchanged irt Egf (times)
    *** cells: NIH3T3<xSrc(mnr)"vSrc"><xArhGef7> in BMLS
    *** times: 0+ 15+ 45+ 90+ min
    *** source: 20375009-Fig-3c

phos(Y619)

  *** xArhGef7[tAb]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: NIH3T3 in BMLS
    *** inhibited by: xArhGef7(Y619F) [substitution]
    *** source: 16892055-Fig-2f

no extras

  *** ArhGef7[Ab]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: NIH3T3 in BMLS
    *** source: 16892055-Fig-2a
  *** ArhGef7[Ab]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: NIH3T3<xEgfR> in BMLS
    *** times: 0 2 4+ 6++ 10+++ 45+ min
    *** source: 16892055-Fig-2b
  *** ArhGef7[Ab]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 15+ 45 90 min
    *** source: 20375009-Fig-3a
  *** xArhGef7[Ab]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: HEK293T<xArhGef7><xCbl> in BMLS
    *** source: 16407834-Fig-3e

======================================================
Coprecipitation with other members of the EgfR complex
======================================================

Cbl--

  *** ArhGef7[Ab] copptby[WB] Cbl[Ab] is increased irt Egf (10 min)
    *** cells: HEK293T in BMS
    *** source: 16407834-Fig-3b
  *** ArhGef7[Ab] copptby[WB] xCbl[tAb] is detectable-but unchanged irt Egf (10 min)
    *** cells: HEK293T<xCbl> in BMS
    *** inhibited by: xCbl(R829A) [substitution]
    *** source: 16407834-Fig-3b
  *** xArhGef7[tAb] copptby[WB] xCbl[tAb] is decreased irt Egf (10 min)
    *** cells: HEK293T<xArhGef7><xCbl> in BMLS
    *** source: 16407834-Fig-3a

===========
Degradation
===========

  *** xArhGef7[tAb] prot-exp[WB] is decreased irt Egf (times)
    *** cells: HEK293T<xArhGef7><xCbl> in BMLS
    *** times: 0++ 5++ 10+ 30+ 60+ min
    *** source: 16407834-Fig-3c











