=======================
Phosphorylation on S422
=======================

Pdpk1--

  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (30 min)
    *** cells: mESCs in BMLS
    *** bkg inhibited by: kPdpk1(L155E)"PIF" [knockin]
    *** source: 16763566-Fig-3b
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (30 min)
    *** cells: mESCs in BMLS
    *** reqs: Pdpk1 [KO]
    *** source: 16763566-Fig-3a

Rsk1-- and/or Rsk2--

  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (tnr)
    *** cells: HELA in BMLS
    *** partially reqs: Rsk1 and/or Rsk2 [RNAi]
    *** source: 16763566-Fig-5a
  *** xEif4b[tAb]IP phos(S422)[phosAb] is increased irt Serum (15 min)
    *** cells: HELA<xEif4b> in BMLS
    *** unaffected by: xRsk1 [addition]
    *** inhibited by: xRsk1(mnr)"KD" [addition]
    *** source: 16763566-Fig-4b
  *** xEif4b[tAb]IP phos(S422)[phosAb] is increased irt Serum (90 min)
    *** cells: HELA<xEif4b> in BMLS
    *** unaffected by: xRsk1 [addition]
    *** inhibited by: xRsk1(mnr)"KD" [addition]
    *** source: 16763566-Fig-4c

not S6k1-- or S6k2--

  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (30 min)
    *** cells: mHepatocytes in BMLS "AminoAcid and Glucose deprived"
    *** does not req: S6k1 or S6k2 [KO]
    *** source: 16763566-Fig-2a

Chemicals

  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (15 min)
    *** cells: HELA in BMLS
    *** inhibited by: FMK [pretreatment]
    *** source: 16763566-Fig-4e
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (30 min)
    *** cells: HELA in BMLS
    *** inhibited by: Rapamycin [addition]
    *** source: 15071500-Fig-5b
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (30 min)
    *** cells: HELA in BMLS
    *** partially inhibited by: Rapamycin [pretreatment]
    *** partially inhibited by: U0126 [pretreatment]
    *** inhibited by: Rapamycin + U0126 [pretreatment]
    *** source: 16763566-Fig-1a
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (30 min)
    *** cells: mHepatocytes in BMLS "AminoAcid and Glucose deprived"
    *** partially inhibited by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-2a
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (times)
    *** cells: HELA in BMLS
    *** times: 0 3 5+ 15++ 60+++ 90+++ min
    *** partially inhibited by: Rapamycin [pretreatment]
    *** partially inhibited by: U0126 [pretreatment]
    *** inhibited by: Rapamycin + U0126 [pretreatment]
    *** source: 16763566-Fig-1c
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (tnr)
    *** cells: HELA in BMLS
    *** partially inhibited by: Rapamycin [pretreatment]
    *** inhibited by: U0126 [pretreatment]
    *** inhibited by: Rapamycin + U0126 [pretreatment]
    *** source: 16763566-Fig-5a
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (30 min)
    *** cells: mESCs in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-3a
  *** xEif4b[tAb]IP phos(S422)[phosAb] is increased irt Serum (15 min)
    *** cells: HELA<xEif4b> in BMLS
    *** inhibited by: FMK [pretreatment]
    *** source: 16763566-Fig-4d
  *** xEif4b[tAb]IP phos(S422)[phosAb] is increased irt Serum (15 min)
    *** cells: HELA<xEif4b> in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 16763566-Fig-4b
  *** xEif4b[tAb]IP phos(S422)[phosAb] is increased irt Serum (15 min)
    *** cells: HELA<xEif4b><xRsk1> in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 16763566-Fig-6a
  *** xEif4b[tAb]IP phos(S422)[phosAb] is increased irt Serum (90 min)
    *** cells: HELA<xEif4b> in BMLS
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-4c

No extras

  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (30 min)
    *** cells: HELA in BMLS
    *** source: 15071500-Fig-5a
  *** Eif4b[phosAb] phos(S422)[phosAb] is increased irt Serum (times)
    *** cells: HELA in BMLS
    *** times: 0 3 5+ 10++ 15++ 30++ min
    *** source: 16763566-Fig-1b




