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Transcription
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inhibited by Akt1--

  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2 in BMS
    *** partially inhibited by: xAkt1(mnr)"CA" [addition]
    *** enhanced by: xPdpk1(mnr)"KD" [addition]
    *** source: 12456685-Fig-2a
  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2<xFoxo1> in BMS
    *** partially inhibited by: xAkt1 [addition]
    *** partially inhibited by: xAkt1(mnr)"CA" [addition]
    *** source: 12456685-Fig-2c

Foxo1--

  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2 in BMS
    *** enhanced by: xFoxo1 [addition]
    *** source: 12456685-Fig-4a
  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2 in BMS
    *** enhanced by: xFoxo1 [addition]
    *** source: 12456685-Fig-2b
  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2 in BMS
    *** enhanced by: xFoxo1 [addition]
    *** source: 12456685-Fig-2d
  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2<xFoxo1> in BMS
    *** bkg enhanced by: xFoxo1(T24A) [substitution]
    *** bkg enhanced by: xFoxo1(T24A/S256A) [substitution]
    *** bkg enhanced by: xFoxo1(T24A/S256A/S319A) [substitution]
    *** source: 12456685-Fig-2d

Lmo4--

  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2 in BMS
    *** enhanced by: xLmo4 [addition]
    *** source: 15677447-Fig-7b
  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2 in BMS
    *** partially reqs: Lmo4 [RNAi]
    *** source: 15677447-Fig-7d

inhibited by Pdpk1--

  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2<xFoxo1> in BMS
    *** partially inhibited by: xPdpk1 [addition]
    *** enhanced by: xPdpk1(mnr)"KD" [addition]
    *** source: 12456685-Fig-2c

Stat3--

  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2 in BMS
    *** enhanced by: xStat3 [addition]
    *** source: 12456685-Fig-4a
  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2<xFoxo1> in BMS
    *** inhibited by: xStat3(mnr)"DN" [addition]
    *** source: 12456685-Fig-4c

Cotreatments

  *** A2m-gene promo-reporter[Luc] is increased irt IL6 (18 hr)
    *** cells: HEPG2 in BMS
    *** partially inhibited by: Ins [cotreatment]
    *** unaffected by: Ins + Wortmannin [cotreatment]
    *** source: 12456685-Fig-1b

No extras

  *** A2m-gene mRNA[Northern] is increased irt IL6 (18 hr)
    *** cells: HEPG2 in BMS
    *** source: 12456685-Fig-1a


