===============
Kinase Activity
===============

Pdpk1--

  *** S6k1[Ab]IP IVKA(peptide)[32P-ATP] is increased irt Igf1 (30 min)
    *** cells: mESCs in BMLS
    *** reqs: Pdpk1 [KO]
    *** source: 12912918(D)

  *** S6k1[Ab]IP IVKA(Crosstide)[32P-ATP] is increased irt Igf1 (45 min)
    *** cells: mESCs in BMLS
    *** source: 10801415-Fig-4

==================================
Phosphorylation on T252 (CST T229)
==================================

  *** xS6k?[tAb]IP phos(T252)[phosAb] is increased irt Igf1 (30 min)
    *** cells: mESCs in BMLS
    *** inhibited by: Rapamycin [addition] no-bkg-control
    *** source: 12912918-Fig-4b

==================================
Phosphorylation on T412 (CST T389)
==================================

not Ikk2--

  *** xS6k1[tAb]IP phos(T412)[phosAb] is increased irt Igf1 (30 min)
    *** cells: MCF7<xS6k1> in BMLS
    *** does not req: Ikk2 [RNAi]
    *** source: 17693255-Fig-3f
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Igf1 (30 min)
    *** cells: mEFs<Ikk2~null> in BMLS
    *** source: 17693255-Fig-3e

Pdpk1--

  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Igf1 (30 min)
    *** cells: mESCs in BMLS
    *** reqs: Pdpk1 [KO]
    *** unaffected by: kPdpk1(L155E) [substitution]
    *** source: 12912918-Fig-4a

Chemicals

  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Igf1 (30 min)
    *** cells: mESCs in BMLS
    *** inhibited by: Rapamycin [addition] no-bkg-control
    *** enhanced by: Okadaic-acid [addition] no-bkg-control
    *** source: 12912918-Fig-4a

no extras

  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Igf1 (30 min)
    *** cells: MCF7 in BMLS
    *** source: 17693255-Fig-3d
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Igf1 (45 min)
    *** cells: mESCs in BMLS
    *** source: 10801415-Fig-4


============================================
Phosphorylation on T444/S447 (CST T421/T424)
============================================

  *** S6k1[phosAb] phos(T444/S447)[phosAb] is increased irt Igf1 (20 min)
    *** cells: mESCs in BMLS
    *** source: 11500364-Fig-S1d
  *** S6k1[phosAb] phos(T444/S447)[phosAb] is increased irt Igf1 (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** unaffected by: Gefitinib [cotreatment]
    *** unaffected by: BMS345541 [cotreatment]
    *** unaffected by: PD325901 [cotreatment]
    *** unaffected by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1


  *** S6k1[Ab] phos[WBMS] is increased irt Igf1 (30 min)
    *** cells: mESCs in BMLS
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 15024086-Fig-5a


