==================
Direct Interaction
==================

Dvl1 required features

  *** rDvl1(1-282)[GST] boundby[WB] rAxin1[MalBP] is detectable
    *** cells: none
    *** inhibited by: rDvl1(1-140) [substitution]
    *** inhibited by: rDvl1(1-82) [substitution]
    *** inhibited by: rDvl1(83-282) [substitution]
    *** unaffected by: rDvl1(284-670) [substitution]
    *** source: 10330181-Fig-5c

Axin1 required features

  *** rDvl1(1-282)[GST] boundby[WB] rAxin1[MalBP] is detectable
    *** cells: none
    *** unaffected by: rAxin1(508-832) [substitution]
    *** inhibited by: rAxin1(1-529) [substitution]
    *** inhibited by: rAxin1(413-832) [substitution]
    *** source: 10330181-Fig-5c
  *** xDvl1[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: COS<xDvl1><xAxin1> in BMS
    *** unaffected by: xAxin1(1-713) [substitution]
    *** inhibited by: xAxin1(1-437) [substitution]
    *** inhibited by: xAxin1(1-229) [substitution]
    *** inhibited by: xAxin1(298-506) [substitution]
    *** partially inhibited by: xAxin1(713-832) [substitution]
    *** source: 10330181-Fig-5b

==========================
Coprecipitation with Axin1
==========================

Dvl1 required features

  *** xAxin1[tAb] copptby[WB] xDvl1[tAb] is detectable
    *** cells: COS<xAxin1><xDvl1><xCsnk1e> in BMS
    *** unaffected by: xDvl1(del(228-250)) [substitution]
    *** source: 12556519-Fig-8a

Does not require Csnk1e--

  *** xAxin1[tAb] copptby[WB] xDvl1[tAb] is detectable
    *** cells: COS<xAxin1><xDvl1> in BMS
    *** unaffected by: xCsnk1e [addition]
    *** unaffected by: xCsnk1e(mnr)"KD" [addition]
    *** source: 11425858-Fig-6

No extras

  *** xAxin1[tAb] copptby[WB] xDvl1[tAb] is detectable
    *** cells: COS<xDvl1><xAxin1> in BMS
    *** source: 10330181-Fig-5a

======================================================
Copreciptiation with other members of the Axin complex
======================================================

  *** xDvl1[tAb] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xDvl1><xApc><xCsnk1e> in BMS
    *** comment: xDvl1 phos[WBMS] is decreased when xCsnk1e"KD" is substituted
    *** source: 11425858-Fig-7
  *** xDvl1[tAb] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xDvl1><xApc><xCsnk1e><xAxin1> in BMS
    *** comment: xDvl1 phos[WBMS] is detectable-but unchanged when xCsnk1e"KD" is substituted
    *** source: 11425858-Fig-7
  *** xDvl1[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: COS<xDvl1><xAxin1> in BMS
    *** unaffected by: xCsnk1e [addition]
    *** unaffected by: xCsnk1e(mnr)"KD" [addition]
    *** source: 11425858-Fig-6a
  *** xDvl1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: COS<xDvl1><xAxin1><xCsnk1e> in BMS
    *** unaffected by: xCsnk1e(mnr)"KD" [substitution]
    *** source: 11425858-Fig-6
