==============================================
Smad7 requires Smurf2 to exit from the nucleus
==============================================

  *** xSmad7[tAb] locatedin(nucleus)[IHC] is decreased itpo xSmurf2(C716A)
    *** cells: MV1LU in BMS
    *** unaffected by: Tgfb1 (1 hr) [stim]
    *** source: 11163210-Fig-3b
  *** xSmad7[tAb] locatedin(nucleus)[IHC] is decreased itpo xSmurf2(C716A)
    *** cells: MV1LU in BMS "treated with Tgfb1 for 1 hr"
    *** partially inhibited by: xSmad7(Y211A) [substitution]
    *** source: 11163210-Fig-3b

==============================================
Smurf2 requires Smad7 to exit from the nucleus
==============================================

  *** xSmurf2(C716A)[tAb] locatedin(nucleus)[IHC] is decreased itpo xSmad7
    *** cells: MV1LU<xTgfbR2><xTgfbR1> in BMS
    *** comment: xSmurf2 colocates with xTgfbRs itpo of xSmad7
    *** source: 11163210-Fig-3a
  *** xSmurf2(C716A)[tAb] locatedin(nucleus)[IHC] is detectable
    *** cells: MV1LU in BMS
    *** unaffected by: xTgfbR1 + xTgfbR2 [addition]
    *** source: 11163210-Fig-3a

================================================
Smurf2/Smad7 coppt requires Smurf2-WW2/3 domains
================================================

  *** xSmad7[tAb] copptby[WB] xSmurf2[tAb] is detectable
    *** cells: HEK293T in BMS
    *** source: 11163210-Fig-1a
  *** xSmad7[tAb] copptby[WB] xSmurf2[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: xSmurf2(del(163-185))"del-WW1" [substitution]
    *** inhibited by: xSmurf2(del(257-279))"del-WW2" [substitution]
    *** inhibited by: xSmurf2(del(303-325))"del-WW3" [substitution]
    *** source: 11163210-Fig-1e
