  *** Adam17[Ab]IP IVProteaseAct(peptide)[FRET] is increased irt IL1b (60 min)
    *** cells: T42 in BMLS
    *** inhibited by: SB203580 [cotreatment]
    *** source: 20188673-Fig-3e
*** Akt1--
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10+ 15 30 min
    *** unaffected by: xIrak4(K213A/K214A)"KD" [addition]
    *** source: 17337443-Fig-3b
  *** Akt1[phosAb] phos(S473)[phosAb] is unchanged irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** source: 19953085-Fig-S1
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt IL1 (times)
    *** cells: mBMMs in BMS
    *** times: 0 5+ 10+ 30 60 120 min
    *** does not req: Irak4 [KO]
    *** source: 14634120-Fig-2d
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 min
    *** does not req: Ikk1 [KO]
    *** does not req: Ikk2 [KO]
    *** comment: decrease in phos at 30 min is not seen in Ikk-null cells
    *** source: 11733537-Fig-2
*** Ampkas--
  *** Ampkas[phosAb] phos(T172)[phosAb] is increased irt IL1 (times)
    *** cells: HELA in BMLS
    *** times: 0 2+ 5++ 10 min
    *** source: 16835226-Fig-8c
  *** AP1-reporter[Luc] is increased irt IL1 (tnr)
    *** cells: HELA in BMS
    *** inhibited by: Geldanamycin [addition]
    *** source: 11864612-Fig-5b
  *** AP1-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** reqs: xTak1 [omission]
    *** inhibited by: xTak1(K158R) [addition]
    *** source: 20038579-Fig-7f
  *** AP1-reporter[Luc] is increased irt IL1b (12 hr)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** inhibited by: xTak1(T178A) [substitution]
    *** inhibited by: xTak1(T184A) [substitution]
    *** inhibited by: xTak1(T178A/T184A) [substitution]
    *** unaffected by: xTak1(T178E/T184E) [substitution]
    *** source: 18617512-Fig-4c
*** Ask1--
  *** Ask1[Ab] copptby[WB] Traf2[Ab] is unchanged irt IL1a (15 min)
    *** cells: L929 in BMS
    *** source: 9774977-Fig-4c
*** Bcar1--
  *** Bcar1[phosAb] phos(Y410)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** bkg inhibited by: PP2 [addition]
    *** source: 19754427-Fig-3b
  *** Bcar1[phosAb] phos(Y410)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** bkg inhibited by: PP2 [addition]
    *** source: 19754427-Fig-3c
*** Bcl3--
  *** Bcl3-gene mRNA[Northern] is increased irt IL1b (2 hr)
    *** cells: mLFs in BMS
    *** source: 15241416-Fig-1a
*** Cbp--
  *** Cbp[Ab] boundto(CcL2-gene)[ChIP] is increased irt IL1a (2 hr)
    *** cells: mEFs in BMS
    *** reqs: Jun [KO]
    *** source: 18443042-Fig-8b
*** CcL1--
  *** CcL1-gene mRNA[RPA] is unchanged irt IL1 (3 hr)
    *** cells: hHepatocytes in BMS
    *** source: 15123776-Fig-2
*** CcL2--
  *** CcL2-gene mRNA[RPA] is increased irt IL1 (3 hr)
    *** cells: hHepatocytes in BMS
    *** source: 15123776-Fig-2
*** CcL3--
  *** CcL3-gene mRNA[RPA] is unchanged irt IL1 (3 hr)
    *** cells: hHepatocytes in BMS
    *** source: 15123776-Fig-2
*** CcL4--
*** CcL5--
*** CcL7--
*** CcL8--
  *** CcL8-gene mRNA[RTPCR] is increased irt IL1b (4 hr)
    *** cells: mEFs<Rela~null><xRela> in BMS
    *** reqs: xRela [omission]
    *** unaffected by: xRela(S468A) [substitution]
    *** source: 16046471-Fig-5c
*** Cd54--
*** Ch25h--
*** Creb1--
*** CxcL2--
  *** CxcL2[Ab] mRNA[RTPCR] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0+ 1++ 3+ hr
    *** inhibited by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-5e
*** Defb1--
  *** Defb1-gene mRNA[RTPCR] is unchanged irt IL1b (times)
    *** cells: hKerats in BMS
    *** times: 0+ 2+ 6+ 18+ 42+ hr
    *** source: 15308104-Fig-5c
*** Defb4a--
  *** Defb4a-gene mRNA[RTPCR] is increased irt IL1b (times)
    *** cells: hKerats in BMS
    *** times: 0+ 2++ 6+++ 18+++ 42++++ hr
    *** source: 15308104-Fig-5c
*** Defb103a--
  *** Defb103a-gene mRNA[RTPCR] is increased irt IL1b (times)
    *** cells: hKerats in BMS
    *** times: 0+ 2+ 6+ 18++ 42++ hr
    *** source: 15308104-Fig-5c
*** Ecm1--
  *** Ecm1-gene mRNA[Northern] is increased irt IL1b (4 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-7c
  *** EgfR[Ab]IP Yphos[pYAb] is increased irt IL1b (30 min)
    *** cells: T42 in BMLS
    *** reqs: P38a [RNAi]
    *** reqs: Adam17 [RNAi]
    *** source: 20188673-Fig-7f
*** Elk1--
*** Erk5--
  *** Erk5[Ab] phos[WBMS] is unchanged irt IL1 (20 min)
    *** cells: HELA in BMLS
    *** source: 9790194-Fig-1a
  *** Erk5[Ab]IP IVKA(Mef2c)[32P-ATP] is unchanged irt IL1 (20 min)
    *** cells: HELA in BMLS
    *** source: 9790194-Fig-1a
*** Faim2--
  *** Faim2-gene mRNA[Northern] is increased irt IL1b (4 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-7c
*** Fos--
  *** Fos-gene mRNA[RTPCR] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 30++ 60+ 120 min
    *** partially inhibited by: kIrak4(K213A/K214A)"KD" [knockin]
    *** source: 17337443-Fig-5b
*** Gsk3s--
  *** Gsk3s[phosAb] phos(SFAE)[phosAb] is unchanged irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** source: 19953085-Fig-S1
*** Hdac3--
  *** Hdac3[Ab] boundto(CcL2-gene)[ChIP] is decreased irt IL1a (2 hr)
    *** cells: mEFs in BMS
    *** source: 18443042-Fig-8b
*** Hif1a--
*** HistH3--
  *** HistH3[AcAb] acetyl(K10/K15)[AcAb] is increased irt IL1a (2 hr)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** reqs: Jun [KO]
    *** source: 18443042-Fig-9b
  *** HistH3{acetyl(K10/K15)}[AcAb] boundto(CcL2-gene)[ChIP] is unchanged irt IL1a (2 hr)
    *** cells: mEFs in BMS
    *** source: 18443042-Fig-8b
  *** HistH3{phos(S11)}[phosAb] boundto(CcL2-gene)[ChIP] is unchanged irt IL1a (2 hr)
    *** cells: mEFs in BMS
    *** source: 18443042-Fig-8b
*** HistH4--
  *** HistH4[AcAb] acetyl(K6/K9/K13/K17)[AcAb] is increased irt IL1a (2 hr)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** reqs: Jun [KO]
    *** source: 18443042-Fig-9b
  *** HistH4{acetyl(K6/K9/K13/K17)}[AcAb] boundto(CcL2-gene)[ChIP] is unchanged irt IL1a (2 hr)
    *** cells: mEFs in BMS
    *** source: 18443042-Fig-8b
*** Hspb1--
*** Hspb1--
  *** Hspb1[phosAb] phos(S78)[phosAb] is increased irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** partially inhibited by: Gefitinib [cotreatment]
    *** unaffected by: BMS345541 [cotreatment]
    *** unaffected by: PD325901 [cotreatment]
    *** inhibited by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1
  *** Hspb1[phosAb] phos(S82)[phosAb] is unchanged irt IL1b (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Mnk1 and/or Mnk2 [DKO]
    *** source: 15254222-Fig-3a
  *** Hspb1[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (15 min)
    *** cells: MRC5 in BMS
    *** source: 19181383-Fig-7a
  *** Hspb1[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (15 min)
    *** cells: MRC5 in BMS
    *** source: 19181383-Fig-7b
*** Ifng--
  *** Ifng-gene mRNA[Northern] is increased irt IL12 (4 hr)
    *** cells: mLCs in BMS "activated with anti-Cd3 for 48 hr"
    *** partially inhibited by: SB203580 [addition]
    *** unaffected by: PD98059 [addition]
    *** source: 10903740-Fig-1b
  *** Ifng-gene mRNA[Northern] is increased irt IL12 (4 hr)
    *** cells: mLCs in BMS "activated with anti-Cd3 for 48 hr"
    *** unaffected by: SB202474 [addition]
    *** partially inhibited by: SB203580 [addition]
    *** partially inhibited by: SB202190 [addition]
    *** source: 10903740-Fig-1a
  *** Ifng-gene mRNA[RPA] is unchanged irt IL1b (4 hr)
    *** cells: mBMNKs<Rag1~null> in BMS
    *** source: 10229825-Fig-1b
  *** Ifng[Ab] secretion[ELISA] is unchanged irt IL1b (4 hr)
    *** cells: mBMNKs<Rag1~null> in BMS
    *** source: 10229825-Fig-1a
*** Ikba--
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 15 30+ 120+ min
    *** comment: reappearance after 15 min reqs Ikk1 [RNAi]
    *** source: 21765415-Fig-6f
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0+ 15 30+ 60+ 120+ min
    *** comment: reappearance after 15 min reqs xTax1bp1 [omission]
    *** comment: reappearance after 15 min inhibited by xTax1bp1(S593A/S666A) [substitution]
    *** source: 21765415-Fig-3b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0+ 15 30+ 120+ min
    *** comment: reappearance after 15 min reqs Ikk1 [RNAi] or xTax1bp1(S593E/S624E) [substitution]
    *** source: 21765415-Fig-7a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0+ 15 30+ 120+ min
    *** comment: reappearance after 15 min reqs xTax1bp1 [omission]
    *** comment: reappearance after 15 min inhibited by xTax1bp1(S593A/S666A) [substitution]
    *** comment: reappearance after 15 min unaffected by xTax1bp1(S593E/S624E) [substitution]
    *** source: 21765415-Fig-7a
  *** xIkk1[tAb] copptby[WB] Tax1bp1[Ab] is increased irt IL1 (15 min)
    *** cells: mEFs<Ikk1~null><xIkk1> in BMS
    *** inhibited by: xIkk1(K44M)"KD" [substitution]
    *** source: 21765415-Fig-1g
*** Ikke--
  *** xIkke[tAb]IP IVKA(Rela)[32P-ATP] is increased irt IL1a (10 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** source: 15489227(D)
*** IL1b--
*** xIL1R1--
  *** xIL1R1[Ab] copptby[WB] TgfbR1[Ab] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-6
  *** xIL1R1[Ab] copptby[WB] TgfbR2[Ab] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-6
*** IL2--
  *** IL2[Ab] secretion[ELISA] is increased irt IL1b (18 hr)
    *** cells: EL4 in BMS
    *** enhanced by: xIrak1 [addition]
    *** enhanced by: xIrak1(K239S)"KD" [addition]
    *** source: 10217414-Fig-4
*** IL6--
*** IL8--
  *** IL18[Ab] secretion[ELISA] is increased irt IL1b (24 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xKsr2 [addition]
    *** source: 16039990-Fig-4
  *** IL22-gene mRNA[RTPCR] is unchanged irt IL1b (times)
    *** cells: hKerats in BMS
    *** times: 0 2 6 18 hr
    *** source: 15308104-Fig-7b
*** IL22-gene--
*** Irak1--
  *** Irak1[Ab] copptby[WB] xPeli2[tAb] is increased irt IL1b (20 min)
    *** cells: HEK293EBNA in BMS
    *** source: 12370331-Fig-2b
  *** Irak1[Ab] copptby[WB] xTifa[tAb] is increased irt IL1 (5 min)
    *** cells: mEFs in BMS
    *** source: 12566447-Fig-5c
  *** Irak1[Ab] copptby[WB] xTraf2[tAb] is unchanged irt IL1 (5 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** unaffected by: xTraf2(87-501) [substitution]
    *** source: 8837778-Fig-4a
  *** Irak1[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** reqs: Myd88 [KO]
    *** source: 16428431(D)
  *** Irak1[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0++ 5++ 15+ 30 min
    *** does not req: Tollip [KO]
    *** comment: reqs Myd88 [KO] at 15 min
    *** source: 16428431(D)
  *** Irak1[Ab] prot-exp[WB] is decreased irt IL1b (10 min)
    *** cells: MRC5 in BMS
    *** source: 19181383-Fig-6a
  *** Irak1[Ab] prot-exp[WB] is decreased irt IL1b (10 min)
    *** cells: MRC5 in BMS
    *** source: 19181383-Fig-6b
  *** Irak1[Ab] prot-exp[WB] is decreased irt IL1b (10 min)
    *** cells: MRC5 in BMS
    *** source: 19181383-Fig-6c
  *** Irak1[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0+++ 3++ 10+ 30 min
    *** unaffected by: xIkk2(K44A)"KD" [addition]
    *** inhibited by: xIrak4(K213A/K214A)"KD" [substitution]
    *** comment: protein degradation is accompanied by mobility shift (ubiq, sumo, or phos)
    *** source: 11960013-Fig-4c
  *** Irak1[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 30 min
    *** inhibited by: kIrak4(K213A/K214A)"KD" [substitution]
    *** source: 17337443-Fig-3a
  *** xIrak1[Ab]IP infraction(nuclear)[WB] is increased irt IL1b (times)
    *** cells: EL4 in BMS
    *** times: 0 5 90+ 120++ min
    *** inhibited by: xIrak1(K239S)"KD" [substitution]
    *** source: 15896328-Fig-2a
  *** Irak1[Ab]IP prot-exp[WB] is decreased irt IL1a (times)
    *** cells: MRC5 in BMLS
    *** times: 0++ 2+ 5 10 20 40 min
    *** comment: delayed by proteasome inhibitors LLL,IEAL,LLNV
    *** comment: delayed by kinase inhibitor K252a
    *** source: 9261174-Fig-5a
  *** Irak1[Ab]IP prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0++ 10++ 30++ 60++ 120+ 240+ min
    *** inhibited by: ALLN [addition]
    *** source: 11518704-Fig-5a
  *** Irak1[Ab]IP prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0++ 1+ 2 5 10 20 30 min
    *** reqs: Irak4 [KO]
    *** source: 15292196(D)
  *** xIrak1[tAb] copptby[WB] xSqstm1[tAb] is increased irt IL1b (10 min)
    *** cells: HEPG2<xTraf6> in BMS
    *** reqs: xTraf6 [omission]
    *** source: 10747026-Fig-7
*** Irak4--
*** Irf1--
  *** Irf1[Ab] mRNA[RTPCR] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0+ 1++ 3+ hr
    *** partially inhibited by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-5e
*** Irf3--
  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is unchanged irt IL1b (8 hr)
    *** cells: HEK293<xTLR3> in BMS
    *** source: 14517278-Fig-1c
  *** Irf3[Ab] oligomerization[NativeWB] is unchanged irt IL1 (1 hr)
    *** cells: U373<xCd14> in BMS
    *** source: 12062447-Fig-4a
*** Irf7--
  *** xIrf7(TAD)[Gal4-DBD] Gal4-reporter[Luc] is unchanged irt IL1b (8 hr)
    *** cells: HEK293<xTLR3> in BMS
    *** source: 14517278-Fig-1c
  *** Irs1[phosAb] phos(S636/S639)[phosAb] is increased irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** unaffected by: Gefitinib [cotreatment]
    *** unaffected by: BMS345541 [cotreatment]
    *** unaffected by: PD325901 [cotreatment]
    *** unaffected by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1
*** Itch--
  *** Itch[Ab] copptby[WB] Rnf11[Ab] is increased irt IL1 (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0 15+ 60+ 120+ min
    *** reqs: xTax1bp1 [omission]
    *** inhibited by: xTax1bp1(S593A/S666A) [substitution]
    *** inhibited by: xTax1bp1(S593A) [substitution]
    *** inhibited by: xTax1bp1(S666A) [substitution]
    *** source: 21765415-Fig-5d
  *** Itch[Ab] copptby[WB] Tnfaip3[Ab] is increased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** reqs: Ikk1 [RNAi]
    *** source: 21765415-Fig-6d
  *** Itch[Ab] copptby[WB] Traf6[Ab] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ 45+ 60 90 120 240 min
    *** reqs: Tnfaip3 [KO]
    *** source: 20185725-Fig-1a
  *** Itch[Ab] copptby[WB] Traf6[Ab] is increased irt IL1 (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0 15+ 30+ 60+ 120 min
    *** reqs: xTax1bp1 [omission]
    *** inhibited by: xTax1bp1(S593A/S666A) [substitution]
    *** source: 21765415-Fig-4b
*** Jnks--
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0 15++ 30+ 60 120 min
    *** comment: decrease after 15 min reqs xTax1bp1 [omission]
    *** comment: decrease after 15 min inhibited by xTax1bp1(S593A/S666A) [substitution]
    *** source: 21765415-Fig-3b
*** Jun--
  *** Jun[Ab] prot-exp[WB] is increased irt IL1a (2 hr)
    *** cells: MRC5 in BMS
    *** unaffected by: SP600125 [addition]
    *** source: 18443042-Fig-4a
  *** Jun[Ab] prot-exp[WB] is increased irt IL1a (times)
    *** cells: MRC5 in BMS
    *** times: 0 30+ 60++ 120++ 180++ 240++ 360++ min
    *** source: 18443042-Fig-4a
*** Lbp--
  *** Lbp-gene mRNA[Northern] is increased irt IL1b (24 hr)
    *** cells: HUH7 in BMS
    *** enhanced by: IL6 [cotreatment]
    *** source: 8668165-Fig-1c
*** Map4k4--
  *** Map4k4-gene mRNA[RTPCR] is unchanged irt IL1b (times)
    *** cells: 3T3L1 in BMS "differentiated into adipocytes"
    *** times: 0+ 2+ 6+ 12+ 24+ 48+ hr
    *** source: 17500068-Fig-3b
*** Map4k5--
  *** Map4k5[Ab]IP IVKA(MBP)[32P-ATP] is unchanged irt IL1 (15 min)
    *** cells: HELA in BMS
    *** source: 9405407-Fig-3e
*** Mapkapk2--
  *** xMapkapk2[tAb] IVKA(Hspb1)[32P-ATP] is increased irt IL1 (30 min)
    *** cells: HELA in BMS
    *** inhibited by: xTak1(K63W) [addition]
    *** source: 11050078-Fig-5c
*** Mek1--
  *** Mek12s[phosAb] phos(SMANS)[phosAb] is unchanged irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** source: 19953085-Fig-S1
*** Mekk1--
*** Mekk2--
  *** xMekk2[tAb]IP phos(S520)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Mekk2~null> in BMS
    *** times: 0 20++ 40+ min
    *** source: 16362041(D)
*** Mekk3--
*** Mkk4--
  *** Mkk4[Ab]IP IVKA(Jnk1,Jun)[32P-ATP] is unchanged irt IL1a (15 min)
    *** cells: mEFs in BMS
    *** source: 11390361-Fig-1b
  *** Mkk4[phosAb] phos(T261)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ min
    *** inhibited by: kIrak4(K213A/K214A)"KD" [substitution]
    *** source: 17337443-Fig-3a
  *** xMkk4[tAb]IP IVKA(Jnk1,Jun)[32P-ATP] is unchanged irt IL1a (30 min)
    *** cells: HEK293 in BMLS
    *** source: 9891090-Fig-9
*** Mlk3--
  *** Mlk3[phosAb] phos(T277/S281)[phosAb] is increased irt IL1b (times)
    *** cells: SKOV3 in BMS
    *** times: 0 1 3+ 5+ 7++ 9++ 15++ min
    *** source: 19586614-Fig-1c
*** Mmp13--
  *** Mmp13-gene mRNA[RTPCR] is increased irt IL1b (24 hr)
    *** cells: hChondrocytes in BMLS
    *** source: 17724016-Fig-4b
*** Mmp13-gene--
  *** Mmp13[Ab] secretion[WB] is increased irt IL1b (24 hr)
    *** cells: hChondrocytes in BMLS
    *** source: 17724016-Fig-4b
*** Mtcp1nb--
  *** Mtcp1nb-gene mRNA[Northern] is increased irt IL1b (4 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-7c
*** Nemo--
  *** Nemo[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0++ 5++ 15++ 30+ min
    *** source: 17197697-Fig-6d
  *** Nemo[phosAb] phos(S376)[phosAb] is increased irt IL1 (5 min)
    *** cells: hSNFs in BMS
    *** unaffected by: 5Z7Oxozeaenol [addition]
    *** source: 17197697-Fig-6e
  *** Nemo[phosAb] phos(S376)[phosAb] is increased irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0 5++ 15++ 30+ min
    *** source: 17197697-Fig-6d
  *** Nemo[phosAb] phos(S376)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xTLR8> in BMS
    *** times: 0 15++ 30+ min
    *** source: 16737960-Fig-4a
  *** xNemo[phosAb] phos(S376)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<xTLR8> in BMS
    *** times: 0 5+ 15+ 30+ min
    *** does not req: Mekk3 [KO]
    *** source: 16737960-Fig-4d
*** Nfkb--
  *** Nfkb-reporter[Luc] is increased irt IL1 (8 hr)
    *** cells: mEFs<Tax1bp1~null> in BMS
    *** inhibited by: xTax1bp1 [addition]
    *** partially inhibited by: xTax1bp1(S593A) [addition]
    *** partially inhibited by: xTax1bp1(S666A) [addition]
    *** inhibited by: xTax1bp1(S593A/S666A) [addition]
    *** source: 21765415-Fig-5b
  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: mEFs in BMS
    *** does not req: Ikk2 [KO]
    *** source: 19666475-Fig-1e
  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: mEFs in BMS
    *** reqs: Ikk1 [KO]
    *** source: 19666475-Fig-5d
  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: mEFs<Ikk1~null><xIkk1> in BMS
    *** reqs: xIkk1 [omission]
    *** unaffected by: xIkk1(1-737)"delNBD" [substitution]
    *** source: 19666475-Fig-5d
  *** Nfkb-reporter[Luc] is increased irt IL1a (5 hr)
    *** cells: mEFs<Ikk2~null><xIkk2> in BMS
    *** does not req: xIkk2 [omission]
    *** unaffected by: xIkk2(1-733)"delNBD" [substitution]
    *** source: 19666475-Fig-1e
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** times: 0 15+ 30++ 60+ min
    *** partially reqs: Ikk1 [KO]
    *** source: 19666475-Fig-5b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** times: 0 15+ 30++ 60+ min
    *** partially reqs: Ikk2 [KO]
    *** source: 19666475-Fig-1d
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs<Ikk1~null><xIkk1> in BMS "nuclear-extracts"
    *** times: 0 15++ 30++ 60+ min
    *** partially reqs: xIkk1 [omission]
    *** partially inhibited by: xIkk1(1-737)"delNBD" [substitution]
    *** source: 19666475-Fig-5b
  *** Nfkb[RE] oligo-binding[EMSA] is increased irt IL1a (times)
    *** cells: mEFs<Ikk2~null><xIkk2> in BMS "nuclear-extracts"
    *** times: 0 15++ 30++ 60+ min
    *** partially reqs: xIkk2 [omission]
    *** unaffected by: xIkk2(1-733)"delNBD" [substitution]
    *** source: 19666475-Fig-1d
*** Nfkb1--
  *** Nfkb1[Ab] boundto(CcL2-gene)[ChIP] is unchanged irt IL1a (2 hr)
    *** cells: mEFs in BMS
    *** source: 18443042-Fig-8b
  *** Nfkb1[Ab] oligo-binding[EMSA] is increased irt IL1a (30 min)
    *** cells: mEFs in BMS "nuclear-extracts"
    *** partially reqs: Ikk1 [KO]
    *** does not req: Ikk2 [KO]
    *** source: 17244613-Fig-2b
  *** Nfkb1[Ab]IP phos(S927)[phosAb] is increased irt IL1a (times)
    *** cells: HELA in BMS "pretreated with MG132"
    *** times: 0 5 15 30++ 60++ 120+ min
    *** source: 11297557-Fig-5b
  *** xNfkb1[Ab]IP prot-stability[35S-pulse-chase] is decreased irt IL1a (times)
    *** cells: HELA<xNfkb1> in BMS
    *** times: 0+ 30 60 min
    *** reversed by: xNfkb1(S927A) [substitution]
    *** source: 11297557-Fig-4a
  *** Nfkb1[Ab]IP prot-stability[35S-pulse-chase] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2 4 hr
    *** does not req: Ikk1 [KO]
    *** source: 11297557-Fig-1a
  *** Nfkb1[Ab]IP prot-stability[35S-pulse-chase] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2 4 hr
    *** partially reqs: Ikk2 [KO]
    *** source: 11297557-Fig-1b
  *** Nfkb1[Ab]IP prot-stability[35S-pulse-chase] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2 4 hr
    *** reqs: Nemo [KO]
    *** source: 11297557-Fig-1c
  *** Nfkb1[phosAb] phos(S932)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** inhibited by: PS1145 [addition]
    *** source: 19754427-Fig-1c
  *** Nfkb1[phosAb] phos(S932)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** unaffected by: PP2 [addition]
    *** source: 19754427-Fig-3b
  *** Nfkb1[phosAb] phos(S932)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMLS
    *** times: 0 5+++ 15++ 30++ 45+ 60+ min
    *** reqs: Irak1 [KO]
    *** source: 19754427-Fig-1a
  *** Nfkb1[phosAb] phos(S932)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMLS
    *** times: 0 10+ 30+ min
    *** source: 18180283-Fig-6b
  *** Nfkb1[phosAb] phos(S932)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMLS
    *** times: 0 2 5++ 10++ 30+ min
    *** inhibited by: xTak1(mnr)"KD" [addition]
    *** source: 18180283-Fig-6a
  *** Nfkb1[phosAb] phos(S932)[phosAb] is unchanged irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null><xTpl2> in BMLS
    *** unaffected by: PS1145 [addition]
    *** source: 19754427-Fig-2b
*** Nfkb2--
  *** Nfkb2[Ab] cleavage[WB] is unchanged irt IL1a (times)
    *** cells: HEK293<xCd40> in BMS
    *** times: 0 30 300 min
    *** source: 12374738-Fig-1d
*** Nik--
  *** xNik(K429A/K430A)[tAb] phos[WBMS-PPase] is increased irt IL1 (30 min)
    *** cells: HEK293 in BMS
    *** inhibited by: xTak1(K63W)"DN" [addition]
    *** source: 10094049-Fig-3a
  *** P38s[Ab] copptby[WB] Adam17[Ab] is increased irt IL1b (15 min)
    *** cells: T42 in BMLS
    *** source: 20188673-Fig-4g
  *** Page1-gene mRNA[Northern] is increased irt IL1b (4 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-7c
*** Peli3--
  *** xPeli3[tAb] copptby[WB] Irak1[Ab] is increased irt IL1a (times)
    *** cells: HEK293 in BMS
    *** times: 0 15+ 30+ 45 min
    *** source: 12874243-Fig-6
  *** xPeli3[tAb] copptby[WB] Nik[Ab] is increased irt IL1a (times)
    *** cells: HEK293 in BMS
    *** times: 0 15 30 45+ min
    *** source: 12874243-Fig-6
  *** xPeli3[tAb] copptby[WB] Tak1[Ab] is increased irt IL1a (times)
    *** cells: HEK293 in BMS
    *** times: 0 15+ 30+ 45 min
    *** source: 12874243-Fig-6
  *** xPeli3[tAb] copptby[WB] Traf6[Ab] is increased irt IL1a (times)
    *** cells: HEK293 in BMS
    *** times: 0 15+ 30+ 45 min
    *** source: 12874243-Fig-6
*** Pkcz--
*** Pol2--
  *** Pol2[Ab] boundto(CcL2-gene)[ChIP] is increased irt IL1a (times)
    *** cells: mEFs in BMLS
    *** times: 0 15+ 30++ 60+ 120+ min
    *** reqs: Jun [KO]
    *** source: 18443042-Fig-7a
  *** ProTnf-gene mRNA[RTPCR] is increased irt IL1b (times)
    *** cells: mEFs in BMLS
    *** times: 0 2++ 4+ hr
    *** does not req: Peli1 [KO]
    *** source: 19734906-Fig-5a
*** ProTnf-gene--
  *** Psoriasin-gene mRNA[RTPCR] is increased irt IL1b (times)
    *** cells: hKerats in BMS
    *** times: 0+ 18++ 42++ hr
    *** source: 15308104-Fig-6f
*** Psoriasin-gene--
*** Ptgs--
  *** Ptgs2-gene mRNA[Northern] is increased irt IL1b (16 hr)
    *** cells: mEFs in BMS
    *** does not req: Tab2 [KO]
    *** source: 12556483-Fig-3c
  *** Ptgs2-gene mRNA[Northern] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4+ hr
    *** reqs: Myd88 [KO]
    *** source: 15241416-Fig-1b
*** Rela--
  *** Rela[Ab] copptby[WB] Hdac3[Ab] is unchanged irt IL1a (30 min)
    *** cells: HEK293T<xIL1R1> in BMLS "nuclear-extracts"
    *** source: 18443042-Fig-10e
  *** Rela[Ab] copptby[WB] Pkcz[Ab] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10+ 20+ min
    *** inhibited by: Lactacystin [addition]
    *** source: 11684013-Fig-4c
*** Rnf11--
  *** Rnf11[Ab] copptby[WB] Traf6[Ab] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ 45 60 90 120 240 min
    *** reqs: Tnfaip3 [KO]
    *** source: 20185725-Fig-1a
  *** Rnf11[Ab] copptby[WB] Traf6[Ab] is increased irt IL1 (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0 15+ 30+ 60+ 120 min
    *** reqs: xTax1bp1 [omission]
    *** inhibited by: xTax1bp1(S593A/S666A) [substitution]
    *** source: 21765415-Fig-4b
*** RoRc-- RoRc-gene--
  *** RoRc-gene mRNA[RTPCR] is unchanged irt IL1b (3 days)
    *** cells: hNaiveCD4TCs in BMS
    *** source: 18454151-Fig-2b
*** Rsk1--
  *** Rsk1[phosAb] phos(T359/S363)[phosAb] is increased irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** unaffected by: Gefitinib [cotreatment]
    *** partially inhibited by: BMS345541 [cotreatment]
    *** partially inhibited by: PD325901 [cotreatment]
    *** unaffected by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1
*** Rsks--
  *** Rsks[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 min
    *** does not req: Ikk1 [KO]
    *** does not req: Ikk2 [KO]
    *** comment: decrease in phos at 30 min is not seen in Ikk-null cells
    *** source: 11733537-Fig-2
*** S6k1--
  *** SBE-reporter[Luc] is increased irt IL1b (6 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-3b
  *** SBE-reporter[Luc] is increased irt IL1b (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** reqs: IL1R1 [RNAi]
    *** reqs: TgfbR1 [RNAi]
    *** reqs: TgfbR2 [RNAi]
    *** inhibited by: xIkba(S32A/S36A)"SR" [addition]
    *** reqs: Smad2 [RNAi]
    *** source: 17360530-Fig-5c
*** Smad2--
  *** Smad2[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (1 hr)
    *** cells: BJ in BMS "pretreated with CHX"
    *** source: 17360530-Fig-3c
  *** Smad2[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (1 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS "pretreated with CHX"
    *** partially reqs: IL1R1 [RNAi]
    *** reqs: TgfbR1 [RNAi]
    *** reqs: TgfbR2 [RNAi]
    *** unaffected by: xIkba(S32A/S36A)"SR" [addition]
    *** source: 17360530-Fig-5a
  *** Smad2[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (1 hr)
    *** cells: MEL29 in BMS "pretreated with CHX"
    *** source: 17360530-Fig-3c
  *** Smad2[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (1 hr)
    *** cells: T98G in BMS "pretreated with CHX"
    *** source: 17360530-Fig-3c
  *** Smad2[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (1 hr)
    *** cells: WI38 in BMS "pretreated with CHX"
    *** source: 17360530-Fig-3c
  *** Smad2[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS "pretreated with CHX"
    *** times: 0+ 5+ 15+ 30++ 60++ 120++ min
    *** source: 17360530-Fig-2a
  *** Smad2[phosAb] phos(sitenr)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS "pretreated with CHX"
    *** times: 0++ 30+++ 60+++ 120+++ 240+++ 480++ 960++ 1440+ min
    *** does not req: Irak1 [RNAi]
    *** does not req: Myd88 [RNAi]
    *** source: 17360530-Fig-2b
*** SRE-reporter--
  *** SRE-reporter[Luc] is increased irt IL1 (10 hr)
    *** cells: CHO in BMLS
    *** partially inhibited by: xMkk4(mnr)"DN" [addition]
    *** source: 9111305-Fig-5b
  *** SRE-reporter[Luc] is increased irt IL1 (10 hr)
    *** cells: CHO in BMLS
    *** unaffected by: SB203580 [addition]
    *** source: 9111305-Fig-5b
  *** SRE-reporter[Luc] is increased irt IL1 (10 hr)
    *** cells: NIH3T3 in BMLS
    *** partially inhibited by: SB203580 [addition]
    *** source: 9111305-Fig-6b
  *** SRE-reporter[Luc] is increased irt IL1 (10 hr)
    *** cells: NIH3T3 in BMLS
    *** partially inhibited by: xMkk4(mnr)"DN" [addition]
    *** source: 9111305-Fig-6b
  *** Stat3[phosAb] phos(Y705)[phosAb] is decreased irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** unaffected by: Gefitinib [cotreatment]
    *** unaffected by: BMS345541 [cotreatment]
    *** unaffected by: PD325901 [cotreatment]
    *** unaffected by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1
*** Tab1--
*** Tab2--
  *** Tab2[Ab] copptby[WB] xPeli1[tAb] is unchanged irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0 10 30 60 min
    *** source: 12496252-Fig-2b
*** Tab3--
*** Tak1--
  *** Tak1[Ab] copptby[WB] xPeli1[tAb] is unchanged irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0 10 30 60 min
    *** source: 12496252-Fig-2b
*** Tax1bp1--
  *** Tax1bp1[Ab] prot-exp[WB] is increased irt IL1 (times)
    *** cells: mBMMs in BMS
    *** times: 0 15+ 60+ min
    *** comment: increase is slight and could be due to Ab affinity to phos Tax1bp1
    *** source: 21765415-Fig-2k
  *** Tax1bp1[Ab]IP prot-exp[WB] is unchanged irt IL1 (15 min)
    *** cells: mEFs<Ikk1~null><xIkk1> in BMS
    *** unaffected by: xIkk1(K44M)"KD" [substitution]
    *** source: 21765415-Fig-1g
*** xTbk1--
  *** xTbk1[tAb]IP IVKA(Rela)[32P-ATP] is increased irt IL1a (10 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** source: 15489227(D)
  *** xTgfa[Ab] secretion[ELISA] is increased irt IL1b (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** reqs: P38a [RNAi]
    *** source: 20188673-Fig-2c
  *** Tgfa[Ab] secretion[ELISA] is increased irt IL1b (60 min)
    *** cells: T42 in BMLS
    *** inhibited by: SB203580 [pretreatment]
    *** source: 20188673-Fig-1e
  *** xTgfa[Ab] secretion[ELISA] is increased irt IL1b (60 min)
    *** cells: T42 in BMLS
    *** reqs: P38a [RNAi]
    *** reqs: Adam17 [RNAi]
    *** source: 20188673-Fig-7e
*** TgfbR1--
  *** TgfbR1[Ab] copptby[WB] xIL1R1[Ab] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-6
*** TgfbR2--
  *** TgfbR2[Ab] copptby[WB] xIL1R1[Ab] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-6
    *** source: 17360530-Fig-7b
*** Tnf--
  *** Tnf[Ab] mRNA[RTPCR] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0+ 1++ 3+ hr
    *** inhibited by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-5e
  *** Tnf[Ab] secretion[ELISA] is increased irt IL1b (tnr)
    *** cells: mEFs in BMS
    *** reqs: Irak4 [KO]
    *** source: 11923871(D)
*** Tnfaip3--
*** TnfR1--
  *** TnfR1[Ab]IP IVKA(Ikba)[32P-ATP] is unchanged irt IL1 (5 min)
    *** cells: mEFs in BMS
    *** source: 10795740-Fig-4e
  *** Tp53[phosAb] phos(S15)[phosAb] is unchanged irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** source: 19953085-Fig-S1
*** Tpl2--
  *** xTpl2[tAb] copptby[WB] xTnip2[tAb] is decreased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** partially inhibited by: Compound-1 [addition]
    *** source: 19754427-Fig-9a
  *** xTpl2[tAb] copptby[WB] xTnip2[tAb] is decreased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null> in BMLS
    *** unaffected by: xTpl2(D270A) [substitution]
    *** unaffected by: xTpl2(T290A) [substitution]
    *** source: 19754427-Fig-9a
*** Traf2--
  *** Traf2[Ab] copptby[WB] Tab2[Ab] is unchanged irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3 15 min
    *** source: 14633987-Fig-6b
  *** Traf2[Ab] copptby[WB] Tab3[Ab] is unchanged irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3 15 min
    *** source: 14633987-Fig-6b
*** Traf3--
  *** Traf3[Ab] copptby[WB] IL1Rap[Ab] is increased irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0 5+ 10+ 20+ min
    *** source: 16306937-Fig-S2b
*** Traf6--
  *** Traf6[Ab] copptby[WB] Mekk3[Ab] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 10++ 20+ 30 min
    *** source: 19843958-Fig-3c
  *** Traf6[Ab] copptby[WB] Rnf11[Ab] is increased irt IL1 (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0 15+ 60+ 120+ min
    *** reqs: xTax1bp1 [omission]
    *** inhibited by: xTax1bp1(S593A/S666A) [substitution]
    *** inhibited by: xTax1bp1(S593A) [substitution]
    *** inhibited by: xTax1bp1(S666A) [substitution]
    *** source: 21765415-Fig-5d
  *** Traf6[Ab] copptby[WB] Sqstm1[Ab] is increased irt IL1b (times)
    *** cells: HEPG2 in BMS
    *** times: 0 15+ 30+ min
    *** source: 10747026-Fig-6b
  *** xTraf6[tAb] copptby[WB] Sqstm1[Ab] is increased irt IL1b (times)
    *** cells: HEPG2 in BMS
    *** times: 0 5+ 15++ 30++ min
    *** source: 10747026-Fig-6a
*** Ubc13--
  *** Ubc13[Ab] copptby[WB] xTnfaip3[tAb] is detectable
    *** cells: mEFs<Tnfaip3~null><xTnfaip3> in BMS "treated with IL1 for 30-60 min"
    *** inhibited by: xTnfaip3(547-775) [substitution]
    *** inhibited by: xTnfaip3(del(247-699)) [substitution]
    *** source: 20185725-Fig-4f
  *** Ubc13[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mBMDCs in BMS
    *** times: 0++ 2++ 4+ 6 hr
    *** partially repressed by: Tnfaip3 [RNAi]
    *** source: 20185725-Fig-3c
  *** Ubc13[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2+ 4+ 6 hr
    *** does not req: Itch [KO]
    *** source: 20185725-Fig-S5d
  *** Ubc13[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2+ 4+ 6 hr
    *** does not req: Rnf11 [RNAi]
    *** source: 20185725-Fig-S5b
  *** Ubc13[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2+ 4+ 6 hr
    *** repressed by: Tax1bp1 [KO]
    *** source: 20185725-Fig-S4c
  *** Ubc13[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2+ 4+ 6 hr
    *** repressed by: Tnfaip3 [KO]
    *** source: 20185725-Fig-S4a
  *** Ubc13[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2+ 4+ 6 hr
    *** reversed by: MG132 [pretreatment]
    *** source: 20185725-Fig-3f
  *** Ubc13[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tnfaip3~null><xTnfaip3> in BMS
    *** times: 0+ 1+ 2+ 4+ 6 hr
    *** comment: reversed by xTnfaip3(C103A) [subsitution]
    *** comment: reversed by xTnfaip3(C624A/C627A) [subsitution]
    *** source: 20185725-Fig-S8b
  *** Ubc13[Ab]IP ubiq[UbAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 1+ 2+ 3++ 4++ hr
    *** unaffected by: CHX [pretreatment]
    *** source: 20185725-Fig-S3b
  *** Ubc13[Ab]IP ubiq[UbAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 3+ 4++ hr
    *** reqs: Tnfaip3 [KO]
    *** reqs: Tax1bp1 [KO]
    *** source: 20185725-Fig-3a
*** Ube2c--
  *** Ube2c[Ab] prot-exp[WB] is unchanged irt IL1 (times)
    *** cells: mBMDCs in BMS
    *** times: 0++ 2++ 4+ 6 hr
    *** unaffected by: Tnfaip3 [RNAi]
    *** source: 20185725-Fig-3c
*** Ube2d3--
  *** Ube2d3[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2+ 4+ 6 hr
    *** reversed by: MG132 [pretreatment]
    *** source: 20185725-Fig-3f
*** Ubiq--
  *** Ubiq[K63UbAb] copptby[WB] Ripk1[Ab] is increased irt IL1 (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0 15++ 30++ 60+ 120 min
    *** comment: decrease after 30 min reqs xTax1bp1 [omission]
    *** comment: decrease after 30 min inhibited by xTax1bp1(S593A/S666A) [substitution]
    *** source: 21765415-Fig-3b
