Required Proteins

not Dusp1--

  *** xErk5[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** inhibited by: xDusp1 [addition]
    *** source: 10473620-Fig-4c

not Dusp6--

  *** xErk5[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** inhibited by: xDusp6 [addition]
    *** source: 10473620-Fig-4d

not Erks--

  *** Erk5[Ab] phos[WBMS] is increased irt Egf (15 min)
    *** cells: HELA in BMLS
    *** does not req: Erk5 [RNAi]
    *** source: 16581779-Fig-5b

Hras--

  *** Erk5[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: PC12 in BMLS
    *** inhibited by: xHras(S17N)"DN" [addition]
    *** source: 10473620-Fig-3d
  *** xErk5[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** inhibited by: xHras(S17N)"DN" [addition]
    *** source: 10473620-Fig-3c
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (20 min)
    *** cells: HELA in BMLS
    *** unaffected by: xHras(S17N)"DN" [addition]
    *** source: 9790194-Fig-2b

not Mek1--

  *** xErk5[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** unaffected by: xMek1(mnr)"DN" [addition]
    *** source: 10473620-Fig-4e

Mek5--

  *** xErk5[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** inhibited by: xMek5(S311A/T315A)"DN" [addition]
    *** source: 10473620-Fig-4e
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (20 min)
    *** cells: HELA in BMLS
    *** partially inhibited by: xMek5(mnr)"DN" [addition]
    *** source: 9790194-Fig-2b

Mekk2--

  *** Erk5[Ab] phos[WBMS] is increased irt Egf (15 min)
    *** cells: HELA in BMLS
    *** reqs: Mekk2 [RNAi]
    *** source: 16581779-Fig-5b

Mekk3--

  *** Erk5[Ab] phos[WBMS] is increased irt Egf (15 min)
    *** cells: HELA in BMLS
    *** inhibited by: xMekk3(K391W)"DN" [addition]
    *** source: 10593883-Fig-4b

=========
Chemicals
=========

  *** Erk5[Ab]IP IVKA(Mek5,Mef2c)[32P-ATP] is increased irt Egf (5 min)
    *** cells: C2C12 in BMLS
    *** inhibited by: Forskolin + IBMX [addition]
    *** source: 16581779(D)
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (times)
    *** cells: HELA in BMLS
    *** times: 0 1+ 10+ 25+ min
    *** inhibited by: Forskolin + IBMX [addition]
    *** source: 16581779-Fig-1b
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (times)
    *** cells: HELA in BMLS
    *** times: 0 5+ 15++ 30++ min
    *** inhibited by: Forskolin + IBMX [addition]
    *** source: 16581779-Fig-1c
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (15 min)
    *** cells: HELA in BMLS
    *** inhibited by: PGE2 + IBMX + Probenecid [addition]
    *** source: 16581779-Fig-1d
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (15 min)
    *** cells: HELA in BMLS
    *** unaffected by: myr-PKI-peptide [addition]
    *** source: 16581779-Fig-2b
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (15 min)
    *** cells: HELA in BMLS
    *** unaffected by: H89 [addition]
    *** source: 16581779-Fig-2b
  *** xErk5[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** inhibited by: PD98059 [addition] no-bkg-control
    *** inhibited by: U0126 [addition] no-bkg-control
    *** source: 10473620-Fig-4a
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (20 min)
    *** cells: HELA in BMLS
    *** inhibited by: PD153035 [addition]
    *** source: 9790194-Fig-1d
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (10 min)
    *** cells: MIMCD3 in BMLS
    *** unaffected by: PD98059 [pretreatment] no-bkg-control
    *** inhibited by: U0126 [pretreatment] no-bkg-control
    *** source: 1118451-Fig-3a
  *** Erk5[Ab]IP phos(sitenr)[phosAb] is increased irt Egf (10 min)
    *** cells: MIMCD3 in BMLS
    *** unaffected by: PD98059 [pretreatment] no-bkg-control
    *** inhibited by: U0126 [pretreatment] no-bkg-control
    *** source: 1118451-Fig-3b

=========
No Extras
=========

  *** Erk5[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Egf (times)
    *** cells: COS7 in BMLS
    *** times: 0 5++ 30+ min
    *** source: 10473620-Fig-2c
  *** Erk5[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0 5++ 30+ min
    *** source: 10473620-Fig-2c
  *** xErk5[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** source: 10473620-Fig-2a
  *** xErk5[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0 5+ 30 min
    *** source: 10473620-Fig-2b
  *** Erk5[phosAb] phos(sitenr)[phosAb] is increased irt Egf (5 min)
    *** cells: PC6 in BMLS
    *** source: 15632082-Fig-1c
  *** Erk5[Ab]IP IVKA(Mef2c)[32P-ATP] is increased irt Egf (20 min)
    *** cells: HELA in BMLS
    *** source: 9790194-Fig-1a
  *** Erk5[Ab]IP IVKA(Mef2c)[32P-ATP] is increased irt Egf (20 min)
    *** cells: HELA in BMLS
    *** source: 9790194-Fig-1c
  *** Erk5[Ab]IP IVKA(Mef2c)[32P-ATP] is increased irt Egf (times)
    *** cells: HELA in BMLS
    *** times: 0 5+ 15++ 30++ 60+ 120 min
    *** source: 9790194-Fig-1b
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (20 min)
    *** cells: HELA in BMLS
    *** source: 9790194-Fig-1a
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (20 min)
    *** cells: HELA in BMLS
    *** source: 9790194-Fig-1c
  *** Erk5[Ab] phos[WBMS] is increased irt Egf (times)
    *** cells: HELA in BMLS
    *** times: 0 5+ 15++ 30++ 60+ 120 min
    *** source: 9790194-Fig-1b
  *** Erk5[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Egf (10 min)
    *** cells: MIMCD3 in BMLS
    *** source: 1118451-Fig-3d
