mod IL2RULES is inc ALLOPS .

var xout : Soup .
vars clo clm clr cli clc nuo num nui nuc : Soup .
vars moo mom moi moc mio mim mii mic : Soup .
vars ero erm eri erc pxo pxm pxi pxc : Soup .
vars gao gam gai gac lyo lym lyi lyc : Soup .
vars eeo eem eei eec leo lem lei lec : Soup .
vars cpo cpm cpi cpc ct ptc sig : Soup .
var il2rc : Soup .

*** Starting state: IL2Rb and Jak1 in IL2R complex
*** IL2Ra and IL2Rg recruited irt IL2?

  *** ~/evidence/IL2-Evidence/00IL2-Evidence.txt


rl[1011.IL2R.irt.IL2]:
  {XOut  | xout  IL2                             }
  {IL2RC | il2rc IL2Rb      IL2Rg                }
  {CLm   | clm   IL2Ra                           }
  =>
  {XOut  | xout                                  }
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLm   | clm   IL2Ra                           } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/IL2R.irt.IL2.1011.txt

*** Akt--

rl[1092.Akt1.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2  [Pi3k - Yphos] }
  {CLi   | cli   [Rac1 - GTP]                                    }
  {CLc   | clc   [Syk - act]  Akt1                               }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2  [Pi3k - Yphos] }
  {CLi   | cli   [Rac1 - GTP]                                    }
  {CLc   | clc   [Syk - act]  [Akt1 - act]                       } .
  -------------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Akt1.irt.IL2.1092.txt


*** Bcl2-- Bcl2-gene--

rl[1101.Bcl2-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Bcl2-gene                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Bcl2-gene - on]                } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Bcl2-gene.irt.IL2.1101.txt

*** Bclxl-- Bclxl-gene--

rl[1182.Bclxl-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Bclxl-gene                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Bclxl-gene - on]                } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Bclxl-gene.irt.IL2.1182.txt

*** Cd69--

***(
rl[1103.Cd69.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLm   | clm                                   }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLm   | clm    Cd69                           } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Cd69.irt.IL2.1103.txt
)***
*** Cdc2-- Cdc2-gene--

rl[1165.Cdc2-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Cdc2-gene                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Cdc2-gene - on]                } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/Cdc2-gene.irt.IL2.1165.txt

*** Cdk2-- Cdk2-gene--

rl[1105.Cdk2-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Cdk2-gene                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Cdk2-gene - on]                } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Cdk2-gene.irt.IL2.1105.txt

*** Cdk6-- Cdk6-gene--

rl[1187.Cdk6-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Cdk6-gene                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Cdk6-gene - on]                } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Cdk6-gene.irt.IL2.1187.txt

*** Cish--  Cish-gene--

rl[1183.Cish-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Cish-gene                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Cish-gene - on]                } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Cish-gene.irt.IL2.1183.txt

*** CyclinC-- CyclinC-gene--

rl[1109.CyclinC-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    CyclinC-gene                   }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [CyclinC-gene - on]             } .
  ------------------------------------------------
  *** ~/evidence/IL2-Evidence/CyclinC-gene.irt.IL2.1109.txt

*** CyclinD2-- CyclinD2-gene--

rl[1110.CyclinD2-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    CyclinD2-gene                  }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [CyclinD2-gene - on]            } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/CyclinD2-gene.irt.IL2.1110.txt

*** CyclinD3-- CyclinD3-gene--

rl[1112.CyclinD3-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    CyclinD3-gene                  }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [CyclinD3-gene - on]            } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/CyclinD3-gene.irt.IL2.1112.txt

*** Dpp4--

***(
rl[1113.Dpp4.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLm   | clm                                 }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLm   | clm    Dpp4                         } .
  ------------------------------------------------
  *** ~/evidence/IL2-Evidence/Dpp4.irt.IL2.1113.txt
)***
*** Elk1--

rl[1114.Elk1.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Elk1                           }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Elk1 - act]                    } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Elk1.irt.IL2.1114.txt

*** Erks-- Erk1-- Erk2--

rl[1119.Erks.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   Shp2 Erks                       }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   Shp2 [Erks - act]               } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Erks.irt.IL2.1119.txt

*** Fak2--

rl[1120.Fak2.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {CLc   | clc   Fak2                                           }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {CLc   | clc   [Fak2 - act]                                   } .
  -----------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Fak2.irt.IL2.1120.txt

*** Fos-- Fos-gene--

rl[1123.Fos-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {NUc   | nuc    Fos-gene                                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {NUc   | nuc   [Fos-gene - on]                                } .
  -----------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Fos-gene.irt.IL2.1123.txt

*** Fosb-- Fosb-gene--

rl[1129.Fosb-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Fosb-gene                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Fosb-gene - on]                } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Fosb-gene.irt.IL2.1129.txt

*** Fosl1-- Fosl1-gene--

rl[1130.Fosl1-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Fosl1-gene                     }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Fosl1-gene - on]               } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Fosl1-gene.irt.IL2.1130.txt

*** Foxp3-- Foxp3-gene--

rl[1188.Foxp3-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Foxp3-gene                     }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Foxp3-gene - on]               } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Foxp3-gene.irt.IL2.1188.txt

*** Fyn--

rl[1133.Fyn.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLi   | cli    Fyn                            }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLi   | cli   [Fyn - act]                     } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Fyn.irt.IL2.1133.txt

*** Gab2--

rl[1141.Gab2.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {CLc   | clc   Gab2                                           }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {CLc   | clc   [Gab2 - Yphos]                                 } .
  -----------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Gab2.irt.IL2.1141.txt

*** Grb2--

rl[1143.Grb2.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2      }
  {CLc   | clc    Grb2                                }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 Grb2 }
  {CLc   | clc                                        } .
  --------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Grb2.irt.IL2.1143.txt

*** Hras--

rl[1148.Hras.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLi   | cli   [Hras - GDP]                    }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLi   | cli   [Hras - GTP]                    } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/Hras.irt.IL2.1148.txt

*** Irs1--

rl[1150.Irs1.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    Irs1                           }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [Irs1 - Yphos]                  } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Irs1.irt.IL2.1150.txt

*** Jak1--

rl[1156.Jak1.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2  Jak1          }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak1 - Yphos] } .
  -----------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Jak1.irt.IL2.1156.txt

*** Jak3--

rl[1158.Irs1.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2                }
  {CLc   | clc    Jak3                                          }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {CLc   | clc                                                  } .
  -----------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Jak3.irt.IL2.1158.txt

*** Jnks--  Jnk1--  Jnk2-- Jnk3--

rl[1159.Jnks.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   Jnks                            }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [Jnks - act]                    } .
  ------------------------------------------------
  *** ~/evidence/IL2-Evidence/Jnks.irt.IL2.1159.txt

*** Jun-gene--

rl[1163.Jun-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Jun-gene                       }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Jun-gene - on]                 } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/Jun-gene.irt.IL2.1163.txt

*** Junb-gene--

rl[1164.Junb-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Junb-gene                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Junb-gene - on]                } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/Junb-gene.irt.IL2.1164.txt

*** Lck--

rl[1166.Lck.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    Lck                            }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [Lck - act]                     } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Lck.irt.IL2.1166.txt

*** Lyn--

rl[1167.Lyn.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    Lyn                            }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [Lyn - act]                     } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Lyn.irt.IL2.1167.txt

*** Mapkapk2--

rl[1169.Mapkapk2.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    Mapkapk2                       }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [Mapkapk2 - act]                } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Mapkapk2.irt.IL2.1169.txt

*** Max-- Max-gene--

rl[1170.Max-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Max-gene                       }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Max-gene - on]                 } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/Max-gene.irt.IL2.1170.txt

*** Mek1--

rl[1171.Mek1.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    Mek1                           }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [Mek1 - act]                    } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Mek1.irt.IL2.1171.txt

*** Myb-- Myb-gene--

rl[1172.Myb-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Myb-gene                       }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Myb-gene - on]                 } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/Myb-gene.irt.IL2.1172.txt

*** Myc-- Myc-gene--

rl[1173.Myc-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    Stam Stam2                     }
  {NUc   | nuc    Myc-gene                       }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    Stam Stam2                     }
  {NUc   | nuc   [Myc-gene - on]                 } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/Myc-gene.irt.IL2.1173.txt

*** P38s--

rl[1176.P38s.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    P38s                           }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [P38s - act]                    } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/P38s.irt.IL2.1176.txt

*** Pi3k--  Pik3rs--

rl[1177.Pi3k.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2                }
  {CLc   | clc    Pi3k                                          }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Pi3k - Yphos] }
  {CLc   | clc                                                  } .
  -----------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Pi3k.irt.IL2.1177.txt

*** Rac1--

rl[1178.Rac1.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLi   | cli   [Rac1 - GDP]                    }
  {CLc   | clc   [Syk - act]                     }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLi   | cli   [Rac1 - GTP]                    }
  {CLc   | clc   [Syk - act]                     } .
  ---------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Rac1.irt.IL2.1178.txt

*** Raf1--

rl[1184.Raf1.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    Raf1                           }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [Raf1 - act]                    } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/Raf1.irt.IL2.1184.txt

*** S6ks--

rl[1189.S6ks.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc    S6ks                           }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [S6ks - act]                    } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/S6ks.irt.IL2.1189.txt

*** Shc1--

rl[1145.Shc1.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2                }
  {CLc   | clc    Shc1                                          }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Shc1 - Yphos] }
  {CLc   | clc                                                  } .
  -----------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Shc1.irt.IL2.1145.txt

*** Shp2--

rl[1185.Shp2.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2                }
  {CLc   | clc    Shp2                                          }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Shp2 - Yphos] }
  {CLc   | clc                                                  } .
  -----------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Shp2.irt.IL2.1185.txt

*** Socs3-- Socs3-gene--

rl[1186.Socs3-gene.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc    Socs3-gene                     }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {NUc   | nuc   [Socs3-gene - on]               } .
  --------------------------------------------------
  *** ~/evidence/IL2-Evidence/Socs3-gene.irt.IL2.1186.txt

*** Sos1--

rl[1147.Grb2.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2      }
  {CLc   | clc    Sos1                                }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 Sos1 }
  {CLc   | clc                                        } .
  -------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Sos1.irt.IL2.1147.txt

*** Stam--

rl[1190.Stam.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   Stam                            }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [Stam - Yphos]                  } .
  ---------------------------------------------------
  *** ~/evidence/IL2-Evidence/Stam.irt.IL2.1190.txt

*** Stat3--

rl[1180.Stat3.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2  }
  {CLc   | clc   Stat3                            }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 }
  {CLc   | clc   [Stat3 - Yphos act]             } .
  -------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Stat3.irt.IL2.1180.txt

*** Stat5s--

rl[1181.Stat5s.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2  
                 [Jak1 - Yphos] [Jak3 - Yphos]        }
  {CLc   | clc   stat5s:Stat5S                        }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2
                 [Jak1 - Yphos] [Jak3 - Yphos]        }
  {CLc   | clc   [stat5s:Stat5S - Yphos act]          } .
  -------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Stat5s.irt.IL2.1181.txt

*** Syk--

rl[1179.Syk.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {CLc   | clc   Syk                                            }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {CLc   | clc   [Syk - act]                                    } .
  ------------------------------------------------------------------
  *** ~/evidence/IL2-Evidence/Syk.irt.IL2.1179.txt

**********************************************************************
*** Proliferation - Thymidine Incorporation

rl[1245.Proliferation.irt.IL2]:
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {CLc   | clc   [Fak2 - act] [stat5s:Stat5S - Yphos act]       }
  {Sig   | sig   QUIESCENT                                      }
  =>
  {IL2RC | il2rc IL2Ra [IL2Rb - Yphos] IL2Rg IL2 [Jak3 - Yphos] }
  {CLc   | clc   [Fak2 - act] [stat5s:Stat5S - Yphos act]       }
  {Sig   | sig   PROLIFERATION                                  } .
  -----------------------------------------------------------------
  *** ~/evidence/IL4-Evidence/



endm

