=====================================
Decrease in Nfkb1 protein expression
=====================================

Nemo--  ???

  *** Nfkb1[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: 70Z3 in BMS
    *** times: 0++ 20+ 60+ min
    *** reqs: Nemo [KO]
    *** source: 11158290-Fig-7

requires proteasomal degradation

  *** Nfkb1[Ab] prot-exp[WB] is decreased irt Lps (60 min)
    *** cells: mBMMs in BMS
    *** reversed by: MG132 [pretreatment]
    *** source: 15169888-Fig-9b
  *** Nfkb1[Ab]IP prot-exp[WB] is decreased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** reversed by: MG132 [pretreatment]
    *** reversed by: Lactacystin [pretreatment]
    *** source: 15199157-Fig-8d
  *** Nfkb1[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 7++ 15+ 30+ min
    *** reversed by: MG132 [pretreatment]
    *** source: 15485931-Fig-2b

requires S927 phos site

  *** xNfkb1[Ab] prot-exp[WB] is decreased irt Lps (15 min)
    *** cells: mBMMs<Nfkb1~null><xNfkb1> in BMS
    *** reversed by: xNfkb1(S921A/S923A/S927A) [substitution]
    *** source: 15199157-Fig-9c
  *** xNfkb1[tAb] prot-exp[WB] is decreased irt Lps (15 min)
    *** cells: RAW2647<xNfkb1> in BMS
    *** reversed by: xNfkb1(S921A/S923A/S927A) [substitution]
    *** source: 15199157-Fig-9c

no extras

  *** Nfkb1[Ab]IP prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 5++ 10+ 25+ 50+ min
    *** source: 15199157-Fig-7a
  *** Nfkb1[Ab]IP prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 7++ 15++ 30+ min
    *** source: 15485931-Fig-1c
  *** Nfkb1[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: RAW2647<xTpl2> in BMS
    *** times: 0+ 15+ 30+ 45+ 60 min
    *** source: 15699325-Fig-3
  *** Nfkb1[Ab] prot-exp[WB] is detectable-but unchanged irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 10+ 30+ 60+ min
    *** source: 15169888-Fig-9a
  *** Nfkb1[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 10++ 20++ 30++ 45++ 60+ min
    *** source: 12667451-Fig-6a

=====================================
Decrease in Tnip2 protein expression
=====================================

  *** Tnip2[Ab] prot-exp[WB] is decreased irt Lps (60 min)
    *** cells: mBMMs in BMS
    *** reversed by: MG132 [pretreatment]
    *** source: 15169888-Fig-9b
  *** Tnip2[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 10++ 30++ 60+ min
    *** source: 15169888-Fig-9a

============================
Release of Tpl2 from complex
============================

  *** xTpl2[tAb] copptby[WB] Nfkb1[Ab] is decreased irt Lps (times)
    *** cells: RAW2647<xTpl2> in BMS
    *** times: 0++ 15++ 30+ 45 60 min
    *** comment: decrease is in the p58 band only
    *** reversed by: xTpl2(T290A) [substitution]
    *** enhanced by: xTpl2(T290D) [substitution]
    *** source: 15699325-Fig-4
  *** xTpl2[tAb] copptby[WB] Nfkb1[Ab] is decreased irt Lps (times)
    *** cells: RAW2647<xTpl2> in BMS "pretreated with MG132"
    *** times: 0+ 15+ 30 45 60 min
    *** comment: decrease is in the p58 band only
    *** source: 15699325-Fig-3
  *** Tpl2[Ab] copptby[WB] Nfkb1[Ab] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 15+ 25 min
    *** comment: only Tpl2p58 band is decreased
    *** reversed by: PS1145 [pretreatment]
    *** comment: decrease correlates with decrease in Nfkb1 prot-exp
    *** source: 15199157-Fig-6a
