===============
Kinase Activity
===============

  *** rPkcz IVKA(peptide)[32P-ATP] is increased by rPdpk1
    *** cells: none
    *** enhanced by: PE + PS + PIP3 [addition]
    *** inhibited by: xPdpk1(mnr)"KD" [substitution]
    *** source: 9768361-Fig-4

  *** xPkcz[tAb]IP IVKA(MBP)[32P-ATP] is increased itpo xPdpk1
    *** cells: HEK293 in BMLS
    *** inhibited by: xPkcz(T401A) [substitution]
    *** inhibited by: xPkcz(T401E) [substitution]
    *** source: 10464256-Fig-1
  *** xPkcz[tAb]IP IVKA(MBP)[32P-ATP] is increased itpo xPdpk1
    *** cells: NIH3T3 in BMLS
    *** inhibited by: xPdpk1(mnr)"KD" [substitution]
    *** inhibited by: xPdpk1(T410A) [substitution]
    *** source: 9768361-Fig-2a
  *** xPkcz[tAb]IP phos(T410)[phosAb] is increased itpo xPdpk1
    *** cells: HEK293 in BMS
    *** inhibited by: xPdpk1(mnr)"KD" [substitution]
    *** source: 9768361-Fig-3b

  *** xPkcz[tAb]IP IVKA(MBP)[32P-ATP] is increased itpo xPik3c?(mnr)"CAAX"
    *** cells: HEK293 in BMLS
    *** source: 9768361-Fig-1b

phos(410)

  *** rPkcz[phosAb] phos(T410)[phosAb] is increased by rPdpk1
    *** cells: none
    *** enhanced by: PE + PS + PIP3 [addition]
    *** unaffected by: PE + PS [addition]
    *** inhibited by: rPdpk1(mnr)"KD" [substitution]
    *** source: 9768361-Fig-4
  *** xPkcz[phosAb] phos(T410)[phosAb] is increased itpo xPdpk1
    *** cells: HEK293 in BMLS
    *** inhibited by: LY294002 [addition]
    *** source: 9748166-Fig-3a
  *** xPkcz[tAb]IP phos(T410)[phosAb] is increased itpo xPdpk1
    *** cells: HEK293 in BMLS
    *** source: 10464256-Fig-1

phos

  *** rPkcz[32P] phos[32P-ATP] is increased by rPdpk1
    *** cells: none
    *** source: 9748166-Fig-1a
  *** rPkcz[32P] phos[32P-ATP] is increased by rPdpk1
    *** cells: none
    *** enhanced by: PE + PS + PIP3 [addition]
    *** unaffected by: PE + PS [addition]
    *** inhibited by: rPdpk1(mnr)"KD" [substitution]
    *** source: 9768361-Fig-4
  *** xPkcz[tAb]IP phos[32Pi] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xPdpk1 [addition]
    *** inhibited by: xPdpk1(mnr)"DN" [addition]
    *** inhibited by: xPdpk1(T410A) [addition]
    *** source: 9768361-Fig-2b

interaction with Pdpk1

  *** xPdpk1[Ab] copptby[WB] xPkcz[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 9748166-Fig-2
  *** Pkcz[Ab] copptby[WB] xPdpk1[tAb] is detectable
    *** cells: NIH3T3 in BMLS
    *** unaffected by: Pdgf (10,20 min) [stim]
    *** source: 9768361-Fig-5

