mod DRUGRULES is inc ALLOPS .

var xout clc nuc chr : Soup .

  *** ~/evidence/Drug-Evidence/00Drug-evidence.txt

*** Atm--

rl[251.Atm.acetyl.irt.Bleomycin]:
  {XOut | xout  Bleomycin                    }
  {NUc  | nuc   Tip60 Atm                    }
  =>
  {XOut | xout  Bleomycin                    }
  {NUc  | nuc   Tip60 [Atm - acetyl(K 3016)] } .
  ----------------------------------------------
  *** ~/evidence/Drug-Evidence/Atm.acetyl.irt.Bleomycin.251.txt

rl[238.Atm.phos.irt.Bleomycin]:
  {XOut | xout  Bleomycin                          }
  {NUc  | nuc  [Atm - acetyl(K 3016)]              }
  =>
  {XOut | xout  Bleomycin                          }
  {NUc  | nuc  [Atm - acetyl(K 3016) phos(S 1981)] } .
  -----------------------------------------------------
  *** ~/evidence/Drug-Evidence/Atm.phos.irt.Bleomycin.238.txt

rl[059.Atm.phos.irt.Etoposide]:
  {XOut | xout  Etoposide           }
  {NUc  | nuc   Atm                 }
  =>
  {XOut | xout  Etoposide           }
  {NUc  | nuc  [Atm - phos(S 1981)] } .
  -------------------------------------
  *** ~/evidence/Drug-Evidence/Atm.phos.irt.Etoposide.059.txt

rl[067.Atm.to.cyto.irt.Etoposide]:
  {XOut | xout  Etoposide           }
  {CLc  | clc                       }
  {NUc  | nuc  [Atm - phos(S 1981)] }
  =>
  {XOut | xout  Etoposide           }
  {CLc  | clc  [Atm - phos(S 1981)] }
  {NUc  | nuc                       } .
  -------------------------------------
  *** ~/evidence/Drug-Evidence/Atm.to.cyto.irt.Etoposide.067.txt

rl[230.Atm.irt.Hydroxyurea]:
  {XOut | xout  Hydroxyurea          }
  {NUc  | nuc   Atm                  }
  =>
  {XOut | xout  Hydroxyurea          }
  {NUc  | nuc  [Atm -  phos(S 1981)] } .
  --------------------------------------
  *** ~/evidence/Drug-Evidence/Atm.irt.Hydroxyurea.230.txt

rl[198.Atm.irt.NCS]:
  {XOut | xout  NCS                  }
  {NUc  | nuc   Atm                  }
  =>
  {XOut | xout  NCS                  }
  {NUc  | nuc  [Atm -  phos(S 1981)] } .
  --------------------------------------
  *** ~/evidence/Drug-Evidence/Atm.irt.NCS.198.txt

*** Bax--

rl[1471.Bax-gene.irt.Adriamycin]:
  {XOut | xout  Adriamycin      }
  {NUc  | nuc   Bax-gene        }
  =>
  {XOut | xout  Adriamycin      }
  {NUc  | nuc   [Bax-gene - on] } .
  --------------------------------------
  *** ~/evidence/Drug-Evidence/Bax-gene.irt.Adriamycin.1471.txt

*** Cdkn1a--

rl[1443.Cdkn1a-gene.irt.Adriamycin]:
  {XOut | xout  Adriamycin                   }
  {NUc  | nuc   Pin1 Tp53 Cdkn1a-gene        }
  =>
  {XOut | xout  Adriamycin                   }
  {NUc  | nuc   Pin1 Tp53 [Cdkn1a-gene - on] } .
  -------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Cdkn1a-gene.irt.Adriamycin.1443.txt

rl[1473.Cdkn1a-gene.irt.5Fluorouracil]:
  {XOut | xout  5Fluorouracil            }
  {NUc  | nuc   Setd7 Cdkn1a-gene        }
  =>
  {XOut | xout  5Fluorouracil            }
  {NUc  | nuc   Setd7 [Cdkn1a-gene - on] } .
  -------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Cdkn1a-gene.irt.5Fluorouracil.1473.txt

*** Chek1--

rl[229.Chek1.irt.Hydroxyurea]:
  {XOut | xout  Hydroxyurea                     }
  {NUc  | nuc   Atr Chek1                       }
  =>
  {XOut | xout  Hydroxyurea                     }
  {NUc  | nuc   Atr [Chek1 - phos(S 317)]       } .
  ------------------------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Chek1.irt.Hydroxyurea.229.txt

rl[293.Chek1.irt.NCS]:
  {XOut | xout  NCS                             }
  {NUc  | nuc   Atr Chek1                       }
  =>
  {XOut | xout  NCS                             }
  {NUc  | nuc   Atr [Chek1 - phos(S 317)]       } .
  ------------------------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Chek1.irt.NCS.293.txt

*** Chek2--

rl[1445.Chek2.irt.Adriamycin]:
  {XOut | xout  Adriamycin       }
  {NUc  | nuc   Chek2            }
  =>
  {XOut | xout  Adriamycin       }
  {NUc  | nuc   [Chek2 - phos]   } .
  -------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Chek2.irt.Adriamycin.1445.txt

rl[256.Chek2.irt.Bleomycin]:
  {XOut | xout  Bleomycin          }
  {NUc  | nuc   [Atm - acetyl(K 3016)]  Chek2               }
  =>
  {XOut | xout  Bleomycin          }
  {NUc  | nuc   [Atm - acetyl(K 3016)] [Chek2 - phos(T 68)] } .
  ------------------------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Chek2.irt.Bleomycin.256.txt

rl[238.Chek2.irt.Hydroxyurea]:
  {XOut | xout  Hydroxyurea          }
  {NUc  | nuc   Chek2                }
  =>
  {XOut | xout  Hydroxyurea          }
  {NUc  | nuc   [Chek2 - phos(T 68)] } .
  ------------------------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Chek2.irt.Hydroxyurea.238.txt

rl[294.Chek2.irt.NCS]:
  {XOut | xout  NCS                                                         }
  {NUc  | nuc   [Atm - act] Mre11 [Nbs1 - phos(S 343)] Chek2                }
  =>
  {XOut | xout  NCS                                                         }
  {NUc  | nuc   [Atm - act] Mre11 [Nbs1 - phos(S 343)] [Chek2 - phos(T 68)] } .
  -----------------------------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Chek2.irt.NCS.294.txt

*** H2ax--

rl[331.H2ax.irt.Bleomycin]:
  {XOut | xout  Bleomycin                }
  {CHR  | chr   DSB  H2ax                }
  =>
  {XOut | xout  Bleomycin                }
  {CHR  | chr   DSB [H2ax - phos(S 140)] } .
  -----------------------------------------------------------
  *** ~/evidence/Drug-Evidence/H2ax.irt.Bleomycin.331.txt

*** Ikba--

rl[045.Ikba.irt.Camptothecin]:
  {XOut | xout Camptothecin                    }
  {CLc  | clc  [Nemo - ubiq] Ikba              }
  =>
  {XOut | xout Camptothecin                    }
  {CLc  | clc  [Nemo - ubiq] [Ikba - degraded] } .
  -----------------------------------------------------
  *** ~/evidence/Drug-Evidence/Ikba.irt.Camptothecin.045.txt

rl[062.Ikba.irt.Etoposide]:
  {XOut | xout Etoposide                            }
  {CLc  | clc  Erc1 [Nemo - ubiq] Ikba              }
  =>
  {XOut | xout Etoposide                            }
  {CLc  | clc  Erc1 [Nemo - ubiq] [Ikba - degraded] } .
  -----------------------------------------------------
  *** ~/evidence/Drug-Evidence/Ikba.irt.Etoposide.062.txt

*** Ikks--

rl[055.Ikks.irt.Camptothecin]:
  {XOut | xout Camptothecin                                            }
  {CLc  | clc  Erc1 Tak1 (Ikk1 : Ikk2 : Nemo)                          }
  =>
  {XOut | xout Camptothecin                                            }
  {CLc  | clc  Erc1 Tak1 ([Ikk1 - act] : [Ikk2 - act] : [Nemo - ubiq]) } .
  ------------------------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Ikks.irt.Camptothecin.055.txt

rl[079.Ikks.irt.Etoposide]:
  {XOut | xout Etoposide                                               }
  {CLc  | clc  Erc1 Tak1 (Ikk1 : Ikk2 : Nemo)                          }
  =>
  {XOut | xout Etoposide                                               }
  {CLc  | clc  Erc1 Tak1 ([Ikk1 - act] : [Ikk2 - act] : [Nemo - ubiq]) } .
  ------------------------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Ikks.irt.Etoposide.079.txt


*** Mdm2--

rl[1446.Mdm2-gene.irt.Adriamycin]:
  {XOut | xout  Adriamycin            }
  {NUc  | nuc   Pin1 Mdm2-gene        }
  =>
  {XOut | xout  Adriamycin            }
  {NUc  | nuc   Pin1 [Mdm2-gene - on] } .
  --------------------------------------
  *** ~/evidence/Drug-Evidence/Mdm2-gene.irt.Adriamycin.1446.txt

rl[1474.Mdm2-gene.irt.5Fluorouracil]:
  {XOut | xout  5Fluorouracil   }
  {NUc  | nuc   Mdm2-gene       }
  =>
  {XOut | xout  5Fluorouracil   }
  {NUc  | nuc  [Mdm2-gene - on] } .
  -------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Mdm2-gene.irt.5Fluorouracil.1474.txt

*** Mdm4--

rl[202.Mdm4.phos.irt.NCS]:
  {XOut | xout  NCS                              }
  {NUc  | nuc   [Atm - act] Mdm4                 }
  =>
  {XOut | xout  NCS                              }
  {NUc  | nuc   [Atm - act] [Mdm4 - phos(S 403)] } .
  --------------------------------------------------
  *** ~/evidence/Drug-Evidence/Mdm4.phos.irt.NCS.202.txt

rl[208.Mdm4.ubiq.irt.NCS]:
  {XOut | xout  NCS                    }
  {NUc  | nuc   [Mdm4 - phos(S 403)]   }
  =>
  {XOut | xout  NCS                    }
  {NUc  | nuc   [Mdm4 - ubiq]          } .
  --------------------------------------------------
  *** ~/evidence/Drug-Evidence/Mdm4.ubiq.irt.NCS.202.txt

rl[211.Mdm4.degraded.irt.NCS]:
  {XOut | xout  NCS                    }
  {NUc  | nuc   [Mdm4 - ubiq]          }
  =>
  {XOut | xout  NCS                    }
  {NUc  | nuc   [Mdm4 - degraded]      } .
  --------------------------------------------------
  *** ~/evidence/Drug-Evidence/Mdm4.degraded.irt.NCS.211.txt

*** Nemo--

rl[043.Nemo.irt.Adriamycin]:
  {XOut | xout Adriamycin          }
  {CLc  | clc  Nemo                }
  =>
  {XOut | xout Adriamycin          }
  {CLc  | clc  [Nemo - phos(S 85)] } .
  ------------------------------------------
  *** ~/evidence/Drug-Evidence/Nemo.irt.Adriamycin.043.txt

rl[071.Nemo.sumo.irt.Etoposide]:
  {XOut | xout Etoposide            }
  {CLc  | clc  Nemo                 }
  {NUc  | nuc                       } 
  =>
  {XOut | xout Etoposide            }
  {CLc  | clc                       }
  {NUc  | nuc  [Nemo - sumo]        } .
  ------------------------------------------
  *** ~/evidence/Drug-Evidence/Nemo.sumo.irt.Etoposide.071.txt

rl[070.Nemo.phos.irt.Etoposide]:
  {XOut | xout  Etoposide                       }
  {NUc  | nuc   [Atm - act] [Nemo - sumo]       }
  =>
  {XOut | xout  Etoposide                       }
  {NUc  | nuc   [Atm - act] [Nemo - phos(S 85)] } .
  -------------------------------------------------
  *** ~/evidence/Drug-Evidence/Nemo.phos.irt.Etoposide.070.txt

rl[074.Nemo.ubiq.irt.Etoposide]:
  {XOut | xout  Etoposide                       }
  {NUc  | nuc   [Atm - act] [Nemo - phos(S 85)] }
  => 
  {XOut | xout  Etoposide                       }
  {NUc  | nuc   [Atm - act] [Nemo - ubiq]       } .
  -------------------------------------------------
  *** ~/evidence/Drug-Evidence/Nemo.ubiq.irt.Etoposide.074.txt

rl[078.Nemo.to.cyto.irt.Etoposide]:
  {XOut | xout  Etoposide            }
  {CLc  | clc                        }
  {NUc  | nuc   [Nemo - ubiq]        }
  => 
  {XOut | xout  Etoposide            }
  {CLc  | clc   [Nemo - ubiq]        }
  {NUc  | nuc                        } .
  -------------------------------------------------
  *** ~/evidence/Drug-Evidence/Nemo.to.cyto.irt.Etoposide.078.txt

*** Prkdc--

rl[247.Prkdc.irt.Bleomycin]:
  {XOut | xout  Bleomycin                                 }
  {NUc  | nuc   Tip60 Prkdc                               }
  =>
  {XOut | xout  Bleomycin                                 }
  {NUc  | nuc   Tip60 [Prkdc - phos(S 2056) phos(T 2609)] } .
  -----------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Prkdc.irt.Bleomycin.247.txt

rl[338.Tip60.irt.Bleomycin]:
  {XOut | xout  Bleomycin     }
  {NUc  | nuc   Tip60         }
  =>
  {XOut | xout  Bleomycin     }
  {NUc  | nuc   [Tip60 - act] } .
  -----------------------------------
  *** ~/evidence/Drug-Evidence/Tip60.irt.Bleomycin.338.txt

*** Tp53--

rl[1444.Tp53.irt.Adriamycin]:
  {XOut | xout  Adriamycin   }
  {NUc  | nuc   Tp53         }
  =>
  {XOut | xout  Adriamycin          }
  {NUc  | nuc   [Tp53 - phos(S 15)] } .
  -----------------------------------
  *** ~/evidence/Drug-Evidence/Tp53.irt.Adriamycin.1444.txt

rl[259.Tp53.irt.Bleomycin]:
  {XOut | xout  Bleomycin                                  }
  {NUc  | nuc   [Atm - acetyl(K 3016)]  Tp53               }
  =>
  {XOut | xout  Bleomycin                                  }
  {NUc  | nuc   [Atm - acetyl(K 3016)] [Tp53 - phos(S 15)] } .
  ------------------------------------------------------------
  *** ~/evidence/Drug-Evidence/Tp53.irt.Bleomycin.259.txt

rl[212.Tp53.irt.NCS]:
  {XOut | xout  NCS                             }
  {NUc  | nuc   [Atm - act]  Tp53               }
  =>
  {XOut | xout  NCS                             }
  {NUc  | nuc   [Atm - act] [Tp53 - phos(S 15)] } .
  -------------------------------------------------
  *** ~/evidence/Drug-Evidence/Tp53.irt.NCS.212.txt


*** Tp53aip1--

rl[1447.Tp53aip1-gene.irt.Adriamycin]:
  {XOut | xout  Adriamycin                }
  {NUc  | nuc   Tp53  Tp53aip1-gene       }
  =>
  {XOut | xout  Adriamycin                }
  {NUc  | nuc   Tp53 [Tp53aip1-gene - on] } .
  --------------------------------------------------
  *** ~/evidence/Drug-Evidence/Tp53aip1-gene.irt.Adriamycin.1447.txt

*** TrailR2--

rl[1448.TrailR2-gene.irt.Adriamycin]:
  {XOut | xout  Adriamycin              }
  {NUc  | nuc  Pin1  TrailR2-gene       }
  =>
  {XOut | xout  Adriamycin              }
  {NUc  | nuc  Pin1 [TrailR2-gene - on] } .
  --------------------------------------------------
  *** ~/evidence/Drug-Evidence/TrailR2-gene.irt.Adriamycin.1448.txt


