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Rac1 GTP binding
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reqs ArhGef4--

  *** xRac1(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431 in BMLS
    *** partially reqs: ArhGef4 [RNAi]
    *** source: 18653540-Fig-2f
  *** xRac1(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431 in BMLS
    *** partially reqs: ArhGef4 [RNAi]
    *** source: 18653540-Fig-8b
  *** xRac1(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431<ArhGef4~null><xArhGef4> in BMLS
    *** inhibited by: xArhGef4(Y94F) [substitution]
    *** source: 18653540-Fig-8b
  *** xRac1(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: HELA in BMLS
    *** partially reqs: ArhGef4 [RNAi]
    *** source: 18653540-Fig-S4
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (2 min)
    *** cells: A431 in BMLS
    *** partially reqs: ArhGef4 [RNAi]
    *** source: 18653540-Fig-2g

reqs Nckipsd-- 

  *** xRac1[tAb] GTP-association[BDPD] is increased irt Egf (7 min)
    *** cells: HEK293T<xRac1> in BMS "membrane-fractions"
    *** reqs: Nckipsd [RNAi]
    *** source: 14765113-Fig-3d

reqs Ptk6-- kinase activity

  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (15 min)
    *** cells: COS1 in BMLS
    *** inhibited by: xPtk6(L219M)"KD" [addition]
    *** source: 15572663-Fig-5f
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (15 min)
    *** cells: COS1 in BMLS
    *** inhibited by: xPtk6(L219M)"KD" [addition]
    *** source: 15572663-Fig-4a,4b

reqs Pxn--  tyrosine phosphorylation sites

  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (15 min)
    *** cells: COS1 in BMLS
    *** inhibited by: xPxn(Y31F/Y118F)"DN" [addition]
    *** source: 15572663-Fig-5f

reqs Vav2--

  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (5 min)
    *** cells: COS7<xVav2> in BMS
    *** partially inhibited by: xVav2(R425C) [substitution]
    *** source: 12454019-Fig-6
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (5 min)
    *** cells: COS7<xVav2> in BMS
    *** reqs: xVav2 [omission]
    *** source: 12454019-Fig-4
  *** xRac1(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431 in BMLS
    *** partially reqs: Vav2 [RNAi]
    *** source: 18653540-Fig-1c
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (2 min)
    *** cells: A431 in BMLS
    *** partially reqs: Vav2 [RNAi]
    *** source: 18653540-Fig-1d
  *** xRac1[tAb] GTP-association[BDPD] is increased irt Egf (7 min)
    *** cells: HEK293T<xRac1><xNckipsd> in BMS "membrane-fractions"
    *** inhibited by: xVav2(R425G) [addition]
    *** source: 14765113-Fig-3c

reqs Tiam1--

  *** xRac1(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431 in BMLS
    *** partially reqs: Tiam1 [RNAi]
    *** source: 18653540-Fig-1c
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (2 min)
    *** cells: A431 in BMLS
    *** partially reqs: Tiam1 [RNAi]
    *** source: 18653540-Fig-1d

does not req Sos1--

  *** xRac1(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431 in BMLS
    *** does not req: Sos1 or Sos2 [RNAi]
    *** source: 18653540-Fig-2f
  *** xRac1(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431 in BMLS
    *** does not req: Sos1 or Sos2 [RNAi]
    *** source: 18653540-Fig-1c

Chemicals

  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (tnr)
    *** cells: COS7 in BMLS
    *** unaffected by: CytochalasinD [addition]
    *** unaffected by: LatrunculinB [addition]
    *** source: 15034142-Fig-S3a
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (tnr)
    *** cells: COS7 in BMLS
    *** partially inhibited by: STI571 [addition] no-bkg-control
    *** source: 15039778-Fig-4e
  *** xRac1[tAb] GTP-association[BDPD] is increased irt Egf (3 min)
    *** cells: COS7 in BMS
    *** inhibited by: Wortmannin [addition]
    *** source: 12515821-Fig-4c
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (5 min)
    *** cells: COS7<xVav2> in BMS
    *** inhibited by: LY294002 [addition]
    *** source: 12454019-Fig-5a
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (1 min)
    *** cells: rVSMCs in BMLS
    *** inhibited by: AG1478 [addition]
    *** bkg inhibited by: Genistein [addition]
    *** source: 17350025-Fig-3a
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (1 min)
    *** cells: rVSMCs in BMLS
    *** unaffected by: AG1296 [addition]
    *** partially inhibited by: PP1 [addition]
    *** source: 17350025-Fig-4a

No extras

  *** xRac1[tAb] GTP-association[BDPD] is increased irt Egf (3 min)
    *** cells: COS7 in BMS
    *** source: 12515821-Fig-4a
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (1 min)
    *** cells: NIH3T3<xEgfR><xAbi1> in BMLS
    *** source: 16182283-Fig-3a
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (1 min)
    *** cells: NIH3T3<xEgfR> in BMLS
    *** source: 16182283-Fig-3b
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (3 min)
    *** cells: COS1 in BMLS
    *** source: 14699061-Fig-7d
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: COS1 in BMLS
    *** times: 0 1++ 3++ 5++ 15+ min
    *** source: 14699061-Fig-3a
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: rVSMCs in BMLS
    *** times: 0 1++ 5+ 15+ 30 60 min
    *** source: 17350025-Fig-1a
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: HEK293T<xNckipsd> in BMS "membrane-fractions"
    *** times: 0+ 2++ 5++ 20+++ 20+ min
    *** source: 14765113-Fig-3b
  *** xRac1[tAb] GTP-association[BDPD] is increased irt Egf (7 min)
    *** cells: HEK293T<xRac1> in BMS "membrane-fractions"
    *** source: 14765113-Fig-3c
  *** xRac1[tAb] GTP-association[BDPD] is increased irt Egf (7 min)
    *** cells: HEK293T<xRac1><xNckipsd> in BMS "membrane-fractions"
    *** source: 14765113-Fig-3c

