============
dimerization
============

Azi2--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: HELA in BMS
    *** times: 0 20+ min
    *** reqs: Azi2 [RNAi]
    *** source: 15611223-Fig-4c

Hmgb1-- and/or Hmgb2-- and/or Hmgb3--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC-transfection (times)
    *** cells: mEFs in BMS
    *** times: 0 2 4+ hr
    *** partially reqs: Hmgb1 and/or Hmgb2 and/or Hmgb3 [KO]
    *** source: 19890330-Fig-2a

not Ikke--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4++ hr
    *** does not req: Ikke [KO]
    *** source: 15210742-Fig-4b

inhibited by Pin1--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (3 hr)
    *** cells: HEK293<xTLR3> in BMS
    *** inhibited by: xPin1 [addition]
    *** unaffected by: xPin1(W34A)"WW-domain-mutant" [addition]
    *** unaffected by: xPin1(K63A)"peptidyl-prolyl-isomerase-domain-mutant" [addition]
    *** source: 16699525-Fig-1e
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: HEK293<xTLR3> in BMS
    *** times: 0 3++ 9+ hr
    *** inhibited by: xPin1 [addition]
    *** comment: inhibition by xPin1 is inhibited by MG132
    *** source: 16699525-Fig-3d
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: U373<xCd14> in BMS
    *** times: 0 1+++ 3++ 9+ hr
    *** repressed by: Pin1 [RNAi]
    *** source: 16699525-Fig-3e

not Rig1--

  *** xIrf3[tAb] oligomerization[NativeWB] is increased irt PolyIC (1 hr)
    *** cells: L929 in BMS
    *** unaffected by: xRig1(del(Nterm))"DN" [addition]
    *** source: 15208624-Fig-6a

inhibited by Tnfaip3--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC
    *** cells: HEK293<xTLR3> in BMS
    *** inhibited by: xTnfaip3 [addition]
    *** source: 15661910-Fig-2c

Trif--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: mLFs in BMS
    *** times: 0 30 60++ 120+ min
    *** reqs: Trif [KO]
    *** source: 12855817-Fig-3a
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: mPECs in BMS
    *** times: 0 20 40+ 60++ min
    *** reqs: Trif [KO]
    *** source: 12872135-Fig-2g

not Ticam2--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: mLFs in BMS
    *** times: 0 1 2+ hr
    *** does not req: Ticam2 [KO]
    *** source: 14556004(D)

Tbk1--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: mEFs in BMS "immortalized"
    *** times: 0 2+ 4++ hr
    *** reqs: Tbk1 and/or Ikke [DKO]
    *** source: 15210742-Fig-6b
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4++ hr
    *** does not req: Ikke [KO]
    *** reqs: Tbk1 [KO]
    *** source: 15210742-Fig-4b

chemicals

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (1 hr)
    *** cells: U373<xCd14> in BMS
    *** inhibited by: Staurosporine [addition]
    *** inhibited by: TPCK [addition]
    *** unaffected by: TLCK [addition]
    *** unaffected by: PD98059 [addition]
    *** unaffected by: SB202190 [addition]
    *** unaffected by: Hypericin [addition]
    *** unaffected by: Calphostin [addition]
    *** inhibited by: Tilorone [addition]
    *** inhibited by: Tilorone-874 [addition]
    *** inhibited by: Acridine-Orange [addition]
    *** inhibited by: Geldanamycin [addition]
    *** source: 12062447-Fig-3a,3b
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (times)
    *** cells: HEK293<xTLR3> in BMS
    *** times: 0 3++ 9+ hr
    *** unaffected by: MG132 [addition]
    *** source: 16699525-Fig-3d

no extras

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (1 hr)
    *** cells: U373 in BMS
    *** source: 12062447-Fig-1a
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (tnr)
    *** cells: HELA in BMS
    *** source: 12539043-Fig-5b
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt PolyIC (tnr)
    *** cells: mEFs in BMS
    *** source: 15208624-Fig-S5
