========================
Phosphorylation by P38a
========================

  *** rElk1(307-428) phos[32P-ATP] is increased by rP38a{act}
    *** cells: none
    *** source: 9155018-Fig-8a
  *** rElk1[32P] phos[32P-ATP] is increased by xP38a{act}[tAb]IP
    *** cells: none
    *** IPfrom: COS1 in BMS "treated with UV for tnr"
    *** source: 8622669-Fig-4e
  *** rElk1(310-428)[32P] phos[32P-ATP] is increased by xP38a[Ab]IP
    *** cells: none
    *** IPfrom: COS7<xP38a> in BMS "treated with UV"
    *** source: 9111305-Fig-1a
  *** rElk1[32P] phos[32P-ATP] is increased by xP38a[Ab]IP
    *** cells: none
    *** IPfrom: COS7<xP38a> in BMS "treated with UV"
    *** source: 9111305-Fig-1a
  *** rElk1(205-428)[32P] phos[32P-ATP] is increased by xP38a[tAb]IP
    *** cells: none
    *** IPfrom: COS1<xP38a> in BMS "treated with UV for 30 min"
    *** partially inhibited by: rElk1(205-428/R314A/K316A)"M1" [substitution]
    *** partially inhibited by: rElk1(205-428/R317A/K319A)"M2" [substitution]
    *** inhibited by: rElk1(205-428/L323A/S324A)"M3" [substitution]
    *** unaffected by: rElk1(205-428/L323A/S324A)"M3" [substitution]
    *** unaffected by: rElk1(205-428/L319A/L321A)"M5" [substitution]
    *** source: 9501095-Fig-3b
  *** rElk1[32P] phos[32P-ATP] is increased by xP38a[tAb]IP
    *** cells: none
    *** IPfrom: COS1<xP38a> in BMS "treated with UV for 30 min"
    *** unaffected by: rElk1(del(310-334)) [substitution]
    *** source: 9501095-Fig-2b

=======================
Phosphorylation by P38b
=======================

  *** rElk1(205-428)[32P] phos[32P-ATP] is increased by rP38b{act}
    *** cells: none
    *** source: 16713578-Fig-3d
  *** rElk1(205-428)[32P] phos[32P-ATP] is increased by xP38b[tAb]IP
    *** cells: none
    *** IPfrom: COS1<xP38b> in BMS "treated with UV for 30 min"
    *** partially inhibited by: rElk1(205-428/R314A/K316A)"M1" [substitution]
    *** partially inhibited by: rElk1(205-428/R317A/K319A)"M2" [substitution]
    *** inhibited by: rElk1(205-428/L323A/S324A)"M3" [substitution]
    *** unaffected by: rElk1(205-428/L323A/S324A)"M3" [substitution]
    *** unaffected by: rElk1(205-428/L319A/L321A)"M5" [substitution]
    *** source: 9501095-Fig-3b
  *** rElk1[32P] phos[32P-ATP] is increased by xP38b[tAb]IP
    *** cells: none
    *** IPfrom: COS1<xP38b> in BMS "treated with UV for 30 min"
    *** unaffected by: rElk1(del(310-334)) [substitution]
    *** source: 9501095-Fig-2b

=======================
Phosphorylation by P38g
=======================

  *** rElk1(205-428)[32P] phos[32P-ATP] is increased by xP38g[tAb]IP
    *** cells: none
    *** IPfrom: COS1<xP38g> in BMS "treated with UV for 30 min"
    *** source: 9501095-Fig-1b
  *** rElk1(205-428)[32P] phos[32P-ATP] is increased by xP38g[tAb]IP
    *** cells: none
    *** IPfrom: COS1<xP38g> in BMS "treated with UV for 30 min"
    *** unaffected by: rElk1(205-428/R314A/K316A)"M1" [substitution]
    *** unaffected by: rElk1(205-428/R317A/K319A)"M2" [substitution]
    *** unaffected by: rElk1(205-428/L323A/S324A)"M3" [substitution]
    *** unaffected by: rElk1(205-428/L323A/S324A)"M3" [substitution]
    *** unaffected by: rElk1(205-428/L319A/L321A)"M5" [substitution]
    *** source: 9501095-Fig-3b
  *** rElk1[32P] phos[32P-ATP] is increased by xP38g[tAb]IP
    *** cells: none
    *** IPfrom: COS1<xP38g> in BMS "treated with UV for 30 min"
    *** unaffected by: rElk1(del(310-334)) [substitution]
    *** source: 9501095-Fig-2b


=================================
Activation by P38a and Mkk3/Mkk6
=================================

  *** xElk1[Gal4-DBD] Gal4-reporter[Luc] is increased itpo (xMkk3(S189E/T193E) + xP38a)
    *** cells: CHO in BMS
    *** source: 8622669-Fig-4d
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is unchanged itpo xP38a
    *** cells: CHO in BMS
    *** source: 9430721-Fig-8a
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased itpo xP38a
    *** cells: CHO in BMS
    *** enhanced by: xMkk3(S189E/T193E)"CA" [addition]
    *** enhanced by: xMkk6(S207E/T211E)"CA" [addition]
    *** source: 8663524-Fig-9
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased itpo (xP38a + xMkk3(S218E/T222E)"CA")
    *** cells: CHO in BMS
    *** reqs: both [omissions]
    *** source: 9430721-Fig-8a
  *** xElk1[Gal4-DBD] Gal4-reporter[Luc] is increased itpo (xMkk3(mnr)"CA" + xP38a)
    *** cells: CHO in BMLS
    *** inhibited by: SB203580 [addition]
    *** source: 9111305-Fig-4
  *** xElk1[Gal4-DBD] Gal4-reporter[Luc] is increased itpo (xMkk3(mnr)"CA" + xP38a)
    *** cells: CHO in BMLS
    *** inhibited by: xElk1(S383A)[Gal4-DBD] [substitution]
    *** source: 9111305-Fig-4

===========================
Activation by P38b and Mkk3
===========================

  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased itpo xP38b
    *** cells: CHO in BMS
    *** enhanced by: xMkk3(S189E/T193E)"CA" [addition]
    *** unaffected by: xMkk6(S207E/T211E)"CA" [addition]
    *** source: 8663524-Fig-9
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is unchanged itpo (xP38b + xMkk3(S218E/T222E)"CA")
    *** cells: CHO in BMS
    *** source: 9430721-Fig-8a
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is unchanged itpo xP38b
    *** cells: CHO in BMS
    *** source: 9430721-Fig-8b

===========================
Activation by P38g and Mkk3
===========================

  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased itpo (xP38g + xMkk3(S218E/T222E)"CA")
    *** cells: CHO in BMS
    *** reqs: both [omissions]
    *** source: 9430721-Fig-8c
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is unchanged itpo xP38g
    *** cells: CHO in BMS
    *** source: 9430721-Fig-8c

====================
Activation itpo Mkk6
====================

  *** xElk1(205-428)[Gal4-DBD] Gal4-reporter[Luc] is increased itpo xMkk6(mnr)"CA"
    *** cells: HEK293 in BMS
    *** enhanced by: xPias2a [addition]
    *** source: 16713578-Fig-5a



