=================
Required Proteins
=================

Mlk3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (24 hr)
    *** cells: FAO in BMS
    *** enhanced by: xMlk3 [addition]
    *** partially inhibited by: xMlk3(mnr)"DN" [addition]
    *** source: 15069087-Fig-7b

Smad7--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 30++ 120+++ 360+++ 720++ min
    *** reqs: Smad7 [RNAi]
    *** source: 15684397-Fig-4a

Tak1--  K63ubiq

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HEK293T<xTak1><xUbiq> in BMS
    *** times: 0+ 2+ 5++ 15 min
    *** inhibited by: xTak1(K34R) [substitution]
    *** source: 18758450-Fig-5f
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HEK293T<xTak1><xUbiq> in BMS
    *** times: 0+ 2++ 5++ 15 min
    *** inhibited by: xUbiq(K63R) [substitution]
    *** unaffected by: xUbiq(K48R) [substitution]
    *** source: 18758450-Fig-1b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HEK293T<xTak1><xUbiq> in BMS
    *** times: 0+ 2++ 5++ 15 min
    *** source: 18758450-Fig-1a

Traf6--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (5 min)
    *** cells: HEK293T<xTraf6><xTgfbR1(mnr)"CA"> in BMS
    *** inhibited by: xTgfbR1(mnr/E161A)"CA/Traf6-binding-mut" [substitution]
    *** source: 18758450-Fig-3d
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (5 min)
    *** cells: mEFs<xTraf6> in BMS
    *** inhibited by: xTraf6(C70A) [substitution]
    *** source: 18758450-Fig-5b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HEK293T<xTak1><xUbiq> in BMS
    *** times: 0 2+++ 5++ 15+ min
    *** inhibited by: xTraf6(mnr)"DN" [substitution]
    *** source: 18758450-Fig-4b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0 5 15 30+ 60++ min
    *** reqs: Traf6 [RNAi]
    *** source: 18758450-Fig-5d
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0 15 30+ 60+ 120++ min
    *** inhibited by: xTgfbR1(mnr/E161A)"CA-Traf6-binding-mut" [addition]
    *** source: 18758450-Fig-S4f

===========
other stuff
===========

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (1 hr)
    *** cells: NIH3T3 in BMS
    *** unaffected by: xPpm1a [addition]
    *** source: 16751101-Fig-S8b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5+ 10++ 15+ 30+ min
    *** inhibited by: xTak1(K158R) [substitution]
    *** partially inhibited by: xTak1(K34R) [substitution]
    *** source: 20837137-Fig-4a

chemicals

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HEK293T in BMS
    *** times: 0 2+ 5+ 15+ min
    *** unaffected by: SB431542 [pretreatment]
    *** source: 18758450-Fig-S3a

no extras

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: FAO in BMS
    *** times: 0 1 4 8+ 12+ 16++ 20++ 24++ hr
    *** source: 15069087-Fig-7a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HEK293 in BMS
    *** times: 0 15+ 30+ 60+ min
    *** source: 10085140-Fig-5a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: RGM1 in BMLS
    *** times: 0+ 5+ 15+ 30++ 60++ 120+++ min
    *** source: 15326485-Fig-2b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb2 (times)
    *** cells: ATDC5 in BMLS
    *** times: 0 15+ 30++ 60+++ 120++ 240 min
    *** source: 11278290-Fig-3b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HEK293T in BMS
    *** times: 0 15+ 30+ 60+ min
    *** source: 18758450-Fig-2a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 2++ 5++ 15++ min
    *** source: 18758450-Fig-5a


