  *** Ikk2[phosAb] phos(S177/S181)[phosAb] is increased itpo xTab1
    *** cells: HEK293T<xTak1> in BMS
    *** enhanced by: xTiprl [addition]
    *** comment: addition of Tiprl causes a large upshift in Ikk2
    *** source: 18456659-Fig-1a
  *** Ikk2[phosAb] phos(S177/S181)[phosAb] is increased itpo xTab1
    *** cells: HEK293T<xTak1> in BMS
    *** unaffected by: xIgbp1 [addition]
    *** source: 18456659-Fig-1a
  *** xIkk2[tAb]IP phos(sitenr)[phosAb] is increased itpo xTak1
    *** cells: mEFs<Tak1~null><xIkk2><xTab1> in BMS
    *** partially inhibited by: xTak1(T178A) [substitution]
    *** partially inhibited by: xTak1(T184A) [substitution]
    *** inhibited by: xTak1(T178A/T184A) [substitution]
    *** source: 18617512-Fig-3a

  *** rIkk2(K44M)[32P] phos[32P-ATP] is increased by Tak1{ubiq}[Ab]IP
    *** cells: none
    *** IPfrom: HELA in BMS
    *** comment: Tak1 IP was ubiquitinated with (rTraf6 + rUbiq + pUbe1 + rUbc13 + rUev1a)
    *** inhibited by: rIkk2(K44M/S177A/S181A) [substitution]
    *** source: 11460167-Fig-1d

===================================================
requires Ubiquitination of something in the Tak1 IP
===================================================

  *** rIkk2(K44M)[32P] phos[32P-ATP] is increased by Tak1{ubiq}[Ab]IP
    *** cells: none
    *** IPfrom: HELA in BMS
    *** comment: Tak1 IP was ubiquitinated with (rTraf6 + rUbiq + pUbe1 + rUbc13 + rUev1a)
    *** reqs: rUbc13 and/or rUev1a [omission]
    *** source: 11460167-Fig-1d

