phos(S1798)

  *** xTsc2[tAb]IP phos(RXRXXS-T)[phosAb] is increased irt PMA (15 min)
    *** cells: HEK293<xTsc1><xTsc2> in BMS
    *** unaffected by: xTsc2(S981A) [substitution]
    *** unaffected by: xTsc2(S1420A) [substitution]
    *** inhibited by: xTsc2(S1798A) [substitution]
    *** partially inhibited by: xTsc2(S939A/T1462A) [substitution]
    *** bkg inhibited by: xTsc2(S939A/T1462A/S1798A) [substitution]
    *** source: 15342917-Fig-5a
  *** xTsc2[tAb]IP phos(RXRXXS-T)[phosAb] is increased irt PMA (15 min)
    *** cells: HEK293<xTsc1><xTsc2> in BMS
    *** comment: xTsc2 was shown by MS to be phosed on S939, S981, S1420, S1789
    *** source: 15342917-Fig-4a

Chemicals

  *** Tsc2[Ab]IP phos(RXRXXS-T)[phosAb] is increased irt PMA (15 min)
    *** cells: HEK293 in BMS
    *** inhibited by: U0126 [pretreatment]
    *** inhibited by: Bisindolylmaleimide-I [pretreatment]
    *** unaffected by: Wortmannin [pretreatment]
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 15342917-Fig-1b
  *** xTsc2[tAb] copptby[WB] xTsc1[tAb] is decreased irt PMA (40 min)
    *** cells: HEK293<xTsc1><xTsc2> in BMS
    *** reversed by: U0126 [pretreatment]
    *** source: 15851026-Fig-4b
  *** xTsc2[tAb]IP phos(RXRXXS-T)[phosAb] is increased irt PMA (15 min)
    *** cells: HEK293<xTsc1><xTsc2> in BMS
    *** inhibited by: U0126 [pretreatment]
    *** source: 15342917-Fig-1b
  *** xTsc2[tAb]IP phos(RXRXXS-T)[phosAb] is increased irt PMA (15 min)
    *** cells: HEK293<xTsc1><xTsc2> in BMS
    *** inhibited by: U0126 [pretreatment]
    *** source: 15342917-Fig-2c
  *** xTsc2[tAb]IP phos(RXRXXS-T)[phosAb] is increased irt PMA (15 min)
    *** cells: HEK293<xTsc1><xTsc2><xS6k1> in BMLS
    *** unaffected by: Wortmannin [pretreatment]
    *** unaffected by: Rapamycin [pretreatment]
    *** inhibited by: U0126 [pretreatment]
    *** source: 15342917-Fig-1a
  *** xTsc2[tAb]IP STphos[pSTAb] is increased irt PMA (40 min)
    *** cells: HEK293<xTsc2> in BMLS
    *** inhibited by: U0126 [pretreatment] no-bkg-control
    *** source: 15851026-Fig-1a

