mod HGFRULES is inc ALLOPS .

var xout : Soup .
vars clo clm clr cli clc nuo num nui nuc : Soup .
vars sig : Soup .
var hgfrc pxnc : Soup .
*** var AnyLoc : LocName .
*** var anyloc : Soup .

*** ~/evidence/Hgf-Evidence/00HgfEvidence.txt

rl[1282.HgfR.irt.Hgf]:
  {XOut  | xout  Hgf                    }
  {HgfRC | hgfrc HgfR                   }
  =>
  {XOut  | xout                         }
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/HgfR.irt.Hgf.1282.txt

*** from common rules

rl[1306c.Bcar1.Crk.complex]:
  {CLc  | clc  [Bcar1 - Yphos]   Crk  }
  =>
  {CLc  | clc ([Bcar1 - Yphos] : Crk) } .
  ----------------------------------------
  *** ~/evidence/Common-Rule-Evidence/Bcar1.Crk.complex.1306c.txt

*** Akt1--

rl[1283.Akt1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc     Pi3k Akt1            }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc     Pi3k [Akt1 - act]    } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Akt1.irt.Hgf.1283.txt

*** Bad--

rl[1305.Bad.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)                     }
  {CLc   | clc   [Akt1 - act]  Bad                          }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)                     }
  {CLc   | clc   [Akt1 - act] [Bad - phos(S 75) phos(S 99)] } .
  -------------------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Bad.irt.Hgf.1305.txt

*** Bcar1-- Crk--

rl[1307.Bcar1.Crk.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)  }
  {CLc   | clc   ([Bcar1 - Yphos] : Crk) }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)  }
  {CLc   | clc     Bcar1 Crk             } .
  ------------------------------------------
  *** ~/evidence/Hgf-Evidence/Bcar1.Crk.irt.Hgf.1307.txt

*** Cbl--

rl[1320.Cbl.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)               }
  {CLc   | clc    Cbl                                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) [Cbl - Yphos] }
  {CLc   | clc                                        } .
  ------------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Cbl.irt.Hgf.1320.txt

*** Cdc42--

rl[1311.Cdc42.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Cdc42 - GDP]         }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Cdc42 - GTP]         } .
  --------------------------------------------
  *** ~/evidence/Hgf-Evidence/Cdc42.irt.Hgf.1311.txt

*** Creb1--

rl[1284.Creb1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     Creb1                }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [Creb1 - act]         } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Creb1.irt.Hgf.1284.txt

*** Crk--

rl[1314.Crk.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)               }
  {CLc   | clc    Crk                                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) [Crk - Yphos] }
  {CLc   | clc                                        } .
  ------------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Crk.irt.Hgf.1314.txt

*** CrkL--

rl[1309.CrkL.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)                }
  {CLc   | clc    CrkL                                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) [CrkL - Yphos] }
  {CLc   | clc                                         } .
  --------------------------------------------------------
  *** ~/evidence/Hgf-Evidence/CrkL.irt.Hgf.1309.txt

*** Ctnnb1--

rl[1330.Ctnnb1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) Ctnnb1 }
  {NUc   | nuc                                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)        }
  {NUc   | nuc    [Ctnnb1 - Yphos]             } .
  ------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Ctnnb1.irt.Hgf.1330.txt

*** Eif4ebp1--

rl[1332.Eif4ebp1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)   }
  {CLc   | clc     Eif4ebp1               }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)   }
  {CLc   | clc    [Eif4ebp1 - phos(S 65)] } .
  -------------------------------------------
  *** ~/evidence/Hgf-Evidence/Eif4ebp1.irt.Hgf.1332.txt

*** Elk1--

rl[1313.Elk1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     Elk1                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [Elk1 - act]          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Elk1.irt.Hgf.1313.txt

*** Erks--

rl[1285.Erks.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)      }
  {CLc   | clc     Erks                      }
  {PxnC  | pxnc   [Pxn - Yphos]              }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)      }
  {CLc   | clc                               }
  {PxnC  | pxnc   [Pxn - Yphos] [Erks - act] } .
  ---------------------------------------------
  *** ~/evidence/Hgf-Evidence/Erks.irt.Hgf.1285.txt

*** Ets--

rl[1321.Ets1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     Ets1                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [Ets1 - act]          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Ets1.irt.Hgf.1321.txt

*** Fak1--

rl[1295.Fak1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)          }
  {CLc   | clc     Fak1                          }
  {PxnC  | pxnc   [Pxn - Yphos  phos(S 83)]      }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)          }
  {CLc   | clc                                   }
  {PxnC  | pxnc   [Pxn - Yphos  phos(S 83)] Fak1 } .
  --------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Fak1.irt.Hgf.1295.txt

*** Fak2--

rl[1331.Fak2.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)  }
  {CLc   | clc     Fak2                  }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)  }
  {CLc   | clc    [Fak2 - phos(Y 402)]   } .
  --------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Fak2.irt.Hgf.1331.txt

*** Fos--

rl[1315.Fos-gene.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     Fos-gene             }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [Fos-gene - on]       } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Fos-gene.irt.Hgf.1315.txt

*** Foxo1--

rl[1318.Foxo1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     Foxo1                }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [Foxo1 - phos(S 256)] } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Foxo1.irt.Hgf.1318.txt

*** Gab1--

rl[1308.Gab1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)                 }
  {PxnC  | pxnc   [Src - act]                           }
  {CLc   | clc    Gab1                                  }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)  [Gab1 - Yphos] }
  {PxnC  | pxnc   [Src - act]                           }
  {CLc   | clc                                          } .
  ---------------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Gab1.irt.Hgf.1308.txt

*** Gab2--

rl[1325.Gab2.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)                 }
  {CLc   | clc    Gab2                                  }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)  [Gab2 - Yphos] }
  {CLc   | clc                                          } .
  ---------------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Gab2.irt.Hgf.1325.txt

*** Grb2--

rl[1326.Grb2.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)       }
  {CLc   | clc    Grb2                        }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)  Grb2 }
  {CLc   | clc                                } .
  -----------------------------------------------
  *** ~/evidence/Hgf-Evidence/Grb2.irt.Hgf.1326.txt

*** Gsk3s--

rl[1329.Gsk3s.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)            }
  {CLc   | clc   [Akt1 - act]  [Gsk3s - act]       }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)            }
  {CLc   | clc   [Akt1 - act] [Gsk3s - phos(SFAE)] } .
  -----------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Gsk3s.irt.Hgf.1329.txt

*** Hras--

rl[1286.Hras.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Hras - GDP]          }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Hras - GTP]          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Hras.irt.Hgf.1286.txt

*** IL6--

rl[1333.IL6-gene.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     IL6-gene             }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [IL6-gene - on]       } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/IL6-gene.irt.Hgf.1333.txt

*** Jnks--

rl[1287.Jnks.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)              }
  {CLc   | clc   (Crk : [Gab1 - Yphos])  Jnks        }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)              }
  {CLc   | clc   (Crk : [Gab1 - Yphos]) [Jnks - act] } .
  ------------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Jnks.irt.Hgf.1287.txt

*** Lkb1--

rl[1288.Lkb1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc     Lkb1                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc    [Lkb1 - phos(S 428)]  } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Lkb1.irt.Hgf.1288.txt

*** Mmp1--

rl[1327.Mmp1-gene.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     Mmp1-gene            }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [Mmp1-gene - on]      } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Mmp1-gene.irt.Hgf.1327.txt

*** Mmp9--

rl[1328.Mmp9-gene.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     Mmp9-gene            }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [Mmp9-gene - on]      } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Mmp9-gene.irt.Hgf.1328.txt

*** Mras--

rl[1289.Mras.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Mras - GDP]          }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Mras - GTP]          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Mras.irt.Hgf.1289.txt

*** Myc--

rl[1316.Myc-gene.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     Myc-gene             }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [Myc-gene - on]       } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Myc-gene.irt.Hgf.1316.txt

*** P38s--

rl[1290.P38s.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc     P38s                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc    [P38s - act]          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/P38s.irt.Hgf.1290.txt

*** Pak1--

rl[1312.Pak1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc     Pak1                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc    [Pak1 - act]          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Pak1.irt.Hgf.1312.txt

*** Pai1--  Pai1-gene--

rl[1291.Pai1-gene.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc     Pai1-gene            }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {NUc   | nuc    [Pai1-gene - on]      } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Pai1-gene.irt.Hgf.1291.txt

*** Pi3k--

rl[1319.Pi3k.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)                 }
  {CLc   | clc    Pi3k                                  }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)  [Pi3k - Yphos] }
  {CLc   | clc                                          } .
  ---------------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Pi3k.irt.Hgf.1319.txt

*** Plcg1--

rl[1303.Plcg1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc     Plcg1                }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc    [Plcg1 - Yphos]       } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Plcg1.irt.Hgf.1303.txt

*** Pxn--

rl[1292.Pxn.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)    }
  {PxnC  | pxnc    Pxn                     }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)    }
  {PxnC  | pxnc   [Pxn - Yphos]            } .
  --------------------------------------------
  *** ~/evidence/Hgf-Evidence/Pxn.irt.Hgf.1292.txt

rl[1294.Pxn.irt.Erks.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)                 }
  {PxnC  | pxnc   [Erks - act] [Pxn - Yphos]            }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)                 }
  {PxnC  | pxnc   [Erks - act] [Pxn - Yphos phos(S 83)] } .
  --------------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Pxn.irt.Erks.Hgf.1294.txt

*** Rac1--

rl[1293.Rac1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)    }
  {PxnC  | pxnc   [Pxn - Yphos phos(S 83)] }
  {CLi   | cli    [Rac1 - GDP]             }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)    }
  {PxnC  | pxnc   [Pxn - Yphos phos(S 83)] }
  {CLi   | cli    [Rac1 - GTP]             } .
  --------------------------------------------
  *** ~/evidence/Hgf-Evidence/Rac1.irt.Hgf.1293.txt

*** Raf1--

rl[1297.Raf1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {PxnC  | pxnc    Pxn                  }
  {CLc   | clc     Raf1                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {PxnC  | pxnc    Pxn [Raf1 - act]     }
  {CLc   | clc                          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Raf1.irt.Hgf.1297.txt

*** Rala--

rl[1298.Rala.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Rala - GDP]          }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Rala - GTP]          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Rala.irt.Hgf.1298.txt

*** Rap1s--

rl[1310.Rap1s.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Rap1s - GDP]          }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLi   | cli    [Rap1s - GTP]          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Rap1s.irt.Hgf.1310.txt

*** Rps6--

rl[1299.Rps6.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)            }
  {CLc   | clc     Rps6                            }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)            }
  {CLc   | clc   [Rps6 - phos(S 235) phos(S 236) ] } .
  -----------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Rps6.irt.Hgf.1299.txt

*** Rsk1--

rl[1160.Rsk1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)            }
  {CLc   | clc     Rsk1                            }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)            }
  {CLc   | clc    [Rsk1 - phos(T 359) phos(S 363)] } .
  ----------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Rsk1.irt.Hgf.1160.txt

*** S6k1--

rl[1302.S6k1.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc     S6k1                 }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc    [S6k1 - act]          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/S6k1.irt.Hgf.1302.txt

*** Smad2--

rl[1162.Smad2.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)             }
  {CLc   | clc     Smad2                            }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)             }
  {CLc   | clc    [Smad2 - phos(S 250) phos(S 255)] } .
  -----------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Smad2.irt.Hgf.1162.txt

*** Smad3--

rl[1300.Smad3.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)             }
  {CLc   | clc     Smad3                            }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf)             }
  {CLc   | clc    [Smad3 - phos(S 208) phos(S 213)] } .
  -----------------------------------------------------
  *** ~/evidence/Hgf-Evidence/Smad3.irt.Hgf.1300.txt

*** Src--

rl[1301.Src.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {PxnC  | pxnc    Pxn                  }
  {CLi   | cli     Src                  }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {PxnC  | pxnc    Pxn [Src - act]      }
  {CLi   | cli                          } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Src.irt.Hgf.1301.txt

*** Stat3--

rl[1334.Stat3.irt.Hgf]:
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc     Stat3                }
  =>
  {HgfRC | hgfrc ([HgfR - Yphos] : Hgf) }
  {CLc   | clc    [Stat3 - phos(Y 705)] } .
  -----------------------------------------
  *** ~/evidence/Hgf-Evidence/Stat3.irt.Hgf.1334.txt



endm
