================
Smad3 phos(T179)
================

  *** Smad3[phosAb] phos(T179)[phosAb] is increased irt Egf (times)
    *** cells: MV1LU in BMLS
    *** times: 0+ 5++ 15+++ 30+++ 60+++ 120+++ 240++ 480++ hr
    *** source: 16156666-Fig-1d
  *** Smad3[phosAb] phos(T179)[phosAb] is increased irt Egf (30 min)
    *** cells: MV1LU in BMLS
    *** source: 16156666-Fig-1a
  *** Smad3[phosAb] phos(T179)[phosAb] is increased irt Egf (tnr)
    *** cells: MV1LU in BMLS
    *** inhibited by: U0126 [addition] no-bkg-control
    *** inhibited by: PD98059 [addition] no-bkg-control
    *** source: 16156666-Fig-2
  *** Smad3[phosAb] phos(T179)[phosAb] is increased irt Egf (30 min)
    *** cells: HACAT in BMLS
    *** source: 15241418-Fig-S5b

================
Smad3 phos(S204)
================

  *** Smad3[phosAb] phos(S204)[phosAb] is increased irt Egf (times)
    *** cells: MV1LU in BMLS
    *** times: 0+ 5+ 15++ 30++ 60++ 120++ 240++ 480++ hr
    *** source: 16156666-Fig-1d
  *** Smad3[phosAb] phos(S204)[phosAb] is increased irt Egf (30 min)
    *** cells: HACAT in BMLS
    *** source: 15241418-Fig-S5b
  *** Smad3[phosAb] phos(S204)[phosAb] is increased irt Egf (30 min)
    *** cells: MV1LU in BMLS
    *** source: 16156666-Fig-1a
  *** Smad3[phosAb] phos(S204)[phosAb] is increased irt Egf (tnr)
    *** cells: MV1LU in BMLS
    *** inhibited by: U0126 [addition] no-bkg-control
    *** inhibited by: PD98059 [addition] no-bkg-control
    *** source: 16156666-Fig-2

================
Smad3 phos(S208)
================

  *** Smad3[phosAb] phos(S208)[phosAb] is increased irt Egf (times)
    *** cells: MV1LU in BMLS
    *** times: 0 5++ 15+++ 30++ 60++ 120++ 240+ 480+ hr
    *** source: 16156666-Fig-1d
  *** Smad3[phosAb] phos(S208)[phosAb] is increased irt Egf (30 min)
    *** cells: HACAT in BMLS
    *** source: 15241418-Fig-S5b
  *** Smad3[phosAb] phos(S208)[phosAb] is increased irt Egf (30 min)
    *** cells: MV1LU in BMLS
    *** source: 16156666-Fig-1a
  *** Smad3[phosAb] phos(S208)[phosAb] is increased irt Egf (tnr)
    *** cells: MV1LU in BMLS
    *** inhibited by: U0126 [addition] no-bkg-control
    *** inhibited by: PD98059 [addition] no-bkg-control
    *** source: 16156666-Fig-2

====================
not Smad3 phos(S208)
====================

  *** Smad3[phosAb] phos(S213)[phosAb] is unchanged irt Egf (30 min)
    *** cells: HACAT in BMLS
    *** source: 15241418-Fig-S5b
  *** Smad3[phosAb] phos(S213)[phosAb] is unchanged irt Egf (30 min)
    *** cells: MV1LU in BMLS
    *** source: 16156666-Fig-1a

==================
not Smad3 phos(T8)
==================

  *** Smad3[phosAb] phos(T8)[phosAb] is unchanged irt Egf (30 min)
    *** cells: HACAT in BMLS
    *** source: 15241418-Fig-S5b


  *** xSmad3[tAb]IP phos[32Pi] is increased irt Egf (30 min)
    *** cells: R1BL17<TgfbR1~null> in BMS
    *** bkg inhibited by: xSmad3(S422A/S423A/S425A) [substitution]
    *** source: 10197981-Fig-6a

======================
not S422A/S423A/S425A
======================

  *** xSmad3(S422A/S423A/S425A)[tAb]IP phos[32Pi] is increased irt Egf (30 min)
    *** cells: R1BL17<TgfbR1~null> in BMS
    *** source: 10197981-Fig-5e

=====================
requirement for Erks from common rules only
=====================

  *** rSmad3(307-428)[GST] phos[32P-ATP] is increased by rErk2{act}
    *** cells: none
    *** comment: rErk2 is activated with Mek1
    *** source: 16156666-Fig-3
  *** rSmad3[phosAb] phos(T179)[phosAb] is increased by rErk2{act}
    *** cells: none
    *** comment: rErk2 is activated with Mek1
    *** source: 16156666-Fig-1b
  *** rSmad3[phosAb] phos(S204)[phosAb] is increased by rErk2{act}
    *** cells: none
    *** comment: rErk2 is activated with Mek1
    *** source: 16156666-Fig-1b
  *** rSmad3[phosAb] phos(S208)[phosAb] is increased by rErk2{act}
    *** cells: none
    *** comment: rErk2 is activated with Mek1
    *** source: 16156666-Fig-1b
  *** rSmad3[phosAb] phos(S213)[phosAb] is increased by rErk2{act}
    *** cells: none
    *** comment: rErk2 is activated with Mek1
    *** source: 16156666-Fig-1b
