=================
Required Proteins
=================

Ikk1--

  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: HELA<xIkk1> in BMS
    *** inhibited by: xIkk1(K44M) [substitution]
    *** source: 9346241-Fig-7

Ikk2--

  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: HELA<xIkk2> in BMS
    *** inhibited by: xIkk2(K44A) [substitution]
    *** source: 9346241-Fig-7

Tak1--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5+ 10++ 15++ 30+ min
    *** partially reqs: xTak1 [omission]
    *** partially inhibited by: xTak1(T178A/T184A) [substitution]
    *** source: 18617512-Fig-4d

=======================================================
requirement for phos(S536) by similarity with TnfRules
=======================================================

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt IL1 (times)
    *** cells: HELA in BMS
    *** times: 0 12++ 30++ 60+ 120 min
    *** source: 15489227(D)
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ 60+ 90+ 120+ min
    *** source: 14690596-Fig-5c
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt IL1 (30 min)
    *** cells: mEFs in BMS
    *** does not req: Pkcz [KO]
    *** source: 11684013-Fig-3b
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt IL1a (30 min)
    *** cells: HEK293T<xIL1R1> in BMLS
    *** source: 18443042-Fig-10e

================================================
Rela does not req Jun for relocation to nucleus
But coppts with Jun when in the nucleus
================================================

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt IL1a (times)
    *** cells: mEFs in BMLS
    *** times: 0 15+++ 30++ 60+ min
    *** does not req: Jun [KO]
    *** source: 18443042-Fig-10a

  *** Rela[Ab] copptby[WB] Jun[Ab] is increased irt IL1a (30 min)
    *** cells: HEK293T<xIL1R1> in BMLS "nuclear-extracts"
    *** source: 18443042-Fig-10e
  *** Rela[Ab] copptby[WB] Jun{phos(S73)}[phosAb] is increased irt IL1a (30 min)
    *** cells: HEK293T<xIL1R1> in BMLS "nuclear-extracts"
    *** source: 18443042-Fig-10e

no extras

  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: HELA<xJnk1> in BMS    
    *** source: 9346241-Fig-7
