*** Actb--
  *** Actb-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3+ 6++ 18+ 24+ 36+ 48+ hr
    *** source: 10092780-Fig-2a
*** Akt1--
  *** Akt1[Ab] prot-exp[WB] is unchanged irt IL2 (5 hr)
    *** cells: mSpBlasts in BMS "IL2-deprived"
    *** source: 11486019-Fig-1b
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt IL2 (3 min)
    *** cells: mLCs<IgM~neg><IgG~neg> in BMS "Cytokine-starved"
    *** reqs: Irs2 [KO]
    *** does not req: Stat6 [KO]
    *** source: 11739727-Fig-5c
*** AP1--
  *** AP1-reporter[CAT] is increased irt IL2 (18 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** unaffected by: xRb1(mnr)"DN" [addition] no-bkg-control
    *** source: 9390691-Fig-2b
*** Bclxl-- Bclxl-gene--
*** DNA-synthesis--
  *** DNA-synthesis[BRDU] is increased irt IL2 (42 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** unaffected by: xPik3c?(mnr)"CA" [addition]
    *** unaffected by: xPik3c?(mnr)"KD" [addition]
    *** source: 9390691-Fig-5d
*** Cd69--
  *** Cd69[Ab] surface-exp[FACS] is increased irt IL2 (3 days)
    *** cells: hNKCs in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 10843677-Fig-5
  *** Cd69[Ab] surface-exp[FACS] is increased irt IL2 (3 days)
    *** cells: hNKCs in BMLS
    *** unaffected by: SB203580 [pretreatment]
    *** source: 10843677-Fig-5
*** Cdk2--
*** Cdk4--
  *** Cdk4[Ab] prot-exp[WB] is unchanged irt IL2 (18 hr)
    *** cells: mSpCs in BMS
    *** source: 10072077-Fig-6a
*** Cdk6--
*** Cdkn1b--
  *** Cdkn1b[Ab] prot-exp[WB] is decreased irt IL2 (20 hr)
    *** cells: hIL2RTCs in BMS "IL2-deprived"
    *** reversed by: LY294002 [cotreatment]
    *** source: 9390691-Fig-7b
  *** Cdkn1b[Ab] prot-exp[WB] is decreased irt IL2 (20 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** reversed by: LY294002 [cotreatment]
    *** source: 9390691-Fig-7a
  *** Cdkn1b[Ab] prot-exp[WB] is decreased irt IL2 (28 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** source: 10962581-Fig-3a
  *** Cdkn1b[Ab] prot-exp[WB] is decreased irt IL2 (times)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** times: 0++ 4++ 8++ 12+ 16+ 20+ 24+ hr
    *** source: 9390691-Fig-3a
  *** Cdkn1b[Ab] prot-exp[WB] is unchanged irt IL2 (18 hr)
    *** cells: mSpCs in BMS
    *** source: 10072077-Fig-6a
*** Cish--
  *** Cish-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: 32DCL in BMS "IL3-deprived"
    *** times: 0 30 60+ 120++ min
    *** source: 10654938-Fig-5a
  *** Cish-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: 32DCL<xStat5a> in BMS "IL3-deprived"
    *** times: 0 30 60+ 120++ min
    *** partially inhibited by: xStat5a(del(740-793)) [substitution]
    *** inhibited by: xStat5a(del(751-793)) [substitution]
    *** unaffected by: xStat5a(del(762-793)) [substitution]
    *** unaffected by: xStat5a(del(773-793)) [substitution]
    *** source: 10654938-Fig-5a
*** Creb--
  *** Creb-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3+ 6+++ 18+ 24+ 36++ 48+ hr
    *** source: 10092780-Fig-2c
  *** Crem-gene mRNA[MicroArray] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** does not req: Stat5a or Stat5b [DKO]
    *** source: 16757175-Fig-6b
  *** Ctcf-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3+ 6++ 18++ 24+++ 36+++ 48+ hr
    *** source: 10092780-Fig-2b
  *** Ctnnb1-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3+ 6++ 18+ 24+ 36+ 48+ hr
    *** source: 10092780-Fig-2a
*** CyclinA--
  *** CyclinA2-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: BAFB03<xIL2Rb> in BMS "IL3 deprived"
    *** times: 0 3 6+ 9+ 12+ 15++ 18+++ 21++ 24++ hr
    *** unaffected by: xIL2Rb(del(312-383)) [substitution]
    *** source: 1535827-Fig-2a
  *** CyclinA2[Ab] prot-exp[WB] is unchanged irt IL2 (18 hr)
    *** cells: mSpCs in BMS
    *** source: 10072077-Fig-6a
  *** CyclinA2[Ab] prot-exp[WB] is unchanged irt IL2 (18 hr)
    *** cells: mSpCs in BMS
    *** source: 10072077-Fig-6b
*** CyclinB--
  *** CyclinB?-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: BAFB03<xIL2Rb> in BMS "IL3 deprived"
    *** times: 0+ 3+ 6+ 9++ 12++ 15++ 18++ 21++ 24++ hr
    *** partially inhibited by: xIL2Rb(del(312-383)) [substitution]
    *** source: 1535827-Fig-2a
*** CyclinD2--
*** CyclinD3--
*** CyclinE--
  *** CyclinE?-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: BAFB03<xIL2Rb> in BMS "IL3 deprived"
    *** times: 0 3 6+ 9+ 12+ 15+ 18+ 21+ 24+ hr
    *** unaffected by: xIL2Rb(del(312-383)) [substitution]
    *** source: 1535827-Fig-2a
  *** CyclinEs[Ab] prot-exp[WB] is unchanged irt IL2 (18 hr)
    *** cells: mSpCs in BMS
    *** source: 10072077-Fig-6a
*** Dpp4--
  *** Dpp4[Ab] surface-exp[FACS] is increased irt IL2 (3 days)
    *** cells: hNKCs in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 10843677-Fig-5
  *** Dpp4[Ab] surface-exp[FACS] is increased irt IL2 (3 days)
    *** cells: hNKCs in BMLS
    *** unaffected by: SB203580 [pretreatment]
    *** source: 10843677-Fig-5
*** Dusp5--
  *** Dusp5-gene mRNA[Northern] is increased irt IL2 (4 hr)
    *** cells: hPHAblasts in BMS "IL2-PHA-deprived"
    *** source: 12435740-Fig-4
  *** Dusp5-gene mRNA[RTPCR] is increased irt IL2 (times)
    *** cells: hPHAblasts in BMS "PHA-deprived"
    *** times: 0 30++ 120++ 240++ 480+ 1440+ min
    *** source: 12435740-Fig-5b
  *** Dusp5[Ab] prot-exp[WB] is increased irt IL2 (times)
    *** cells: hPHAblasts in BMS "PHA-deprived"
    *** times: 0+ 30+ 120++ 240++ 480+ 1440+ min
    *** source: 12435740-Fig-5c
*** Dusp16--
  *** Dusp16-gene mRNA[MicroArray] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** partially reqs: Stat5a and/or Stat5b [DKO]
    *** source: 16757175-Fig-6b
*** E2f4--
  *** E2f4-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3++ 6+++ 18+ 24+ 36++ 48+ hr
    *** source: 10092780-Fig-2c
  *** E2fRE-reporter[CAT] is increased irt IL2 (18 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** inhibited by: xRb1(mnr)"DN" [addition] no-bkg-control
    *** source: 9390691-Fig-2b
  *** E2fRE-reporter[CAT] is increased irt IL2 (18 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** unaffected by: PD98059 [pretreatment]
    *** source: 9390691-Fig-4c
  *** E2fRE-reporter[CAT] is increased irt IL2 (18 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** unaffected by: xStat5? [addition]
    *** unaffected by: xStat5?(mnr)"DN" [addition]
    *** source: 9390691-Fig-4e
  *** E2fRE-reporter[CAT] is increased irt IL2 (times)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** times: 0 4 8+ 12++ 24+++ hr
    *** source: 9390691-Fig-1a
  *** E2fRE-reporter[Luc] is increased irt IL2 (18 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** source: 10373522-Fig-4a
  *** E2fRE-reporter[Luc] is increased irt IL2 (18 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** source: 10373522-Fig-5a
  *** E2fRE-reporter[Luc] is increased irt IL2 (22 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** source: 10373522-Fig-1a
*** Elk1--
*** Erks--
  *** Fes[Ab] copptby[WB] Pik3rs[Ab] is unchanged irt IL2 (times)
    *** cells: CTLL2 in BMLS
    *** times: 0 1 5 15 min
    *** source: 8916957-Fig-2
  *** Fes[Ab] copptby[WB] Pik3rs[Ab] is unchanged irt IL2 (times)
    *** cells: HT2 in BMLS
    *** times: 0 1 5 15 min
    *** source: 8916957-Fig-2
*** Fos--
*** Foxp3--
  *** Foxp3-gene mRNA[RTPCR] is increased irt IL2 (6 hr)
    *** cells: hPBMCs<Cd4~pos><IL2Ra~pos> in BMS
    *** enhanced by: anti-Cd3 [cotreatment]
    *** source: 16645171-Fig-1a
  *** Foxp3-gene mRNA[RTPCR] is increased irt IL2 (6 hr)
    *** cells: hPBMCs<Cd4~pos><IL2Ra~pos> in BMS
    *** source: 16645171-Fig-1c
  *** Foxp3-gene mRNA[RTPCR] is increased irt IL2 (18 hr)
    *** cells: hPBMCs<Cd3e~neg><Cd56~pos> in BMS "pretreated with 5Aza2Deoxycytidine"
    *** source: 16645171-Fig-1c
  *** Foxp3-gene mRNA[RTPCR] is increased irt IL2 (18 hr)
    *** cells: NKL in BMS "pretreated with 5Aza2Deoxycytidine"
    *** source: 16645171-Fig-1c
  *** Foxp3[Ab] prot-exp[WB] is increased irt IL2 (18 hr)
    *** cells: hPBMCs<Cd4~pos><IL2Ra~pos> in BMS
    *** source: 16645171-Fig-1b
*** GAS--
  *** GAS-reporter[Luc] is increased irt IL2 (8 hr)
    *** cells: NB2 in BMS
    *** source: 7479881-Fig-3
  *** GAS-reporter[Luc] is increased irt IL2 (8 hr)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null><xJak3> in BMLS
    *** unaffected by: xPtpn6 [addition]
    *** source: 9590209-Fig-4a
  *** GAS-reporter[Luc] is increased irt IL2 (8 hr)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null><xJak3> in BMLS
    *** unaffected by: xPtpn6(mnr)"DN" [addition]
    *** source: 9590209-Fig-4b
  *** GAS-reporter[Luc] is increased irt IL2 (12 hr)
    *** cells: KIT225 in BMS
    *** inhibited by: xGab2 [addition]
    *** unaffected by: xGab2(Y614F) [addition]
    *** inhibited by: xGab2(S623A) [addition]
    *** source: 15356145-Fig-7a
  *** GAS-reporter[Luc] is increased irt IL2 (24 hr)
    *** cells: 32D<xIL2Rb> in BMS
    *** partially inhibited by: xCish [addition]
    *** source: 10514520-Fig-8a
  *** Gzma-gene mRNA[Northern] is increased irt IL2 (3 hr)
    *** cells: hNKCs in BMS
    *** source: 8103068-Fig-2
*** Gzmb--
  *** Gzmb-gene mRNA[Northern] is increased irt IL2 (3 hr)
    *** cells: hNKCs in BMS
    *** source: 8103068-Fig-2
  *** Gzmb-gene mRNA[Northern] is increased irt IL2 (3 hr)
    *** cells: hNKCs in BMS
    *** source: 8103068-Fig-3a
  *** Gzmb-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: SAM19<IL2Ra~null> in BMS
    *** times: 0 4+ 6+ 8+ hr
    *** inhibited by: Rapamycin [cotreatment]
    *** source: 10544201-Fig-1b
*** Ifng--
  *** Ifng-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: mSpTCs in BMS "IL2-deprived" "preactivated with IL2, anti-Cd3e, anti-Cd28 for 48 hr"
    *** times: 0 1+ 2++ 4+ 8+ 17 24+ 36 hr
    *** source: 16757175-Fig-6a
  *** Ifng[Ab] secretion[ELISA] is increased irt IL2 (3 days)
    *** cells: hNKCs in BMLS
    *** enhanced by: SB203580 [pretreatment]
    *** source: 10843677-Fig-6b
  *** Ifng[Ab] secretion[ELISA] is increased irt IL2 (3 days)
    *** cells: hNKCs in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 10843677-Fig-4
  *** Ifng[Ab] secretion[ELISA] is increased irt IL2 (times)
    *** cells: hPBMCs in BMS "Cd45ra-pos cultured with anti-Cd3 + anti-Cd28"
    *** times: 3 6+ days
    *** source: 11114383-Fig-6c
  *** Ifng[Ab] secretion[ELISA] is increased irt IL2 (times)
    *** cells: hPBMCs in BMS "Cd45ro-pos cultured with anti-Cd3 + anti-Cd28"
    *** times: 3+ 6++ days
    *** source: 11114383-Fig-6c
*** IL1b--
  *** IL1b-gene mRNA[MicroArray] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** does not req: Stat5a or Stat5b [DKO]
    *** source: 16757175-Fig-6b
*** IL2Ra--
  *** IL2Ra-gene mRNA[Northern] is decreased irt IL2-deprivation (times)
    *** cells: CTLL2 in BMS
    *** times: 0+++ 1+++ 6++ 12+ 24+ 48 hr
    *** source: 1280821-Fig-5a
  *** IL2Ra-gene mRNA[Northern] is increased irt IL2 (4 hr)
    *** cells: hPHAblasts in BMS "IL2-PHA-deprived"
    *** source: 12435740-Fig-4
  *** IL2Ra-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3+ 6+++ 18+++ 24+++ 36+++ 48++ hr
    *** source: 10092780-Fig-1c
  *** IL2Ra-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** times: 0 1 6+++ 12++ 24+ 48 hr
    *** source: 1280821-Fig-5a
  *** IL2Ra-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** times: 0 1+ 2+++ 4+++ 6++ 8++ 12++ hr
    *** source: 1280821-Fig-5b
  *** IL2Ra-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: mSpTCs in BMS "IL2-deprived" "preactivated with IL2, anti-Cd3e, anti-Cd28 for 48 hr"
    *** times: 0 1 2+ 4++ 8++ 17+ 24+ 36+ hr
    *** source: 16757175-Fig-6a
  *** IL2Ra[Ab] surface-exp[FACS] is detectable
    *** cells: CTLL2 in BMS "4 days after last IL2 feeding"
    *** source: 3110787-Fig-3
  *** IL2Ra[Ab] surface-exp[FACS] is detectable
    *** cells: mSpCs in BMS "treated with anti-Cd3 for 48 hr"
    *** reqs: Stat5a and/or Stat5b [DKO]
    *** source: 11485747-Fig-6
  *** IL2Ra[Ab] surface-exp[FACS] is increased irt IL2 (12 hr)
    *** cells: BCL1 in BMS "pretreated with IL5 for 12 hrs"
    *** comment: increase reqs IL5 pretreatment
    *** comment: increase is reversed if IL4 is added to the IL5 pretreatment
    *** source: 2295790-Fig-6
  *** IL2Ra[Ab] surface-exp[FACS] is increased irt IL2 (17 hr)
    *** cells: mThyCs<Cd4~pos> in BMS
    *** inhibited by: CsA [cotreatment]
    *** source: 12065418-Fig-8a
  *** IL2Ra[Ab] surface-exp[FACS] is increased irt IL2 (17 hr)
    *** cells: mThyCs<Cd8~pos> in BMS
    *** inhibited by: CsA [cotreatment]
    *** source: 12065418-Fig-8a
  *** IL2Ra[Ab] surface-exp[FACS] is increased irt IL2 (24 hr)
    *** cells: mSpCs in BMS "pretreated with anti-Cd3 for 48 hr"
    *** reqs: Stat5a and/or Stat5b [DKO]
    *** source: 11485747-Fig-6
  *** IL2Ra[Ab] surface-exp[FACS] is unchanged irt IL2 (3 days)
    *** cells: mSpBCs in BMS
    *** source: 3110787-Table-4
*** IL2Rg--
  *** IL2Rg-gene mRNA[Northern] is unchanged irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3+ 6+ 18+ 24+ 36+ 48+ hr
    *** source: 10092780-Fig-1c
*** IL4R--
  *** IL4R-gene mRNA[Northern] is increased irt IL2 (4 hr)
    *** cells: hPHAblasts in BMS "IL2-PHA-deprived"
    *** source: 12435740-Fig-4
*** IL6--
  *** IL6-gene mRNA[MicroArray] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** reqs: Stat5a and/or Stat5b [DKO]
    *** source: 16757175-Fig-6b
*** IL23R-- IL23R-gene--
  *** IL23R-gene mRNA[RTPCR] is unchanged irt IL2 (6 days)
    *** cells: hNaiveCD4TCs in BMS
    *** source: 18454151-Fig-4d
*** Irf1--
  *** Irf1-gene mRNA[Northern] is increased irt IL2 (4 hr)
    *** cells: NK33 in BMS "pretreated with CHX"
    *** enhanced by: IL12 [cotreatment]
    *** source: 10358173-Fig-3c
  *** Irf1-gene mRNA[RPA] is increased irt IL2 (4 hr)
    *** cells: hPHAblasts in BMS
    *** source: 10358173-Fig-1c
  *** Irf1-gene mRNA[RPA] is increased irt IL2 (4 hr)
    *** cells: NK33 in BMS
    *** enhanced by: IL12 [cotreatment]
    *** source: 10358173-Fig-3a
  *** Irf1-gene mRNA[RPA] is increased irt IL2 (4 hr)
    *** cells: NK33 in BMS
    *** source: 10358173-Fig-1b
  *** Irf1-gene mRNA[RPA] is increased irt IL2 (4 hr)
    *** cells: NK33 in BMS "pretreated with CHX"
    *** enhanced by: IL12 [cotreatment]
    *** source: 10358173-Fig-3b
*** Irs2--
  *** Irs2[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMLS
    *** source: 7499365-Fig-1b
  *** Irs2[Ab]IP Yphos[pYAb] is unchanged irt IL2 (30 min)
    *** cells: mThyCs in BMS "treated with PMA + Ionomycin for 20 hr, followed by 4 hr medium alone"
    *** unaffected by: xIkba(mnr)"del-Nterm" [addition]
    *** source: 11160275-Fig-3b
*** Isg15--
  *** Isg15-gene mRNA[RPA] is unchanged irt IL2 (4 hr)
    *** cells: NK33 in BMS
    *** source: 10358173-Fig-3a
  *** Isg15-gene mRNA[RPA] is unchanged irt IL2 (4 hr)
    *** cells: NK33 in BMS "pretreated with CHX"
    *** source: 10358173-Fig-3b
*** Itk--
  *** Itk-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** times: 0 1 6+++ 12++ 24+ 48 hr
    *** source: 1280821-Fig-5a
  *** Itk-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** times: 0 1+ 2+++ 4+++ 6++ 8++ 12++ hr
    *** source: 1280821-Fig-5b
*** Jak2--
  *** Jak2[Ab] copptby[WB] Stam[Ab] is unchanged irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 9133424-Fig-4
  *** Jak2[Ab] copptby[WB] Stam2[Ab] is unchanged irt IL2 (10 min)
    *** cells: TF1 in BMS
    *** source: 10899310-Fig-2b
  *** Jak2[Ab]IP IVKA(auto)[32P-ATP] is unchanged irt IL2 (5 min)
    *** cells: BAFB03<IL2Rb~null><xIL2Rb> in BMS "Growth-factor-deprived"
    *** source: 7973659-Fig-2a
  *** Jak2[Ab]IP Yphos[pYAb] is detectable-but unchanged irt IL2 (15 min)
    *** cells: KIT225 in BMS
    *** source: 7988557-Fig-1a
  *** Jak2[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: TF1 in BMS
    *** source: 10899310-Fig-2b
  *** Jak2[Ab]IP Yphos[pYAb] is unchanged irt IL2 (tnr)
    *** cells: NK33 in BMS
    *** source: 7973658-Fig-1d
*** Jun--
*** Jund--  Jund-gene--
  *** Jund-gene mRNA[Northern] is unchanged irt IL2 (times)
    *** cells: BAFB03<xIL2Rb> in BMS "IL3 deprived"
    *** times: 0+ 10+ 30+ 60+ 180+ 360+ min
    *** unaffected by: xIL2Rb(del(312-383)) [substitution]
    *** source: 1535827-Fig-3
  *** Kpna1-gene mRNA[Northern] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** comment: inhibited by preactivation with IL2, anti-Cd3e, anti-Cd28 for 48 hr
    *** source: 16757175-Fig-5
  *** Mad-gene mRNA[MicroArray] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** does not req: Stat5a or Stat5b [DKO]
    *** source: 16757175-Fig-6b
  *** Mapkapk3-gene mRNA[Northern] is increased irt IL2 (4 hr)
    *** cells: hPHAblasts in BMS "IL2-PHA-deprived"
    *** source: 12435740-Fig-4
*** Myb--
*** Myc--
*** Ncl--
  *** Ncl-gene mRNA[Northern] is decreased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0++ 3+ 6+ 18+ 24++ 36+ 48 hr
    *** source: 10092780-Fig-2c
*** Nr4a2--
  *** Nr4a2-gene mRNA[MicroArray] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** partially reqs: Stat5a and/or Stat5b [DKO]
    *** source: 16757175-Fig-6b
*** Pi3k--
*** Pkcz--
  *** Pkcz[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (30 min)
    *** cells: TS1<xIL2Ra><xIL2Rb> in BMS "IL2-deprived"
    *** bkg inhibited by: Wortmannin [pretreatment]
    *** source: 9029085-Fig-6
  *** Pkcz[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL2 (30 min)
    *** cells: TS1<xIL2Ra><xIL2Rb> in BMS "IL2-deprived"
    *** partially inhibited by: ToxinB [pretreatment]
    *** source: 9029085-Fig-4a
*** Prf1
  *** Prf1-gene mRNA[Northern] is increased irt IL2 (3 hr)
    *** cells: hNKCs in BMS
    *** source: 8103068-Fig-2
  *** Prf1-gene mRNA[Northern] is increased irt IL2 (3 hr)
    *** cells: hNKCs in BMS
    *** source: 8103068-Fig-3a
  *** Prf1-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: mSpTCs in BMS "IL2-deprived" "preactivated with IL2, anti-Cd3e, anti-Cd28 for 48 hr"
    *** times: 0 1 2+ 4++ 8++ 17+ 24+ 36+ hr
    *** source: 16757175-Fig-6a
  *** Prf1-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: SAM19<IL2Ra~null> in BMS
    *** times: 0 4+ 6+ 8+ hr
    *** unaffected by: CHX [cotreatment]
    *** source: 10544201-Fig-1a
  *** Prf1-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: SAM19<IL2Ra~null> in BMS
    *** times: 0 4+ 6+ 8+ hr
    *** unaffected by: Rapamycin [cotreatment]
    *** source: 10544201-Fig-1b
*** Proliferation--
  *** ProTnf-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** times: 0 1+ 2+ 4+ 8+ 18 hr
    *** source: 9541574-Fig-1
*** Rac1--
*** Raf1--
*** Raf1--  Raf1-gene--
  *** Raf1-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: hIL2RTCs in BMHIS "IL2-deprived for 12-14 hr"
    *** times: 0 2+ 6++ 8+++ 12++++ 20++++ hr
    *** comment: no control for total RNA
    *** source: 1708096-Fig-2
*** Rasa1--
  *** Rasa1[Ab] copptby[WB] Socs3[Ab] is increased irt IL2 (times)
    *** cells: CTLL2 in BMLS
    *** times: 0 1+ 6 hr
    *** comment: increase in coppt corresponds with increase in total Socs3 protein
    *** source: 11331873-Fig-3c
*** Rass
  *** Rass[Ab]IP GTP-association[TLC] is increased irt IL2 (24 hr)
    *** cells: TS1<xIL2Ra><xIL2Rb> in BMHIS
    *** partially inhibited by: xHras(S17N)"DN" [addition]
    *** source: 8805624-Fig-3
*** Rb1--
  *** Rb1[Ab] phos[WBMS] is increased irt IL2 (20 hr)
    *** cells: hIL2RTCs in BMS "IL2-deprived"
    *** inhibited by: LY294002 [cotreatment]
    *** source: 9390691-Fig-7b
  *** Rb1[Ab] phos[WBMS] is increased irt IL2 (20 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** bkg inhibited by: LY294002 [cotreatment]
    *** source: 9390691-Fig-7a
*** Rbl2--
  *** Rbl2[Ab] phos[WBMS] is increased irt IL2 (20 hr)
    *** cells: hIL2RTCs in BMS "IL2-deprived"
    *** inhibited by: LY294002 [cotreatment]
    *** source: 9390691-Fig-7b
  *** Rbl2[Ab] phos[WBMS] is increased irt IL2 (20 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** partially inhibited by: LY294002 [cotreatment]
    *** source: 9390691-Fig-7a
*** RoRc-- RoRc-gene--
  *** RoRc-gene mRNA[RTPCR] is unchanged irt IL2 (6 days)
    *** cells: hNaiveCD4TCs in BMS
    *** source: 18454151-Fig-4d
  *** RoRc-gene mRNA[RTPCR] is unchanged irt IL2 (3 days)
    *** cells: hNaiveCD4TCs in BMS
    *** source: 18454151-Fig-2b
*** Rpl10--
  *** Rpl10-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3+ 6++ 18+ 24+ 36+ 48+ hr
    *** source: 10092780-Fig-2b
*** Rsks--
  *** Rsks[Ab]IP IVKA(snr)[32P-ATP] is increased irt IL2 (10 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** source: 7528328-Fig-1b
*** S6ks--
*** Shp2--
*** Smpd1--
  *** Smpd1-gene mRNA[Northern] is unchanged irt IL2 (24 hr)
    *** cells: KHYG1 in BMS "IL2-deprived"
    *** source: 15271800-Fig-6a
  *** Smpd1[Ab] prot-exp[WB] is decreased irt IL2 (24 hr)
    *** cells: KHYG1 in BMS "IL2-deprived"
    *** source: 15271800-Fig-6b
*** Socs2--
  *** Socs2[Ab] prot-exp[WB] is increased irt IL2 (times)
    *** cells: hPHAblasts in BMLS
    *** times: 0 1 2 4+ 8++ hr
    *** source: 16199887-Fig-1b
*** Socs3-- 
  *** Sox18-gene mRNA[MicroArray] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** does not req: Stat5a or Stat5b [DKO]
    *** source: 16757175-Fig-6b
*** SRE--
  *** SRE-reporter[Luc] is increased irt IL2 (8 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** enhanced by: xGab2 [addition]
    *** partially inhibited by: xGab2(Y614F) [addition]
    *** source: 15170389-Fig-3b
  *** SRE-reporter[Luc] is increased irt IL2 (8 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** inhibited by: xRhoa(S19N) [addition]
    *** source: 15170389-Fig-5a
  *** SRE-reporter[Luc] is increased irt IL2 (8 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** source: 15170389-Fig-5b
  *** SRE-reporter[Luc] is increased irt IL2 (8 hr)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** unaffected by: xShp2 [addition]
    *** inhibited by: xShp2(C459S) [addition]
    *** source: 15170389-Fig-3b
*** Stam--
*** Stam2--
  *** Stam2[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: MOLT4<xIL2Rb> in BMS
    *** source: 10899310-Fig-1
*** Stat1--
  *** Stat1[Ab] oligo-binding[EMSA] is detectable-but unchanged irt IL2 (7 min)
    *** cells: YT in BMS "nuclear-extracts"
    *** oligo: GAS 5-GCCTGATTTCCCCGAAATGACGG-3
    *** source: 7479881-Fig-2c
  *** Stat1[Ab] oligo-binding[EMSA] is increased irt IL2 (10 min)
    *** cells: NKL in BMS "IL2-deprived"
    *** source: 7544001-Fig-4b
  *** Stat1[Ab] oligo-binding[EMSA] is unchanged irt IL2 (7 min)
    *** cells: NB2 in BMS "nuclear-extracts"
    *** oligo: GAS 5-GCCTGATTTCCCCGAAATGACGG-3
    *** source: 7479881-Fig-1b
  *** Stat1[Ab] oligo-binding[EMSA] is unchanged irt IL2 (10 min)
    *** cells: ED40515<xIL2Rg> in BMS
    *** oligo: GAS 5-GCCTGATTTCCCCGAAATGATGA-3
    *** source: 10421845-Fig-2d
  *** Stat1[Ab] snaggedby[WB] oligo[biotin] is increased irt IL2 (10 min)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** oligo: GAS 5-GTATTTCCCAGAAAAGGAAC-3
    *** source: 10602027-Fig-4
  *** Stat1[Ab] snaggedby[WB] oligo[biotin] is unchanged irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** oligo: "FcgR-GAS" 5-GTATTTCCCAGAAAAGGAAC-3
    *** source: 7988557-Fig-9b
  *** Stat1[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7568001-Fig-2d
  *** Stat1[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** source: 7760829-Fig-4a
  *** Stat1[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: KIT225 in BMS
    *** source: 7988557-Fig-8a
  *** Stat1[phosAb] phos(Y701)[phosAb] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7544001-Fig-2b
  *** Stat1[phosAb] phos(Y701)[phosAb] is increased irt IL2 (20 min)
    *** cells: hPHAblasts in BMS
    *** comment: bkg is enhanced when Ifng was added to PHA during blasting
    *** source: 9454765-Fig-1a
  *** Stat1[phosAb] phos(Y701)[phosAb] is increased irt IL2 (20 min)
    *** cells: hPHAblasts in BMS
    *** source: 9454765-Fig-1b
  *** Stat1[phosAb] phos(Y701)[phosAb] is increased irt IL2 (20 min)
    *** cells: hPHAblasts in BMS
    *** source: 9454765-Fig-6a
  *** Stat1[phosAb] phos(Y701)[phosAb] is increased irt IL2 (times)
    *** cells: hPHAblasts in BMS
    *** times: 0 1++ 15++ 30++ 60++ 180+ 300+ min
    *** source: 7544001-Fig-2a
  *** Stat1[phosAb] phos(Y701)[phosAb] is unchanged irt IL2 (15 min)
    *** cells: hPBTCs<Itgb2~pos><Cd8~pos><Cd56~neg><Cd4~neg><Cd20~neg> in BMS
    *** unaffected by: IL12 [cotreatment]
    *** source: 10201984-Fig-4a
*** Stat2--
  *** Stat2[Ab] oligo-binding[EMSA] is unchanged irt IL2 (10 min)
    *** cells: NKL in BMS "IL2-deprived"
    *** source: 7544001-Fig-4b
  *** Stat2[Ab] oligo-binding[EMSA] is unchanged irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** oligo: "GRR" 5-ACGATGTTTCAAGGATTTGAGATGTATTTCCCAGAAAAG-3
    *** source: 7568001-Fig-3a
  *** Stat2[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7568001-Fig-2d
  *** Stat2[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** source: 7760829-Fig-4a
*** Stat3--
*** Stat4--
  *** Stat4[Ab] boundto(IL2Ra-gene)[ChIP] is unchanged irt IL2 (4 hr)
    *** cells: mSpCs in BMS "pretreated with anti-Cd3 for 72 hr"
    *** source: 14660657-Fig-3
  *** Stat4[Ab] oligo-binding[EMSA] is unchanged irt IL2 (10 min)
    *** cells: NKL in BMS "IL2-deprived"
    *** source: 7544001-Fig-4b
  *** Stat4[Ab] oligo-binding[EMSA] is unchanged irt IL2 (20 min)
    *** cells: NKL in BMS "IL2-deprived"
    *** source: 12372421-Fig-4b
  *** Stat4[Ab] phos[WBMS] is unchanged irt IL2 (20 min)
    *** cells: hPHAblasts in BMS
    *** source: 9454765-Fig-4a
  *** Stat4[Ab] snaggedby[WB] oligo[biotin] is unchanged irt IL2 (1 hr)
    *** cells: mSpCs in BMS "pretreated with anti-Cd3 for 72 hr"
    *** source: 14660657-Fig-2b
  *** Stat4[Ab]IP Yphos[pYAb] is increased irt IL2 (20 min)
    *** cells: hPHAblasts in BMS
    *** comment: response inhibited when IL4 was added to PHA during blasting
    *** source: 9454765-Fig-4b
  *** Stat4[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: hPHAblasts<Cd3e~neg> in BMS
    *** source: 7638186-Fig-3a
  *** Stat4[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** source: 7760829-Fig-4a
  *** Stat4[Ab]IP Yphos[pYAb] is unchanged irt IL2 (20 min)
    *** cells: hPHAblasts in BMS
    *** source: 11114383-Fig-7d
*** Stat5--
*** Stat5a--
  *** Stat5a[Ab]IP Yphos[pYAb] is detectable-but unchanged irt IL2 (30 min)
    *** cells: mThyCs in BMS "treated with PMA + Ionomycin for 16 hr"
    *** source: 11160275-Fig-7c
*** Stat5b--
  *** Stat5b[Ab]IP Yphos[pYAb] is detectable-but unchanged irt IL2 (30 min)
    *** cells: mThyCs in BMS "treated with PMA + Ionomycin for 16 hr"
    *** source: 11160275-Fig-7c
*** Stat5s--
  *** Stat5s[Ab] oligo-binding[EMSA] is detectable-but unchanged irt IL2 (30 min)
    *** cells: mTCs in BMS "treated with anti-Cd3 + anti-Cd28 for 16 hr"
    *** source: 11160275-Fig-7b
  *** Stat5s[Ab] oligo-binding[EMSA] is detectable-but unchanged irt IL2 (30 min)
    *** cells: mThyCs in BMS "treated with PMA + Ionomycin + Cd28 for 20 hr"
    *** source: 11160275-Fig-7a
*** Stat6--
  *** Stat6[Ab] oligo-binding[EMSA] is unchanged irt IL2 (10 min)
    *** cells: NKL in BMS "IL2-deprived"
    *** source: 7544001-Fig-4b
  *** Stat6[Ab] snaggedby[WB] oligo[biotin] is unchanged irt IL2 (10 min)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** oligo: GAS 5-GTATTTCCCAGAAAAGGAAC-3
    *** source: 10602027-Fig-4
  *** Stat6[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** source: 7760829-Fig-4a
  *** Stat6[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** source: 7760829-Fig-4c
  *** Stat6[phosAb] phos(sitenr)[phosAb] is unchanged irt IL2 (times)
    *** cells: hPHAblasts in BMS "IL2-PHA-deprived"
    *** times: 0 10 30 min
    *** source: 12435740-Fig-5a
*** StatRE--
  *** StatRE-reporter[Luc] is increased irt IL2 (5 hr)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null><xJak3> in BMS
    *** unaffected by: xLck(mnr)"KD" [addition]
    *** source: 10825200-Fig-1c
  *** StatRE-reporter[Luc] is increased irt IL2 (5 hr)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null><xJak3> in BMS
    *** unaffected by: xSyk(mnr)"KD" [addition]
    *** source: 10825200-Fig-4c
  *** StatRE-reporter[Luc] is increased irt IL2 (5 hr)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null><xJak3><xLck(mnr)"CA"> in BMS
    *** inhibited by: xJak3(K855A)"KD" [substitution]
    *** source: 10825200-Fig-1d
  *** StatRE-reporter[Luc] is increased irt IL2 (5 hr)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null><xJak3><xSyk> in BMS
    *** inhibited by: xJak3(K855A)"KD" [substitution]
    *** source: 10825200-Fig-4d
  *** StatRE-reporter[Luc] is unchanged irt IL2 (5 hr)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null> in BMS
    *** enhanced by: xLck(mnr)"CA" [substitution]
    *** source: 10825200-Fig-1b
  *** StatRE-reporter[Luc] is unchanged irt IL2 (5 hr)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null> in BMS
    *** source: 10825200-Fig-4b
*** Syk--
  *** TcRb-gene mRNA[Northern] is unchanged irt IL2 (3 hr)
    *** cells: hNKCs in BMS
    *** source: 8103068-Fig-3a
*** DNA-synthesis--
*** Tirap--
  *** Tirap-gene mRNA[Northern] is increased irt IL2 (4 hr)
    *** cells: hPHAblasts in BMS "IL2-PHA-deprived"
    *** source: 12435740-Fig-4
*** Tnf--
*** Tnfaip3--
  *** Tnfaip3-gene mRNA[MicroArray] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** does not req: Stat5a or Stat5b [DKO]
    *** source: 16757175-Fig-6b
*** Trail--
  *** Trail-gene mRNA[Northern] is increased irt IL2 (4 hr)
    *** cells: hPHAblasts in BMS "IL2-PHA-deprived"
    *** source: 12435740-Fig-4
*** TRE--
  *** TRE-reporter[Luc] is increased irt IL2 (24 hr)
    *** cells: AE7 in BMS
    *** inhibited by: xDok2 [addition]
    *** source: 9697832-Fig-6a
  *** Tsc22d3-gene mRNA[Northern] is decreased irt IL2 (4 hr)
    *** cells: hPHAblasts in BMS "IL2-PHA-deprived"
    *** source: 12435740-Fig-4
  *** Tuba1a-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3+ 6++ 18++ 24++ 36++ 48+ hr
    *** source: 10092780-Fig-2a
*** Tyk2--
  *** Tyk2[Ab] copptby[WB] Stam2[Ab] is unchanged irt IL2 (10 min)
    *** cells: DAUDI in BMS
    *** source: 10899310-Fig-2d
  *** Tyk2[Ab] Yphos[pYAb-ppt] is unchanged irt IL2 (10 min)
    *** cells: hPHAblasts in BMS
    *** source: 7528775-Fig-2a
  *** Tyk2[Ab] Yphos[pYAb-ppt] is unchanged irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7988557-Fig-2b
  *** Tyk2[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: DAUDI in BMS
    *** source: 10899310-Fig-2d
  *** Tyk2[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7988557-Fig-2c
  *** Tyk2[Ab]IP Yphos[pYAb] is unchanged irt IL2 (15 min)
    *** cells: KIT225 in BMS
    *** source: 7988557-Fig-1a
  *** Tyk2[Ab]IP Yphos[pYAb] is unchanged irt IL2 (tnr)
    *** cells: NK33 in BMS
    *** source: 7973658-Fig-1b
*** Ugcg--
  *** Ugcg-gene mRNA[Northern] is increased irt IL2 (24 hr)
    *** cells: KHYG1 in BMS "IL2-deprived"
    *** source: 15271800-Fig-6a
  *** Ugcg[Ab] prot-exp[WB] is increased irt IL2 (24 hr)
    *** cells: KHYG1 in BMS "IL2-deprived"
    *** source: 15271800-Fig-6b
*** Vps37b--
  *** Vps37b-gene mRNA[MicroArray] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** does not req: Stat5a or Stat5b [DKO]
    *** source: 16757175-Fig-6b
*** Zfand2a--
  *** Zfand2a-gene mRNA[Northern] is increased irt IL2 (90 min)
    *** cells: mSpTCs in BMS "IL2-deprived"
    *** comment: inhibited by preactivation with IL2, anti-Cd3e, anti-Cd28 for 48 hr
    *** source: 16757175-Fig-5
*** Zhx1--
  *** Zhx1-gene mRNA[Northern] is increased irt IL2 (times)
    *** cells: C301 in BMS
    *** times: 0+ 3+ 6+++ 18+ 24+ 36++ 48+ hr
    *** source: 10092780-Fig-2c
