===========================
Semi-direct phosphorylation
===========================

phos(S473)

  *** rAkt1[phosAb] phos(S473)[phosAb] is increased by (Mtor[Ab]IP + Rictor[Ab]IP)
    *** cells: none
    *** IPfrom: HELA in BMS
    *** source: 21464307-Fig-3b
  *** rAkt1[phosAb] phos(S473)[phosAb] is increased by (xMtor[tAb]IP + xRictor[tAb]IP)
    *** cells: none
    *** IPfrom: HEK293<xMtor><xRictor> in BMS
    *** source: 21464307-Fig-3a

  *** rAkt1[phosAb] phos(S473)[phosAb] is increased by Mtor[Ab]IP
    *** cells: none
    *** IPfrom: HELA<xTbk1> in BMS
    *** unaffected by: xTbk1(mnr)"KD" [substitution]
    *** source: 21464307-Fig-4d
  *** rAkt1[phosAb] phos(S473)[phosAb] is increased by Rictor[Ab]IP
    *** cells: none
    *** IPfrom: HELA<xTbk1> in BMS
    *** unaffected by: xTbk1(mnr)"KD" [substitution]
    *** source: 21464307-Fig-4d

phos(T308)

  *** rAkt1[phosAb] phos(T308)[phosAb] is unchanged by (Mtor[Ab]IP + Rictor[Ab]IP)
    *** cells: none
    *** IPfrom: HELA in BMS
    *** source: 21464307-Fig-3b
  *** rAkt1[phosAb] phos(T308)[phosAb] is unchanged by (xMtor[tAb]IP + xRictor[tAb]IP)
    *** cells: none
    *** IPfrom: HEK293<xMtor><xRictor> in BMS
    *** source: 21464307-Fig-3a


=============================================
Basal Phosphorylation on S473
=============================================

Mlst8--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mEFs<xSgk1(61-431)> in BMS
    *** reqs: Mlst8 [RNAi]
    *** source: 18925875-Fig-1d

Mtor--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: 786O in BMS
    *** partially reqs: Mtor [RNAi]
    *** source: 19114562-Fig-1
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: A549 in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** reqs: Mtor [RNAi]
    *** source: 16962653-Fig-S1b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HELA in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HT29 in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: M059J in BMLS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-S2
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: PC3 in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2b
  ------ contradictions -----------------------------
  *** Akt1[phosAb] phos(S473)[phosAb] is increased itao Mtor [RNAi]
    *** cells: PC3 in BMS
    *** source: 18339839-Fig-2c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased itao Mtor [RNAi]
    *** cells: MDAMB231 in BMS
    *** source: 18339839-Fig-2c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased itao Mtor [RNAi]
    *** cells: MDAMB231 in BMS
    *** source: 18339839-Fig-2d
  *** Akt1[phosAb] phos(S473)[phosAb] is increased itao Mtor [RNAi]
    *** cells: MCF7 in BMS
    *** source: 18339839-Fig-2c

*** not Raptor--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: 786O in BMS
    *** does not req: Raptor [RNAi]
    *** source: 19114562-Fig-1
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: WM35<xMtor> in BMS
    *** does not req: Raptor [RNAi]
    *** source: 18570873-Fig-7a

Rictor--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: A549 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HELA in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HT29 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: M059J in BMLS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-S2
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: PC3 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Rictor [RNAi]
    *** source: 16919458-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HELA in BMS
    *** reqs: Rictor [RNAi]
    *** source: 16919458-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MCF7 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 18339839-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MDAMB231 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 18339839-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: MDAMB231 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 18339839-Fig-2d
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: PC3 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 18339839-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: 786O in BMS
    *** reqs: Rictor [RNAi]
    *** source: 19114562-Fig-1
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: WM35<xMtor> in BMS
    *** reqs: Rictor [RNAi]
    *** source: 18570873-Fig-7a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mEFs<xSgk1(61-431)> in BMS
    *** reqs: Rictor [RNAi]
    *** source: 18925875-Fig-1a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mEFs<xSgk1> in BMS
    *** reqs: Rictor [RNAi]
    *** source: 18925875-Fig-1c

Sin1--

  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Sin1 [RNAi]
    *** source: 16919458-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HELA in BMS
    *** reqs: Sin1 [RNAi]
    *** source: 16919458-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mEFs in BMS
    *** reqs: Sin1 [KO]
    *** source: 16962653-Fig-6b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mEFs in BMLS
    *** reqs: Sin1 [KO]
    *** source: 16962653-Fig-6b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** reqs: Sin1 [RNAi]
    *** source: 16962653-Fig-S1b
  *** Akt1[phosAb] phos(S473)[phosAb] is detectable
    *** cells: mEFs<xSgk1(61-431)> in BMS
    *** reqs: Sin1 [RNAi]
    *** source: 18925875-Fig-1e

=============================================
Basal Phosphorylation on T308
=============================================

Mtor--

  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: A549 in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HELA in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HT29 in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: PC3 in BMS
    *** reqs: Mtor [RNAi]
    *** source: 15718470-Fig-2b
  ------ contradictions -----------------------------
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** does not req: Mtor [RNAi]
    *** source: 17043309-Fig-2b

*** not Raptor--

  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: WM35<xMtor> in BMS
    *** does not req: Raptor [RNAi]
    *** source: 18570873-Fig-7a
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** does not req: Raptor [RNAi]
    *** source: 17043309-Fig-2b

*** Rictor--

  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: A549 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HELA in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HT29 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2a
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: PC3 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 15718470-Fig-2b
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** reqs: Rictor [RNAi]
    *** source: 17043309-Fig-2b
  ------ contradictions -----------------------------
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: WM35<xMtor> in BMS
    *** does not req: Rictor [RNAi]
    *** source: 18570873-Fig-7a

Sin1--

  *** Akt1[phosAb] phos(T308)[phosAb] is detectable
    *** cells: HEK293 in BMS
    *** partially reqs: Sin1 [RNAi]
    *** source: 17043309-Fig-2b

=====================================================================
Akt phos(S473) but not phos(T308) is increased by overexpressed Mtor
=====================================================================

  *** Akt1[phosAb] phos(S473)[phosAb] is increased itpo xMtor
    *** cells: WM35 in BMS
    *** source: 18570873-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased itpo xMtor
    *** cells: WM35 in BMS
    *** source: 18570873-Fig-3b
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable-but unchanged itpo xMtor
    *** cells: WM35 in BMS
    *** source: 18570873-Fig-3a
  *** Akt1[phosAb] phos(T308)[phosAb] is detectable-but unchanged itpo xMtor
    *** cells: WM35 in BMS
    *** source: 18570873-Fig-3b
  *** xAkt1[phosAb] phos(S473)[phosAb] is increased itpo xSin1
    *** cells: HEK293 in BMS
    *** source: 17043309-Fig-2c
  *** xAkt1[phosAb] phos(S473)[phosAb] is unchanged itpo xRaptor
    *** cells: HEK293 in BMS
    *** source: 17043309-Fig-2c
