not Casp1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: mPECs in BMS
    *** times: 0 5++ 15++ min
    *** does not req: Casp1 [KO]
    *** source: 17360653(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: THP1 in BMS
    *** times: 0 5+ 10+ 15++ 30++ 60++ 120 min
    *** unaffected by: Ac-YVAD-CMK [addition]
    *** source: 17360653(D)

not Ikk1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 min
    *** does not req: Ikk1 [KO]
    *** comment: decrease in phos at 30 min is not seen in Ikk-null cells
    *** source: 11733537-Fig-2

not Ikk2--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 min
    *** does not req: Ikk2 [KO]
    *** comment: decrease in phos at 30 min is not seen in Ikk-null cells
    *** source: 11733537-Fig-2

Irak1--

  *** P38a[Ab]IP IVKA(Mapkapk2)[32P-ATP] is increased irt IL1b (10 min)
    *** cells: mEFs in BMLS
    *** reqs: Irak1 [KO]
    *** source: 9625767(D)
  *** xP38a[tAb]IP IVKA(MBP)[32P-ATP] is increased irt IL1a (30 min)
    *** cells: HEK293 in BMS
    *** inhibited by: xIrak1(del(218-507))"DN" [addition]
    *** source: 10346818-Fig-1b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Irak1~null><xIrak1> in BMS
    *** times: 0 5++ 10++ 20+ 40 min
    *** reqs: xIrak1 [omission]
    *** unaffected by: xIrak1(K134R/K180R)"Ubiq-binding-site-mut" [substitution]
    *** source: 18347055-Fig-5c

Irak4--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10+ 30 60 min
    *** reqs: Irak4 [KO]
    *** source: 11923871(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: hFibros<Irak4~null> in BMS
    *** times: 0  10+ 20+ min
    *** reqs: Irak4 [KO]
    *** unaffected by: xIrak4(K213M/K214M)"KD" [addition]
    *** source: 15084582(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30+ min
    *** unaffected by: kIrak4(K213M/K214M)"KD" [substitution]
    *** source: 17470642-Fig-6e
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ min
    *** inhibited by: kIrak4(K213M/K214M)"KD" [substitution]
    *** source: 17337443-Fig-3a

Mekk1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: mESCs in BMS
    *** times: 0 10+ 30+ 60 min
    *** inhibited by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 10805784-Fig-2

not Mekk3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1a (times)
    *** cells: mEFs in BMLS
    *** times: 0 10++ 15++ 30+ min
    *** does not req: Mekk3 [KO]
    *** source: 18021073-Fig-8b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ 40+ 60+ min
    *** reqs: Mekk3 [KO]
    *** source: 14661019(D)

not Mkk4-- or Mkk7--

  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10++ 15+ 30+ 60+ min
    *** does not req: Mkk4 [KO]
    *** does not req: Mkk7 [KO]
    *** does not req: Mkk4 or Mkk7 [DKO]
    *** source: 11390361-Fig-5b

not Mlk3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 8++ 10++ 12++ 15++ 30 60 min
    *** does not req: Mlk3 [KO]
    *** source: 15831472(D)

not Nfkbiz--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 60 min
    *** does not req: Nfkbiz [KO]
    *** source: 15241416-Fig-S3b

not Pak1-- or Pak2--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (15 min)
    *** cells: HELA in BMS
    *** does not req: Pak1 or Pak2 [DRNAi]
    *** source: 16574378-Fig-4d

not Ripk1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10+ 15+ min
    *** does not req: Ripk1 [KO]
    *** source: 12776182-Fig-1c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30 60 min
    *** does not req: Ripk1 [KO]
    *** source: 14585994-Fig-1b

not Tab1-

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30+ 60 120 240 min
    *** does not req: Tab1 [KO]
    *** source: 16260493(D)

Tab2-- or Tab3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30+ 60 120 240 min
    *** does not req: Tab2 [KO]
    *** source: 16260493(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 20+ min
    *** does not req: Tab2 [KO]
    *** source: 12556483-Fig-4b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (10 min)
    *** cells: HELA in BMS
    *** partially reqs: Tab2 [RNAi]
    *** partially reqs: Tab3 [RNAi]
    *** reqs: Tab2 and/or Tab3 [DRNAi]
    *** source: 14633987-Fig-7c

Tak1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ 30 min
    *** partially reqs: Tak1 [KO]
    *** source: 16186825-Fig-3c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30+ 60 120 240 min
    *** reqs: Tak1 [KO]
    *** source: 16260493(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Tak1~null> in BMS
    *** times: 0+ 5++ 10++ 15++ 30+ min
    *** enhanced by: xTak1 [addition]
    *** partially inhibited by: xTak1(K158R) [addition]
    *** source: 20038579-Fig-7b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5++ 10++ 15++ 30+ min
    *** partially reqs: xTak1 [omission]
    *** partially inhibited by: xTak1(T178A/T184A) [substitution]
    *** source: 18617512-Fig-4d

not Ticam2--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 20+ 30 min
    *** does not req: Ticam2 [KO]
    *** source: 14556004(D)

not Tollip--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15+++ 30++ 60+ 180++ min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)

not Traf2--

  *** P38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30 60 min
    *** does not req: Traf2 [KO]
    *** source: 14585994-Fig-2a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10+ 15 min
    *** does not req: Traf2 [KO]
    *** source: 12776182-Fig-1c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (20 min)
    *** cells: EJ in BMS
    *** does not req: Traf2 [RNAi]
    *** source: 16260598-Fig-3e
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (20 min)
    *** cells: mEFs in BMS
    *** does not req: Traf2 [RNAi]
    *** source: 16260598-Fig-4b

Traf6--

  *** xP38a[tAb]IP IVKA(MBP)[32P-ATP] is increased irt IL1a (30 min)
    *** cells: HEK293 in BMS
    *** inhibited by: xTraf6(289-522)"DN" [addition]
    *** source: 10346818-Fig-1b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5+ 10++ 20+ min
    *** reqs: xTraf6 [omission]
    *** inhibited by: xTraf6(C70A)"E3-mut" [substitution]
    *** source: 18347055-Fig-3g
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5+ 15+ 30+ min
    *** inhibited by: xTraf6(110-522)"T6dR" [substitution]
    *** unaffected by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-S12e
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 30+ 60 360 720 1440 min
    *** unaffected by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-S12e
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0 5+ 20+ min
    *** reqs: xTraf6 [omission]
    *** inhibited by: xTraf6(C70A) [substitution]
    *** unaffected by: xTraf6(mnr)"K32-518R" [substitution]
    *** source: 19112497-Fig-3e

not Tpl2--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ 30+ 45 60 min
    *** does not req: Tpl2 [KO]
    *** source: 15833743-Fig-1c

Ubc13--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15++ min
    *** reqs: Ubc13 [KO]
    *** source: 19843958-Fig-4c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 15+ min
    *** comment: reqs Ubc13 [KO] at 5 min only
    *** source: 19843958-Fig-S8a


=========
chemicals
=========

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** unaffected by: PP2 [addition]
    *** source: 19754427-Fig-3b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** unaffected by: PS1145 [addition]
    *** source: 19754427-Fig-1c
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt IL1 (20 min)
    *** cells: HELA in BMS
    *** unaffected by: MG132 [addition]
    *** source: 16371247-Fig-3b
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt IL1 (20 min)
    *** cells: HELA in BMS
    *** unaffected by: SC514 [addition]
    *** source: 16371247-Fig-3c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (20 min)
    *** cells: HELA in BMS
    *** unaffected by: PP1 [addition]
    *** source: 16371247-Fig-5a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1a (30 min)
    *** cells: HEPG2 in BMLS "plated on collagen"
    *** unaffected by: Gefitinib [cotreatment]
    *** partially inhibited by: BMS345541 [cotreatment]
    *** unaffected by: PD325901 [cotreatment]
    *** unaffected by: PHA818637 [cotreatment]
    *** unaffected by: ZSTK474 [cotreatment]
    *** source: 19953085-Fig-S1
  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt IL1 (times)
    *** cells: CHO in BMLS
    *** times: 0 15+++ 30++ 60+ min
    *** partially inhibited by: SB203580 [addition]
    *** source: 9111305-Fig-5c
  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt IL1 (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 15+ 30+ 60++ min
    *** partially inhibited by: SB203580 [addition]
    *** source: 9111305-Fig-6c



=========
no extras
=========

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: mKidneyCells in BMS
    *** times: 0 15+ 30+ min
    *** source: 16737960-Fig-1d
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: 3T3L1 in BMS "differentiated into adipocytes"
    *** times: 0 5++ 10++ 15++ 30+ 60 120 360 720 min
    *** source: 17500068-Fig-4b
  *** P38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt IL1a (times)
    *** cells: HELA in BMS
    *** times: 0+ 15++ 30++ 60+ 120 min
    *** source: 7535770-Fig-6
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt IL1a (15 min)
    *** cells: HELA in BMS
    *** source: 9430721-Fig-5
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is unchanged irt IL1b (20 min)
    *** cells: HELA in BMS
    *** source: 8663524-Fig-5
  *** xP38b[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt IL1a (times)
    *** cells: HELA in BMS
    *** times: 0 15 45+ min
    *** source: 9430721-Fig-5
  *** xP38b[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt IL1b (20 min)
    *** cells: HELA in BMS
    *** source: 8663524-Fig-5
  *** xP38g[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt IL1a (15 min)
    *** cells: HELA in BMS
    *** source: 9430721-Fig-5
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1 (1 hr)
    *** cells: U373<xCd14> in BMS
    *** source: 12062447-Fig-4a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0 5+ 10++ 20++ min
    *** source: 16306937-Fig-S2b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTLR8> in BMS
    *** times: 0 15+ 30+ min
    *** source: 16737960-Fig-1c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt IL1b (15 min)
    *** cells: T42 in BMLS
    *** source: 20188673-Fig-4g
