===============
Kinase Activity
===============

Irak1--  ???

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (tnr)
    *** cells: HEK293 in BMS
    *** does not req: Irak1 [null-mut]
    *** source: 10373513-Fig-7a
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (tnr)
    *** cells: HEK293 in BMS
    *** partially reqs: Irak1 [null-mut]
    *** source: 10373513-Fig-7b

Map4k5--

  *** xJnk3[tAb]IP IVKA(Jun)[32P-ATP] is increased irt UV (15 min)
    *** cells: HEK293T in BMS
    *** reqs: Map4k5 [AntiSense]
    *** source: 9405407-Fig-4b

not Mekk3--

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (tnr)
    *** cells: mEFs in BMS
    *** does not req: Mekk3 [KO]
    *** source: 14661019(D)

not Mekk4--

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt UV (1 hr)
    *** cells: COS7 in BMLS
    *** unaffected by: xMekk4(K1371R)"DN" [addition]
    *** source: 9305639-Fig-11b

Mkk4-- and Mkk7--

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30++ 60++ 120+ 240+ min
    *** partially reqs: Mkk4 [KO]
    *** partially reqs: Mkk7 [KO]
    *** reqs: Mkk4 and/or Mkk7 [DKO]
    *** source: 11390361-Fig-5a

Myd88--  ???

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (tnr)
    *** cells: HEK293 in BMS
    *** partially reqs: Myd88 [null-mut]
    *** source: 10373513-Fig-7b

Jnk1 features

  *** xJnk1[tAb]IP IVKA(Jun)[InGelKinase] is increased irt UV (1 hr)
    *** cells: COS<xJnk1> in BMS
    *** inhibited by: xJnk1(T183A) [substitution]
    *** inhibited by: xJnk1(Y185F) [substitution]
    *** inhibited by: xJnk1(T183A/Y185F) [substitution]
    *** source: 8137421-Fig-9d
  *** xJnk1[tAb]IP phos[32Pi] is increased irt UV (1 hr)
    *** cells: COS<xJnk1> in BMS
    *** bkg inhibited by: xJnk1(T183A) [substitution]
    *** inhibited by: xJnk1(Y185F) [substitution]
    *** inhibited by: xJnk1(T183A/Y185F) [substitution]
    *** source: 8137421-Fig-9b


no extras

  *** Jnk1[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt UV (times)
    *** cells: HELA in BMS
    *** times: 0+ 15++ 30++ 60++ 120++ min
    *** source: 7535770-Fig-4
  *** Jnk1[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (60 min)
    *** cells: PC12 in BMLS
    *** source: 9094716-Fig-2b
  *** Jnk1[Ab]IP IVKA(Stat3)[32P-ATP] is increased irt UV (30 min)
    *** cells: COS1 in BMS
    *** source: 10521505-Fig-2a
  *** xJnk1[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt UV (1 hr)
    *** cells: COS1 in BMS
    *** source: 8622669-Fig-2a
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt UV (5 min)
    *** cells: COS7 in BMS
    *** source: 8805275-Fig-4a
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt UV (20 min)
    *** cells: HELA in BMS
    *** source: 9535930-Fig-3a
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt UV (tnr)
    *** cells: HEK293 in BMS
    *** source: 9135144-Fig-5a
  *** Jnks[Ab] copptby[WB] Mekk1[Ab] is increased irt UV (60 min)
    *** cells: HEK293 in BMS
    *** source: 12228228-Fig-7b
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (1 hr)
    *** cells: hFibros in BMS
    *** source: 11283254-Fig-2b
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (1 hr)
    *** cells: MDCK in BMLS
    *** source: 9405400-Fig-1b
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (60 min)
    *** cells: HEK293 in BMS
    *** source: 12228228-Fig-4b
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (times)
    *** cells: mEFs in BMS
    *** times: 0 30++ 60++ 120++ 480+ 960+ min
    *** source: 11390361-Fig-4d
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt UV (1 hr)
    *** cells: COS<xJnk1> in BMS
    *** enhanced by: xHras(Q61L) [addition]
    *** source: 8137421-Fig-5a
  *** xJnk1[tAb]IP IVKA(Jun)[InGelKinase] is increased irt UV (1 hr)
    *** cells: COS<xJnk1> in BMS
    *** source: 8137421-Fig-1a
  *** xJnk1[tAb]IP IVKA(Jun)[InGelKinase] is increased irt UV (1 hr)
    *** cells: COS<xJnk1> in BMS
    *** source: 8137421-Fig-1d
  *** xJnk1[tAb]IP IVKA(Jun)[InGelKinase] is increased irt UV (times)
    *** cells: COS<xJnk1> in BMS
    *** times: 0 15+ 30++ 60+++ 90++ 120+ min
    *** source: 8137421-Fig-1c
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (times)
    *** cells: HELA in BMLS
    *** times: 0 5 10+ 15++ 30++ 45++ 60++ min
    *** source: 8846788-Fig-1
  *** Jnk1[Ab]IP IVKA(Jun)[32P-ATP] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** source: 11777913-Fig-4b
  *** xJnk1[Ab]IP IVKA(Elk1)[32P-ATP] is increased irt UV (30 min)
    *** cells: NIH3T3<xJnk1> in BMLS
    *** source: 8548291-Fig-3a
  *** xJnk3[Ab]IP IVKA(Elk1)[32P-ATP] is increased irt UV (30 min)
    *** cells: NIH3T3<xJnk3> in BMLS
    *** source: 8548291-Fig-3a

===========================
Phosphorylation on TPY Site
===========================

chemicals

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: LY294002 [pretreatment]
    *** unaffected by: xPik3c?(mnr)"DN" [addition]
    *** source: 11350959-Fig-4
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMS
    *** unaffected by: H89 [pretreatment]
    *** inhibited by: PD98059 [pretreatment]
    *** unaffected by: SB202190 [pretreatment]
    *** source: 11441012-Fig-5d
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt UV (times)
    *** cells: JB6CL41 in BMS
    *** times: 0 15+ 30++ 60+ 120 min
    *** unaffected by: H89 [pretreatment]
    *** source: 11441012-Fig-4c
  *** Jnks[phosAb] phos(TEY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** unaffected by: SB202190 [pretreatment]
    *** source: 11983683-Fig-2c

other

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: xJnk1(mnr)"DN" [addition]
    *** source: 11896587-Fig-2a
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt UV (tnr)
    *** cells: H1299<Tp53~null><xTp53> in BMS
    *** inhibited by: xDusp10 [addition]
    *** source: 11283254-Fig-5a

no extras

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt UV (times)
    *** cells: VH10 in BMLS
    *** times: 0 15+ 120+ min
    *** source: 12110590-Fig-1d
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt UV (times)
    *** cells: JB6CL41 in BMS
    *** times: 0 15++ 30+ 60+ min
    *** source: 11441012-Fig-3c


