=============
Transcription
=============

Tpl2--

  *** Ptgs2-gene mRNA[RTPCR] is increased irt Lps (1 hr)
    *** cells: mBMMs in BMS
    *** partially reqs: Tpl2 [KO]
    *** source: 12234923-Fig-3a
  *** Ptgs2-gene promo-reporter[Luc] is increased irt Lps (12 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xTpl2(mnr)"KD" [addition]
    *** source: 12234923-Fig-3c

chemicals

  *** Ptgs2-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: RAW2647 in BMS
    *** unaffected by: SB203580 [pretreatment]
    *** unaffected by: PD98059 [pretreatment]
    *** partially inhibited by: SB203580 + PD98059 [pretreatment]
    *** inhibited by: Ro318220 [pretreatment]
    *** source: 10706690-Fig-5b
  *** Ptgs2-gene promo-reporter[Luc] is increased irt Lps (12 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: PD98059 [pretreatment]
    *** inhibited by: Ro318220 [pretreatment]
    *** source: 12234923-Fig-6c

no extras

  *** Ptgs2-gene mRNA[MicroArray] is increased irt Lps (3 hr)
    *** cells: THP1 in BMS
    *** source: 22833096-Table-S1a
  *** Ptgs2-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 2+ 4+ 6+ 8+ hr
    *** source: 10706690-Fig-5a

===========
Translation
===========

Nfkb1--

  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (2 hr)
    *** cells: mBMMs<Nfkb1~null><xNfkb1> in BMS
    *** partially reqs: xNfkb1 [omission]
    *** source: 12667451-Fig-5a
  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 20 60 120+ 360+ min
    *** partially reqs: Nfkb1 [KO]
    *** source: 12667451-Fig-5a

Tpl2--

  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 60 180+ 270++ 360++ 600++ min
    *** partially reqs: Tpl2 [KO]
    *** source: 12234923-Fig-2a

chemicals

  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** partially inhibited by: H89 [pretreatment]
    *** source: 10706690-Fig-6c
  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** partially inhibited by: SB203580 [pretreatment]
    *** partially inhibited by: PD98059 [pretreatment]
    *** inhibited by: SB203580 + PD98059 [pretreatment]
    *** inhibited by: Ro318220 [pretreatment]
    *** source: 10706690-Fig-4b
  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS
    *** inhibited by: PS1145 [pretreatment]
    *** source: 15199157-Fig-1e

no extras

  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 3+ 6+ hr
    *** source: 10706690-Fig-7d
  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 30 60 120+ 240++ 360++ 720++ min
    *** source: 10706690-Fig-4a
  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 30 180+ 360+ min
    *** source: 12234923-Fig-S1b
  *** Ptgs2[Ab] prot-exp[WB] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 30 180+ 360++ min
    *** source: 12234923-Fig-S1b


==============
PGE2 secretion
==============

Tpl2--


  *** PGE2[Ab] secretion[ELISA] is increased irt Lps (270 min)
    *** cells: mBMMs in BMS
    *** times: 0 180+ 270++ 360++ 600++ min
    *** inhibited by: PD98059 [pretreatment]
    *** source: 12234923-Fig-1

chemicals

  *** PGE2[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 180+ 270++ 360++ 600++ min
    *** reqs: Tpl2 [KO]
    *** source: 12234923-Fig-1
