===============
Kinase activity
===============

  *** rIkk2[32P] phos[32P-ATP] is detectable
    *** cells: none
    *** source: 11520989-Fig-4b
  *** rIkk2[32P] phos[32P-ATP] is detectable
    *** cells: none
    *** unaffected by: rIkba [addition]
    *** unaffected by: rIkba(D31A) [addition]
    *** unaffected by: rIkba(D31E) [addition]
    *** unaffected by: rIkba(G33A) [addition]
    *** unaffected by: rIkba(S32A/S36A) [addition]
    *** source: 10514433-Fig-2a

  *** xIkk2[tAb]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** source: 12559944-Fig-4c
  *** xIkk2[tAb]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: HEK293T in BMS
    *** source: 14585847-Fig-3a,3b
  *** xIkk2[tAb]IP IVKA(Ikba)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** source: 12559944-Fig-4c
  *** xIkk2[tAb]IP IVKA(Ikba)[32P-ATP] is detectable
    *** cells: HELA in BMS
    *** source: 9689078-Fig-2a
  *** xIkk2[tAb]IP IVKA(Rela)[32P-ATP] is detectable
    *** cells: HELA in BMS
    *** source: 10521409-Fig-4c

Ikk2 attributes

  *** xIkk2[tAb]IP IVKA(Ikba)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** inhibited by: xIkk2(S177A/S181A) [substitution]
    *** unaffected by: xIkk2(S177A) [substitution]
    *** unaffected by: xIkk2(S181A) [substitution]
    *** source: 10195894-Fig-2c
  *** xIkk2[tAb]IP IVKA(Ikba)[32P-ATP] is detectable
    *** cells: HELA in BMS
    *** inhibited by: xIkk2(mnr)"KD" [substitution]
    *** source: 11864612-Fig-1b
  *** xIkk2[tAb]IP IVKA(Ikba)[32P-ATP] is detectable
    *** cells: HELA in BMS
    *** inhibited by: xIkk2(S177A/S181A) [substitution]
    *** partially inhibited by: xIkk2(S177A) [substitution]
    *** partially inhibited by: xIkk2(S181A) [substitution]
    *** source: 10195894-Fig-2b

reqs Muc1--

  *** Ikk2[Ab]IP IVKA(Ikba)[32P-ATP] is detectable
    *** cells: ZR751<xMuc1> in BMS
    *** reqs: Muc1 [RNAi]
    *** source: 18037881-Fig-3e

inhibited by Ppp2cb

  *** xIkk2[tAb]IP IVKA(Ikba)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** inhibited by: xPpp2cb [addition]
    *** unaffected by: xPpp2cb(R179G)"phosphatase-defective-mut" [addition]
    *** source: 14585847-Fig-3a,3b

===============
Phosphorylation
===============

  *** Ikk2[Ab]IP phos(S181)[phosAb] is detectable
    *** cells: ZR751<xMuc1> in BMS
    *** reqs: Muc1 [RNAi]
    *** source: 18037881-Fig-3d
  *** xIkk2[tAb]IP phos[32Pi] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xPpp2cb [addition]
    *** unaffected by: xPpp2cb(R179G)"phosphatase-defective-mut" [addition]
    *** source: 14585847-Fig-2b

================
Coprecipitations
================

not Azi2--

  *** xIkk2[tAb] copptby[WB] xAzi2[tAb] is undetectable
    *** cells: HEK293T in BMS
    *** source: 14560022-Fig-2c

Irf7--

  *** Ikk2[Ab] copptby[WB] Irf7[Ab] is detectable
    *** cells: mBMfDCs in BMS
    *** source: 16612387-Fig-3d

Mavs--

  *** xIkk2[tAb] copptby[WB] xMavs[tAb] is detectable
    *** cells: HEK293T in BMS
    *** source: 16177806-Fig-3a

Mekk3--

  *** Ikk2[Ab] copptby[WB] xMekk3[tAb] is undetectable
    *** cells: HEK293 in BMS
    *** source: 15572679-Fig-8a

Nemo--

  *** Ikk2[Ab] copptby[WB] Nemo[Ab] is detectable
    *** cells: ZR751<xMuc1> in BMS
    *** reqs: Muc1 [RNAi]
    *** source: 18037881-Fig-3b
  *** xIkk2[tAb] copptby[WB] xNemo[Ab] is detectable
    *** cells: HEK293 in BMS
    *** source: 12133833-Fig-4c
  *** Ikk2[Ab] copptby[WB] xNemo[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 15572679-Fig-8a

not Nod1--

  *** xIkk2[tAb] copptby[WB] xNod1[tAb] is undetectable
    *** cells: HEK293 in BMS
    *** source: 10329646(D)

Pkca--

  *** xIkk2[tAb] copptby[WB] xPkca[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10022904-Fig-1a

Pkci--

  *** xIkk2[tAb] copptby[WB] xPkci[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10022904-Fig-1a

Pkcz--

  *** xIkk2[tAb] copptby[WB] xPkcz[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10022904-Fig-1b

Ppp2cb--

  *** Ikk2[Ab] copptby[WB] Ppp2cb[Ab] is detectable
    *** cells: HELA in BMS
    *** source: 14585847-Fig-1d
  *** Ikk2[Ab] copptby[WB] xPpp2cb[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 14585847-Fig-1b

Trpc4ap--

  *** xIkk2[tAb] copptby[WB] xTrpc4ap[tAb] is detectable
    *** cells: COS7 in BMS
    *** source: 14585990-Fig-7a
