=============
Gal4 Activity
=============

Azi2-- ???

  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR4><xMd2><xCd14> in BMS
    *** bkg inhibited by: xAzi2(158-270)"DN" [addition]
    *** source: 15611223-Fig-3d

not Pin1-- inhibitory

  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Lps (tnr)
    *** cells: U373<xCd14> in BMS
    *** inhibited by: xPin1 [addition]
    *** source: 16699525-Fig-1i

Tirap--

  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Lps (4 hr)
    *** cells: U373 in BMS
    *** inhibited by: xTirap(P125H)"DN" [addition]
    *** source: 12062447-Fig-5a

Trif--

  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293 in BMS
    *** reqs: Trif [RNAi]
    *** source: 14519765(D)

Ticam2--

  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293 in BMS
    *** reqs: Ticam2 [RNAi]
    *** source: 14519765(D)
  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Lps (8 hr)
    *** cells: HEK293<xTLR4><xMd2> in BMS
    *** partially inhibited by: xTicam2(C113H)"DN" [addition]
    *** source: 14517278-Fig-1c,4b

not TLR3--

  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293 in BMS
    *** does not req: TLR3 [RNAi]
    *** source: 14519765(D)

=============
Oligo-binding
=============

  *** Irf3[Ab] oligo-binding[EMSA] is increased irt Lps (1 hr)
    *** cells: U373<xCd14> in BMS
    *** source: 12062447-Fig-2a

===============
Phosphorylation
===============

phos(S339)

  *** Irf3[phosAb] phos(S339)[phosAb] is increased irt Lps (2 hr)
    *** cells: U373<xCd14> in BMS
    *** source: 16699525-Fig-2h
  *** Irf3[phosAb] phos(S339)[phosAb] is increased irt Lps (times)
    *** cells: U373<xCd14> in BMS
    *** times: 0 1+ 3++ 9++ hr
    *** source: 16699525-Fig-S1a

phos(S396)

  *** Irf3[phosAb] phos(S396)[phosAb] is increased irt Lps (times)
    *** cells: U373<xCd14> in BMS
    *** times: 0 1+ 3 9 hr
    *** source: 16699525-Fig-S1b

chemicals

  *** Irf3[phosAb] phos(sitenr)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 20 40+ min
    *** inhibited by: Dynasore [addition]
    *** source: 18297073-Fig-1c



