=============================================================
phosphorylation of Mek1 on S218/S222 in the presence of Pak2
requires Mek1 kinase activity
=============================================================

  *** rMek1[phosAb] phos(S218/S222)[phosAb] is increased by rPak3
    *** cells: none
    *** comment: rxn also contains rErk2-KD
    *** inhibited by: rMek1(K97A)"KD" [substitution]
    *** inhibited by: rMek1(S298A) [substitution]
    *** unaffected by: rMek1(T292A) [substitution]
    *** source: 17314031-Fig-4a

=======================================
phosphorylation of Mek1 on S298 by Pak2
=======================================

  *** rMek1[phosAb] phos(S298)[phosAb] is increased by rPak3
    *** cells: none
    *** comment: rxn also contains rErk2-KD
    *** unaffected by: rMek1(K97A)"KD" [substitution]
    *** inhibited by: rMek1(S298A) [substitution]
    *** unaffected by: rMek1(T292A) [substitution]
    *** source: 17314031-Fig-4a
  *** rMek1[phosAb] phos(S298)[phosAb] is increased by rPak3
    *** cells: none
    *** unaffected by: rMek1(T292A) [substitution]
    *** inhibited by: rMek1(T292D) [substitution]
    *** source: 14993270-Fig-5a
  *** rMek1[phosAb] phos(S298)[phosAb] is increased by rPak3
    *** cells: none
    *** source: 12876277-Fig-2a

=======================================
phosphorylation of Mek1 by Pak2
=======================================

  *** rMek1[32P] phos[32P-ATP] is increased by rPak3
    *** cells: none
    *** source: 12876277-Fig-2a
