========================
Tyrosine Phosphorylation
========================

  *** Shp2[Ab]IP Yphos[pYAb] is increased irt IL2 (5 min)
    *** cells: HEK293T<xIL2Ra><xIL2Rb><xIL2Rg><xJak3><xGab2> in BMS
    *** inhibited by: xIL2Rb(Y338F) [substitution]
    *** source: 10849428-Fig-4b
  *** Shp2[Ab]IP Yphos[pYAb] is increased irt IL2 (5 min)
    *** cells: hPBTCs in BMLS
    *** source: 9973481-Fig-1a

===========================
Recruitment to IL2R complex
===========================

Gab2--

  *** Shp2[Ab] copptby[WB] Gab2[Ab] is increased irt IL2 (times)
    *** cells: KIT225 in BMS "starved"
    *** times: 0 5++ 10++ 30++ 60++ 90+ min
    *** unaffected by: U0126 [pretreatment]
    *** source: 15356145-Fig-4
  *** Shp2[Ab] copptby[WB] xGab2[tAb] is increased irt IL2 (10 min)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** inhibited by: xGab2(Y614F) [substitution]
    *** source: 15170389-Fig-2a

Grb2--

  *** Shp2[Ab] copptby[WB] Grb2[Ab] is increased irt IL2 (5 min)
    *** cells: hPBTCs in BMS
    *** source: 9590209-Fig-1c
  *** Shp2[Ab] copptby[WB] Grb2[Ab] is increased irt IL2 (times)
    *** cells: NK33 in BMS
    *** times: 0 5+ 20++ min
    *** source: 9590209-Fig-1a

Jak1--

  *** Shp2[Ab] copptby[WB] Jak1[Ab] is detectable-but unchanged irt IL2 (5 min)
    *** cells: hPBTCs in BMS
    *** source: 9590209-Fig-2d

Jak3--

  *** Shp2[Ab] copptby[WB] Jak3[Ab] is detectable-but unchanged irt IL2 (5 min)
    *** cells: hPBTCs in BMS
    *** source: 9590209-Fig-2c
  *** Shp2[Ab] copptby[WB] Jak3[Ab] is detectable-but unchanged irt IL2 (5 min)
    *** cells: NK33 in BMS
    *** source: 9590209-Fig-2a

Pi3k--

  *** Shp2[Ab] copptby[WB] Pik3rs[Ab] is increased irt IL2 (5 min)
    *** cells: hPBTCs in BMS
    *** source: 9590209-Fig-1d
  *** Shp2[Ab] copptby[WB] Pik3rs[Ab] is increased irt IL2 (times)
    *** cells: NK33 in BMS
    *** times: 0 5++ 10++ 15+ min
    *** source: 9590209-Fig-1b

