==========================
Relocation to InsR complex
==========================

  *** Pi3k[Ab] copptby[WB] Irs1[Ab] is increased irt Ins (times)
    *** cells: FAO in BMLS
    *** times: 0 1+ 10+ min
    *** source: 10688912(D)
  *** Pi3k[Ab] copptby[WB] Irs2[Ab] is increased irt Ins (times)
    *** cells: FAO in BMLS
    *** times: 0 1+ 10+ min
    *** source: 10688912(D)
  *** Pik3rs[Ab] copptby[WB] Grb2[Ab] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xInsR(Y1158F) [substitution]
    *** unaffected by: xInsR(Y1162F/T1163F) [substitution]
    *** source: 7806540-Fig-1a
  *** Pik3rs[Ab] copptby[WB] Irs1[Ab] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xInsR(Y1158F) [substitution]
    *** unaffected by: xInsR(Y1162F/T1163F) [substitution]
    *** inhibited by: xInsR(Y1158F/T1162F) [substitution]
    *** source: 7806540-Fig-1a
  *** Pik3rs[Ab] copptby[WB] Irs1[Ab] is increased irt Ins (30 min)
    *** cells: MDAMB453 in BMLS
    *** enhanced by: xTsc1 [addition]
    *** enhanced by: xTsc1(mnr)"SSAA" [addition]
    *** unaffected by: xTsc1(mnr)"SSDD" [addition]
    *** source: 18949383-Fig-2a

============================
Phosphorylation on Tyrosine
============================

  *** Pik3c2b[Ab] Yphos[pYAb-ppt] is increased irt Ins (5 min)
    *** cells: HEK293 in BMLS
    *** source: 10805725-Fig-5a
  *** Pik3c2b[Ab] Yphos[pYAb-ppt] is unchanged irt Ins (5 min)
    *** cells: COS7 in BMLS
    *** source: 10805725-Fig-5c
  *** Pik3r1[Ab] Yphos[pYAb-ppt] is increased irt Ins (5 min)
    *** cells: HEK293 in BMLS
    *** source: 10805725-Fig-5b
  *** Pik3r1[Ab] Yphos[pYAb-ppt] is unchanged irt Ins (5 min)
    *** cells: COS7 in BMLS
    *** source: 10805725-Fig-5d

=====================
Lipid Kinase Activity
=====================

  *** Pik3r1[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Ins (10 min)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 11777913-Fig-7c
