  --- Gal4-act
  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased itpo xIkke
    *** cells: HEK293T in BMS
    *** source: 12692549-Fig-2a
  --- dimerization
  *** xIrf3[tAb] oligomerization[NativeWB] is increased itpo xIkke
    *** cells: HEK293T in BMS
    *** source: 14703513-Fig-3a
  *** xIrf3[tAb] oligomerization[NativeWB] is increased itpo xIkke
    *** cells: HEK293 in BMS
    *** source: 16199137-Fig-4a
  --- phos(S386)
  *** xIrf3[phosAb] phos(S386)[phosAb] is increased itpo xIkke
    *** cells: HEK293T in BMS
    *** source: 14703513-Fig-3a
  --- phos(S396)
  *** Irf3[phosAb] phos(S396)[phosAb] is increased itpo xIkke
    *** cells: VERO in BMS
    *** source: 12702806-Fig-2a
  *** xIrf3[phosAb] phos(S396)[phosAb] is increased itpo xIkke
    *** cells: HEK293 in BMS
    *** comment: only the dimer (not monomer) is phosed
    *** source: 16199137-Fig-4b
  --- oligo-binding
  *** xIrf3[Ab] oligo-binding[EMSA] is increased itpo xIkke
    *** cells: HEK293 in BMS "whole cell lysates"
    *** source: 12702806-Fig-2c
  *** Irf3[Ab] oligo-binding[ELISA] is increased itpo xIkke
    *** cells: HEK293 in BMS
    *** source: 16199137-Fig-5a
  --- relocation
  *** xIrf3[XFP] locatedin(nucleus)[IHC] is increased itpo xIkke
    *** cells: COS7 in BMS
    *** inhibited by: xIkke(K38A) [substitution]
    *** source: 12702806-Fig-2b
  *** xIrf3[XFP] locatedin(nucleus)[IHC] is increased itpo xIkke
    *** cells: HEK293 in BMS
    *** inhibited by: xIkke(K38A) [substitution]
    *** source: 16199137-Fig-4c
  --- RE-reporter
  *** ISRE-reporter[Luc] is increased itpo xIkke
    *** cells: MDCK in BMHIS
    *** inhibited by: xRac1(T17N)"DN" [addition]
    *** inhibited by: xPak1(K299R)"DN" [addition]
    *** source: 15178328-Fig-5a
  --- direct phos
  *** rIrf3(380-427)[32P] phos[32P-ATP] is increased by rIkke
    *** cells: none
    *** unaffected by: rIrf3((380-427)/S385A/S386A) [substitution]
    *** partially inhibited by: rIrf3((380-427)/S396A/S398A/S402A/T404A/S405A) [substitution]
    *** inhibited by: rIrf3((380-427)/S385A/S386A/S396A/S398A/S402A/T404A/S405A) [substitution]
    *** source: 14679297-Fig-1a
  *** rIrf3(382-414)[32P] phos[32P-ATP] is increased by rIkke
    *** cells: none
    *** inhibited by: rIrf3((382-414)/S405A/T404A/S405A) [substitution]
    *** source: 15367631-Fig-8a

