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Requirement for TLR4 Lbp Md2 Cd14 from review articles - need data
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Ampka1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0+ 5+ 15 30+ 45+ 60+ min
    *** reqs: Ampka1 [RNAi]
    *** source: 22833096-Fig-2g

Casp1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0+ 20 30 60+ min
    *** reqs: Casp1 [KO]
    *** source: 17360653-Fig-1b

not Cebpb--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mSPImacs in BMS
    *** times: 0++ 10+ 30 60+ 120++ min
    *** does not req: Cebpb [KO]
    *** source: 19733238-Fig-3c

Ikk1--  ???

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10+ 30 60 min
    *** partially reqs: Ikk1 [KO]
    *** source: 12759443-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mSpBCs in BMS
    *** times: 0+ 60 90 min
    *** does not req: Ikk1 [KO]
    *** source: 11520989-Fig-2a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15+ 30 60 min
    *** does not req: Ikk1 [KO]
    *** source: 17244613-Fig-1f

Ikk2-- ???

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10+ 30 60 min
    *** reqs: Ikk2 [KO]
    *** source: 12759443-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (45 min)
    *** cells: hMDMacs in BMS
    *** unaffected by: xIkk2(mnr)"DN" [addition]
    *** source: 14630816(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (45 min)
    *** cells: hUVECs in BMS
    *** unaffected by: xIkk2(mnr)"DN" [addition]
    *** source: 14630816(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15+ 30 60 min
    *** reqs: Ikk2 [KO]
    *** source: 17244613-Fig-1f

Ikk1 and/or Ikk2--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 60+ 120+ min
    *** reqs: Ikk1 and/or Ikk2 [DKO]
    *** source: 10898787-Fig-2b

not Irak3--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 10+ 20 60 min
    *** repressed by: Irak3 [KO]
    *** source: 12150927-Fig-4b

Irak4--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0++ 1+ 2 3 hr
    *** partially reqs: Irak4 [KO]
    *** source: 11923871(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 30 60+ 120+ min
    *** reqs: Irak4 [KO]
    *** source: 14634120-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 10 30 min
    *** inhibited by: xIrak4(K213M/K214M)"KD" [addition]
    *** source: 17470642-Fig-6a

Myd88-- ???  replaced by Trif ???

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 15+ 30 45+ 90++ min
    *** partially reqs: Myd88 [KO]
    *** source: 11607032-Fig-6a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 20 30 60 min
    *** partially reqs: Myd88 [KO]
    *** comment: Myd88 is needed at 60 min not 20,30 min
    *** partially reqs: Myd88 and/or Tradd [DKO]
    *** source: 18641654-Fig-5e
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0++ 30+ 60 min
    *** comment: reqs Myd88 [KO] at 30 min not 60 min
    *** comment: reqs Myd88 and/or Tradd [DKO] at both 30 and 60 min
    *** source: 18641654-Fig-5d
  --- no
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (45 min)
    *** cells: hMDMacs in BMS
    *** unaffected by: xMyd88(F56N/del(1-53))"DN" [addition]
    *** source: 14630816(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (45 min)
    *** cells: hUVECs in BMS
    *** unaffected by: xMyd88(F56N/del(1-53))"DN" [addition]
    *** source: 14630816(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 30 60+ 120+ min
    *** does not req: Myd88 [KO]
    *** source: 14634120-Fig-1c

Nemo--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15+ 30 60 min
    *** reqs: Nemo [KO]
    *** source: 17244613-Fig-1f
  ------ does not req Nemo(S85) ----------------------
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(S85A) [substitution]
    *** source: 16497931-Fig-1b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (30 min)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(ubiq/S85A) [substitution]
    *** source: 16497931-Fig-3b
  ------ does not req Nemo(K277/K309) ----------------------
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (1 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(K277A) [substitution]
    *** unaffected by: xNemo(K309A) [substitution]
    *** source: 14651848-Fig-2d
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (1 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(K277A/K309A) [substitution]
    *** source: 14651848-Fig-2e


Nfkb1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 15 30 min
    *** does not req: Nfkb1 [KO]
    *** source: 12667451-Fig-1e


not Nlrp3--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 10+ 20 60 min
    *** does not req: Nlrp3 [KO]
    *** source: 16407890(D)

not Nod2--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 10+ 20 60 min
    *** does not req: Nod2 [KO]
    *** source: 16407890(D)

not Pias1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS "cytoplasmic-extracts"
    *** times: 0++ 10 30+ 60++ min
    *** unaffected by: Pias1 [KO]
    *** source: 15657437-Fig-6a

not Ripk1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 5+ 15 30+ min
    *** does not req: Ripk1 [KO]
    *** source: 12654725-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 30 45 90+ min
    *** reqs: Ripk1 and/or Myd88 [DKO]
    *** source: 16115877-Fig-4a,4b,4c

not Socs1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0+ 15+ 30 60+ 360+ hr
    *** comment: delayed by 30 min in Socs1-null cells
    *** source: 12433365-Fig-5d

Tak1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mSpBCs in BMS
    *** times: 0+ 15+ 30 60 min
    *** reqs: Tak1 [KO]
    *** source: 16186825(D)

Trif--  ???

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0+ 10+ 30 60 min
    *** does not req: Trif [KO]
    *** does not req: Myd88 [KO]
    *** reqs: Trif and/or Myd88 [DKO]
    *** source: 12872135-Fig-5b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0++ 10 30+ 60++ min
    *** does not req: Trif [KO]
    *** source: 12872135-Fig-2a

not Tirap--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (45 min)
    *** cells: hMDMacs in BMS
    *** unaffected by: xTirap(P125H)"DN" [addition]
    *** source: 14630816(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (45 min)
    *** cells: hUVECs in BMS
    *** unaffected by: xTirap(P125H)"DN" [addition]
    *** source: 14630816(D)

not TLR3--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 20 60 120+ min
    *** does not req: TLR3 [KO]
    *** source: 11607032-Fig-3d

not Tollip--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 20 40+ 75+ min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0+ 10 30 min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)

Traf6--

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 10+ 30 60 min
    *** partially reqs: Traf6 [KO]
    *** source: 16306937-Fig-4a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mSMacs in BMS
    *** times: 0+ 10 20 30 60 90 min
    *** partially reqs: Traf6 [KO]
    *** source: 15322147-Fig-3a

chemicals

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10+ 30 60+ min
    *** inhibited by: LY294002 [addition]
    *** source: 12759443-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (30 min)
    *** cells: THP1 in BMS
    *** reversed by: Lps [preconditioning]
    *** source: 21220427-Fig-6c
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0+ 5+ 30 60 min
    *** reversed by: Lps [preconditioning]
    *** source: 21220427-Fig-2
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (60 min)
    *** cells: 70Z3 in BMS
    *** inhibited by: ALLN [addition]
    *** source: 9150141-Fig-5a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** reversed by: 15dPGJ2 [pretreatment]
    *** source: 15199157-Fig-2c
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (20 min)
    *** cells: mBMMs in BMS "cytoplasmic extracts"
    *** reversed by: PS1145 [pretreatment]
    *** source: 15199157-Fig-1a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** reversed by: Bay117082 [pretreatment]
    *** source: 15485931-Fig-5b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 7 15 30+ min
    *** reversed by: MG132 [pretreatment]
    *** source: 15485931-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0+ 5+ 10 30 60 min
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-1a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0++ 5++ 10+ 30 min
    *** reversed by: MG132 [pretreatment]
    *** source: 19898473-Fig-S2c

other

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (30 min)
    *** cells: HEK293<xTLR4><xMd2> in BMS
    *** reversed by: xTnfaip3 [addition]
    *** source: 21220427-Fig-7a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 30 60+ min
    *** comment: reappearance of Ikba after 30 min reqs Tax1bp1 [KO]
    *** source: 20185725-Fig-S1e

no extras

  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: hPBMCs in BMS
    *** times: 0+ 30 60+ 120+ 300+ min
    *** source: 15925273(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0+ 30 60+ 120+ 300+ min
    *** source: 15925273(D)
  *** Ikba[Ab] prot-exp[WB] is unchanged irt Lps (times)
    *** cells: J774A1 in BMS
    *** times: 0+ 30+ 60+ 120+ 300+ min
    *** source: 15925273(D)
  *** Ikba[Ab] prot-exp[WB] is unchanged irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10+ 20+ 40+ 60+ min
    *** source: 14661019(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0++ 10+ 30 60 120+ 240++ min
    *** source: 12759443-Fig-1e
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0+ 5 10 15 30 60 min
    *** source: 16415872-Fig-1a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0++ 10++ 20+ 30 60+ 120++ min
    *** source: 10477696-Fig-6a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0++ 15++ 30++ 45+ 60 75 90++ 105+ 120+ 135+ min
    *** source: 10455128-Fig-5a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0++ 15+ 30 60 90 120 180+ min
    *** source: 9804806-Fig-3
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: THP1 in BMS "treated with PMA (2 days)"
    *** times: 0+ 30 60+ 120+ 300+ min
    *** source: 15925273(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0++ 2++ 5++ 10 20 30+ min
    *** source: 12842894-Fig-2c
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0++ 10 30+ 60+ 120+ min
    *** source: 12759443-Fig-1b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0+ 7 15 30+ 60+ 90+ min
    *** source: 12096038-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: 70Z3 in BMS
    *** times: 0+ 30 60 120 min
    *** source: 9150141-Fig-4a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS "immortalized"
    *** times: 0+ 5 10 20 40 60+ min
    *** source: 22065573-Fig-3a
