===================================================
Smad7 requires Smurf1 with NES to exit the nucleus
===================================================

  *** xSmad7[tAb] locatedin(nucleus)[IHC] is decreased itpo xSmurf1(C710A)"CIA"
    *** cells: HELA in BMS
    *** inhibited by: xSmurf1(I638A/L640A)"NES-mut" [substitution]
    *** source: 12519765-Fig-4c,4d
  *** xSmad7[tAb] locatedin(cytoplasm)[IHC] is increased itpo xSmurf1
    *** cells: HELA<xTgfbR1(mnr)"CA"> in BMS
    *** unaffected by: xSmurf1(del(22-37))"del-C2-domain" [substitution]
    *** comment: pattern may not extend as far as cellmembrane itpo xSmurf1(del(22-37))
    *** source: 12151385-Fig-1c
  *** xSmad7[tAb] locatedin(cytoplasm)[IHC] is increased itpo xSmurf1
    *** cells: HELA<xTgfbR1(mnr)"CA"> in BMS
    *** unaffected by: xSmurf1(del(22-37))"del-C2-domain" [substitution]
    *** comment: pattern may not extend as far as cellmembrane itpo xSmurf1(del(22-37))
    *** source: 12151385-Fig-1d

=============================================
Smad7/Smurf1 require Crm1 to exit the nucleus
==============================================

  *** xSmad7[tAb] locatedin(nucleus)[IHC] is decreased itpo xSmurf1(C710A)"CIA"
    *** cells: HELA in BMS
    *** inhibited by: LMB [addition]
    *** source: 12519765-Fig-1a,1b

