=============
Transcription
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Cd38--  ???

  *** Ifng-gene mRNA[RTPCR] is increased irt IL12 (tnr)
    *** cells: hPBTCs in BMS "preactivated with Cd3/Cd28"
    *** unaffected by: anti-Cd28 [cotreatment]
    *** source: 15522880-Fig-2

IfngR1--

  *** Ifng-gene mRNA[RTPCR] is increased irt IL12 (2 days)
    *** cells: mSpCD4TCs in BMS
    *** reqs: IfngR1 [KO]
    *** source: 19409816-Fig-2b
  *** Ifng-gene mRNA[RTPCR] is increased irt IL12 (times)
    *** cells: mSpCD4TCs in BMS "pretreated with anti-Cd3 + anti-Cd28 + anti-IL4 (48 hr)"
    *** times: 0 1+ 2++ 3+ 4 5 days
    *** partially reqs: IfngR1 [KO]
    *** source: 19409816-Fig-4c

IL4--  ???

  *** Ifng-gene mRNA[RPA] is increased irt IL12 (4 hr)
    *** cells: NK33 in BMS
    *** partially inhibited by: IL4 [cotreatment]
    *** source: 10358173-Fig-6

IL18--  ???

  *** Ifng-gene mRNA[Northern] is increased irt IL12 (72 hr)
    *** cells: mLNCs<Cd4~pos> in BMS "cotreated with anti-Cd3/anti-Cd28 for 72 hr"
    *** unaffected by: IL18 [cotreatment]
    *** source: 11786664-Fig-3a
  *** Ifng-gene mRNA[RPA] is increased irt IL12 (4 hr)
    *** cells: mBMNKs<Rag1~null> in BMS
    *** enhanced by: IL18 [cotreatment]
    *** enhanced by: anti-Cd28 [cotreatment]
    *** bkg enhanced by: CHX [cotreatment]
    *** source: 10229825-Fig-3
  *** Ifng-gene mRNA[RTPCR] is increased irt IL12 (24 hr)
    *** cells: mPECs in BMS
    *** enhanced by: IL18 [cotreatment]
    *** source: 11207258-Fig-3a
  *** Ifng-gene mRNA[RPA] is increased irt IL12 (4 hr)
    *** cells: mBMNKs<Rag1~null> in BMS
    *** enhanced by: IL18 [cotreatment]
    *** enhanced by: anti-Cd28 [cotreatment]
    *** source: 10229825-Fig-2b
  *** Ifng-gene mRNA[RTPCR] is increased irt IL12 (24 hr)
    *** cells: mPECs in BMS
    *** enhanced by: IL18 [cotreatment]
    *** source: 11207258-Fig-6c
  *** Ifng-gene mRNA[RPA] is increased irt IL12 (4 hr)
    *** cells: mBMNKs<Rag1~null> in BMS
    *** enhanced by: IL18 [cotreatment]
    *** unaffected by: IL6 [cotreatment]
    *** unaffected by: IL15 [cotreatment]
    *** unaffected by: Tnf [cotreatment]
    *** unaffected by: IL1b [cotreatment]
    *** source: 10229825-Fig-1b

reqs Stat4--

  *** Ifng-gene mRNA[RTPCR] is increased irt IL12 (6 hr)
    *** cells: mSpCs<Stat4~null><xStat4> in BMS
    *** reqs: xStat4 [omission]
    *** inhibited by: xStat4(Y693F)[phosAb] [substitution]
    *** inhibited by: xStat4(S721A)[phosAb] [substitution]
    *** source: 12213961-Fig-3a

Chemicals

  *** Ifng-gene mRNA[Northern] is increased irt IL12 (4 hr) 
    *** cells: mSpTh1 in BMS "OVA-specific" "pretreated with IL18 for 4 hr"
    *** unaffected by: CHX [pretreatment]
    *** source: 1175814-Fig-1b

No extras

  *** Ifng-gene mRNA[Northern] is increased irt IL12 (4 hr)
    *** cells: 3F6 in BMS
    *** source: 10097133-Fig-1a
  *** Ifng-gene mRNA[RTPCR] is increased irt IL12 (tnr)
    *** cells: hPBTCs in BMS "preactivated with Cd3/Cd28"
    *** unaffected by: CsA [pretreatment]
    *** partially inhibited by: Rapamycin [pretreatment]
    *** source: 15522880-Fig-2
  *** Ifng-gene mRNA[Northern] is increased irt IL12 (3 hr)
    *** cells: hPBTCs in BMS "activated"
    *** enhanced by: IL18 [cotreatment]
    *** source: 10925275-Fig-6
  *** Ifng-gene mRNA[RTPCR] is increased irt IL12 (times)
    *** cells: mSpCD4TCs in BMS "pretreated with anti-Cd3 (48 hr)"
    *** times: 0 1+ 2++ 3+ 4 5 6 days
    *** source: 19409816-Fig-2a
  *** Ifng-gene mRNA[RTPCR] is increased irt IL12 (times)
    *** cells: mSpCD4TCs in BMS "pretreated with anti-Cd3 (72 hr)"
    *** times: 0 1+ 2++ 3+++ 4 5 6 days
    *** source: 19409816-Fig-2a

Contradictions

  *** Ifng-gene mRNA[Northern] is detectable-but unchanged irt IL12 (72 hr)
    *** cells: mLNCs<Cd8~pos> in BMS "cotreated with anti-Cd3/anti-Cd28 for 72 hr"
    *** unaffected by: IL18 [cotreatment]
    *** source: 11786664-Fig-3a
  *** Ifng-gene promo-reporter[Luc] is unchanged irt IL12 (15 hr)
    *** cells: EL4 in BMS
    *** source: 7722452-Fig-6


=========
Secretion
=========

not Mtor--

  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (24 hr)
    *** cells: hPBTCs in BMS "preactivated with Cd3/Cd28"
    *** does not req: Mtor [RNAi]
    *** source: 15522880-Fig-6a

reqs Ripk2--

  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (24 hr)
    *** cells: mSpCs in BMS
    *** reqs: Ripk2 [KO]
    *** source: 11894097-Fig-3f

reqs Sphk2--

  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (tnr)
    *** cells: 2D6 in BMS
    *** partially inhibited by: xSphk2(G212D)"DN" [addition]
    *** enhanced by: xSphk2 [addition] 
    *** source: 12874225-Fig-5
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (tnr)
    *** cells: mSpTCs in BMS "activated with anti-Cd3/anti-Cd28"
    *** partially inhibited by: xSphk2(G212D)"DN" [addition]
    *** source: 12874225-Fig-6

reqs Stat4--

  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (24 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS "stimulated with anti-Cd3 and anti-Cd28 for 48 hr"
    *** reqs: Stat4 [KO]
    *** enhanced by: IL18 [cotreatment]
    *** source: 11466347-Fig-9a
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (44 hr)
    *** cells: mSpCs<Stat4~null><xStat4> in BMS
    *** reqs: xStat4 [omission]
    *** inhibited by: xStat4(Y693F)[phosAb] [substitution]
    *** inhibited by: xStat4(S721A)[phosAb] [substitution]
    *** source: 12213961-Fig-3b
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (44 hr)
    *** cells: mSpCs<Stat4~null><xStat4><xIL12Rb2> in BMS
    *** reqs: xStat4 [omission]
    *** inhibited by: xStat4(Y693F)[phosAb] [substitution]
    *** partially inhibited by: xStat4(S721A)[phosAb] [substitution]
    *** source: 12213961-Fig-3c
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (48 hr)
    *** cells: mSpCs in BMS "activated with anti-Cd3 for 48 hr"
    *** reqs: Stat4 [KO]
    *** source: 11120802-Fig-3b
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (36 hr)
    *** cells: mLNTCs in BMS "cotreated with anti-Cd3 + anti-Cd28"
    *** reqs: Stat4 [KO]
    *** source: 14734615-Fig-1
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (36 hr)
    *** cells: mLNCD4TCs in BMS "cotreated with anti-Cd3 + anti-Cd28"
    *** reqs: Stat4 [KO]
    *** source: 14734615-Fig-2a
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (36 hr)
    *** cells: mLNCD8TCs in BMS "cotreated with anti-Cd3 + anti-Cd28"
    *** reqs: Stat4 [KO]
    *** source: 14734615-Fig-2a



Chemicals

  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (20 hr)
    *** cells: hPBTCs in BMS "preactivated with Cd3/Cd28"
    *** unaffected by: CsA [pretreatment]
    *** partially inhibited by: Rapamycin [pretreatment]
    *** source: 15522880-Fig-1a

Effect of cotreatments

  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (4 hr)
    *** cells: mBMNKs<Rag1~null> in BMS
    *** enhanced by: IL18 [cotreatment]
    *** enhanced by: anti-Cd28 [cotreatment]
    *** source: 10229825-Fig-2a
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (4 hr)
    *** cells: mBMNKs<Rag1~null> in BMS
    *** enhanced by: IL18 [cotreatment]
    *** unaffected by: IL6 [cotreatment]
    *** unaffected by: IL15 [cotreatment]
    *** unaffected by: Tnf [cotreatment]
    *** unaffected by: IL1b [cotreatment]
    *** source: 10229825-Fig-1a
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (48 hr)
    *** cells: mBMCs in BMS "pretreated with IL2 for 7-9 days"
    *** unaffected by: anti-Tnf [cotreatment]
    *** unaffected by: anti-IL1a [cotreatment]
    *** inhibited by: anti-IL1b [cotreatment]
    *** source: 7594594-Table-2
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (20 hr)
    *** cells: hPBTCs in BMS "preactivated with Cd3/Cd28"
    *** enhanced by: anti-Cd28 [cotreatment]
    *** source: 15522880-Fig-1a
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (48 hr)
    *** cells: mSpCs in BMS "activated with anti-Cd3 for 48 hr"
    *** enhanced by: IL18 [cotreatment]
    *** source: 11120802-Fig-3b

No extras

  *** Ifng[Ab] secretion[ELISA] is increased irt IL2 (72 hr)
    *** cells: mLNCs<Cd4~pos> in BMS "cotreated with anti-Cd3/anti-Cd28 for 72 hr"
    *** source: 11786664-Fig-1a
  *** Ifng[Ab] secretion[ELISA] is increased irt IL12 (48 hr)
    *** cells: hPBMCs<Cd4~pos> in BMS
    *** source: 9558063-Fig-1b


