=============================================
Jak1 is constitutively associated with IL2Rb
=============================================

  *** Jak1[Ab] copptby[WB] IL2Rb[Ab] is detectable
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3b
  *** Jak1[Ab] copptby[WB] IL2Rb[Ab] is detectable-but unchanged irt IL2 (tnr)
    *** cells: YT in BMS
    *** source: 7973658-Fig-2
  *** xJak1[Ab] copptby[WB] xIL2Rb[Ab] is detectable
    *** cells: COS7 in BMS
    *** source: 7973658-Fig-3a
  *** Jak1[Ab] copptby[WB] IL2Rb[Ab] is detectable-but unchanged irt IL2 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** source: 10373548-Fig-3b
  *** Jak1[Ab] copptby[WB] IL2Rb[Ab] is detectable-but unchanged irt IL2 (15 min)
    *** cells: BAF3<IL2Rb~null><xIL2Rb> in BMS
    *** comment: Yphos of coppt Jak1 is increased irt IL2
    *** comment: Yphos of coppt Jak1 irt IL2 is decreased itpo xSocs3
    *** source: 10373548-Fig-3c

================================================================
Jak1 is not associated with IL2Rg even after IL2 stim
How does this correlate with the assembly of an IL2Rabc complex?
================================================================

  *** Jak1[Ab] copptby[WB] IL2Rg[Ab] is unchanged irt IL2 (15 min)
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3a
  *** Jak1[Ab] copptby[WB] IL2Rg[Ab] is unchanged irt IL2 (tnr)
    *** cells: YT in BMS
    *** source: 7973658-Fig-2
  *** xJak1[Ab] copptby[WB] xIL2Rg[Ab] is undetectable
    *** cells: COS7 in BMS
    *** source: 7973658-Fig-3b

=================================
Jak1 is not associated with IL2Ra
=================================

  *** xJak1[Ab] copptby[WB] xIL2Ra[Ab] is undetectable
    *** cells: COS7 in BMS
    *** source: 7973658-Fig-3c

===========
Other coppt
===========

  *** Jak1[Ab] copptby[WB] Irs1[Ab] is increased irt IL2 (15 min)
    *** cells: hPBMCs in BMLS
    *** source: 7499365-Fig-2b
  *** Jak1[Ab] copptby[WB] Irs2[Ab] is detectable-but unchanged irt IL2 (15 min)
    *** cells: hPHAblasts in BMLS
    *** source: 7499365-Fig-2b
  *** Jak1[Ab] copptby[WB] Stam[Ab] is unchanged irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 9133424-Fig-4
  *** Jak1[Ab] copptby[WB] Stam2[Ab] is unchanged irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 10899310-Fig-2c
  *** Jak1[Ab] copptby[WB] xSocs3[Ab] is increased irt IL2 (times)
    *** cells: BAF3<IL2Rb~null><xIL2Rb> in BMS "treated with MG132"
    *** times: 0 15+ 30+ min
    *** source: 10373548-Fig-3c
  *** Jak1[Ab] snaggedby[WB] rSocs3[GST] is increased irt IL2 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** comment: coppt Jak1 is Yphosed
    *** source: 10373548-Fig-3b

==========
Jak1 Yphos
==========

IL2Rg--

  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: ED40515<xIL2Rg(1-290)"M1"> in BMS
    *** inhibited by: xIL2Rg((1-312)/P266A/P269A)"PA2" [substitution]
    *** source: 10421845-Fig-5a
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: ED40515<xIL2Rg> in BMS
    *** inhibited by: xIL2Rg(1-290)"M1" [substitution]
    *** partially inhibited by: xIL2Rg(1-321)"M2" [substitution]
    *** source: 10421845-Fig-2a

Jak3 --

  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (5 min)
    *** cells: BAFB03 in BMS "IL3-deprived"
    *** unaffected by: xJak3 [addition]
    *** inhibited by: xJak3(mnr)"del-kinase-domain" [addition]
    *** source: 7568005-Fig-2b


=========
No extras
=========

  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 10899310-Fig-2c
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7973658-Fig-1a
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: BAFB03<xIL2Rb> in BMS "IL2-deprived"
    *** times: 0 10+ 30+ 60+ min
    *** source: 9512511-Fig-1a
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: ED40515<xIL2Rg> in BMS
    *** times: 0 10+ 30+ 60+ min
    *** source: 9512511-Fig-1a
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: hIL2RTCs in BMS "IL2-deprived"
    *** times: 0 10+ 30+ 60+ min
    *** source: 9512511-Fig-1a
  *** Jak1[Ab] Yphos[pYAb-ppt] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7988557-Fig-2b
  *** Jak1[Ab] Yphos[pYAb-ppt] is increased irt IL2 (times)
    *** cells: KIT225 in BMS
    *** times: 0 5+ 15+ 30+ 60+ 120+ min
    *** source: 7988557-Fig-1b
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7988557-Fig-2c
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: KIT225 in BMS
    *** source: 7988557-Fig-1a
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7568001-Fig-1b
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: BAFB03<IL2Rb~null><xIL2Rb(1-379)"H4"> in BMS
    *** source: 7777534-Fig-3c
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** source: 7760829-Fig-4c
  *** Jak1[Ab] Yphos[pYAb-ppt] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7528775-Fig-3b
  *** Jak1[Ab]IP Yphos[pYAb] is unchanged irt IL2 (times)
    *** cells: hPBMCs in BMS
    *** times: 0 5 15 min
    *** source: 9092570-Fig-3c
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: hIL2RTCs in BMS
    *** times: 0 5+ 15+ min
    *** source: 9092570-Fig-3c

===============
Kinase Activity
===============

  *** Jak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7988557-Fig-3
  *** Jak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7973658-Fig-1f
  *** Jak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: BAFB03<IL2Rb~null><xIL2Rb> in BMS "Growth-factor-deprived"
    *** source: 7973659-Fig-2a
  *** Jak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (15 min)
    *** cells: KIT225 in BMS
    *** source: 7988557-Fig-3
