===============
Kinase Activity
===============

IL2Rb--

  *** S6k1[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt IL2 (45 min)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS "IL3-deprived"
    *** inhibited by: xIL2Rb(del(264-322))"SD-1" [substitution]
    *** source: 7528328-Fig-3

Chemicals--

  *** S6k1[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt IL2 (45 min)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS "IL3-deprived"
    *** inhibited by: Wortmannin [pretreatment] no-bkg-control
    *** source: 7528328-Fig-5a
  *** S6k1[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt IL2 (45 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** inhibited by: Forskolin + IBMX [cotreatment] no-bkg-control
    *** inhibited by: Rapamycin [cotreatment] no-bkg-control
    *** source: 7528328-Fig-5b
  *** S6k1[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt IL2 (45 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** inhibited by: Wortmannin [pretreatment] no-bkg-control
    *** inhibited by: Rapamycin [pretreatment] no-bkg-control
    *** source: 7528328-Fig-5b
  *** S6k1[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt IL2 (45 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** unaffected by: PMA (15 hr) [pretreatment]
    *** source: 7528328-Fig-2
  *** S6k1[Ab]IP IVKA(snr)[32P-ATP] is increased irt IL2 (20 min)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 7760801-Fig-3
  *** S6k1[Ab]IP IVKA(snr)[32P-ATP] is increased irt IL2 (20 min)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** inhibited by: Wortmannin [pretreatment]
    *** source: 7760801-Fig-3

no extras--

  *** S6k1[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt IL2 (45 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** source: 7528328-Fig-1c

==================================
Phosphorylation at unreported site
==================================

  *** S6ks[phosAb] phos(sitenr)[phosAb] is increased irt IL2 (10 min)
    *** cells: hThymicBlasts in BMS "IL2-deprived"
    *** inhibited by: Rapamycin [pretreatment] no-bkg-control
    *** inhibited by: LY294002 [pretreatment] no-bkg-control
    *** inhibited by: Wortmannin [pretreatment] no-bkg-control
    *** source: 12681450-Fig-6c

=====================
Total Phosphorylation
=====================

  *** S6ks[Ab] phos[WBMS] is increased irt IL2 (times)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** times: 0 45+ 260+ 1440+ min
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 10373522-Fig-2b

