=====================================
Proteins Required for mRNA expression
=====================================

Irak4--

  *** CcL2-gene mRNA[RTPCR] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 1+ 2++ 4+++ 6++ hr
    *** partially inhibited by: kIrak4(K213A/K214A)"KD" [knockin]
    *** source: 17337443-Fig-5b

Jnk1-- and/or Jnk2--

  *** CcL2-gene mRNA[RTPCR] is increased irt IL1a (2 hr)
    *** cells: mEFs in BMLS
    *** bkg reqs: Jnk1 and/or Jnk2 [KO]
    *** source: 18443042-Fig-1c
  *** CcL2-gene mRNA[RTPCR] is increased irt IL1a (2 hr)
    *** cells: MRC5 in BMS
    *** inhibited by: SP600125 [addition]
    *** source: 18443042-Fig-4b

Jun-- ???

  *** CcL2-gene mRNA[RTPCR] is increased irt IL1a (2 hr)
    *** cells: mEFs in BMS
    *** bkg reqs: Jun [KO]
    *** source: 18443042-Fig-9a
  *** CcL2-gene mRNA[RTPCR] is increased irt IL1a (times)
    *** cells: mEFs in BMLS
    *** times: 0 15+ 30++ 60+++ 120++ 180+ 240+ min
    *** bkg reqs: Jun [KO]
    *** inhibited by: kJun(S63A/S73A) [substitution]
    *** source: 18443042-Fig-1c
  *** CcL2-gene mRNA[RTPCR] is increased irt IL1a (times)
    *** cells: mEFs in BMLS
    *** times: 0 15+ 30++ 60+++ 120+++ min
    *** reqs: Jun [KO]
    *** source: 18443042-Fig-7b
  *** CcL2-gene promo-reporter[Luc] is increased irt IL1a (4 hr)
    *** cells: HEK293T<xIL1R1> in BMS
    *** comment: enhanced by xJun{dimer} [addition]
    *** comment: unaffected by xJun/Fos{dimer} [addition]
    *** comment: enhanced by xJun/Atf2{dimer} [addition]
    *** source: 18443042-Fig-6b

=========
Chemicals
=========

  *** CcL2-gene mRNA[RTPCR] is increased irt IL1a (2 hr)
    *** cells: mEFs in BMS
    *** bkg inhibited by: TrichostatinA [addition]
    *** source: 18443042-Fig-9a

=========
no extras
=========

  *** CcL2-gene mRNA[RTPCR] is increased irt IL1a (times)
    *** cells: MRC5 in BMS
    *** times: 0 30+ 60++ 120+++ 180+++ 240++++ 360+++++ min
    *** source: 18443042-Fig-4a

=========
Secretion
=========

  *** CcL2[Ab] mRNA[RTPCR] is increased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0+ 1++ 3+ hr
    *** inhibited by: xTraf6(C242A/C249A)"T6mZ5" [substitution]
    *** source: 19843958-Fig-5e
  *** CcL2[Ab] secretion[ELISA] is increased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0 16+ 24++ 40+++ hr
    *** partially inhibited by: kIrak4(K213A/K214A)"KD" [knockin]
    *** source: 17337443-Fig-6a
