=============================================================================
needs evidence that Vav2 is recruited to the EgfR complex in response to Egf
=============================================================================

======================
requirement for Shp2
======================

  *** Vav2[Ab]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: mEFs<Shp2~null><xShp2> in BMLS
    *** times: 0 5+ 15+ min
    *** partially reqs: xShp2 [omission]
    *** source: 14967142-Fig-2a

===================
requirement for Src
===================

  *** Vav2[Ab]IP Yphos[pYAb] is increased irt Egf (5 min)
    *** cells: mEFs<Src~null><Yes1~null><Fyn~null><xSrc> in BMLS
    *** bkg reqs: xSrc [omission]
    *** source: 14967142-Fig-2c

===========================================
Tyrosine phosphorylation in response to Egf
===========================================

  *** xVav2[tAb]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: COS7 in BMLS
    *** times: 0 5+ 10++ min
    *** source: 14506284-Fig-8b
  *** Vav2[Ab]IP Yphos[pYAb] is increased irt Egf (5 min)
    *** cells: HELA in BMLS
    *** source: 10618391-Fig-3
  *** Vav2[Ab]IP Yphos[pYAb] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** inhibited by: PD168393 [addition] no-bkg-control
    *** inhibited by: PD153095 [addition] no-bkg-control
    *** source: 12454019-Fig-2d
  *** xVav2[tAb]IP Yphos[pYAb] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** partially inhibited by: xVav2(W673R) [substitution]
    *** partially inhibited by: xVav2(G693R) [substitution]
    *** source: 12454019-Fig-3a
  *** xVav2[tAb]IP Yphos[pYAb] is increased irt Egf (5 min)
    *** cells: COS7 in BMS
    *** partially inhibited by: xVav2(Y172F) [substitution]
    *** partially inhibited by: xVav2(Y142F/Y172F) [substitution]
    *** inhibited by: xVav2(Y159F/Y172F) [substitution]
    *** partially inhibited by: xVav2(Y159F) [substitution]
    *** source: 12454019-Fig-2a
  *** Vav2[Ab]IP Yphos[pYAb] is increased irt Egf (15 min)
    *** cells: NIH3T3 in BMS
    *** source: 11448999-Fig-7a
  *** Vav2[phosAb] phos(Y172)[phosAb] is increased irt Egf (2 min)
    *** cells: A431 in BMLS
    *** source: 18653540-Fig-S1a
  *** xVav2[Ab]IP phos(Y172)[phosAb] is increased irt Egf (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 5+ 10+ min
    *** source: 10669745-Fig-9d
  *** xVav2[Ab]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 5+ 10+ min
    *** source: 10669745-Fig-9d
  *** xVav2[tAb]IP Yphos[pYAb] is increased irt Egf (10 min)
    *** cells: COS7<xNckipsd><xVav2> in BMS "Membrane-fraction"
    *** source: 14765113-Fig-1b
