*** Accs--
  *** Accs[phosAb] phos(MSGLH)[phosAb] is unchanged irt Ins (4 hr)
    *** cells: ARPE19 in BMLS
    *** source: 16516166-Fig-2
  *** Accs[phosAb] phos(MSGLH)[phosAb] is unchanged irt Ins (15 min)
    *** cells: rCMCs in BSS "containing Calcium and BSA" "in suspension"
    *** source: 14978242(D)
  *** Accs[phosAb] phos(MSGLH)[phosAb] is unchanged irt Ins (tnr)
    *** cells: CHOK1 in BMS
    *** source: 12194824(D)
*** Akt1--
  *** Akt1[Ab] copptby[WB] Mdm2[Ab] is decreased irt Ins (times)
    *** cells: MCF7 in BMLS
    *** times: 0+ 5 15 30 45 60 min
    *** source: 11504915-Fig-2d
  *** xAkt1[tAb] copptby[WB] xMlk3[GST] is decreased irt Ins (30 min)
    *** cells: HEPG2<xAkt1><xMlk3> in BMLS
    *** reversed by: xMlk3(5111-847) [substitution]
    *** source: 12458207-Fig-2c
*** Ampk--
  *** Ampk[phosAb] phos(T172)[phosAb] is unchanged irt Ins (4 hr)
    *** cells: ARPE19 in BMLS
    *** source: 16516166-Fig-2
  *** Ampk[phosAb] phos(T172)[phosAb] is unchanged irt Ins (30 min)
    *** cells: RAT1A in BMLS
    *** source: 16027121-Fig-4a
  *** Ampkas[phosAb] phos(T172)[phosAb] is decreased irt Ins (30 min)
    *** cells: rCMCs in BSS "containing Calcium and BSA"
    *** source: 15557332(D)
*** APkcs--
  *** APkcs[Ab]IP IVKA(auto)[32P-ATP] is increased irt Ins (10 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** source: 11463795-Fig-9a
  *** APkcs[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ins (10 min)
    *** cells: rAPCs in BMS "membrane fraction"
    *** source: 10464256-Fig-3
  *** APkcs[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ins (10 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** inhibited by: Ro318220 [addition]
    *** inhibited by: Wortmannin [addition]
    *** source: 10464256-Fig-6,7,8
  *** APkcs[Ab]IP IVKA(snr)[32P-ATP] is increased irt Ins (10 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** inhibited by: Wortmannin [addition]
    *** unaffected by: PD98059 [addition]
    *** unaffected by: Dantrolene [addition]
    *** source: 11463795-Table-1
*** Atf2--
*** Bcar1--
  *** Bcar1[Ab] copptby[WB] Crk[Ab] is decreased irt Ins (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0+ 5 10 20 min
    *** source: 9348226-Fig-1b
  *** Bcar1[Ab]IP Yphos[pYAb] is decreased irt Ins (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0++ 1+ 5+ 10+ 20 min
    *** source: 9348226-Fig-1a
  *** Braf[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5+ 10+ 20+ 30+ 60+ min
    *** comment: best response was obtained with primers to TSS+3100 (exon2)
    *** source: 20929976-Fig-3b
  *** Braf{phos(T599/S602)}[phosAb] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5+ 10+ 20+ 30+ 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-3b
*** Calm--
  *** Calm[Ab] copptby[WB] Eef2k[Ab] is decreased irt Ins (30 min)
    *** cells: KB in BMLS
    *** reversed by: Rapamycin [pretreatment]
    *** unaffected by: Ro318220 + U0126 [pretreatment]
    *** source: 15024086-Fig-6a
*** Cbl--
  *** Cbl[Ab] copptby[WB] Crk[Ab] is unchanged irt Ins (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0 1 5 10 20 min
    *** source: 9348226-Fig-3b
  *** Cbl[Ab]IP IVLKA(PtdIns)[TLC] is unchanged irt Ins (5 min)
    *** cells: PC12 in BMLS
    *** source: 8550620-Fig-2
  *** Cbl[Ab]IP Yphos[pYAb] is unchanged irt Ins (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0 1 5 10 20 min
    *** source: 9348226-Fig-3a
*** Crk--
*** Dok1--
  *** Dusp1[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5+ 10++ 20+ 30+ 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-3b
*** Eef2--
*** Eef2k--
  *** Eif2s1[phosAb] phos(S51)[phosAb] is unchanged irt Ins (45 min)
    *** cells: HEK293 in BMLS
    *** source: 12777372-Fig-1e
*** Eif3a--
*** Eif3b--
  *** Eif3b[Ab] copptby[WB] S6k1[Ab] is decreased irt Ins (30 min)
    *** cells: HEK293E in BMLS
    *** unaffected by: Rapamycin [addition]
    *** source: 16286006-Fig-1c
*** Eif3i--
*** Eif4a1--
*** Eif4b--
  *** Eif4b[Ab] copptby[WB] Eif3b[Ab] is decreased irt Ins (15 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** unaffected by: Rapamycin [addition]
    *** source: 16541103-Fig-S2
  *** Eif4b[Ab] copptby[WB] Eif3b[Ab] is decreased irt Ins (15 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** unaffected by: Rapamycin [addition]
    *** unaffected by: AminoAcids (15 min) [stim]
    *** source: 16541103-Fig-6c
  *** Eif4b[Ab] copptby[WB] Eif3b[Ab] is decreased irt Ins (times)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** times: 0+ 1+ 3+ 5 15 30 60+ min
    *** source: 16541103-Fig-7a
  *** Eif4b[Ab] copptby[WB] Eif3b[Ab] is increased irt Ins (30 min)
    *** cells: HEK293E in BMLS
    *** inhibited by: Rapamycin [addition]
    *** source: 16286006-Fig-4a
  *** Eif4b[Ab] copptby[WB] Eif3b[Ab] is increased irt Ins (30 min)
    *** cells: HEK293E<xS6k1> in BMLS
    *** inhibited by: Rapamycin [addition]
    *** inhibited by: xS6k1(T412A) [substitution]
    *** source: 16286006-Fig-4c
  *** Eif4b[Ab] copptby[WB] Eif3b[Ab] is increased irt Ins (times)
    *** cells: HEK293E in BMLS
    *** times: 0 2+ 5+ 10+ 20+ 30++ min
    *** source: 16286006-Fig-5a
  *** xEif4b[tAb] copptby[WB] Eif3b[Ab] is increased irt Ins (30 min)
    *** cells: HEK293E in BMLS
    *** inhibited by: xEif4b(S422A) [substitution]
    *** inhibited by: Rapamycin [addition]
    *** source: 16286006-Fig-4b
*** Eif4e---
  *** Eif4e[Ab] snaggedby[WB] capped-mRNA[m7GTP] is detectable-but unchanged irt Ins (10 min)
    *** cells: CHO<xInsR><xRaptor> in BMLS
    *** comment: cells were lysed without detergent
    *** source: 12150926-Fig-5a
  *** Eif4e[Ab] snaggedby[WB] capped-mRNA[m7GTP] is detectable-but unchanged irt Ins (30 min)
    *** cells: HEK293<xEif4ebp1> in BMLS
    *** unaffected by: xEif4ebp1(S101A) [substitution]
    *** source: 12588975-Fig-2d
  *** Eif4e[phosAb] phos(S209)[phosAb] is increased irt Ins (times)
    *** cells: HC11 in BMLS
    *** times: 0 7+ 15++ min
    *** inhibited by: LY294002 [addition]
    *** unaffected by: Rapamycin [addition]
    *** source: 16984645-Fig-5
*** Eif4ebp1--
*** Eif4ebp3--
  *** xEif4ebp3[Ab] snaggedby[WB] capped-mRNA[m7GTP] is detectable-but unchanged irt Ins (30 min)
    *** cells: HEK293<xEif4ebp3> in BMLS
    *** unaffected by: xEif4ebp3(A84E) [substitution]
    *** source: 12588975-Fig-5b
*** Eif4g--
  *** Eif4g1[phosAb] phos(S1147)[phosAb] is increased irt Ins (15 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** inhibited by: Rapamycin [addition]
    *** unaffected by: FK506 [addition]
    *** unaffected by: Rapamycin + FK506 [addition]
    *** source: 16541103-Fig-3e
  *** Eif4g1[phosAb] phos(S1147)[phosAb] is increased irt Ins (times)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** times: 0 1 3 5 15+ 30+ 60+ min
    *** source: 16541103-Fig-7a
  *** Eif4g1[phosAb] phos(S1147)[phosAb] is increased irt Ins (times)
    *** cells: HELA in BMLS
    *** times: 0 3 5 10+ 15++ 30++ min
    *** source: 16763566-Fig-1b
  *** Eif4g1[phosAb] phos(S1147)[phosAb] is unchanged irt Ins (45 min)
    *** cells: HEK293 in BMLS
    *** comment: reversed by reox after Ins treatment
    *** source: 12777372-Fig-1f
*** Elk1--
  *** Elk1[phosAb] phos(sitenr)[phosAb] is increased irt Ins (60 min)
    *** cells: HEPG2 in BMS
    *** inhibited by: xRin1 [addition]
    *** inhibited by: xRin1(mnr)"Nterm" [addition]
    *** inhibited by: xRin1(mnr)"Dterm" [addition]
    *** bkg enhanced by: xRin1(mnr/del(429-490)) [addition]
    *** source: 16457816-Fig-7b
*** Eps8--
  *** Eps8[Ab] Yphos[pYAb-ppt] is unchanged irt Ins (10 min)
    *** cells: NIH3T3<xEgfR> in BMS
    *** source: 8404850-Fig-5
  *** Eps8[Ab] Yphos[pYAb-ppt] is unchanged irt Ins (10 min)
    *** cells: NIH3T3<xInsR> in BMS
    *** source: 8404850-Fig-5
*** Erks--
  *** Erks[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5+++ 10+++ 20++ 30+ 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-3b
  *** Erks{phos(TEY)}[phosAb] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5+++ 10++ 20+ 30 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-3b
  *** Erks{phos(TEY)}[phosAb] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 10++ 30+ 60 min
    *** reqs: xInsR [omission]
    *** comment: primers to Exon1 (TSS+232 bp) were used
    *** source: 20929976-Fig-S1b
*** Flna--
  *** Flna[phosAb] phos(S2152)[phosAb] is decreased irt Ins (20 min)
    *** cells: 3Y1 in BMLS
    *** source: 15024089-Fig-5a
*** Foxo1--
*** Foxo4--
*** Foxo13s--
*** Gab1--
  *** Gab1[Ab] copptby[WB] Pik3rs[Ab] is unchanged irt Ins (tnr)
    *** cells: mEFs in BMLS
    *** source: 19401591-Fig-5d
  *** Gab1[Ab]IP IVLKA(PtdIns)[TLC] is unchanged irt Ins (10 min)
    *** cells: L6<xFgfR1> in BMLS
    *** source: 11353842-Fig-4a
  *** Gab1[Ab]IP Yphos[pYAb] is unchanged irt Ins (10 min)
    *** cells: L6<xFgfR1> in BMLS
    *** source: 11353842-Fig-4a
  *** Gab1[phosAb] phos(Y627)[phosAb] is unchanged irt Ins (tnr)
    *** cells: mEFs in BMLS
    *** source: 19401591-Fig-4c
*** Glut1--
  *** Glut1[Ab] infraction(membrane)[WB] is unchanged irt Ins (30 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** source: 11463795-Fig-2a
*** Glut4--
  *** Glut4[Ab] infraction(membrane)[WB] is increased irt Ins (30 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** source: 11463795-Fig-2a
*** Grb2--
  *** Grb2[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5+++ 10++ 20++ 30+ 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-2c
  *** Grb2[Ab] copptby[WB] Shc1[Ab] is increased irt Ins (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0 1+ 10+ 30+ 60+ 120+ min
    *** unaffected by: PD98059 [addition]
    *** source: 7592690-Fig-1d
*** Grb10--
  *** Gsk3b[phosAb] phos(S9)[phosAb] is increased irt Ins (times)
    *** cells: MCF10A in BMLS
    *** times: 0 10++ 30+ 60+ min
    *** source: 15026412-Fig-3b
*** Gsk3s--
*** Hif1a--
  *** Hif1a[Ab] prot-exp[WB] is increased irt Ins (4 hr)
    *** cells: ARPE19 in BMLS
    *** inhibited by: Aicar [cotreatment]
    *** inhibited by: Metformin [cotreatment]
    *** source: 16516166-Fig-4b
  *** Hif1a[Ab] prot-exp[WB] is increased irt Ins (4 hr)
    *** cells: ARPE19 in BMLS
    *** inhibited by: Aicar [cotreatment]
    *** source: 16516166-Fig-4a
  *** Hif1a[Ab] prot-exp[WB] is unchanged irt Ins (45 min)
    *** cells: HEK293 in BMLS
    *** source: 12777372-Fig-1e
  *** HistH3{methyl(K27)}[MeAb] boundto(Egr1-gene)[ChIP] is unchanged irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 10 30 60 min
    *** unaffected by: xInsR [omission]
    *** comment: primers to Exon1 (TSS+232 bp) were used
    *** source: 20929976-Fig-S1b
*** Ins--
  *** Ins[125I] internalization[Surface-strip] is detectable
    *** cells: HEPG2 in BMS
    *** partially reqs: Rin1 [RNAi]
    *** does not req: Rin2 [RNAi]
    *** partially reqs: Rin3 [RNAi]
    *** source: 16457816-Fig-5a
  *** Ins[125I] internalization[Surface-strip] is increased irt Ins (times)
    *** cells: HEPG2 in BMS
    *** times: 0 5+ 10+ 20+ min
    *** enhanced by: xRin1 [addition]
    *** enhanced by: xRin1(mnr)"Cterm" [addition]
    *** inhibited by: xRin1(mnr)"Nterm" [addition]
    *** inhibited by: xRin1(del(429-490)) [addition]
    *** source: 16457816-Fig-2c
  *** Ins[125I] internalization[Surface-strip] is increased itpo xRab5a
    *** cells: HEPG2 in BMS "treated with Ins for 10 min"
    *** inhibited by: xRab5a(S34N) [substitution]
    *** source: 16457816-Fig-2d
  *** Ins[125I] internalization[Surface-strip] is increased itpo xRin1
    *** cells: HEPG2 in BMS "treated with Ins for 10 min"
    *** enhanced by: xRab5a [addition]
    *** inhibited by: xRab5a(S34N) [addition]
    *** source: 16457816-Fig-2d
  *** InsR-gene mRNA[RTPCR] is detectable-but unchanged irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0+ 10+ 30+ 60+ min
    *** source: 20929976-Fig-S1a
  *** InsR-gene mRNA[RTPCR] is unchanged irt Ins (times)
    *** cells: HCT in BMLS
    *** times: 0 10 30 60 min
    *** source: 20929976-Fig-S1a
  *** InsR[125I] surface-exp[125I-ligand] is decreased irt Ins (times)
    *** cells: HEPG2 in BMS
    *** times: 0++++ 1+++ 2++ 3+ 4+ min
    *** reversed by: xRin1(del(429-490)) [addition]
    *** enhanced by: xRin1 [addition]
    *** source: 16457816-Fig-2c
  *** InsR[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5++ 10++ 20++ 30+ 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-2c
  *** InsR[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 10++ 30+ 60 min
    *** reqs: xInsR [omission]
    *** comment: primers to Exon1 (TSS+232 bp) were used
    *** source: 20929976-Fig-S1b
  *** InsR{phos(Y1185)}[phosAb] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5++ 10+ 20+ 30+ 60 min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-2c
  *** InsR{phos(Y1185)}[phosAb] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 10++ 30+ 60 min
    *** reqs: xInsR [omission]
    *** comment: primers to Exon1 (TSS+232 bp) were used
    *** source: 20929976-Fig-S1b
*** Irs1--
*** Irs2--
*** Jnks--
*** Jun--
*** Lkb1--
  *** Lkb1[phosAb] phos(S428)[phosAb] is increased irt Ins (tnr)
    *** cells: MEWO in BMLS
    *** source: 19274086-Fig-2a
  *** Lkb1[phosAb] phos(S428)[phosAb] is unchanged irt Ins (tnr)
    *** cells: 3731T in BMLS
    *** source: 19274086-Fig-2a
  *** Mek12s[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5+++ 10++ 20+ 30+ 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-3b
  *** Mek12s{phos(SMANS)}[phosAb] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5+++ 10++ 20+ 30+ 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-3b
*** Mlk3--
  *** Mlk3[Ab] copptby[WB] Akt1[Ab] is decreased irt Ins (30 min)
    *** cells: HEPG2 in BMLS
    *** source: 12458207-Fig-2a
  *** xMlk3[tAb]IP IVKA(Mkk7)[32P-ATP] is decreased irt Ins (30 min)
    *** cells: HEK293<xAkt1><xMlk3> in BMLS
    *** reversed by: LY294002 [cotreatment]
    *** source: 12458207-Fig-2e
*** Msk1--
  *** Msk1[Ab]IP IVKA(peptide)[32P-ATP] is unchanged irt Ins (5 min)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** unaffected by: SB202190 [pretreatment]
    *** enhanced by: LY294002 [pretreatment]
    *** source: 11350959-Fig-9c
  *** Msk1[Ab]IP IVKA(peptide)[32P-ATP] is unchanged irt Ins (times)
    *** cells: JB6CL41 in BMLS
    *** times: 0+ 5+ 15+ 30+ 60+ min
    *** source: 11350959-Fig-8b
*** Mtor--
  *** Mtor[Ab] copptby[WB] Raptor[Ab] is decreased irt Ins (15 min)
    *** cells: HEK293E in BMLS
    *** source: 17386266-Fig-3g
  *** Mtor[Ab] copptby[WB] Raptor[Ab] is decreased irt Ins (15 min)
    *** cells: HELA in BMLS
    *** source: 17386266-Fig-3g
  *** Mtor[Ab] copptby[WB] Raptor[Ab] is detectable-but unchanged irt Ins (10 min)
    *** cells: HEK293E in BMLS
    *** source: 17386266-Fig-1c
  *** Mtor[Ab] copptby[WB] Raptor[Ab] is detectable-but unchanged irt Ins (10 min)
    *** cells: HELA in BMLS
    *** source: 17386266-Fig-1c
  *** Mtor[Ab] copptby[WB] Raptor[Ab] is detectable-but unchanged irt Ins (10 min)
    *** cells: mEFs in BMLS
    *** source: 17386266-Fig-1c
  *** Mtor[Ab] copptby[WB] Raptor[Ab] is detectable-but unchanged irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** source: 17386266-Fig-3g
*** Nck1--
  *** Nck1[Ab] copptby[WB] xDok1[tAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xDok1(Y361F) [substitution]
    *** source: 10202139-Fig-6
*** Nos3--
  *** Nos3[phosAb] phos(S1177)[phosAb] is increased irt Ins (times)
    *** cells: hAECs in BSS
    *** times: 0 30++ 60++ 120+ min
    *** unaffected by: xAmpka1(D159A)"DN" [addition]
    *** source: 12791703(D)
*** P38s--
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Ins (8 min)
    *** cells: HEPG2 in BMS
    *** unaffected by: xRin1(mnr/del(429-490)) [addition]
    *** unaffected by: xRin1 [addition]
    *** source: 16457816-Fig-4g
  *** xP38s[phosAb] phos(TGY)[phosAb] is increased irt Ins (15 min)
    *** cells: mEFs<Jnk1~null><Jnk2~null> in BMLS
    *** partially inhibited by: xRala(S28N)"DN" [addition]
    *** source: 12110590-Fig-5c
  *** P38s[phosAb] phos(TGY)[phosAb] is unchanged irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** source: 11777913-Fig-2c
  *** P38s[phosAb] phos(TGY)[phosAb] is unchanged irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD169316 [pretreatment]
    *** source: 11777913-Fig-2a
  *** P38s[phosAb] phos(TGY)[phosAb] is unchanged irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: SB202190 [pretreatment]
    *** source: 11777913-Fig-2b
  *** P38s[phosAb] phos(TGY)[phosAb] is unchanged irt Ins (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: U0126 [pretreatment]
    *** source: 11777913-Fig-2d
*** Pi3k--
*** Pkca--
  *** Pkca[phosAb] phos(S657)[phosAb] is detectable-but unchanged irt Ins (30 min)
    *** cells: mEFs in BMS
    *** source: 21464307-Fig-S2a
*** Pkcd--
  *** Pkcd[phosAb] phos(T507)[phosAb] is increased irt Ins (times)
    *** cells: MCF10A in BMLS
    *** times: 0 5+ 30+ min
    *** does not req: RalGds [RNAi]
    *** source: 18285454-Fig-5b
  *** Pkcd[phosAb] phos(T507)[phosAb] is increased irt Ins (times)
    *** cells: MCF10A in BMLS
    *** times: 0 5+ 30+ min
    *** partially inhibited by: LY294002 [addition] no-bkg-control
    *** source: 18285454-Fig-5b
*** Pkci--
  *** xPkci[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Ins (10 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** source: 10464256-Fig-4
*** Pkcz--
  *** xPkcz[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Ins (10 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** unaffected by: xPkcz(T410E) [substitution]
    *** source: 10464256-Fig-4
  *** Pkcz[Ab]IP phos(T410)[phosAb] is unchanged irt Ins (10 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** source: 10464256-Fig-7
  *** xPkcz[tAb]IP IVKA(snr)[32P-ATP] is increased irt Ins (10 min)
    *** cells: rAPCs in BMS "serum and nutrient starved"
    *** unaffected by: xErk2(mnr)"KD" [addition]
    *** inhibited by: xPdpk1(mnr)"KD" [addition]
    *** source: 11463795-Table-1
  *** Pol2[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5+++ 10++ 20++ 30+ 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-1c
  *** Pol2[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 10++ 30+ 60 min
    *** reqs: xInsR [omission]
    *** comment: primers to Exon1 (TSS+232 bp) were used
    *** source: 20929976-Fig-S1b
*** Pxn--
  *** Pxn[Ab] copptby[WB] Crk[Ab] is increased irt Ins (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0 1+ 5++ 10++ 20++ min
    *** source: 9348226-Fig-2b
  *** Pxn[Ab]IP Yphos[pYAb] is decreased irt Ins (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0+++ 1++ 5+ 10++ 20++ min
    *** source: 9348226-Fig-2a
*** Rac1--
  *** Rac1[Ab] GTP-association[BDPD] is increased irt Ins (10 min)
    *** cells: NIH3T3 in BMS
    *** source: 11788587-Fig-8a
*** Raf1--
  *** Raf1[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 3 5 10+ 15+ 30+ min
    *** inhibited by: PD98059 [addition]
    *** source: 7673108-Fig-1b
  *** Raf1[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 5+ 30+ min
    *** inhibited by: xMek1(K97R)"DN" [addition]
    *** source: 7673108-Fig-4b
  *** Raf1[phosAb] phos(sitenr)[phosAb] is increased irt Ins (8 min)
    *** cells: HEPG2 in BMS
    *** inhibited by: xRin1 [addition]
    *** inhibited by: xRin1(mnr)"Nterm" [addition]
    *** inhibited by: xRin1(mnr)"Dterm" [addition]
    *** bkg enhanced by: xRin1(mnr/del(429-490)) [addition]
    *** source: 16457816-Fig-4c
*** Rap1a--
  *** Rap1s[Ab] copptby[WB] Raf1[Ab] is decreased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0++ 1+ 3+ 5 15+ 30+ min
    *** source: 9564038-Fig-1a
  *** Rap1s[Ab] GTP-association[BDPD] is decreased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0++ 1++ 3++ 5+ 15+ 30+ min
    *** source: 9564038-Fig-2
  *** Rap1s[Ab] GTP-association[BDPD] is unchanged irt Ins (times)
    *** cells: NIH3T3<xInsR> in BMLS
    *** times: 0 1+ min
    *** source: 9774335-Fig-1b
*** Raptor--
  *** Raptor[Ab] copptby[WB] Mtor[Ab] is detectable-but unchanged irt Ins (10 min)
    *** cells: HEK293E in BMLS
    *** source: 17386266-Fig-1b
  *** Raptor[Ab] copptby[WB] Mtor[Ab] is detectable-but unchanged irt Ins (times)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** times: 0+ 5+ 10+ 30+ min
    *** source: 17510057-Fig-3a
*** Rasa1--
*** Rhoq--
*** Rictor--
  *** Rictor[Ab] copptby[WB] Mtor[Ab] is decreased irt Ins (15 min)
    *** cells: mEFs in BMLS
    *** source: 16962653-Fig-5d
  *** Rictor[Ab]IP IVKA(Akt1)(S473)[phosAb] is increased irt Ins (15 min)
    *** cells: HELA in BMS
    *** source: 17043309-Fig-4d
  *** Rictor[Ab]IP IVKA(Akt1)(S473)[phosAb] is increased irt Ins (20 min)
    *** cells: HELA in BMLS
    *** source: 16919458-Fig-S3
*** Rps6--
  *** Rps6[Ab] copptby[WB] Eif3b[Ab] is detectable-but unchanged irt Ins (15 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** source: 16541103-Fig-5a
  *** Rps6[Ab] copptby[WB] Eif3b[Ab] is detectable-but unchanged irt Ins (30 min)
    *** cells: HEK293E in BMLS
    *** source: 16286006-Fig-4a
  *** Rsk2[Ab]IP IVKA(Rps6)[32P-ATP] is unchanged irt Ins (15 min)
    *** cells: HEK293E in BMLS
    *** unaffected by: FMK [pretreatment]
    *** source: 17360704-Fig-4b
*** Rsks--
  *** Rsks[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 2+ 5++ 10++ 30+ 60+ min
    *** source: 8626428-Fig-1a
  *** Rsks[Ab] phos[WBMS] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 5+ 30+ min
    *** partially inhibited by: xMek1(K97R)"DN" [addition]
    *** source: 7673108-Fig-4c
  *** Rsks[phosAb] phos(FSFV)[phosAb] is unchanged irt Ins (15 min)
    *** cells: HEK293E in BMLS
    *** unaffected by: FMK [pretreatment]
    *** source: 17360704-Fig-4b
  *** Rsks[phosAb] phos(T359/S363)[phosAb] is increased irt Ins (5 min)
    *** cells: MEWO in BMLS
    *** source: 19274086-Fig-2a
  *** Rsks[phosAb] phos(T359/S363)[phosAb] is unchanged irt Ins (5 min)
    *** cells: 3731T in BMLS
    *** source: 19274086-Fig-2a
*** S6k1--
*** S6k2--
  *** xS6k2[tAb]IP IVKA(Rps6)[32P-ATP] is increased irt Ins (10 min)
    *** cells: CHO<xInsR> in BMLS
    *** source: 11733037-Fig-2b
*** xSgk1--
  *** xSgk1[tAb]IP IVKA(Foxo3)[32P-ATP] is increased irt Ins (15 min)
    *** cells: HEK293<xSgk1> in BMLS
    *** source: 11154281-Fig-1a
*** Sh2d3a--
  *** xSh2d3a[tAb]IP Yphos[pYAb] is increased irt Ins (10 min)
    *** cells: CHO<xInsR> in BMLS
    *** source: 10187783-Fig-3b
*** Shc1--
*** Sin1--
  *** xSin1[tAb]IP IVKA(Akt1)(S473)[phosAb] is increased irt Ins (20 min)
    *** cells: HELA in BMLS
    *** source: 16919458-Fig-4a
*** Smad3--
  *** Smad3[Ab]IP STphos[pSTAb] is increased irt Ins (20 min)
    *** cells: HEK293T in BMS
    *** partially reqs: Pdpk1 [RNAi]
    *** source: 17327236-Fig-3c
  *** xSmad3[tAb] copptby[WB] xPdpk1[GST] is increased irt Ins (20 min)
    *** cells: HEK293T in BMS
    *** inhibited by: Wortmannin [addition] no-bkg-control
    *** source: 17327236-Fig-3b
*** Smad4--
  *** Smad4[Ab]IP STphos[pSTAb] is increased irt Ins (20 min)
    *** cells: HEK293T in BMS
    *** partially reqs: Pdpk1 [RNAi]
    *** source: 17327236-Fig-3c
  *** xSmad4[tAb] copptby[WB] xPdpk1[GST] is increased irt Ins (20 min)
    *** cells: HEK293T in BMS
    *** inhibited by: Wortmannin [addition] no-bkg-control
    *** source: 17327236-Fig-3b
*** Smad7--
  *** xSmad7[tAb] copptby[WB] xPdpk1[GST] is increased irt Ins (20 min)
    *** cells: HEK293T in BMS
    *** inhibited by: Wortmannin [addition] no-bkg-control
    *** source: 17327236-Fig-3b
*** Sos1--
  *** Sos1[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5++ 10++ 20++ 30++ 60+ min
    *** comment: best response was obtained with primers to TSS+232
    *** source: 20929976-Fig-2c
  *** Sos1[Ab] copptby[WB] Shc1[Ab] is increased irt Ins (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0 1+ 5+ 10 40 120 min
    *** comment: unaffected by PD98059 [addition] at 1-5 min
    *** comment: inhibited by PD98059 [addition] at 10-120 min
    *** source: 7592690-Fig-1c
*** Srf--
  *** Srf[Ab] boundto(Egr1-gene)[ChIP] is increased irt Ins (times)
    *** cells: HCT<xInsR> in BMLS
    *** times: 0 5 10+ 20+ 30 60 min
    *** comment: best response was obtained with primers to TSS-252
    *** source: 20929976-Fig-3b
*** Stat3--
  *** Stat3[Ab] locatedin(nucleus)[IHC] is unchanged irt Ins (10 min)
    *** cells: HEPG2 in BMLS "pretreated with LY294002"
    *** source: 12456685-Fig-5
  *** Stat3[phosAb] phos(Y705)[phosAb] is unchanged irt Ins (15 min)
    *** cells: HEPG2 in BMLS
    *** source: 12456685-Fig-3c
*** Stat5s--
  *** Stat5s[phosAb] phos(DGYV)[phosAb] is increased irt Ins (tnr)
    *** cells: mEFs in BMLS
    *** times: 0 2++ 5++ 15+ min
    *** does not req: Gnai1 or Gnai3 [KO]
    *** source: 19401591-Fig-2c
*** TCF-reporter--
  *** TCF-reporter[Luc] is unchanged irt Ins (times)
    *** cells: MCF10A in BMLS
    *** times: 0 3 6 9 12 hr
    *** source: 15026412-Fig-3a
*** Tnk2--
  *** xTnk2[Ab]IP Yphos[pYAb] is increased irt Ins (5 min)
    *** cells: L6 in BMLS
    *** source: 16777958-Fig-2c
*** TRE-reporter--
  *** TRE-reporter[Luc] is increased irt Ins (6 hr)
    *** cells: NIH3T3<xInsR> in BMLS
    *** inhibited by: xHras(T17N)"DN" [addition]
    *** partially inhibited by: xRala(S28N)"DN" [addition]
    *** source: 12110590-Fig-5b
*** Tsc1--
  *** xTsc1[tAb] copptby[WB] xTsc2[tAb] is decreased irt Ins (20 min)
    *** cells: DROSOPHILAS2<xTsc1><xTsc2> in BMLS
    *** reversed by: xTsc2(T437A/S924A/T1054A/T1518A)"dAktP" [substitution]
    *** comment: aa numbers refer to drosophila Tsc2 Q9U9B0
    *** comment: drome S924 corresponds to human S981
    *** comment: drome T1518 corresponds to human T1492
    *** source: 12172554-Fig-2b
*** Tsc2--
*** Vegfa--
  *** Vegfa-gene mRNA[RTPCR] is increased irt Ins (4 hr)
    *** cells: ARPE19 in BMLS
    *** unaffected by: Aicar [pretreatment]
    *** source: 16516166-Fig-1
*** Vps34--
  *** Vps34[Ab]IP IVLKA(PtdIns)[TLC] is unchanged irt Ins (30 min)
    *** cells: GRCLR73 in BMLS
    *** source: 16049009-Fig-2a
  *** xYwha?[tAb] copptby[WB] xPras40[tAb] is increased irt Ins (20 min)
    *** cells: HEK293T<xPras40> in BMLS
    *** bkg inhibited by: Wortmannin [pretreatment]
    *** source: 17277771-Fig-S4a
*** Ywhas--
  *** Ywhas[Ab] copptby[WB] xPras40[Ab] is increased irt Ins (10 min)
    *** cells: HEK293<xPras40> in BMLS
    *** source: 12524439-Fig-7b
