*** AP1--
  *** AP1-reporter[Luc] is increased irt anti-Cd3 + anti-Cd28 (20 hr) 
    *** cells: JURKAT<Pten~null><xBraf> in BMS
    *** unaffected by: xBraf(T598A/S601A) [substitution]
    *** source: 15339934-Fig-6b
*** Csk--
  *** Csk[Ab] copptby[WB] Pag1[Ab] is decreased irt anti-Cd3 + anti-Cd28 (tnr)
    *** cells: hPBTCs in BMS
    *** source: 10790433-Fig-9a
*** Erks--
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt anti-Cd3 + anti-Cd28 (10 min)
    *** cells: JURKAT<Pten~null> in BMLS
    *** partially reqs: Mlk3 [RNAi]
    *** source: 15258589-Fig-2e
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt anti-Cd3 + anti-Cd28 (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 10+ 20+ min
    *** unaffected by: xUbc13(C87A)"DN" [addition]
    *** unaffected by: xUbe2d1(C85A)"DN" [addition]
    *** unaffected by: xTraf6(294-530)"DN" [addition]
    *** does not req: Traf6 [RNAi]
    *** does not req: Tak1 [RNAi]
    *** unaffected by: xTak1(K63W)"DN" [addition]
    *** does not req: Traf2 [RNAi]
    *** does not req: Malt1 [RNAi]
    *** source: 15125833-Fig-2a,3b,4b,4c,4d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt anti-Cd3 + anti-Cd28 (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 30++ 60+ 120+ 180+ 240 360 min
    *** source: 15339934-Fig-5d
*** Fos--
  *** Fos[Ab] prot-exp[WB] is detectable-but unchanged irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNTCs in BMS
    *** does not req: Stat4 [KO]
    *** source: 14734615-Fig-7a
  *** Fos[Ab] prot-exp[WB] is detectable-but unchanged irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNTCs in BMS
    *** unaffected by: IL12 [cotreatment]
    *** source: 14734615-Fig-7a
  *** Fos[Ab] prot-exp[WB] is detectable-but unchanged irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNTCs in BMS "nuclear extracts"
    *** does not req: Stat4 [KO]
    *** source: 14734615-Fig-7b
  *** Fos[Ab] prot-exp[WB] is detectable-but unchanged irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNTCs in BMS "nuclear extracts"
    *** unaffected by: IL12 [cotreatment]
    *** source: 14734615-Fig-7b
*** Ifng--
  *** Ifng-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (times)
    *** cells: hCBLs<Cd4~pos> in BMS
    *** times: 0 6+ 24+ 48+ hr
    *** unaffected by: anti-Ifng [cotreatment]
    *** enhanced by: IL12 [cotreatment]
    *** enhanced by: IL12 + anti-Ifng [cotreatment]
    *** enhanced by: anti-IL12 + Ifng [cotreatment]
    *** source: 16220539-Fig-2a
  *** Ifng[Ab] secretion[ELISA] is increased irt anti-Cd3 + anti-Cd28 (24 hr)
    *** cells: hTh1 in BMS
    *** source: 10925275-Fig-7
  *** Ifng[Ab] secretion[ELISA] is increased irt anti-Cd3 + anti-Cd28 (24 hr)
    *** cells: mLNTCs in BMS
    *** reqs: Stat4 [KO]
    *** source: 14734615-Fig-4a
  *** Ifng[Ab] secretion[ELISA] is increased irt anti-Cd3 + anti-Cd28 (72 hr)
    *** cells: hTh1 in BMS
    *** reqs: anti-Cd3 [omission]
    *** reqs: anti-Cd28 [omission]
    *** source: 9531298-Fig-2
  *** Ifng[Ab] secretion[ELISA] is unchanged irt anti-Cd3 + anti-Cd28 (24 hr)
    *** cells: hTh2 in BMS
    *** source: 10925275-Fig-7
*** IL2--
  *** IL2-gene promo-reporter[Luc] is increased irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: JURKAT<Pten~null><xBraf> in BMS
    *** inhibited by: xBraf(T598A/S601A) [substitution]
    *** source: 15339934-Fig-5a
  *** IL2[Ab] secretion[ELISA] is increased irt anti-Cd3 + anti-Cd28 (48 hr)
    *** cells: JURKAT<Pten~null> in BMS
    *** inhibited by: U0126 [pretreatment] no-bkg-control
    *** source: 15339934-Fig-5c
  *** IL2[Ab] secretion[ELISA] is increased irt anti-Cd3 + anti-Cd28 (48 hr)
    *** cells: JURKAT<Pten~null> in BMS
    *** inhibited by: U0126 [pretreatment] no-bkg-control
    *** source: 15339934-Fig-5e
  *** IL2[Ab] secretion[ELISA] is increased irt anti-Cd3 + anti-Cd28 (48 hr)
    *** cells: JURKAT<Pten~null> in BMS
    *** unaffected by: xBraf [addition]
    *** inhibited by: xBraf(T598A/S601A) [substitution]
    *** source: 15339934-Fig-5b
*** IL4--
  *** IL4[Ab] secretion[ELISA] is increased irt anti-Cd3 + anti-Cd28 (72 hr)
    *** cells: hTh2 in BMS
    *** reqs: anti-Cd3 [omission]
    *** reqs: anti-Cd28 [omission]
    *** source: 9531298-Fig-2
*** IL10Rb--
  *** IL10Rb-gene mRNA[RTPCR] is detectable-but unchanged irt anti-Cd3 + anti-Cd28 (times)
    *** cells: hPBTCs in BMS
    *** times: 0+ 6+ 18+ 42+ 66+ hr
    *** source: 15308104-Fig-1b
*** IL12--
  *** IL12[Ab] receptor-binding[FACS] is increased irt anti-Cd3 + anti-Cd28 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS
    *** does not req: Ifng [KO]
    *** source: 11466347-Fig-2
  *** IL12[Ab] receptor-binding[FACS] is increased irt anti-Cd3 + anti-Cd28 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS
    *** does not req: Stat4 [KO]
    *** source: 11466347-Fig-2
*** IL12Rb1--
  *** IL12Rb1-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNCD8TCs in BMS
    *** does not req: Stat4 [KO]
    *** source: 14734615-Fig-3
  *** IL12Rb1-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNCD8TCs in BMS
    *** unaffected by: IL12 [cotreatment]
    *** source: 14734615-Fig-3
*** IL12Rb2--
  *** IL12Rb2-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNCD8TCs in BMS
    *** does not req: Stat4 [KO]
    *** source: 14734615-Fig-3
  *** IL12Rb2-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNCD8TCs in BMS
    *** unaffected by: IL12 [cotreatment]
    *** source: 14734615-Fig-3
  *** IL12Rb2-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (times)
    *** cells: hCBLs<Cd4~pos> in BMS
    *** times: 0 6+ 24+ 48+ hr
    *** unaffected by: anti-Ifng [cotreatment]
    *** enhanced by: IL12 [cotreatment]
    *** enhanced by: IL12 + anti-Ifng [cotreatment]
    *** unaffected by: anti-IL12 + Ifng [cotreatment]
    *** source: 16220539-Fig-2a
*** IL18--
  *** IL18[Ab] receptor-binding[FACS] is unchanged irt anti-Cd3 + anti-Cd28 (48 hr)
    *** cells: mLNCs<Mhc2s~neg><SIg~neg> in BMS
    *** source: 11466347-Fig-2
*** IL22--
  *** IL22-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (tnr)
    *** cells: hPBMCs in BMS
    *** source: 15120652-Fig-1
  *** IL22-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (tnr)
    *** cells: hPHAblasts in BMS
    *** source: 15120652-Fig-1
  *** IL22-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (tnr)
    *** cells: hTh1 in BMS
    *** source: 15120652-Fig-1
*** IL22Ra1--
  *** IL22Ra1-gene mRNA[RTPCR] is unchanged irt anti-Cd3 + anti-Cd28 (times)
    *** cells: hPBTCs in BMS
    *** times: 0 6 18 42 66 hr
    *** source: 15308104-Fig-1b
  *** IL22Ra1-gene mRNA[RTPCR] is unchanged irt anti-Cd3 + anti-Cd28 (tnr)
    *** cells: hPBMCs in BMS
    *** source: 15120652-Fig-1
  *** IL22Ra1-gene mRNA[RTPCR] is unchanged irt anti-Cd3 + anti-Cd28 (tnr)
    *** cells: hPHAblasts in BMS
    *** source: 15120652-Fig-1
  *** IL22Ra1-gene mRNA[RTPCR] is unchanged irt anti-Cd3 + anti-Cd28 (tnr)
    *** cells: hTh1 in BMS
    *** source: 15120652-Fig-1
*** Jnks--
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt anti-Cd3 + anti-Cd28 (10 min)
    *** cells: JURKAT<Pten~null> in BMLS
    *** reqs: Mlk3 [RNAi]
    *** source: 15258589-Fig-2e
*** Jun--
  *** Jun[Ab] prot-exp[WB] is increased irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNTCs in BMS
    *** does not req: Stat4 [KO]
    *** source: 14734615-Fig-7a
  *** Jun[Ab] prot-exp[WB] is increased irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNTCs in BMS
    *** unaffected by: IL12 [cotreatment]
    *** source: 14734615-Fig-7a
  *** Jun[Ab] prot-exp[WB] is increased irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNTCs in BMS "nuclear extracts"
    *** comment: nuclear Jun is phosed on S63 [phosAb]
    *** does not req: Stat4 [KO]
    *** source: 14734615-Fig-7b
  *** Jun[Ab] prot-exp[WB] is increased irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNTCs in BMS "nuclear extracts"
    *** unaffected by: IL12 [cotreatment]
    *** source: 14734615-Fig-7b
*** Mek12s--
  *** Mek12s[phosAb] phos(sitenr)[phosAb] is increased irt anti-Cd3 + anti-Cd28 (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 30++ 60+ 120+ 180+ 240 360 min
    *** source: 15339934-Fig-5d
*** Nemo--
  *** Nemo[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt anti-Cd3 + anti-Cd28 (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 10+ 20+ min
    *** inhibited by: xUbc13(C87A)"DN" [addition]
    *** unaffected by: xUbe2d1(C85A)"DN" [addition]
    *** partially inhibited by: xTraf6(294-530)"DN" [addition]
    *** partially reqs: Traf6 [RNAi]
    *** partially inhibited by: xTak1(K63W)"DN" [addition]
    *** partially reqs: Tak1 [RNAi]
    *** partially reqs: Traf2 [RNAi]
    *** partially reqs: Malt1 [RNAi]
    *** source: 15125833-Fig-2a,3b,4b,4c,4d
*** P38s--
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt anti-Cd3 + anti-Cd28 (10 min)
    *** cells: JURKAT<Pten~null> in BMLS
    *** partially reqs: Mlk3 [RNAi]
    *** source: 15258589-Fig-2e
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt anti-Cd3 + anti-Cd28 (10 min)
    *** cells: JURKAT<Pten~null> in BMLS
    *** reqs: Mlk3 [RNAi]
    *** source: 15258589-Fig-2e
*** Pag1--
  *** Pag1[Ab]IP Yphos[pYAb] is decreased irt anti-Cd3 + anti-Cd28 (tnr)
    *** cells: hPBTCs in BMS
    *** source: 10790433-Fig-9a
*** Stat4--
  *** Stat4[Ab] prot-exp[WB] is detectable-but unchanged irt anti-Cd3 + anti-Cd28 (12 hr)
    *** cells: mLNTCs in BMS
    *** unaffected by: IL12 [cotreatment]
    *** source: 14734615-Fig-7a
  *** Stat4[Ab]IP Yphos[pYAb] is increased irt anti-Cd3 + anti-Cd28 (times)
    *** cells: mLNTCs in BMS
    *** times: 0 12 24+ 36++ hr
    *** source: 14734615-Fig-4b
*** Tbet--
  *** Tbet-gene mRNA[RTPCR] is increased irt anti-Cd3 + anti-Cd28 (times)
    *** cells: hCBLs<Cd4~pos> in BMS
    *** times: 0 6+ 24+ 48+ hr
    *** partially inhibited by: anti-Ifng [cotreatment]
    *** enhanced by: IL12 [cotreatment]
    *** enhanced by: IL12 + anti-Ifng [cotreatment]
    *** enhanced by: anti-IL12 + Ifng [cotreatment]
    *** source: 16220539-Fig-2a
*** DNA-synthesis--
  *** DNA-synthesis[3H-Thymidine] is increased irt anti-Cd3 + anti-Cd28 (40 hr)
    *** cells: mTCs in BMS
    *** inhibited by: xIkba(mnr)"del-Nterm" [addition]
    *** source: 11160275-Fig-1b
  *** DNA-synthesis[3H-Thymidine] is increased irt anti-Cd3 + anti-Cd28 (40 hr)
    *** cells: mTCs in BMS
    *** unaffected by: IL2 [cotreatment]
    *** unaffected by: IL4 [cotreatment]
    *** source: 11160275-Fig-1b
  *** DNA-synthesis[3H-Thymidine] is increased irt anti-Cd3 + anti-Cd28 (48 hr)
    *** cells: mLCs<Cd4~pos><Lselectin~pos> in BMS
    *** does not req: Irs2 [KO]
    *** does not req: Stat6 [KO]
    *** source: 11739727-Fig-3a
  *** DNA-synthesis[3H-Thymidine] is increased irt anti-Cd3 + anti-Cd28 (56 hr)
    *** cells: mTCs in BMS
    *** partially inhibited by: xIkba(mnr)"del-Nterm" [addition]
    *** source: 11160275-Fig-8
  *** DNA-synthesis[3H-Thymidine] is increased irt anti-Cd3 + anti-Cd28 (56 hr)
    *** cells: mTCs in BMS
    *** unaffected by: IL12 [cotreatment]
    *** source: 11160275-Fig-8
