============
Dimerization
============

not Irak4--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 30 60+ 120+ 180++ 240++ min
    *** does not req: Irak4 [KO]
    *** source: 14634120-Fig-2a

not Pin1--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: U373<xCd14> in BMS
    *** times: 0 1+++ 3++ 9+ hr
    *** repressed by: Pin1 [RNAi]
    *** source: 16699525-Fig-3f

Pkce--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 30+ 60+ min
    *** reqs: Pkce [KO]
    *** source: 16757566-Fig-5b

Ticam2--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1+ 2+ hr
    *** reqs: Ticam2 [KO]
    *** source: 14556004(D)

not Tirap--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 30+ 60+ min
    *** does not req: Tirap [KO]
    *** source: 12447441-Fig-5d

Traf3--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (10 min)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** reqs: xTraf3 [omission]
    *** unaffected by: xTraf3(K107R) [substitution]
    *** unaffected by: xTraf3(K156R) [substitution]
    *** unaffected by: xTraf3(K107R/K156R) [substitution]
    *** unaffected by: xTraf3(K138R/K156R) [substitution]
    *** source: 19898473-Fig-5d
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** times: 0 30+ 60+ min
    *** reqs: xTraf3 [omission]
    *** inhibited by: xTraf3(C68A/H70A) [substitution]
    *** source: 19898473-Fig-5b
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0+ 30++ 60++ min
    *** reqs: Traf3 [RNAi]
    *** source: 19898473-Fig-S5

not Traf6--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0+ 30++ 60++ min
    *** does not req: Traf6 [RNAi]
    *** source: 19898473-Fig-S5

Trif--

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 20 40+ 60++ min
    *** reqs: Trif [KO]
    *** source: 12872135-Fig-2g
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 30 60+ 120++ min
    *** reqs: Trif [KO]
    *** source: 12855817-Fig-3b

chemicals

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (1 hr)
    *** cells: U373<xCd14> in BMS
    *** inhibited by: Staurosporine [addition]
    *** inhibited by: TPCK [addition]
    *** unaffected by: TLCK [addition]
    *** unaffected by: PD98059 [addition]
    *** unaffected by: SB202190 [addition]
    *** unaffected by: Hypericin [addition]
    *** unaffected by: Calphostin [addition]
    *** unaffected by: Acridine-Orange [addition]
    *** unaffected by: Tilorone [addition]
    *** unaffected by: Tilorone-874 [addition]
    *** unaffected by: Geldanamycin [addition]
    *** source: 12062447-Fig-3a,3b
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 30+ 60++ 120++ min
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-1c

no extras

  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1++ 2+ 4 hr
    *** source: 12096038-Fig-2a
  *** Irf3[Ab] oligomerization[NativeWB] is increased irt Lps (times)
    *** cells: U373 in BMS
    *** times: 0 30 60+ 120++ 240+ min
    *** source: 12062447-Fig-1a,1b
  *** xIrf3[tAb] oligomerization[NativeWB] is increased irt Lps (2 hr)
    *** cells: U373<xCd14> in BMS
    *** inhibited by: xIrf3(S385A) [substitution]
    *** inhibited by: xIrf3(S386A) [substitution]
    *** source: 12062447-Fig-2b



