mod POLYICRULES is inc ALLOPS .

var xout : Soup .
var tlr3c : Soup .
vars clo clm clr cli clc nuo num nui nuc : Soup .
vars moo mom moi moc mio mim mii mic : Soup .
vars ero erm eri erc pxo pxm pxi pxc : Soup .
vars gao gam gai gac lyo lym lyi lyc : Soup .
vars eeo eem eei eec leo lem lei lec : Soup .
vars cpo cpm cpi cpc ptc sig ct : Soup .

**************************************************************************

*** ~/evidence/PolyIC-Evidence/00PolyIC-evidence.txt

rl[425.TLR3.onby.PolyIC]:
  {XOut  | xout   PolyIC           }
  {TLR3C | tlr3c  TLR3             }
  =>
  {XOut | xout                     }
  {TLR3C | tlr3c (TLR3 : PolyIC)   } .
  --------------------------------------
  *** Polyinosinic acid:cytidylic acid [polyIC],
    *** which has been extensively used to mimic dsRNA,
    *** is recognized by TLR3 [17190786(R),11607032]
  *** TLR3 is located in the ER 16858407(D)

*** CcL5--
*** CcL5-gene--

rl[475.CcL5-gene.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)   }
  {NUc   | nuc    CcL5-gene        }

  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)   }
  {NUc   | nuc   [CcL5-gene - on]  } .
  -----------------------------------------
  *** ~/evidence/PolyIC-Evidence/CcL5-gene.irt.PolyIC.475.txt

*** Erks--

rl[83.ErkS.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif     }
  {CLc   | clc  Erks Tradd                }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif     }
  {CLc   | clc [Erks - phos(TEY)] Tradd   } .
  ---------------------------------------------
  *** ~/evidence/PolyIC-Evidence/ErkS.irt.PolyIC.83.txt

*** Ifna4--

rl[476.Ifna4-gene.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)   }
  {NUc   | nuc    Ifna4-gene       }

  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)   }
  {NUc   | nuc   [Ifna4-gene - on] } .
  -------------------------------------
  *** ~/evidence/PolyIC-Evidence/Ifna4-gene.irt.PolyIC.476.txt

*** Ifnb1--
*** Ifnb1-gene--

rl[455.Ifnb1-gene.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif                         }
  {CLc   | clc    Irf7                                        }
  {NUc   | nuc    [Irf3 - irf3mods:ModSet] Ifnb1-gene         }

  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif                         }
  {CLc   | clc    Irf7                                        }
  {NUc   | nuc   [Irf3 - irf3mods:ModSet] [Ifnb1-gene - on]   } .
  ----------------------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Ifnb1-gene.irt.PolyIC.455.txt
  *** Irf7 needs an update

*** Ikba--

rl[326.Ikba.phosed.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC) [Ripk1 - ubiq] Traf6                 }
  {CLc   | clc   (Ikk1 : [Ikk2 - act] : Nemo) (Ikba : Rela)           }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) [Ripk1 - ubiq] Traf6                 }
  {CLc   | clc   (Ikk1 : [Ikk2 - act] : Nemo) ([Ikba - phos] : Rela)  } .
  ----------------------------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Ikba.phosed.irt.PolyIC.326.txt

rl[512.Ikba.degraded.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif (Tab1 : Tab2 : [Tak1 - act])  }
  {CLc   | clc (Ikk1 : [Ikk2 - act] : Nemo) ([Ikba - phos] : Rela)  }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif (Tab1 : Tab2 : [Tak1 - act])  }
  {CLc   | clc (Ikk1 : [Ikk2 - act] : Nemo) Rela [Ikba - degraded]  } .
  -----------------------------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Ikba.degraded.irt.PolyIC.512.txt

*** IKK--

rl[596.IKK.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)                    }
  {CLc   | clc   Peli1 (Ikk1 : Ikk2 : Nemo)         }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)                    }
  {CLc   | clc   Peli1 (Ikk1 : [Ikk2 - act] : Nemo) } .
  -----------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/IKK.irt.PolyIC.596.txt

*** IL6-gene--

rl[477.IL6-gene.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)   }
  {NUc   | nuc    IL6-gene         }

  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)   }
  {NUc   | nuc   [IL6-gene - on]   } .
  -------------------------------------
  *** ~/evidence/PolyIC-Evidence/IL6-gene.irt.PolyIC.477.txt

*** IL8-gene--

rl[484.IL8-gene.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)   }
  {NUc   | nuc    IL8-gene         }

  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)   }
  {NUc   | nuc   [IL8-gene - on]   } .
  -------------------------------------
  *** ~/evidence/PolyIC-Evidence/IL8-gene.irt.PolyIC.484.txt

*** IL12b-gene--

rl[478.IL12b-gene.irt.PolyIC]:
  {TLR3C  | tlr3c (TLR3 : PolyIC) Trif          }
  {CLc    | clc   Peli1                         }
  {NUc    | nuc   IL12b-gene                    }
  =>
  {TLR3C  | tlr3c (TLR3 : PolyIC) Trif          }
  {CLc    | clc   Peli1                         }
  {NUc    | nuc   [IL12b-gene - on]             } .
  -----------------------------------------------
  *** ~/evidence/PolyIC-Evidence/IL12b-gene.irt.PolyIC.478.txt

*** Irf3--

rl[448.Irf3.phos.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)                   }
  {CLc   | clc      Irf3                           }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)                   }
  {CLc   | clc    [Irf3 - phos(S 339) phos(S 396)] } .
  ---------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Irf3.phos.irt.PolyIC.448.txt

rl[449.Irf3.dimer.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)                }
  {CLc   | clc    Irf3                          }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)                }
  {CLc   | clc   [Irf3 - dimer]                 } .
  ---------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Irf3.dimer.irt.PolyIC.449.txt

rl[692.Irf3.to.Nuc.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif      }
  {CLc | clc  Azi2 Tbk1 [Irf3 - dimer]     }
  {NUc | nuc                               }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif      }
  {CLc | clc Azi2 Tbk1                     }
  {NUc | nuc [Irf3 - dimer]                } .
  -----------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Irf3.to.Nuc.irt.PolyIC.692.txt

*** Jnks--

rl[711.JnkS.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)       }
  {CLc | clc Jnks  Tradd               }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)       }
  {CLc | clc [Jnks - act] Tradd        } .
  ----------------------------------------
  *** ~/evidence/PolyIC-Evidence/JnkS.irt.PolyIC.711.txt

*** P38--
*** P38s--

rl[715.P38.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)       }
  {CLc | clc P38s  Tradd               }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)       }
  {CLc | clc [P38s - phos(TGY)] Tradd  } .
  ----------------------------------------
  *** ~/evidence/PolyIC-Evidence/P38.irt.PolyIC.715.txt

*** Rela--

rl[583.Rela.to.Nuc.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)  }
  {CLc | clc  Rela                }
  {NUc | nuc                      } 
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC)  }
  {CLc | clc                      }
  {NUc | nuc  Rela                } .
  -----------------------------------
  *** ~/evidence/PolyIC-Evidence/Rela.to.Nuc.irt.PolyIC.583.txt

*** Ripk1--

rl[742.Ripk1.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif                }
  {CLc   | clc    Peli1 Ripk1                        }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif [Ripk1 - ubiq] }
  {CLc   | clc    Peli1                              } .
  --------------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Ripk1.irt.PolyIC.742.txt

*** Src--

rl[453.Src.to.TLR3.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)                     }
  {CLi   | cli    Src                                }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) [Src - phos(Y 419)] }
  {CLi   | cli                                       } .
  -----------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Src.to.TLR3.irt.PolyIC.453.txt

*** Stat1--

rl[451.Stat1.phos.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC) [Src - phos(Y 419)] Trif }
  {CLc   | clc    Stat1                                     }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) [Src - phos(Y 419)] Trif }
  {CLc   | clc   [Stat1 - phos(Y 701)]                      } .
  -------------------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Stat1.phos.irt.PolyIC.451.txt

*** Tak1-- Tab2--

rl[743.Tak1.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)                              }
  {CLc   | clc   (Tab1 : Tab2 : Tak1)                         }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) (Tab1 : Tab2 : [Tak1 - act]) }
  {CLc   | clc                                                } .
  ---------------------------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Tak1.irt.PolyIC.743.txt

*** Tnf--
*** ProTnf-gene--

rl[456.ProTnf-gene.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif            }
  {CLc    | clc   Peli1 Unc93b1                  }
  {NUc    | nuc   hmgb:HmgbS ProTnf-gene         }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif            }
  {CLc    | clc   Peli1 Unc93b1                  }
  {NUc    | nuc   hmgb:HmgbS [ProTnf-gene - on]  } .
  -----------------------------------------------
  *** ~/evidence/PolyIC-Evidence/ProTnf-gene.irt.PolyIC.456.txt

*** Trif-- 

rl[429.Trif.to.TLR3.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)        }
  {CLc   | clc    Trif                  }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) Trif   }
  {CLc   | clc                          } .
  ------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Trif.to.TLR3.irt.PolyIC.429.txt

*** Traf3--

rl[437.Traf3.to.TLR3.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)       }
  {CLc   | clc    Traf3                }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) Traf3 }
  {CLc   | clc                         } .
  ------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Traf3.to.TLR3.irt.PolyIC.437.txt

*** Traf6--

rl[444.Traf6.to.TLR3.irt.PolyIC]:
  {TLR3C | tlr3c (TLR3 : PolyIC)       }
  {CLc   | clc    Traf6                }
  =>
  {TLR3C | tlr3c (TLR3 : PolyIC) Traf6 }
  {CLc   | clc                         } .
  ------------------------------------------
  *** ~/evidence/PolyIC-Evidence/Traf6.to.TLR3.irt.PolyIC.444.txt




endm
