Ikba-phos/degradation

  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** inhibited by: xIkba(mnr)"non-phosphorylatable" [addition]
    *** source: 15545623-Fig-1c

Proteasome activity

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2 5+ 10+ 20+ min
    *** source: 10521409-Fig-1a,c
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** source: 10521409-Fig-1a,c
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (15 min)
    *** cells: SAOS2 in BMS
    *** partially inhibited by: MG132 [addition]
    *** source: 15073170-Fig-2f

Cebpb--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: mSPImacs in BMS
    *** times: 0 10+ 30+ 60 min
    *** partially reqs: Cebpb [KO]
    *** source: 19733238-Fig-2a

inhibition by Cezanne--

  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (times)
    *** cells: HEK293 in BMS
    *** times: 0 15+ 120 min
    *** partially inhibited by: xCezanne [addition]
    *** unaffected by: xCezanne(C209S) [addition]
    *** source: 18178551-Fig-3b

not Gsk3b--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15++ 30++ 60+ 120+ 240+ 480+ min
    *** does not req: Gsk3b [KO]
    *** source: 10894547-Fig-5h

inhibition by Hdac3--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 10+ 30+ 90+ min
    *** partially inhibited by: xHdac3 [addition]
    *** source: 11533489-Fig-3c

not Ikba--

  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (10 min)
    *** cells: mEFs in BMS
    *** does not req: Ikba [KO]
    *** comment: Rela reqs Ikba[KO] to return to nucleus after removal of Tnf for 60 min
    *** comment: Rela reqs protein synthesis [CHX] to return to nucleus after removal of Tnf for 60 min
    *** source: 11416149-Fig-5

not Jnk1--
not Jnk2--

  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** does not req: Jnk1 or Jnk2 [DKO]
    *** source: 15545623-Fig-1c

not Msk1--
not Msk2--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5 10 15+ 20++ 30++ min
    *** does not req: Msk1 or Msk2 [DKO]
    *** source: 12628924-Fig-8a

Muc1--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: MCF10A in BMS
    *** times: 0 30+ 2+ hr
    *** reqs: Muc1 [RNAi]
    *** source: 18037881-Fig-4a
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS
    *** reqs: Muc1 [RNAi]
    *** source: 18037881-Fig-4b
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (30 min)
    *** cells: mMECs in BMS
    *** reqs: Muc1 [RNAi]
    *** source: 18037881-Fig-4b

not Pias1--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 30++ 60+ min
    *** unaffected by: Pias1 [KO]
    *** source: 17606919-Fig-7b
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30+ min
    *** unaffected by: Pias1 [KO]
    *** source: 15657437-Fig-6b
  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** unaffected by: Pias1 [KO]
    *** source: 15657437-Fig-6a

not Pias4--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 30++ 60+ min
    *** unaffected by: Pias4 [KO]
    *** source: 17606919-Fig-7a

not Pkcz

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** does not req: Pkcz [KO]
    *** source: 11684013-Fig-3b

not Ripk1--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS
    *** does not req: Ripk1 [RNAi]
    *** source: 18037881-Fig-4e

Rsk2-- ???

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: HELA in BMLS "nuclear fraction"
    *** times: 0 10+ 30+ min
    *** does not req: Rsk2 [RNAi]
    *** comment: authors say that Rela to nuc is slower in Rsk2-null cells
    *** source: 20385620-Fig-4b
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: mEFs in BMLS "nuclear fraction"
    *** times: 0 10+ 30+ min
    *** reqs: Rsk2 [RNAi]
    *** source: 20385620-Fig-4e

not Tab1--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS
    *** does not req: Tab1 [RNAi]
    *** source: 18037881-Fig-S5

Tab2--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS
    *** reqs: Tab2 [RNAi]
    *** source: 18037881-Fig-5b

Tak1--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (30 min)
    *** cells: MCF10A in BMS
    *** reqs: Tak1 [RNAi]
    *** source: 18037881-Fig-5a
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: PC3U in BMLS
    *** times: 0 2+ 6+ hr
    *** unaffected by: xTak1 [addition]
    *** partially inhibited by: xTak1(K34R) [addition]
    *** source: 22069318-Fig-8b
  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (times)
    *** cells: PC3U in BMLS
    *** times: 0 2+ 6+ hr
    *** unaffected by: xTak1 [addition]
    *** partially inhibited by: xTak1(K34R) [addition]
    *** source: 22069318-Fig-8b

not TLR3--

  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: RPE1 in BMS
    *** does not req: TLR3 [RNAi]
    *** source: 22611194-Fig-1a

Tpl2--

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30++ min
    *** does not req: Tpl2 [KO]
    *** source: 15833743-Fig-5B
  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (15 min)
    *** cells: mEFs in BMS
    *** does not req: Tpl2 [KO]
    *** source: 15833743-Fig-5C

chemicals

  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: HELA in BMS
    *** inhibited by: SN50 [pretreatment]
    *** source: 10655476-Fig-6c
  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: RPE1 in BMS
    *** unaffected by: Leupeptin [pretreatment]
    *** source: 22611194-Fig-2a
  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: RPE1 in BMS
    *** inhibited by: CHX [pretreatment]
    *** source: 22611194-Fig-3c
  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: RPE1 in BMS
    *** unaffected by: ConcanamycinA [pretreatment]
    *** source: 22611194-Fig-4a
  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: RPE1 in BMS
    *** unaffected by: Dynasore [pretreatment]
    *** source: 22611194-Fig-4b

========================
clues to Rela phos state
========================

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0+ 5++ 20++ min
    *** unaffected by: CalyculinA [addition]
    *** comment: the Rela in the nuc-fraction is phosed on S536 at 5 min
    *** comment: the Rela in the nuc-fraction is less phosed on S536 at 20 min
    *** source: 12842894-Fig-8

======================
Required Rela Features
======================

  *** xRela[tAb] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: HUH7<xRela> in BMS "treated with LMB"
    *** inhibited by: xRela(K301A/R302A/K303A)"NLS-mut" [substitution]
    *** source: 15677444-Fig-6c
  *** xRela[tAb] locatedin(nucleus)[IHC] is increased irt Tnf (30 min)
    *** cells: HUH7<xRela> in BMS "treated with LMB"
    *** inhibited by: xRela(K301A/R302A/K303A)"NLS-mut" [substitution]
    *** source: 15677444-Fig-8

=====
Other
=====

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** comment: partially inhibited by prestim with Egf for 10 min
    *** source: 19393267-Fig-6a
  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 3+ 5++ 10++ min
    *** comment: partially inhibited by prestim with Egf for 10 min
    *** source: 19393267-Fig-6b

=========
no extras
=========

  *** Rela[Ab] infraction(nuclear)[WB] is increased irt Tnf (30 min)
    *** cells: HEK293T in BMS
    *** source: 11533489-Fig-1b
  *** Rela[Ab] locatedin(nucleus)[IHC] is increased irt Tnf (15 min)
    *** cells: mEFs in BMS
    *** source: 11416149-Fig-2a
