=================================
xLkb1 activity requires Lkb1(D194)
=================================

  *** xLkb1[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** inhibited by: xLkb1(D194A)"KD" [substitution]
    *** source: 11297520-Fig-9a
  *** xLkb1[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** inhibited by: xLkb1(D194A)"KD" [substitution]
    *** source: 11297520-Fig-12d
  *** xLkb1[Ab]IP IVKA(Tp53)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** inhibited by: xLkb1(D194A)"KD" [substitution]
    *** source: 11297520-Fig-9a
  *** xLkb1[Ab]IP IVKA(Tp53)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** inhibited by: xLkb1(D194A)"KD" [substitution]
    *** source: 11297520-Fig-12d
  *** xLkb1[Ab]IP IVKA(Ampk,peptide)[32P-ATP] is detectable
    *** cells: A549 in BMS
    *** inhibited by: xLkb1(D194A)"KD" [substitution]
    *** source: 19414597-Fig-4b

==================================
xLkb1 activity requires Lkb1(D176)
==================================

  *** xLkb1[tAb]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: none
    *** IPfrom: HEK293T in BMS
    *** inhibited by: xLkb1(D176Y)"KD"[tAb]IP [substitution]
    *** source: 12805220-Fig-3c

========================================================
xLkb1 activity does not require phos(S307) or phos(S428)
========================================================

  *** xLkb1[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xLkb1(S428A) [substitution]
    *** unaffected by: xLkb1(S428D) [substitution]
    *** source: 11297520-Fig-9a
  *** xLkb1[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xLkb1(S428A) [substitution]
    *** source: 11297520-Fig-12d
  *** xLkb1[Ab]IP IVKA(Tp53)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xLkb1(S428A) [substitution]
    *** unaffected by: xLkb1(S428D) [substitution]
    *** source: 11297520-Fig-9a
  *** xLkb1[Ab]IP IVKA(Tp53)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xLkb1(S428A) [substitution]
    *** source: 11297520-Fig-12d
  *** xLkb1[Ab]IP IVKA(Ampk,peptide)[32P-ATP] is detectable
    *** cells: A549 in BMS
    *** unaffected by: xLkb1(S307A) [substitution]
    *** unaffected by: xLkb1(S428A) [substitution]
    *** unaffected by: xLkb1(S307A/S428A) [substitution]
    *** source: 19414597-Fig-4b

==========================================================================
Lkb1 basal kinase activity does not require Lkb1(303-306) (Strada binding)
==========================================================================

  *** xLkb1[tAb]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: none
    *** IPfrom: HEK293T in BMS
    *** unaffected by: xLkb1(del(303-305)/H306N)[tAb]IP [substitution]
    *** source: 12805220-Fig-3c

================================================
xLkb1 activity does not require C430 prenylation
================================================

  *** xLkb1[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xLkb1(C430A)"prenyl-site-mut" [substitution]
    *** source: 11297520-Fig-12d
  *** xLkb1[Ab]IP IVKA(Tp53)[32P-ATP] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xLkb1(C430A)"prenyl-site-mut" [substitution]
    *** source: 11297520-Fig-12d

=====
other
=====

  *** Lkb1[Ab]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: RAT2 in BMS
    *** source: 11297520-Fig-9a
  *** Lkb1[Ab]IP IVKA(Tp53)[32P-ATP] is detectable
    *** cells: RAT2 in BMS
    *** source: 11297520-Fig-9a
