======================================
Phosphorylation state in growing cells
======================================

  *** xCtnnb1[tAb]IP phos(S33/S37)[phosAb] is detectable
    *** cells: Xembryos<xCtnnb1> in BMS
    *** inhibited by: xCtnnb1(S33Y) [substitution]
    *** inhibited by: xCtnnb1(S37F) [substitution]
    *** inhibited by: xCtnnb1(T41A) [substitution]
    *** inhibited by: xCtnnb1(S45F) [substitution]
    *** inhibited by: xCtnnb1(S33A/S37A/T41A/S45A) [substitution]
    *** source: 11955436-Fig-1e
  *** xCtnnb1[tAb]IP phos(T41/S45)[phosAb] is detectable
    *** cells: Xembryos<xCtnnb1> in BMS
    *** unaffected by: xCtnnb1(S33Y) [substitution]
    *** unaffected by: xCtnnb1(S37F) [substitution]
    *** unaffected by: xCtnnb1(T41A) [substitution]
    *** inhibited by: xCtnnb1(S45F) [substitution]
    *** inhibited by: xCtnnb1(S33A/S37A/T41A/S45A) [substitution]
    *** source: 11955436-Fig-1e
  *** Ctnnb1[phosAb] phos(T41/S45)[phosAb] is detectable
    *** cells: HELA in BMS "treated with MG132"
    *** partially inhibited by: CKI7 [addition]
    *** unaffected by: H89 [addition]
    *** source: 12000790-Fig-5d
  *** xCtnnb1[tAb]IP phos(S45)[phosAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xCtnnb1(K49R) [substitution]
    *** source: 18356165-Fig-2d

  *** xCtnnb1[tAb]IP Yphos[pYAb] is detectable
    *** cells: IEC18<xKras(G12V)"CA"> in BMS
    *** unaffected by: rCtnnb1(Y86F) [substitution]
    *** inhibited by: rCtnnb1(Y142F) [substitution]
    *** inhibited by: rCtnnb1(Y654F) [substitution]
    *** source: 12640114-Fig-4a,4b



=================
Strange Mutations
=================

  *** xCtnnb1(T41A)[tAb]IP phos(S45)[phosAb] is detectable
    *** cells: HEK293T<xCtnnb1(T41A)> in BMS
    *** inhibited by: xCtnnb1(T41A/S45A) [substitution]
    *** source: 12051714-Fig-1c
  *** xCtnnb1(T41A)[tAb]IP phos(S45)[phosAb] is detectable
    *** cells: HEK293T<xCtnnb1(T41A)> in BMS
    *** partially inhibited by: SB216763 [addition]
    *** partially inhibited by: LiCl [addition]
    *** source: 12051714-Fig-3b
  *** xCtnnb1(T41A)[tAb]IP phos(S45)[phosAb] is detectable
    *** cells: HEK293T<xCtnnb1(T41A)> in BMS
    *** unaffected by: xCsnk2a1 [addition]
    *** source: 12051714-Fig-3c

Effect of "creating a surrogate protein kinase A (PKA)-mediated phosphorylation site at S45"

  *** xCtnnb1(T41S/T42R/A43R)[phosAb] phos(S33)[phosAb] is detectable-but unchanged itpo xAxin1
    *** cells: HEK293T<xCtnnb1> in BMS "treated with MG132"
    *** source: 12000790-Fig-4
  *** xCtnnb1(T41S/T42R/A43R)[phosAb] phos(T41/S45)[phosAb] is detectable-but unchanged itpo xAxin1
    *** cells: HEK293T<xCtnnb1> in BMS "treated with MG132"
    *** unaffected by: xGsk3b [addition]
    *** unaffected by: xGsk3b(R96A) [addition]
    *** source: 12000790-Fig-4
  *** xCtnnb1(T41S/T42R/A43R)[phosAb] phos(S33)[phosAb] is increased itpo xGsk3b
    *** cells: HEK293T<xCtnnb1> in BMS "treated with MG132"
    *** inhibited by: xGsk3b(R96A) [substitution]
    *** source: 12000790-Fig-4
  *** xCtnnb1(T41S/T42R/A43R)[phosAb] phos(T41/S45)[phosAb] is detectable
    *** cells: HEK293T<xCtnnb1> in BMS
    *** unaffected by: CKI7 [addition]
    *** source: 12000790-Fig-5c

================
Coprecipitations
================

  *** Ctnnb1[Ab] copptby[WB] Cdh1[Ab] is detectable
    *** cells: A431 in BMS
    *** unaffected by: Egf (10 min) [stim]
    *** source: 11716761-Fig-3
  *** Ctnnb1[Ab] copptby[WB] Cdh1[Ab] is detectable
    *** cells: MCF7 in BMS
    *** unaffected by: Egf (30 min) [stim]
    *** source: 10187801-Fig-5a
  *** Ctnnb1[Ab] copptby[WB] Cdh1[Ab] is detectable
    *** cells: MDCK in BMS
    *** unaffected by: Egf (10 min) [stim]
    *** source: 11716761-Fig-2f
  *** Ctnnb1[Ab] copptby[WB] Cdh1[Ab] is detectable
    *** cells: NBTII in BMS
    *** inhibited by: Pervanadate [addition]
    *** unaffected by: Egf (30 min) [stim]
    *** unaffected by: Fgf1 + Heparin (30 min) [stim]
    *** unaffected by: Orthovanadate [addition]
    *** source: 10187801-Fig-2
  *** Ctnnb1[Ab] copptby[WB] Cdh1[Ab] is detectable
    *** cells: SCC12F in BMS "containing hydrocortisone"
    *** unaffected by: Egf (10 min) [stim]
    *** source: 11716761-Fig-2b
  *** Ctnnb1[Ab] copptby[WB] Pik3rs[Ab] is detectable
    *** cells: EJ in BMS
    *** source: 11716761-Fig-4
  *** Ctnnb1[Ab] copptby[WB] Pik3rs[Ab] is detectable
    *** cells: SCC12F in BMS "containing hydrocortisone"
    *** unaffected by: xHras [addition]
    *** source: 11716761-Fig-4
  *** Ctnnb1[Ab] copptby[WB] Ptprf[Ab] is detectable
    *** cells: MCF7 in BMS
    *** unaffected by: Egf (30 min) [stim]
    *** source: 10187801-Fig-5a
  *** Ctnnb1[Ab] copptby[WB] xCdkn1c[tAb] is undetectable
    *** cells: HEK293T<xCdkn1c> in BMS
    *** unaffected by: xAxin1 [addition]
    *** source: 10228155-Fig-1a
  *** Ctnnb1[Ab] copptby[WB] xFbxw2[tAb] is undetectable
    *** cells: HEK293T<xFbxw2><xAxin1> in BMS
    *** source: 10228155-Fig-2b
  *** Ctnnb1[Ab] copptby[WB] xPpm1a[Ab] is detectable
    *** cells: COS1<xDvl3><xPpm1a> in BMS
    *** source: 10644691-Fig-1a
  *** Ctnnb1[Ab] copptby[WB] xSmad7[tAb] is detectable
    *** cells: COS1 in BMS
    *** partially inhibited by: xSmad7(204-426)"Cterm" [substitution]
    *** inhibited by: xSmad7(1-261)"Nterm" [substitution]
    *** source: 15684397-Fig-1a
