========
Location
========

  *** Tak1[Ab] infraction(cytoplasmic)[WB] is detectable
    *** cells: HEK293 in BMS
    *** comment: Tak1 was also seen in membrane fraction but there was less of it
    *** source: 12242293-Fig-5b

================================
Expressed Tak1 is Ubiquitinated
================================

  *** xTak1[Ab]IP ubiq[tUbAb] is detectable
    *** cells: HEK293T<xUbiq(K63only)> in BMS
    *** unaffected by: xTab1 [addition]
    *** source: 19843958-Fig-S5b

================
Coprecipitations
================

Ikbkap--

  *** Tak1[Ab] copptby[WB] xIkbkap[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10094049-Fig-4c

Ikk1--

  *** xTak1[Ab] copptby[WB] xIkk1[tAb] is detectable
    *** cells: HEK293<xNik> in BMS
    *** reqs: xNik [omission]
    *** source: 10094049-Fig-4b

not Mekk3--  ????

  *** xTak1[tAb] copptby[WB] xMekk3[tAb] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xTab1 [addition]
    *** unaffected by: xTak1(K63A)"KD" [substitution]
    *** comment: coppt Tak1 is not phosed on T187 [phosAb]
    *** source: 16260783-Fig-7a
  *** xTak1[tAb] copptby[WB] xMekk3[tAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xTab1 [addition]
    *** comment: coppt Tak1 is not phosed on (T184/T187)[phosAb]
    *** source: 18206350-Fig-6c
  *** xTak1[tAb] copptby[WB] xMekk3[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: Tnf (15 min) [stim]
    *** unaffected by: xMekk3(S526A/K391M) [substitution]
    *** comment: coppt Tak1 is not phosed on (T184/T187)[phosAb]
    *** source: 18206350-Fig-6b
  *** xMekk3[tAb] copptby[WB] xTak1[tAb] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xTak1(K63A)"KD" [substitution]
    *** source: 16260783-Fig-7a


Nik--

  *** xTak1[Ab] copptby[WB] xNik(K429A/K430A)[tAb] is detectable
    *** cells: HEK293 in BMS
    *** inhibited by: xTab1 [addition]
    *** source: 10094049-Fig-4a
  *** xTak1[Ab] copptby[WB] xNik(K429A/K430A)[tAb] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xTak1(K63W) [substitution]
    *** source: 10094049-Fig-4a

Peli1--

  *** xTak1[Ab] copptby[WB] xPeli1[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 12804775-Fig-1

Peli2--

  *** xTak1[Ab] copptby[WB] xPeli2[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 12804775-Fig-1

Peli3--

  *** xTak1[tAb] copptby[WB] xPeli3[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 12874243-Fig-5b

Ppp6c--

  *** xTak1[tAb] copptby[WB] xPpp6c[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 17079228(D)
  *** xTak1[tAb] copptby[WB] xPpp6c[tAb] is detectable
    *** cells: HEK293<xIL1R1> in BMS
    *** unaffected by: IL1b (tnr) [stim]
    *** unaffected by: xPpp6c(D84N)"KD" [substitution]
    *** source: 17079228(D)

Ripk1--

  *** Tak1[Ab] copptby[WB] xRipk1[tAb] is detectable
    *** cells: HEK293 in BMS
    *** inhibited by: xRipk1(K377R) [substitution]
    *** unaffected by: xRipk1(K396R) [substitution]
    *** unaffected by: xRipk1(K530R) [substitution]
    *** source: 16543241-Fig-5b


Tab1--

  *** xTak1[tAb] copptby[WB] xTab1[tAb] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xTak1(K63A)"KD" [substitution]
    *** comment: coppt Tak1 is phosed on T187 [phosAb]
    *** source: 16260783-Fig-7c
  *** Tak1[Ab] copptby[WB] Tab1[Ab] is detectable
    *** cells: HEK293 in BMS
    *** source: 14670075-Fig-3b

Tab2--

  *** Tak1[Ab] copptby[WB] Tab2[Ab] is detectable
    *** cells: MCF7 in BMS
    *** source: 17384642-Fig-1b
  *** xTak1[tAb] copptby[WB] xTab2[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: xSmad7 [addition]
    *** source: 17384642-Fig-3c
  *** Tak1[Ab] copptby[WB] Tab2[Ab] is detectable
    *** cells: JURKAT<Pten~null><Ripk1~null><xRipk1> in BMS
    *** unaffected by: Tnf (2,5 min) [stim]
    *** unaffected by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** source: 16603398-Fig-4a
  *** xTak1[tAb] copptby[WB] xTab2[Ab] is detectable
    *** cells: HEK293 in BMS
    *** source: 17158499-Fig-1b
  *** xTak1[tAb] snaggedby[WB] rTab2[GST] is detectable
    *** cells: HEK293 in BMS
    *** source: 17158499-Fig-1c
  *** Tak1[Ab] copptby[WB] Tab2[Ab] is detectable
    *** cells: HEK293 in BMS
    *** unaffected by: xTraf6(C70A)"E3-mut" [substitution]
    *** unaffected by: xTraf6(K142R)"DN" [addition]
    *** source: 17135271-Fig-4c
  *** xTak1[tAb] copptby[WB] xTab2[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10882101(D)
  *** Tak1[Ab] copptby[WB] Tab2[Ab] is detectable
    *** cells: HEK293 in BMS
    *** source: 14670075-Fig-3b

Tab3--

  *** xTak1[tAb] snaggedby[WB] rTab3[GST] is detectable
    *** cells: HEK293 in BMS
    *** source: 17158499-Fig-1f
  *** Tak1[Ab] copptby[WB] Tab3[Ab] is detectable
    *** cells: MCF7 in BMS
    *** source: 17384642-Fig-1b
  *** xTak1[tAb] copptby[WB] xTab3[tAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xTab3(1-392) [substitution]
    *** unaffected by: xTab3(393-693) [substitution]
    *** source: 17384642-Fig-3d
  *** xTak1[tAb] copptby[WB] xTab3[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: xSmad7 [addition]
    *** source: 17384642-Fig-3d
  *** Tak1[Ab] copptby[WB] Tab3[Ab] is detectable
    *** cells: HEK293 in BMS
    *** source: 14670075-Fig-3b
  *** xTak1[tAb] copptby[WB] xTab3[tAb] is detectable
    *** cells: HEK293 in BMS
    *** enhanced by: xTab2 [addition]
    *** source: 14633987-Fig-2d

Traf2--

  *** xTak1[tAb] copptby[WB] xTraf2[tAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xSmad7 [addition]
    *** source: 17384642-Fig-6e
  *** Tak1[Ab] copptby[WB] xTraf2[tAb] is undetectable
    *** cells: HEK293 in BMS
    *** source: 10094049-Fig-1c

Traf5--

  *** xTak1[tAb] copptby[WB] xTraf5[tAb] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xSmad7 [addition]
    *** source: 17384642-Fig-S7a

Traf6--

  *** Tak1[Ab] copptby[WB] xTraf6[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10094049-Fig-1c
  *** xTak1[Ab] copptby[WB] xTraf6((1-358)/GyrB)[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: CoumermycinA [addition]
    *** source: 19112497-Fig-2d
  *** xTak1[Ab] copptby[WB] xTraf6((1-358)/GyrB)[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: xTraf6((1-358)/GyrB/C70A) [substitution]
    *** unaffected by: xTraf6((1-358)/GyrB/C70A/mnr)"K32-348R" [substitution]
    *** source: 19112497-Fig-2d
