============================
Phosphorylation on S235/S236
============================

not Ddit4--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is decreased irt Serum-deprivation (times)
    *** cells: mEFs<Tp53~null> in BMS
    *** times: 0++ 3+ 6+ 9+ hr
    *** does not req: Ddit4 [KO]
    *** source: 15545625-Fig-6b

Rsk1-- and/or Rsk2--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Serum (15 min)
    *** cells: HEK293E in BMLS
    *** partially reqs: Rsk1 and/or Rsk2 [RNAi]
    *** source: 17360704-Fig-3b
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Serum (15 min)
    *** cells: HEK293E in BMLS
    *** partially reqs: Rsk1 [RNAi]
    *** partially reqs: Rsk2 [RNAi]
    *** source: 17360704-Fig-3a

S6k1--

  *** Rps6[phosAb] phos(S235)[phosAb] is increased irt Serum (40 min)
    *** cells: mESCs in BMLS
    *** reqs: S6k1 [KO]
    *** source: 11500364-Fig-5a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Serum (15 min)
    *** cells: HEK293E in BMLS
    *** partially reqs: S6k1 [RNAi]
    *** source: 17360704-Fig-3a
  ----- contradiction ------------------------------------------------
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Serum (30 min)
    *** cells: mHepatocytes in BMLS "AminoAcid and Glucose deprived"
    *** does not req: S6k1 or S6k2 [KO]
    *** source: 16763566-Fig-2a

Tsc2--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is decreased irt Serum-deprivation (times)
    *** cells: mEFs<Tp53~null> in BMS
    *** times: 0++ 3+ 6+ 9+ hr
    *** reqs: Tsc2 [KO]
    *** source: 15545625-Fig-6a

chemicals

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Serum (15 min)
    *** cells: HEK293E in BMLS
    *** inhibited by: FMK [pretreatment]
    *** source: 17360704-Fig-4b
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Serum (30 min)
    *** cells: mHepatocytes in BMLS "AminoAcid and Glucose deprived"
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-2a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Serum (45 min)
    *** cells: mEFs<Tp53~null> in BMLS
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 15545625-Fig-1a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Serum (times)
    *** cells: HEK293E in BMLS
    *** times: 0 5+ 10++ 30+++ 60+++ min
    *** partially inhibited by: U0126 [pretreatment]
    *** partially inhibited by: Rapamycin [pretreatment]
    *** source: 17360704-Fig-1a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Serum (times)
    *** cells: HELA in BMLS
    *** times: 0 2+ 5++ 10+++ 30+++ 60+++ min
    *** partially inhibited by: FMK [pretreatment]
    *** source: 17360704-Fig-4a

============================
Phosphorylation on S240/S244
============================

Rsk1-- and/or Rsk2--

  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Serum (15 min)
    *** cells: HEK293E in BMLS
    *** partially reqs: Rsk1 and/or Rsk2 [RNAi]
    *** source: 17360704-Fig-3b
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Serum (15 min)
    *** cells: HEK293E in BMLS
    *** partially reqs: S6k1 [RNAi]
    *** partially reqs: Rsk1 [RNAi]
    *** partially reqs: Rsk2 [RNAi]
    *** source: 17360704-Fig-3a

chemicals

  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Serum (15 min)
    *** cells: HEK293E in BMLS
    *** unaffected by: FMK [pretreatment]
    *** source: 17360704-Fig-4b
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Serum (30 min)
    *** cells: mESCs in BMLS
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-3a
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Serum (30 min)
    *** cells: mESCs in BMLS
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-3b
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Serum (times)
    *** cells: HEK293E in BMLS
    *** times: 0 5 10+ 30++ 60++ min
    *** unaffected by: U0126 [pretreatment]
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 17360704-Fig-1a
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Serum (times)
    *** cells: HELA in BMLS
    *** times: 0 2 5 10+ 30++ 60++ min
    *** unaffected by: FMK [pretreatment]
    *** source: 17360704-Fig-4a
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Serum (times)
    *** cells: HELA in BMLS
    *** times: 0 3+ 5++ 15++ 60+ 90+ min
    *** inhibited by: Rapamycin [pretreatment]
    *** unaffected by: U0126 [pretreatment]
    *** inhibited by: Rapamycin + U0126 [pretreatment]
    *** source: 16763566-Fig-1c

no extras--

  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Serum (times)
    *** cells: HELA in BMLS
    *** times: 0 3 5 10+ 15+ 30++ min
    *** source: 16763566-Fig-1b

=====================================
Phosphorylation on an unreported site
=====================================

  *** Rps6[phosAb] phos(sitenr)[phosAb] is increased irt Serum (30 min)
    *** cells: HELA<xEif4b> in BMLS
    *** unaffected by: U0126 [pretreatment]
    *** source: 16763566-Fig-4b
  *** Rps6[phosAb] phos(sitenr)[phosAb] is increased irt Serum (30 min)
    *** cells: HELA<xEif4b> in BMLS
    *** unaffected by: xRsk1 [addition]
    *** unaffected by: xRsk1(mnr)"KD" [addition]
    *** unaffected by: xRsk1(myr)"CA" [addition]
    *** source: 16763566-Fig-4b
  *** Rps6[phosAb] phos(sitenr)[phosAb] is increased irt Serum (90 min)
    *** cells: HELA<xEif4b> in BMLS
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 16763566-Fig-4c
  *** Rps6[phosAb] phos(sitenr)[phosAb] is increased irt Serum (90 min)
    *** cells: HELA<xEif4b> in BMLS
    *** unaffected by: xRsk1 [addition]
    *** unaffected by: xRsk1(mnr)"KD" [addition]
    *** unaffected by: xRsk1(myr)"CA" [addition]
    *** source: 16763566-Fig-4c

