===============
Kinase Activity
===============

  *** xPtk6[tAb]IP IVKA(auto)[32P-ATP] is increased irt Egf (times)
    *** cells: COS1 in BMLS
    *** times: 0 3 8+ 15++ 20++ 30 min
    *** inhibited by: xPtk6(K219M)"KD" [addition]
    *** source: 15572663-Fig-5a

  *** Ptk6[Ab]IP IVKA(auto)[32P-ATP] is detectable-but unchanged irt Egf (10 min)
    *** cells: T47D in BMLS
    *** source: 15539407-Fig-4b

===========================
Phosphorylation on Tyrosine
===========================

  *** xPtk6[Ab]IP Yphos[pYAb-ppt] is decreased irt Egf (10 min)
    *** cells: COS1<xPtk6> in BMLS
    *** source: 15539407-Fig-3a
  *** xPtk6[Ab]IP Yphos[pYAb-ppt] is decreased irt Egf (10 min)
    *** cells: T47D in BMLS
    *** partially reversed by: LY294002 [cotreatment]
    *** source: 15539407-Fig-4a


==========================
Relocation to EgfR irt Egf
==========================

  *** EgfR[Ab] copptby[WB] xPtk6[Ab] is increased irt Egf (10 min)
    *** cells: COS1<xPtk6> in BMLS
    *** unaffected by: xPtk6(K219M)"KD" [substitution]
    *** unaffected by: xPtk6(Y447F) [substitution]
    *** source: 15539407-Fig-3a

  *** xPtk6[Ab] copptby[WB] EgfR[Ab] is detectable-but unchanged irt Egf (5 min)
    *** cells: MCF10A<xPtk6> in BMS
    *** source: 8940083-Fig-5

==============================================
Coprecipitation with Akt1 is decreased irt Egf
==============================================

  *** xPtk6[Ab] copptby[WB] Akt1[Ab] is decreased irt Egf (10 min)
    *** cells: COS1<xPtk6> in BMS
    *** partially reversed by: xPtk6(Y447F) [substitution]
    *** unaffected by: xPtk6(K219M)"KD" [substitution]
    *** source: 15539407-Fig-2b
  *** xPtk6[Ab] copptby[WB] Akt1[Ab] is decreased irt Egf (10 min)
    *** cells: COS1<xPtk6> in BMLS
    *** reversed by: LY294002 [cotreatment]
    *** source: 15539407-Fig-2d
  *** Ptk6[Ab] copptby[WB] Akt1[tAb] is decreased irt Egf (10 min)
    *** cells: HACAT in BMLS
    *** source: 15539407-Fig-2a
  *** Ptk6[Ab] copptby[WB] Akt1[tAb] is detectable-but unchanged irt Egf (10 min)
    *** cells: T47D in BMLS
    *** unaffected by: LY294002 [cotreatment]
    *** source: 15539407-Fig-4a
  *** xPtk6[Ab] copptby[WB] xAkt1(mnr)"KD"[tAb] is decreased irt Egf (10 min)
    *** cells: COS1<xPtk6><xAkt1> in BMLS
    *** partially reversed by: xPtk6(Y447F) [substitution]
    *** unaffected by: xPtk6(K219M)"KD" [substitution]
    *** source: 15539407-Fig-2c
