============================================================
requirement for Gab1 phos(Y627/Y659) or Gab2 phos(Y614/Y643)
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on Y627 (Gab1) or Y614 (Gab2)

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: HEK293 in BMLS
    *** partially inhibited by: xGab1(Y627F)"DN" [addition]
    *** source: 10788507-Fig-4c
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** partially inhibited by: xGab1(Y627F)"DN" [addition]
    *** source: 10788507-Fig-3c
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** partially inhibited by: xGab1(Y627F)"DN" [addition]
    *** source: 11323411-Fig-2b
  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: VERO in BMLS
    *** unaffected by: xGab1 [addition]
    *** inhibited by: xGab1(Y627F) [addition]
    *** source: 11134009-Fig-7c
  ----------------------------------------------------------------
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: T47D in BMLS
    *** partially inhibited by: xGab2(Y614F)"DN" [addition]
    *** source: 15952937-Fig-2a
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** partially inhibited by: xGab2(Y614F)"DN" [addition]
    *** source: 15952937-Fig-2b

on Y659

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** inhibited by: xGab1(Y659F)"DN" [addition]
    *** source: 11323411-Fig-2b

on Y627 and Y659 (Gab1) Y614 and Y643 (Gab2)

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (5 min)
    *** cells: MDAMB468 in BMLS
    *** inhibited by: xGab1(Y627F/Y659F) [addition]
    *** source: 14665621-Fig-8e
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** bkg inhibited by: xGab1(Y627F/Y659F) [addition]
    *** source: 11323411-Fig-2b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (times)
    *** cells: mEFs<Gab1~null><xGab1> in BMLS
    *** times: 0 10++ 30+ min
    *** partially inhibited by: xGab1(Y627F/Y659F) [substitution]
    *** source: 12629518-Fig-4d
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: T47D in BMLS
    *** inhibited by: xGab1(Y627F/Y659F)"DN" [addition]
    *** source: 15952937-Fig-2a
  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: COS7 in BMLS
    *** inhibited by: xGab1(Y627F/Y659F)"DN" [addition]
    *** source: 15952937-Fig-2b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (5 min)
    *** cells: rHepatocytes in BMLS
    *** unaffected by: xGab2(Y603F/Y632F) [addition]
    *** comment: xGab2 is from rat, human sites are Y614F/Y643F
    *** source: 12464621-Fig-8d

not Y447F or Y472F or Y589F

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: HEK293 in BMLS
    *** unaffected by: xGab1(Y447F/Y472F/Y589F)"Pi3k-binding-mut" [addition]
    *** source: 10788507-Fig-4c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (times)
    *** cells: mEFs<Gab1~null><xGab1> in BMLS
    *** times: 0 10++ 30+ min
    *** unaffected by: xGab1(Y447F/Y472F/Y589F) [substitution]
    *** source: 12629518-Fig-4d

not in PH domain

  *** xErk2[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: HEK293 in BMLS
    *** unaffected by: xGab1(del(10-177))"PH-domain-mut" [addition]
    *** source: 10788507-Fig-4c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (times)
    *** cells: mEFs<Gab1~null><xGab1> in BMLS
    *** times: 0 10++ 30+ min
    *** unaffected by: xGab1(del(14-116))"PH-domain-mut" [substitution]
    *** source: 12629518-Fig-4d
  *** xErk1[tAb]IP IVKA(MBP)[32P-ATP] is increased irt Egf (5 min)
    *** cells: VERO in BMLS
    *** unaffected by: xGab1 [addition]
    *** unaffected by: xGab1(104-694)"PH-domain-mutant" [addition]
    *** source: 11134009-Fig-7c

not Pro-Rich domain

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (times)
    *** cells: mEFs<Gab1~null><xGab1> in BMLS
    *** times: 0 10++ 30+ min
    *** partially inhibited by: xGab1(del(449-531)) [substitution]
    *** source: 12629518-Fig-4d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (5 min)
    *** cells: rHepatocytes in BMLS
    *** unaffected by: xGab2(del(348-355)) [addition]
    *** comment: xGab2 is from rat, human sites are (351-358)
    *** source: 12464621-Fig-6d

modifications unknown

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (times)
    *** cells: mEFs in BMLS
    *** times: 0 5+++ 10+++ 30++ 90+ min
    *** partially reqs: Gab1 [KO]
    *** source: 12629518-Fig-1d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (times)
    *** cells: mEFs in BMLS
    *** times: 0 5++ 15++ 30+ min
    *** partially reqs: Gab1 [KO]
    *** source: 12629518-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (times)
    *** cells: mEFs<Gab1~null><xGab1> in BMLS
    *** times: 0 10++ 30+ min
    *** partially reqs: xGab1 [omission]
    *** source: 12629518-Fig-4d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (5 min)
    *** cells: rHepatocytes in BMLS
    *** enhanced by: xGab2 [addition]
    *** source: 12464621-Fig-8d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Egf (5 min)
    *** cells: rHepatocytes in BMLS
    *** enhanced by: xGab2 [addition]
    *** source: 12464621-Fig-6d


