=================================================
Coprecipitation between Pi4k2a and Dvls irt Wnt3a
=================================================

  *** Dvl3[Ab] copptby[WB] xPi4k2a[tAb] is increased irt Wnt3a (30 min)
    *** cells: HEK293T<xPi4k2a> in BMS
    *** source: 19561074-Fig-5c

===================================
Direct Activation of Pi4k2a by Dvls
===================================

  *** rPi4k2a IVLKA(PtdIns)[TLC] is increased by rDvl1
    *** cells: none
    *** unaffected by: rDvl1(376-503)"Dep" [substitution]
    *** inhibited by: rDvl1(1-200)"Dix" [substitution]
    *** inhibited by: rDvl1(201-375)"Pdz" [substitution]
    *** source: 19561074-Fig-4e
  *** rPi4k2a IVLKA(PtdIns)[TLC] is increased by rDvl1(376-503)"Dep"
    *** cells: none
    *** inhibited by: rDvl1(1-200)"Dix" [substitution]
    *** inhibited by: rDvl1(201-375)"Pdz" [substitution]
    *** source: 19561074-Fig-4d
  *** rPi4k2a IVLKA(PtdIns)[TLC] is increased by rDvl3
    *** cells: none
    *** source: 19561074-Fig-3a

===================
Direct Interactions
===================

Pi4k2a/Dvl1--

  *** rPi4k2a[tAb] boundby[WB] rDvl1[GST] is detectable
    *** cells: none
    *** inhibited by: rDvl1(1-200)"Dix" [substitution]
    *** unaffected by: rDvl1(201-375)"Pdz" [substitution]
    *** partially inhibited by: Dvl1(376-503)"Dep" [substitution]
    *** source: 19561074-Fig-4c
  *** rPi4k2a[tAb] boundby[WB] rDvl1[GST] is detectable
    *** cells: none
    *** source: 19561074-Fig-2c
  *** rDvl1[tAb] boundby[WB] rPi4k2a[GST] is detectable
    *** cells: none
    *** source: 19561074-Fig-2c

Pi4k2a/Pip5k1b--

  *** rPi4k2a[tAb] boundby[WB] rPip5k1b[GST] is detectable
    *** cells: none
    *** source: 19561074-Fig-S2c

===============
Coprecipitation
===============

Pi4k2a/Dvl1--

  *** xPi4k2a[tAb] copptby[WB] xDvl1[tAb] is detectable
    *** cells: HEK293T<xDvl1><xPi4k2a> in BMS
    *** inhibited by: xDvl1(1-200)"Dix" [substitution]
    *** unaffected by: xDvl1(201-375)"Pdz" [substitution]
    *** unaffected by: xDvl1(376-503)"Dep" [substitution]
    *** partially inhibited by: xDvl1(504-695)"Cterm" [substitution]
    *** source: 19561074-Fig-4b
  *** xPi4k2a[tAb] copptby[WB] xDvl1[tAb] is detectable
    *** cells: HEK293T<xDvl1><xPi4k2a> in BMS
    *** source: 19561074-Fig-2b
  *** xPi4k2a[tAb] copptby[WB] xDvl1[tAb] is detectable
    *** cells: HEK293T<xDvl1><xPi4k2a> in BMS
    *** unaffected by: xPip5k1b [addition]
    *** source: 19561074-Fig-5a

Pi4k2a/Pip5k1b--

  *** xPi4k2a[tAb] copptby[WB] xPip5k1b[tAb] is detectable
    *** cells: HEK293T<xPip5k1b><xPi4k2a> in BMS
    *** enhanced by: xDvl1 [addition]
    *** source: 19561074-Fig-S2d
  *** xPi4k2a[tAb] copptby[WB] xPip5k1b[tAb] is detectable
    *** cells: HEK293T<xPip5k1b><xPi4k2a> in BMS
    *** source: 19561074-Fig-5b




















