*** 3TP-reporter--
  *** 3TP-reporter[Luc] is increased irt Tgfb (18 hr)
    *** cells: HEPG2<xSmad2> in BMS
    *** inhibited by: xSmad2(S464A/S465A/S467A) [substitution]
    *** source: 8980228-Fig-5a
  *** 3TP-reporter[Luc] is increased irt Tgfb1 (16 hr)
    *** cells: HACAT in BMS
    *** inhibited by: xCsnk1g2 [addition]
    *** unaffected by: xCsnk1g2(mnr)"KD" [addition]
    *** repressed by: Csnk1g2 [RNAi]
    *** source: 18794808-Fig-2e
  *** 3TP-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: AKR2B in BMLS
    *** partially inhibited by: xErbin [addition]
    *** source: 19289088-Fig-4d
  *** 3TP-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: LY294002 [pretreatment]
    *** source: 16288034-Fig-2c
  *** 3TP-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: mEFs<Smad2~null> in BMLS
    *** source: 16288034-Fig-2c
  *** 3TP-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: mrVSMCs in BMS
    *** inhibited by: xSmad3(mnr)"delC" [addition]
    *** source: 18387947-Fig-9b
  *** 3TP-reporter[Luc] is unchanged irt Tgfb1 (24 hr)
    *** cells: mEFs<Smad3~null> in BMLS
    *** source: 16288034-Fig-2c
*** Akt1--
*** Ampk--
  *** Ampkas[phosAb] phos(T172)[phosAb] is increased irt Tgfb1 (2 hr)
    *** cells: HELA in BMS
    *** comment: HELA cells lack the Lkb1 gene
    *** source: 15485651(D)
  *** Ampkas[phosAb] phos(T172)[phosAb] is increased irt Tgfb1 (2 hr)
    *** cells: PANC1 in BMS
    *** source: 15485651(D)
  *** Ampkas[phosAb] phos(T172)[phosAb] is increased irt Tgfb1 (times)
    *** cells: HEPG2 in BMLS
    *** times: 0 1 3+ 6++ 12++ 24 hr
    *** unaffected by: xSmad2(D407E)"DN" [addition]
    *** source: 16014625(D)
*** ARE--
*** ARE-reporter--
  *** ARE-reporter[Luc] is increased irt Tgfb1 (6 hr)
    *** cells: MDAMB468<xSmad4><xFoxh1> in BMS
    *** unaffected by: xSmad4(del(142-153)) [substitution]
    *** unaffected by: xSmad4(del(153-223)) [substitution]
    *** partially inhibited by: xSmad4(del(263-302)) [substitution]
    *** partially inhibited by: xSmad4(del(223-302)) [substitution]
    *** partially inhibited by: xSmad4(del(153-302)) [substitution]
    *** partially inhibited by: xSmad4(del(153-320)) [substitution]
    *** source: 11074002-Fig-3c
  *** ARE-reporter[Luc] is increased irt Tgfb1 (6 hr)
    *** cells: MDAMB468<xSmad4><xFoxh1> in BMS
    *** unaffected by: xSmad4(L146A/L148A)"NES-mut" [substitution]
    *** source: 11074002-Fig-5c
  *** ARE-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: EPH4 in BMLS
    *** inhibited by: xHras(G12V) [addition]
    *** source: 10197981-Fig-1a
  *** ARE-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: EPH4<xFoxh1> in BMLS
    *** unaffected by: xSmad3 [addition]
    *** unaffected by: xSmad3(T178V/S203A/S207A/S212A) [addition]
    *** source: 10197981-Fig-8b
  *** ARE-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: EPH4<xFoxh1><xHras(mnr)"vRAS"> in BMLS
    *** source: 10197981-Fig-8b
  *** ARE-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: MV1LU<xFoxh1> in BMLS
    *** inhibited by: xHras(G12V) [addition]
    *** source: 10197981-Fig-1b
  *** ARE-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: MV1LU<xFoxh1> in BMLS
    *** partially reqs: Dynlrb1 [RNAi]
    *** source: 17420258-Fig-5b
  *** ARE-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: MV1LU<xFoxh1> in BMLS
    *** reqs: xFoxh1 [omission]
    *** source: 10197981-Fig-1b
  *** ARE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEP3B<xFoxh1> in BMS
    *** partially reqs: Zfyve16 [RNAi]
    *** source: 17272273-Fig-2f
  *** ARE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MV1LU<xFoxh1> in BMS
    *** unaffected by: xSara [addition]
    *** unaffected by: xSara(532-1323) [addition]
    *** inhibited by: xSara(595-1323) [addition]
    *** inhibited by: xSara(665-1323) [addition]
    *** unaffected by: xSara(705-1323) [addition]
    *** unaffected by: xSara(1-664) [addition]
    *** unaffected by: xSara(1-894) [addition]
    *** source: 9865696-Fig-7d
  *** ARE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MV1LUL17<xFoxh1> in BMS
    *** inhibited by: xPias4 [addition]
    *** source: 12904571-Fig-3
  *** ARE-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: AKR2B<xFoxh1> in BMLS
    *** partially reqs: Raptor [RNAi]
    *** partially reqs: Rictor [RNAi]
    *** source: 19117990-Fig-6c
  *** ARE-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: AKR2B<xFoxh1> in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 19117990-Fig-3d
  *** ARE-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: mEFs<Fak1~null><xFak1><Foxh1> in BMLS
    *** does not req: xFak1 [omission]
    *** source: 21454615-Fig-3a
*** Atf2--
*** Bax--
  *** Bax-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HEP3B in BMS
    *** partially reqs: Zfyve16 [RNAi]
    *** source: 17272273-Fig-3c
*** Bcl2l11--
  *** Bcl2l11-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HEP3B in BMS
    *** partially reqs: Zfyve16 [RNAi]
    *** source: 17272273-Fig-3c
*** Bclxl--
  *** Bclxl-gene mRNA[RTPCR] is decreased irt Tgfb1 (24 hr)
    *** cells: HEP3B in BMS
    *** partially reqs: Zfyve16 [RNAi]
    *** source: 17272273-Fig-3c
  *** xBmpR1b[tAb] copptby[WB] xAmhR2[Ab] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: CHO in BMS
    *** source: 10854429(D)
*** CAGA-reporter--
  *** CAGA-reporter[Luc] is increased irt Tgfb1 (8 hr)
    *** cells: HACAT in BMS
    *** inhibited by: SB431542 [addition]
    *** source: 12191474-Fig-1b
  *** CAGA-reporter[Luc] is increased irt Tgfb1 (8 hr)
    *** cells: NIH3T3 in BMS
    *** inhibited by: SB431542 [addition]
    *** source: 12191474-Fig-1b
  *** CAGA-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEP3B in BMS
    *** partially reqs: Zfyve16 [RNAi]
    *** source: 17272273-Fig-2d
  *** CAGA-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEP3B in BMS
    *** partially reqs: Zfyve16 [RNAi]
    *** source: 17272273-Fig-3b
  *** CAGA-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEPG2 in BMS
    *** partially reqs: Zfyve16 [RNAi]
    *** source: 17272273-Fig-2e
  *** CAGA-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEPG2 in BMS
    *** unaffected by: xZfyve16 [addition]
    *** partially inhibited by: xZfyve16(mnr)"del-FYVE-domain" [addition]
    *** source: 17272273-Fig-1b
  *** CAGA-reporter[Luc] is increased irt Tgfb1 (tnr)
    *** cells: MV1LU in BMS
    *** source: 10601313-Fig-4d
*** Casp3--
  *** Casp3[ClAb] cleavage(D175)[ClAb] is increased irt Tgfb1 (24 hr)
    *** cells: FAO in BMS
    *** enhanced by: xMlk3 [addition]
    *** inhibited by: xMlk3(mnr)"DN" [addition]
    *** source: 15069087-Fig-3d
  *** Casp3[ClAb] cleavage(D175)[ClAb] is increased irt Tgfb1 (24 hr)
    *** cells: FAO in BMS
    *** inhibited by: SB203580 [addition]
    *** unaffected by: PD98059 [addition]
    *** unaffected by: SP600125 [addition]
    *** source: 15069087-Fig-8a
  *** Casp3[ClAb] cleavage(D175)[ClAb] is increased irt Tgfb1 (24 hr)
    *** cells: FAO in BMS
    *** inhibited by: xMlk1(mnr)"DN" [addition]
    *** inhibited by: xMlk2(mnr)"DN" [addition]
    *** inhibited by: xMlk3(mnr)"DN" [addition]
    *** source: 15069087-Fig-5
  *** Casp3[ClAb] cleavage(D175)[ClAb] is increased irt Tgfb1 (24 hr)
    *** cells: FAO in BMS
    *** unaffected by: xMlk3 [addition]
    *** inhibited by: xMlk3(mnr)"DN" [addition]
    *** source: 15069087-Fig-6b
  *** Casp3[ClAb] cleavage(D175)[ClAb] is increased irt Tgfb1 (times)
    *** cells: FAO in BMS
    *** times: 0 1 4 12+ 16++ 20++ 24++ hr
    *** source: 15069087-Fig-7a
*** Cav1--
  *** Cav1[Ab] copptby[WB] TgfbR1[Ab] is increased irt Tgfb1 (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 5+ 10++ 20++ 40++ 80++ min
    *** source: 11102446(D)
*** Cdh1--
  *** Cdh1[Ab] prot-exp[IHC] is decreased irt Tgfb1 (48 hr)
    *** cells: NMUMG in BMS
    *** comment: cells change from epithelial to fibroblastic
    *** unaffected by: xPak2(mnr)"DN" [addition]
    *** source: 19289088-Fig-S3a
*** Cdh2--
  *** Cdh2[Ab] prot-exp[IHC] is increased irt Tgfb1 (48 hr)
    *** cells: NMUMG in BMS
    *** comment: cells change from epithelial to fibroblastic
    *** unaffected by: xPak2(mnr)"DN" [addition]
    *** source: 19289088-Fig-S3a
*** Cdk2--
  *** Cdk2-gene mRNA[Northern] is unchanged irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0+ 1+ 2+ 4+ 8+ hr
    *** source: 12150994-Fig-6e
  *** Cdk2[Ab]IP IVKA(Rb1)[32P-ATP] is unchanged irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0+ 1+ 2+ 4+ 8+ hr
    *** source: 12150994-Fig-6e
*** Cdk4--
  *** Cdk4[Ab] prot-exp[WB] is decreased irt Tgfb1 (20 hr)
    *** cells: HACAT in BMS
    *** source: 17327236-Fig-7d
  *** Cdk4[Ab] prot-exp[WB] is decreased irt Tgfb1 (20 hr)
    *** cells: HELA in BMS
    *** source: 17327236-Fig-7d
*** Cdkn1a--
*** Cdkn2b--
*** Col1a1--
  *** Creb1[phosAb] phos(S133)[phosAb] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: mrVSMCs in BMS
    *** times: 0+ 5+ 10+ 15+ 30+ min
    *** source: 18387947-Fig-6
*** Ctnnb1--
  *** Ctnnb1[Ab] copptby[WB] Smad7[Ab] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 2+ 6+ 12++ hr
    *** comment: increase in coppt correlates with increase in prot-exp of both Ctnnb1 and Smad7
    *** source: 15684397-Fig-1c
  *** Ctnnb1[Ab] infraction(nuclear)[WB] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0+ 2++ 6++ 18++ hr
    *** comment: increase correlates with increase in prot-exp of Ctnnb1
    *** source: 15684397-Fig-3g
  *** Ctnnb1[Ab] infraction(nuclear)[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 2++ 6++ 18+ hr
    *** comment: increase correlates with increase in prot-exp of Ctnnb1
    *** source: 15684397-Fig-3g
  *** Ctnnb1[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0 2++ 6+ 12++ hr
    *** comment: Ctnnb1 is located in the membrane/cell contacts at 0-6  in untreated wt and P38a-null cells
    *** reqs: P38a [KO]
    *** source: 15684397-Fig-4c
  *** Ctnnb1[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0 6 12+ hr
    *** comment: Ctnnb1 is located in the membrane/cell contacts in untreated cells
    *** comment: Ctnnb1 is located in the perinuclear-region at 6 hr in treated cells
    *** reqs: Smad7 [RNAi]
    *** source: 15684397-Fig-4b
  *** Ctnnb1[Ab] locatedin(perinuclear-region)[IHC] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0 2 6+ 12++ hr
    *** comment: Ctnnb1 is located in the membrane/cell contacts in untreated cells
    *** source: 15684397-Fig-3e,3f
  *** Ctnnb1[Ab] locatedin(perinuclear-region)[IHC] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0 2+ 6+ 12+ hr
    *** comment: Ctnnb1 is located in the membrane/cell contacts in untreated cells
    *** source: 15684397-Fig-3a,3b,3d
  *** Ctnnb1[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0+ 30++ 120++ 360+++ 720++ min
    *** reqs: Smad7 [RNAi]
    *** source: 15684397-Fig-2a
  *** Ctnnb1[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 2+ 6++ 12+++ hr
    *** reqs: Smad7 [RNAi]
    *** source: 15684397-Fig-1c
  *** Ctnnb1[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 5++ 15+++ 30++++ 60++ 120+++ 360+++ 720+++ 14400++ 28800++ min
    *** source: 15684397-Fig-5a
  *** Ctnnb1[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 30+ 120++ 360++ 720++ min
    *** reqs: Smad7 [RNAi]
    *** source: 15684397-Fig-2a
  *** Ctnnb1[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 30++ 720+++ min
    *** inhibited by: SB203580 [addition]
    *** inhibited by: LY294002 [addition]
    *** source: 15684397-Fig-5c
*** CyclinD1--
  *** CyclinD1[Ab] prot-exp[WB] is decreased irt Tgfb1 (20 hr)
    *** cells: HACAT in BMS
    *** source: 17327236-Fig-7d
  *** CyclinD1[Ab] prot-exp[WB] is decreased irt Tgfb1 (20 hr)
    *** cells: HELA in BMS
    *** source: 17327236-Fig-7d
  *** Cyclophilin-gene mRNA[RTPCR] is unchanged irt Tgfb1 (8 hr)
    *** cells: FAO in BMS
    *** source: 15069087(D)
*** Dapk1--
  *** Dapk1-gene mRNA[Northern] is increased irt Tgfb1 (4 hr)
    *** cells: HEP3B in BMS
    *** enhanced by: CHX [addition]
    *** source: 11740493-Fig-1d
  *** Dapk1-gene mRNA[Northern] is increased irt Tgfb1 (times)
    *** cells: HEP3B in BMS
    *** times: 0 2+ 4++ 8++ hr
    *** source: 11740493-Fig-1c
  *** Dapk1-gene mRNA[RTPCR] is unchanged irt Tgfb1 (24 hr)
    *** cells: HEP3B in BMS
    *** source: 17272273-Fig-3c
  *** Dapk1-gene promo-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: HEP3B in BMS
    *** unaffected by: xSmad2 [addition]
    *** enhanced by: xSmad3 [addition]
    *** unaffected by: xSmad4 [addition]
    *** source: 11740493-Fig-3a
  *** Dapk1-gene promo-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: HEP3B in BMS
    *** unaffected by: xSmad2(mnr)"DN" [addition]
    *** partially inhibited by: xSmad3(mnr)"DN" [addition]
    *** inhibited by: xSmad7(mnr)"DN" [addition]
    *** bkg inhibited by: xSmad7 [addition]
    *** source: 11740493-Fig-3b
  *** Dapk1-gene promo-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: mEFs<Smad3~null><xSmad3> in BMS
    *** reqs: xSmad3 [omission]
    *** source: 11740493-Fig-3c
  *** Dapk1[Ab] prot-exp[WB] is increased irt Tgfb1 (4 hr)
    *** cells: HEP3B in BMS
    *** source: 11740493-Fig-1d
*** DE-reporter--
  *** DE-reporter[Luc] is increased irt Tgfb1 (6 hr)
    *** cells: MDAMB468<xSmad4><xMixer!Xenla> in BMS
    *** unaffected by: xSmad4(L146A/L148A)"NES-mut" [substitution]
    *** source: 11074002-Fig-5c
  *** DE-reporter[Luc] is increased irt Tgfb1 (8 hr)
    *** cells: HACAT in BMS
    *** inhibited by: SB431542 [addition]
    *** source: 12191474-Fig-1b
  *** DE-reporter[Luc] is increased irt Tgfb1 (8 hr)
    *** cells: NIH3T3 in BMS
    *** inhibited by: SB431542 [addition]
    *** source: 12191474-Fig-1b
*** Dynlrb1--
  *** Dynlrb1[Ab] copptby[WB] Smad2[Ab] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMLS
    *** times: 0+ 5+++ 15++ min
    *** source: 17420258-Fig-3
*** E2f4--
  *** E2f4[Ab] copptby[WB] Smad4[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** source: 12150994-Fig-3b
*** E2fRE-reporter--
  *** E2fRE-reporter[Luc] is decreased irt Tgfb1 (18 hr)
    *** cells: EPH4 in BMLS
    *** inhibited by: xHras(G12V) [addition]
    *** source: 10197981-Fig-8a
  *** E2fRE-reporter[Luc] is decreased irt Tgfb1 (18 hr)
    *** cells: EPH4 in BMLS
    *** unaffected by: xSmad3 [addition]
    *** unaffected by: xSmad3(T178V/S203A/S207A/S212A) [addition]
    *** source: 10197981-Fig-8a
  *** E2fRE-reporter[Luc] is decreased irt Tgfb1 (18 hr)
    *** cells: MV1LU in BMS
    *** inhibited by: xHras(G12V) [addition]
    *** source: 10197981-Fig-1c
*** Eea1--
  *** Eea1[Ab] copptby[WB] TgfbR1[Ab] is increased irt Tgfb1 (24 hr)
    *** cells: HK2 in BMLS
    *** source: 15084590(D)
  *** EgfR[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (15 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: AG1295 [cotreatment]
    *** source: 23913859-Fig-1a
  *** EgfR[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (15 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Lapatinib [cotreatment]
    *** source: 23913859-Fig-2b
  *** EgfR[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (18 hr)
    *** cells: AKR2B in BMLS
    *** source: 23913859-Fig-4a
  *** EgfR[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 15 30 60 180 360 540 720 900+ 1080+ 1260+ 1440+ min
    *** source: 23913859-Fig-S1a
*** Egr1--
  *** Egr1!Mouse-gene promo-reporter[Luc] is unchanged irt Tgfb1 (4 hr)
    *** cells: ECV304 in BMLS
    *** source: 11029289-Fig-3a
*** Elk1--
  *** xElk1(205-428)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: hMesangialCells in BMLS "plated on gelatin for 4 hr"
    *** source: 18032789-Fig-4a
  *** xElk1(205-428)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb1 (tnr)
    *** cells: hMesangialCells<xFak1> in BMLS
    *** inhibited by: xFak1(Y397F) [substitution]
    *** inhibited by: xFak1(Y925F) [substitution]
    *** source: 18032789-Fig-6a
  *** xElk1(205-428)[Gal4-DBD] Gal4-reporter[Luc] is unchanged irt Tgfb1 (20 hr)
    *** cells: hMesangialCells in BMLS "plated on PLL for 4 hr"
    *** source: 18032789-Fig-4a
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb2 (20 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-1c
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb2 (20 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: LY294002 [cotreatment]
    *** source: 17440079-Fig-5c
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb2 (20 hr)
    *** cells: AKR2B in BMLS
    *** partially inhibited by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-5c
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb2 (20 hr)
    *** cells: AKR2B in BMLS
    *** partially inhibited by: Pak2(K278R)"DN" [addition]
    *** source: 17440079-Fig-5c
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb2 (20 hr)
    *** cells: AKR2B in BMLS
    *** source: 17440079-Fig-1c
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb2 (20 hr)
    *** cells: AKR2B in BMLS
    *** source: 17440079-Fig-3d
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb2 (20 hr)
    *** cells: mEFs<Smad3~null><xSmad2(S467A)> in BMLS
    *** source: 17440079-Fig-3d
  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is unchanged irt Tgfb2 (20 hr)
    *** cells: MV1LU in BMLS
    *** source: 17440079-Fig-1c
*** Elmo3--
  *** Elmo3-gene mRNA[Northern] is increased irt Tgfb2 (4 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-7b
*** Ep300--
  *** Ep300-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: PC3U<xTgfbR1> in BMS
    *** times: 0 30+ 360++ 720+++ 1440+++ min
    *** inhibited by: xTgfbR1(E161A) [substitution]
    *** source: 21629263-Fig-6d
  *** Ep300[Ab] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (1 hr)
    *** cells: HELA in BMS
    *** source: 17074756-Fig-3g
  *** Ep300[Ab] copptby[WB] TgfbR1[Ab] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0 30+ 360+ min
    *** source: 21629263-Fig-6c
*** Erbin--
  *** Erbin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: LLCPK1 in BMLS
    *** source: 19289088-Fig-2c
  *** Erbin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: MDCK in BMLS
    *** source: 19289088-Fig-2c
  *** Erbin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: MV1LU in BMLS
    *** source: 19289088-Fig-2c
  *** Erbin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: NIH3T3 in BMLS
    *** source: 19289088-Fig-2c
  *** Erbin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: SWISS3T3 in BMLS
    *** source: 19289088-Fig-2c
  *** Erbin[Ab] prot-exp[WB] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** source: 19289088-Fig-2c
*** Ereg--
  *** Ereg[Ab] secretion[ELISA] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 6 12+ 18++ 24+++ hr
    *** source: 23913859-Fig-4c
*** Erk1--
*** Erk2--
*** Erks--
  *** Fak1[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: hMesangialCells in BMLS
    *** times: 0+ 5+ 15+ 30+ 60+ 120+ min
    *** source: 18032789-Fig-1a
*** Fn1--
*** Fos--
  *** Fos-gene mRNA[Northern] is increased irt Tgfb1 (tnr)
    *** cells: mEFs in BMS
    *** partially reqs: Sptbn1 [KO]
    *** comment: response can be rescued with xSptbn1-Cterm
    *** source: 12543979-Fig-3e
  *** xFos[tAb] copptby[WB] xSmad3[tAb] is unchanged irt Tgfb1 (tnr)
    *** cells: COS1 in  BMS
    *** source: 9732876-Fig-2c
*** G1Arrest--
  *** G1Arrest[FACS] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMLS "treated with serum at 0 hr"
    *** does not req: Smad2 [AntiSense]
    *** source: 14555988-Fig-3c
  *** G1Arrest[FACS] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMLS "treated with serum at 0 hr"
    *** partially reqs: Smad4 [AntiSense]
    *** source: 14555988-Fig-3c
  *** G1Arrest[FACS] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMLS "treated with serum at 0 hr"
    *** reqs: Smad3 [AntiSense]
    *** source: 14555988-Fig-3c
  *** G1Arrest[FACS] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMLS "treated with serum at 0 hr"
    *** source: 14555988-Fig-3a
*** Grb2--
  *** Grb2[Ab] copptby[WB] Shc1[Ab] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 1++ 2++ 5++ 10++ 20++ 30+ min
    *** source: 17673906-Fig-7a
  *** Grb2[Ab] copptby[WB] Shc1[Ab] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5+ 10++ min
    *** inhibited by: xShc1(mnr)"CH1/SH2-domains" [substitution]
    *** inhibited by: xShc1(mnr)"PTP/CH1-domains" [substitution]
    *** source: 17673906-Fig-8b
*** Gsk3b--
  *** Gsk3b[phosAb] phos(S9)[phosAb] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 30++ 720+++ min
    *** inhibited by: SB203580 [addition]
    *** inhibited by: LY294002 [addition]
    *** source: 15684397-Fig-5c
*** Gsk3s--
  *** Gsk3s[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (1 hr)
    *** cells: NIH3T3 in BMS
    *** unaffected by: xPpm1a [addition]
    *** source: 16751101-Fig-S8b
*** Hmox1--
  *** Hmox1[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** partially reqs: Smad2 [AntiSense]
    *** source: 14555988-Fig-2a
  *** Hmox1[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** partially reqs: Smad3 [AntiSense]
    *** source: 14555988-Fig-2b
  *** Hmox1[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** partially reqs: Smad4 [AntiSense]
    *** source: 14555988-Fig-2c
*** Hras--
*** Id1--
  *** Id1-gene mRNA[RTPCR] is unchanged irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-7a
  *** Id1[Ab] prot-exp[WB] is decreased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** does not req: Smad2 [AntiSense]
    *** source: 14555988-Fig-2a
  *** Id1[Ab] prot-exp[WB] is decreased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** does not req: Smad4 [AntiSense]
    *** source: 14555988-Fig-2c
  *** Id1[Ab] prot-exp[WB] is decreased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** reqs: Smad3 [AntiSense]
    *** source: 14555988-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is unchanged irt Tgfb2 (1 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** unaffected by: IL1R1 [RNAi]
    *** unaffected by: TgfbR1 [RNAi]
    *** unaffected by: TgfbR2 [RNAi]
    *** unaffected by: xIkba(S32A/S36A)"SR" [addition]
    *** source: 17360530-Fig-5a
*** Ikks--
  *** Ikks[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0 5+ 10++ 15+ 30+ min
    *** inhibited by: xTak1(K158R) [substitution]
    *** unaffected by: xTak1(K34R) [substitution]
    *** source: 20837137-Fig-4a
  *** xIL1R1[Ab] copptby[WB] TgfbR1[Ab] is increased irt Tgfb2 (15 min)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-6
  *** xIL1R1[Ab] copptby[WB] TgfbR2[Ab] is increased irt Tgfb2 (15 min)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-6
*** IL6--
  *** IL6-gene mRNA[RTPCR] is decreased irt Tgfb1 (6 hr)
    *** cells: CMT93 in BMS
    *** source: 17384642-Fig-S3a
  *** IL6-gene mRNA[RTPCR] is decreased irt Tgfb1 (6 hr)
    *** cells: CMT93 in BMS
    *** source: 17384642-Fig-S3b
  *** IL6-gene mRNA[RTPCR] is decreased irt Tgfb1 (6 hr)
    *** cells: mBMMs in BMS
    *** source: 17384642-Fig-S3a
  *** IL6-gene mRNA[RTPCR] is unchanged irt Tgfb1 (8 hr)
    *** cells: mPECs in BMLS
    *** source: 17384642-Fig-4d
  *** IL6-gene mRNA[RTPCR] is unchanged irt Tgfb1 (8 hr)
    *** cells: mPECs in BMLS
    *** source: 17384642-Fig-4e
*** IL21--
  *** IL21-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** source: 17581537-Fig-4c
  *** IL21-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** source: 17581537-Fig-5b
  *** IL21-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** unaffected by: IL21R [KO]
    *** source: 17581537-Fig-4c
  *** IL21-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** unaffected by: RoRc [KO]
    *** source: 17581537-Fig-1a
  *** IL21-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** unaffected by: Stat3 [KO]
    *** source: 17581537-Fig-5b
*** IL23R--
  *** IL23R-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** source: 18368049-Fig-4b
  *** IL23R-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** source: 17581537-Fig-4d
  *** IL23R-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** source: 17581537-Fig-5c
  *** IL23R-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** unaffected by: IL21R [KO]
    *** source: 17581537-Fig-4d
  *** IL23R-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** unaffected by: RoRc [KO]
    *** source: 17581537-Fig-1b
  *** IL23R-gene mRNA[RTPCR] is unchanged irt Tgfb1 (48 hr)
    *** cells: mSpNaiveCD4TCs in BMS "containing anti-Cd3 + anti-Cd28"
    *** unaffected by: Stat3 [KO]
    *** source: 17581537-Fig-5c
*** Itga5--
  *** Itga5[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0 1 2+ 4++ hr
    *** inhibited by: xCsnk1g2 [addition]
    *** inhibited by: xCsnk1g2(1-403)"delNLS" [addition]
    *** source: 18794808-Fig-S6a
  *** Itga5[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0 1 2+ 4++ hr
    *** inhibited by: xCsnk1g2(C399A/C400A/C401A) [addition]
    *** inhibited by: xCsnk1g2(1-354)"delC" [addition]
    *** source: 18794808-Fig-S6b
  *** Itga5[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4++ hr
    *** inhibited by: xCsnk1g2 [addition]
    *** enhanced by: xCsnk1g2(mnr)"KD" [addition]
    *** source: 18794808-Fig-3f
*** Jag1--
  *** Jag1-gene mRNA[RTPCR] is increased irt Tgfb1 (3 hr)
    *** cells: OSACL in BMS
    *** reqs: Ctdsp1 and/or Ctdsp2 [RNAi]
    *** source: 17085434-Fig-6c
*** Jnk1--
*** Jnks--
*** Jun--
  *** Jun[Ab] copptby[WB] xSmad3[tAb] is increased irt Tgfb1 (tnr)
    *** cells: COS1 in  BMS
    *** source: 9732876-Fig-2d
  *** xJun[tAb] copptby[WB] xSmad3[tAb] is increased irt Tgfb1 (tnr)
    *** cells: COS1 in  BMS
    *** source: 9732876-Fig-2c
*** Junb--
  *** Junb-gene mRNA[Northern] is increased irt Tgfb1 (2 hr)
    *** cells: MV1LU in BMS
    *** source: 9786930-Fig-3a
  *** Junb-gene mRNA[Northern] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0 1+ 2+ 4+ 8+ hr
    *** partially inhibited by: xPias4 [addition]
    *** source: 12904571-Fig-3
  *** Junb[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0 1 2+ 4++ hr
    *** inhibited by: xCsnk1g2 [addition]
    *** inhibited by: xCsnk1g2(1-403)"delNLS" [addition]
    *** source: 18794808-Fig-S6a
  *** Junb[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0 1 2+ 4++ hr
    *** inhibited by: xCsnk1g2(C399A/C400A/C401A) [addition]
    *** inhibited by: xCsnk1g2(1-354)"delC" [addition]
    *** source: 18794808-Fig-S6b
  *** Junb[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4++ hr
    *** inhibited by: xCsnk1g2 [addition]
    *** enhanced by: xCsnk1g2(mnr)"KD" [addition]
    *** source: 18794808-Fig-3f
*** Lef1--
  *** Lef1[Ab] copptby[WB] Ctnnb1[Ab] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0+ 30++ 120++ 360++ 720++ min
    *** comment: increase in coppt correlates with increase in prot-exp of both Lef1 and Cttnb1
    *** source: 15684397-Fig-2a
  *** Lef1[Ab] copptby[WB] Ctnnb1[Ab] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 30++ 120++ 360++ 720++ min
    *** comment: increase in coppt correlates with increase in prot-exp of both Lef1 and Cttnb1
    *** source: 15684397-Fig-2a
  *** Lef1[Ab] copptby[WB] Smad7[Ab] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0 2 6+ 12++ hr
    *** comment: increase in coppt correlates with increase in prot-exp of both Lef1 and Smad7
    *** source: 15684397-Fig-1d
  *** Lef1[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0+ 30++ 120+++ 360++ 720+ min
    *** reqs: Smad7 [RNAi]
    *** source: 15684397-Fig-2a
  *** Lef1[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0 2+ 6++ 12+++ hr
    *** inhibited by: CHX [addition]
    *** source: 15684397-Fig-1e
  *** Lef1[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 2++ 6++ 12+++ hr
    *** reqs: Smad7 [RNAi]
    *** source: 15684397-Fig-1d
  *** Lef1[Ab] prot-exp[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 30++ 120++ 360++ 720++ min
    *** reqs: Smad7 [RNAi]
    *** source: 15684397-Fig-2a
*** Map3k12--
  *** Map3k12-gene mRNA[RTPCR] is unchanged irt Tgfb1 (8 hr)
    *** cells: FAO in BMS
    *** source: 15069087(D)
*** Merlin--
  *** Merlin[Ab] copptby[WB] xPak2[tAb] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B<xPak2> in BMLS
    *** unaffected by: xPak2(K278R) [substitution]
    *** unaffected by: xPak2(K278R/L106F) [substitution]
    *** source: 19289088-Fig-S2
  *** Merlin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** source: 19289088-Fig-2c
  *** Merlin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: LLCPK1 in BMLS
    *** source: 19289088-Fig-2c
  *** Merlin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: MDCK in BMLS
    *** source: 19289088-Fig-2c
  *** Merlin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: MV1LU in BMLS
    *** source: 19289088-Fig-2c
  *** Merlin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: NIH3T3 in BMLS
    *** source: 19289088-Fig-2c
  *** Merlin[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (45 min)
    *** cells: SWISS3T3 in BMLS
    *** source: 19289088-Fig-2c
  *** Merlin[phosAb] phos(S518)[phosAb] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** source: 19289088-Fig-2a
  *** Merlin[phosAb] phos(S518)[phosAb] is unchanged irt Tgfb1 (45 min)
    *** cells: MV1LU in BMLS
    *** source: 19289088-Fig-2a
*** Mkk3--
  *** Mkk3[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (times)
    *** cells: mMesangialCells in BMLS
    *** times: 0+ 5++ 15++ 30++ min
    *** source: 19556242-Fig-7b
*** Mkk6--
  *** xMkk6[tAb]IP IVKA(P38a)[32P-ATP] is increased irt Tgfb1 (15 min)
    *** cells: COS7 in BMS
    *** source: 8663074-Fig-4b
  *** Mkk36s[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (times)
    *** cells: FAO in BMS
    *** times: 0 1 4 8+ 12++ 16++ 20++ 24+ hr
    *** source: 15069087-Fig-7a
*** Mlk1--
  *** Mlk1-gene mRNA[RTPCR] is unchanged irt Tgfb1 (8 hr)
    *** cells: FAO in BMS
    *** source: 15069087(D)
*** Mlk2--
  *** Mlk2-gene mRNA[RTPCR] is unchanged irt Tgfb1 (8 hr)
    *** cells: FAO in BMS
    *** source: 15069087(D)
*** Mlk3--
  *** Mlk3-gene mRNA[RTPCR] is unchanged irt Tgfb1 (8 hr)
    *** cells: FAO in BMS
    *** source: 15069087(D)
*** Mmp1--
  *** Mmp1-gene promo-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: MV1LU in BMS
    *** source: 9732876-Fig-1d
  *** Mmp2-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: PC3U<xTgfbR1> in BMS
    *** times: 0 30 360 720+ 1440 min
    *** inhibited by: xTgfbR1(E161A) [substitution]
    *** source: 21629263-Fig-6d
*** Myc--
*** Myc--
*** Nfkb-reporter--
  *** Nfkb-reporter[Luc] is increased irt Tgfb1 (6 hr)
    *** cells: HEPG2 in BMLS
    *** inhibited by: Cl-Radicicol-A [pretreatment] no-bkg-control
    *** unaffected by: SB203580 [pretreatment] no-bkg-control
    *** source: 22069318-Fig-7a
  *** Nfkb-reporter[Luc] is increased irt Tgfb1 (6 hr)
    *** cells: HEPG2 in BMLS
    *** source: 22069318-Fig-7a
  *** Nfkb-reporter[Luc] is increased irt Tgfb2 (4 hr)
    *** cells: HEK293 in BMS
    *** unaffected by: xTLR1 [addition]
    *** enhanced by: xTLR2 [addition]
    *** enhanced by: xTLR5 [addition]
    *** unaffected by: xTLR6 [addition]
    *** source: 17360530-Fig-4
  *** Nfkb-reporter[Luc] is increased irt Tgfb2 (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** partially inhibited by: Tak1(mnr)"DN" [addition]
    *** partially inhibited by: Traf6(mnr)"DN" [addition]
    *** source: 17360530-Fig-1b
  *** Nfkb-reporter[Luc] is increased irt Tgfb2 (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** reqs: IL1R1 [RNAi]
    *** reqs: TgfbR1 [RNAi]
    *** reqs: TgfbR2 [RNAi]
    *** inhibited by: xIkba(S32A/S36A)"SR" [addition]
    *** does not req: Smad2 [RNAi]
    *** source: 17360530-Fig-5e
  *** Nfkb-reporter[Luc] is increased irt Tgfb2 (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** reqs: Irak1 [RNAi]
    *** reqs: Myd88 [RNAi]
    *** source: 17360530-Fig-1a
*** Nuak1
  *** Nuak1[phosAb] phos(S600)[phosAb] is increased irt Tgfb1 (12 hr)
    *** cells: HEPG2 in BMLS
    *** source: 16014625(D)
  *** Numbl-gene mRNA[Northern] is increased irt Tgfb2 (4 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-7b
*** P38s--
  *** P38s[phosAb] phos(TGY)[phosAb] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: PC3U<xTgfbR1> in BMS
    *** times: 0+ 30+ 360+ min
    *** source: 21629263-Fig-2a
*** Pai1--
*** Pai1--
*** Pak2--
  *** Pak2[Ab] copptby[WB] Merlin[Ab] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** source: 19289088-Fig-2a
  *** Pak2[Ab] copptby[WB] Merlin[Ab] is unchanged irt Tgfb1 (45 min)
    *** cells: MV1LU in BMLS
    *** comment: not shown that Pak2 can be detected in this sample
    *** source: 19289088-Fig-2a
  *** Pak2[phosAb] phos(sitenr)[phosAb] is unchanged irt Tgfb1 (1 hr)
    *** cells: NIH3T3 in BMS
    *** unaffected by: xPpm1a [addition]
    *** source: 16751101-Fig-S8b
*** Pak3--
  *** Pak3[Ab]IP IVKA(MBP)[phosAb] is unchanged irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 5 15 30 60 120 min
    *** source: 14612425-Fig-1a
  *** Pak3[Ab]IP IVKA(MBP)[phosAb] is unchanged irt Tgfb1 (times)
    *** cells: MV1LU in BMLS
    *** times: 0 5 15 30 60 120 min
    *** source: 14612425-Fig-1b
*** Pcaf--
  *** Pcaf[Ab] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (1 hr)
    *** cells: HELA in BMS
    *** source: 17074756-Fig-3g
*** PdgfR--
  *** PdgfR[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: AG1295 [cotreatment]
    *** source: 23913859-Fig-1a
  *** PdgfR[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** partially inhibited by: Imatinib [cotreatment]
    *** source: 23913859-Fig-S1a
  *** PdgfR[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0+ 15+ 30+ 60+ 180+ 360++ 540++ 720++ 900++ 1080++ 1260++ 1440++ min
    *** source: 23913859-Fig-S1a
*** Pdpk1--
  *** Pdpk1[Ab] prot-exp[WB] is decreased irt Tgfb1 (20 hr)
    *** cells: HACAT in BMS
    *** source: 17327236-Fig-7d
  *** Pdpk1[Ab] prot-exp[WB] is decreased irt Tgfb1 (20 hr)
    *** cells: HELA in BMS
    *** source: 17327236-Fig-7d
*** Pias4--
  *** Pias4[Ab] copptby[WB] Smad3[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** source: 12904571-Fig-1f
  *** Pias4[Ab] snaggedby[WB] oligo[biotin] is increased irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** oligo: SBE 5-CTAGGATAGCGTCTAGACATAGTCTAGACTGAGTCCTAG-3
    *** source: 12904571-Fig-5b
*** Pik3rs--
  *** Pik3rs[Ab] copptby[WB] Fak1[Ab] is increased irt Tgfb1 (45 min)
    *** cells: AKR2B in BMLS
    *** source: 21454615-Fig-7b
  *** Pik3rs[Ab] copptby[WB] Fak1[Ab] is increased irt Tgfb1 (45 min)
    *** cells: NIH3T3 in BMLS
    *** source: 21454615-Fig-7b
  *** Pik3rs[Ab] copptby[WB] Fak1[Ab] is increased irt Tgfb1 (45 min)
    *** cells: SWISS3T3 in BMLS
    *** source: 21454615-Fig-7b
  *** Pik3rs[Ab] copptby[WB] Fak1[Ab] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMLS
    *** times: 0+ 10++ 30++ 60++ 120++ 240+ min
    *** source: 21454615-Fig-7a
  *** Pik3rs[Ab] copptby[WB] Fak1[Ab] is unchanged irt Tgfb1 (45 min)
    *** cells: HELA in BMLS
    *** source: 21454615-Fig-7b
  *** Pik3rs[Ab] copptby[WB] Fak1[Ab] is unchanged irt Tgfb1 (45 min)
    *** cells: MDCK in BMLS
    *** source: 21454615-Fig-7b
  *** Pik3rs[Ab] copptby[WB] Fak1[Ab] is unchanged irt Tgfb1 (45 min)
    *** cells: MV1LU in BMLS
    *** source: 21454615-Fig-7b
  *** Pik3rs[Ab] copptby[WB] xFak1[Ab] is increased irt Tgfb1 (45 min)
    *** cells: mEFs<Fak1~null><xFak1> in BMLS
    *** reqs: xFak1 [omission]
    *** unaffected by: xFak1(Y397F/P712A/P713A/P872A/P873A) [substitution]
    *** source: 21454615-Fig-8c
  *** Pik3rs[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Tgfb1 (4 hr)
    *** cells: AKR2B in BMLS
    *** source: 21454615-Fig-5a
  *** Pik3rs[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Tgfb1 (4 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: CytochalasinD [pretreatment]
    *** source: 21454615-Fig-5b
  *** Pik3rs[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Tgfb1 (4 hr)
    *** cells: mEFs<Src~null><Yes1~null><Fyn~null> in BMLS
    *** source: 21454615-Fig-5a
  *** Pik3rs[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Tgfb1 (45 min)
    *** cells: mEFs<Fak1~null><xFak1> in BMLS
    *** reqs: xFak1 [omission]
    *** source: 21454615-Fig-2b
  *** Pik3rs[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Tgfb1 (45 min)
    *** cells: mEFs<Fak1~null><xFak1> in BMLS
    *** reqs: xFak1 [omission]
    *** unaffected by: xFak1(Y397F) [substitution]
    *** unaffected by: xFak1(Y397F/K454R) [substitution]
    *** source: 21454615-Fig-6b
  *** Pik3rs[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Tgfb1 (120 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: LY294002 [pretreatment]
    *** source: 16288034-Fig-1a
  *** Pik3rs[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 15 30 60+ 90+ 120+ min
    *** source: 16288034-Fig-1a
  *** Pik3rs[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Tgfb1 (times)
    *** cells: mEFs in BMLS
    *** times: 0 10+ 30+ 60+ 120+ 240+ min
    *** reqs: Fak1 [KO]
    *** source: 21454615-Fig-2a
*** Pkcs--
  *** Pkcs[phosAb] phos(TFCG)[phosAb] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 15++ 30++ 120++ 360++ min
    *** source: 21629263-Fig-5b
  *** Pkcs[phosAb] phos(TFCG)[phosAb] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 30++ 360++ min
    *** reqs: Traf5 [KO]
    *** source: 21629263-Fig-5c
*** Pml--
  *** Pml[Ab] copptby[WB] Smad23s[Ab] is decreased irt Tgfb1 (1 hr)
    *** cells: mEFs in BMS
    *** source: 15356634-Fig-2c
*** Pmlc--
  *** Pmlc-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HEPG2 in BMS
    *** source: 15356634-Fig-S1a
  *** Pmlc-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: mEFs in BMS
    *** source: 15356634-Fig-S1a
  *** Pmlc[Ab] copptby[WB] Sara[Ab] is decreased irt Tgfb1 (1 hr)
    *** cells: mEFs in BMS
    *** source: 15356634-Fig-2e
  *** Pmlc[Ab] prot-exp[WB] is increased irt Tgfb1 (24 hr)
    *** cells: mEFs in BMS
    *** source: 15356634-Fig-S1c
*** Ppm1a--
  *** Ppm1a-gene mRNA[RTPCR] is unchanged irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0+ 8+ 24+ hr
    *** source: 16751101-Fig-4c
*** ProAreg--
  *** ProAreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** does not req: PdgfRa [RNAi]
    *** partially reqs: PdgfRb [RNAi]
    *** partially reqs: PdgfRa and/or PdgfRb [RNAi]
    *** source: 23913859-Fig-1b
  *** ProAreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: AG1295 [cotreatment]
    *** source: 23913859-Fig-1a
  *** ProAreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Imatinib [cotreatment]
    *** source: 23913859-Fig-S1a
  *** ProAreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: U0126 [cotreatment]
    *** source: 23913859-Fig-3a
  *** ProAreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** partially reqs: EgfR [RNAi]
    *** partially reqs: Erbb2 [RNAi]
    *** reqs: EgfR and Erbb2 [RNAi]
    *** source: 23913859-Fig-2c
  *** ProAreg-gene mRNA[RTPCR] is increased irt Tgfb1 (15 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Lapatinib [cotreatment]
    *** source: 23913859-Fig-2b
  *** ProAreg-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 15 30 60 180 360 540+ 720++ 900++ 1080++ 1260++ 1440+ min
    *** source: 23913859-Fig-S1a
*** ProEreg--
  *** ProEreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** does not req: EgfR [RNAi]
    *** partially reqs: Erbb2 [RNAi]
    *** partially reqs: EgfR and/or Erbb2 [RNAi]
    *** source: 23913859-Fig-2c
  *** ProEreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** does not req: PdgfRa [RNAi]
    *** does not req: PdgfRb [RNAi]
    *** reqs: PdgfRa and/or PdgfRb [RNAi]
    *** source: 23913859-Fig-1b
  *** ProEreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: AG1295 [cotreatment]
    *** source: 23913859-Fig-1a
  *** ProEreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Imatinib [cotreatment]
    *** source: 23913859-Fig-S1a
  *** ProEreg-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: U0126 [cotreatment]
    *** source: 23913859-Fig-3a
  *** ProEreg-gene mRNA[RTPCR] is increased irt Tgfb1 (15 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Lapatinib [cotreatment]
    *** source: 23913859-Fig-2b
  *** ProEreg-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 15 30 60 180 360 540+ 720++ 900++ 1080++ 1260++ 1440+ min
    *** inhibited by: AG1295 [cotreatment]
    *** source: 23913859-Fig-S1a
*** ProHbegf--
  *** ProHbegf-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** does not req: PdgfRa [RNAi]
    *** does not req: PdgfRb [RNAi]
    *** does not req: PdgfRa or PdgfRb [RNAi]
    *** source: 23913859-Fig-1b
  *** ProHbegf-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: AG1295 [cotreatment]
    *** source: 23913859-Fig-1a
  *** ProHbegf-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Imatinib [cotreatment]
    *** source: 23913859-Fig-S1a
  *** ProHbegf-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: U0126 [cotreatment]
    *** source: 23913859-Fig-3a
  *** ProHbegf-gene mRNA[RTPCR] is increased irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** partially reqs: EgfR [RNAi]
    *** partially reqs: Erbb2 [RNAi]
    *** partially reqs: EgfR and/or Erbb2 [RNAi]
    *** source: 23913859-Fig-2c
  *** ProHbegf-gene mRNA[RTPCR] is increased irt Tgfb1 (15 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Lapatinib [cotreatment]
    *** source: 23913859-Fig-2b
  *** ProHbegf-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 15 30 60 180 360 540+ 720++ 900++ 1080++ 1260++ 1440+ min
    *** inhibited by: AG1295 [cotreatment]
    *** source: 23913859-Fig-S1a
*** Proliferation--
  *** Proliferation[CellNumber] is increased irt Tgfb1 (48 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Pak2(K278R)"KD" [addition]
    *** source: 14612425-Fig-6b
  *** Proliferation[CellNumber] is increased irt Tgfb2 (48 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: LY294002 [cotreatment]
    *** source: 17440079-Fig-4c
  *** Proliferation[CellNumber] is increased irt Tgfb2 (48 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Pak2(K278R)"DN" [addition]
    *** source: 17440079-Fig-4c
  *** Proliferation[CellNumber] is increased irt Tgfb2 (48 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-4c
*** ProPdgfa--
  *** ProPdgfa-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0+ 15+ 30+ 60+ 180++ 360++ 540++ 720++ 900++ 1080++ 1260++ 1440++ min
    *** source: 23913859-Fig-S1a
*** ProPdgfb--
  *** ProPdgfb-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 15 30 60 180++ 360++ 540++ 720++ 900++ 1080++ 1260++ 1440+ min
    *** source: 23913859-Fig-S1a
*** ProPdgfc--
  *** ProPdgfc-gene mRNA[RTPCR] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0+ 15+ 30+ 60+ 180+ 360+ 540+ 720+ 900+ 1080+ 1260+ 1440+ min
    *** source: 23913859-Fig-S1a
*** Pten--
  *** Pten-gene mRNA[RTPCR] is decreased irt Tgfb1 (24 hr)
    *** cells: BXPC3<Smad4~null> in BMS
    *** inhibited by: PD98059 [addition]
    *** source: 17638924-Fig-5b
  *** Pten-gene mRNA[RTPCR] is decreased irt Tgfb1 (24 hr)
    *** cells: CAPAN1<Smad4~null> in BMS
    *** inhibited by: PD98059 [addition]
    *** source: 17638924-Fig-5a
  *** Pten-gene mRNA[RTPCR] is decreased irt Tgfb1 (times)
    *** cells: BXPC3<Smad4~null> in BMS
    *** times: 0++ 3+ 24 48++ hr
    *** source: 17638924-Fig-3
  *** Pten-gene mRNA[RTPCR] is decreased irt Tgfb1 (times)
    *** cells: CAPAN1<Smad4~null> in BMS
    *** times: 0+ 3+ 24 48+ hr
    *** source: 17638924-Fig-3
  *** Pten[Ab] prot-exp[WB] is decreased irt Tgfb1 (48 hr)
    *** cells: BXPC3<Smad4~null> in BMS
    *** source: 17638924-Fig-4b
  *** Pten[Ab] prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: BXPC3<Smad4~null> in BMS
    *** times: 0++ 6++ 24++ 48+ hr
    *** source: 17638924-Fig-4a
  *** Pten[Ab] prot-exp[WB] is decreased irt Tgfb1 (tnr)
    *** cells: BXPC3<Smad4~null> in BMS
    *** inhibited by: PD98059 [addition]
    *** source: 17638924-Fig-6a
  *** Pten[Ab] prot-exp[WB] is decreased irt Tgfb1 (tnr)
    *** cells: CAPAN1<Smad4~null> in BMS
    *** inhibited by: xKras(mnr)"DN" [addition]
    *** source: 17638924-Fig-6a
*** Raf1--
  *** Raf1[phosAb] phos(sitenr)[phosAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 1++ 2++ 5++ 10++ 20++ 30++ min
    *** source: 17673906-Fig-7c
*** RoRc-- RoRc-gene--
*** Rpl13a--
  *** Rpl13a-gene mRNA[RTPCR] is detectable-but unchanged irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** source: 23913859-Fig-1a
  *** Rpl13a-gene mRNA[RTPCR] is detectable-but unchanged irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** source: 23913859-Fig-3a
  *** Rpl13a-gene mRNA[RTPCR] is detectable-but unchanged irt Tgfb1 (12 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: Imatinib [cotreatment]
    *** source: 23913859-Fig-S1a
  *** Rpl13a-gene mRNA[RTPCR] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0+ 15+ 30+ 60+ 180+ 360+ 540+ 720+ 900+ 1080+ 1260+ 1440+ min
    *** source: 23913859-Fig-S1a
*** S6k1
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Tgfb1 (4 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: LY294002 [pretreatment]
    *** unaffected by: U0126 [pretreatment]
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 19117990-Fig-2a
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Tgfb1 (4 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 19117990-Fig-5b
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Tgfb1 (4 hr)
    *** cells: AKR2B in BMLS
    *** source: 19117990-Fig-1b
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Tgfb1 (4 hr)
    *** cells: IMR90 in BMLS
    *** source: 19117990-Fig-1b
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Tgfb1 (4 hr)
    *** cells: mEFs in BMLS
    *** does not req: Mlst8 [KO]
    *** source: 19117990-Fig-4a
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Tgfb1 (4 hr)
    *** cells: SWISS3T3 in BMLS
    *** source: 19117990-Fig-1b
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Tgfb1 (6 hr)
    *** cells: AKR2B in BMLS
    *** reqs: Raptor [RNAi]
    *** does not req: Rictor [RNAi]
    *** source: 19117990-Fig-4b
  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 30 60 120+ 240++ 360++ 720++ 1440 min
    *** source: 19117990-Fig-1a
  *** S6k1[phosAb] phos(T412)[phosAb] is unchanged irt Tgfb1 (4 hr)
    *** cells: HELA in BMLS
    *** source: 19117990-Fig-1b
  *** S6k1[phosAb] phos(T412)[phosAb] is unchanged irt Tgfb1 (4 hr)
    *** cells: MDCK in BMLS
    *** source: 19117990-Fig-1b
  *** S6k1[phosAb] phos(T412)[phosAb] is unchanged irt Tgfb1 (4 hr)
    *** cells: MV1LU in BMLS
    *** source: 19117990-Fig-1b
  *** S6k1[phosAb] phos(T412)[phosAb] is unchanged irt Tgfb1 (times)
    *** cells: MV1LU in BMLS
    *** times: 0 30 60 120 240 360 720 1440 min
    *** source: 19117990-Fig-1a
  *** xS6k1[tAb]IP phos(T412)[phosAb] is increased irt Tgfb1 (4 hr)
    *** cells: mEFs<Tsc2~null><xTsc2><xS6k1> in BMLS
    *** inhibited by: xTsc2(S939A/T1462A) [substitution]
    *** source: 19117990-Fig-2c
*** Sara--
  *** Sara[Ab] copptby[WB] Smad23s[Ab] is unchanged irt Tgfb1 (1 hr)
    *** cells: mEFs in BMS
    *** source: 15356634-Fig-2c
  *** xSara[tAb] copptby[WB] xSmad2[tAb] is decreased itpo xTgfb1(T204D)"CA"
    *** cells: COS1 in BMS
    *** inhibited by: xTgfbR1(WT) [substitution]
    *** source: 9865696-Fig-3c
  *** xSara[tAb] locatedin(nucleus)[IHC] is increased itpo xSmad2
    *** cells: MV1LU in BMS
    *** enhanced by: xTgfbR1(T204D)"CA" [addition]
    *** source: 9865696-Fig-4d,4e
*** SBE--
*** SBE-reporter--
*** SBE-reporter--
  *** SBE-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: HACAT in BMS
    *** partially reqs: Ctdsp1 and/or Ctdsp2 [RNAi]
    *** source: 17085434-Fig-6a
  *** SBE-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: OSACL in BMS
    *** reqs: Ctdsp1 and/or Ctdsp2 [RNAi]
    *** source: 17085434-Fig-6a
  *** SBE-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: RGM1 in BMLS
    *** source: 15326485-Fig-8c
  *** SBE-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: RGM1<xSmad3> in BMLS
    *** unaffected by: xSmad3(T179V/S204A/S208A/S213A) [substitution]
    *** bkg inhibited by: xSmad3(S416A/S422A/S425A) [substitution]
    *** source: 15326485-Fig-8c
  *** SBE-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: RI14<xSmad3><xSmad4> in BMS
    *** source: 12621041-Fig-5a
  *** SBE-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: SW4807<Smad4~null><xSmad4> in BMS
    *** reqs: xSmad4 [omission]
    *** enhanced by: xSmad4(K159R/K113R) [substitution]
    *** source: 12621041-Fig-5b
  *** SBE-reporter[Luc] is increased irt Tgfb1 (16 hr)
    *** cells: HEPG2 in BMS
    *** repressed by: Csnk1g2 [RNAi]
    *** source: 18794808-Fig-2b
  *** SBE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MDAMB468<Smad4~null><xSmad4> in BMS
    *** enhanced by: xSmad4(K113R) [substitution]
    *** enhanced by: xSmad4(K159R) [substitution]
    *** enhanced by: xSmad4(K113R/K159R) [substitution]
    *** source: 12740389-Fig-6b
  *** SBE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MDAMB468<Smad4~null><xSmad4> in BMS
    *** enhanced by: xSmad4(K159R) [substitution]
    *** source: 12740389-Fig-6a
  *** SBE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MDAMB468<Smad4~null><xSmad4> in BMS
    *** source: 12740389-Fig-6c
  *** SBE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: SW4807<Smad4~null><xSmad4> in BMS
    *** bkg reqs: xSmad4 [omission]
    *** source: 14750902-Fig-3a
  *** SBE-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: AKR2B in BMLS
    *** partially inhibited by: xErbin [addition]
    *** source: 19289088-Fig-4d
  *** SBE-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: LY294002 [pretreatment]
    *** source: 16288034-Fig-2c
  *** SBE-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 19117990-Fig-3d
  *** SBE-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: AKR2B<xFoxh1> in BMLS
    *** does not req: Raptor [RNAi]
    *** does not req: Rictor [RNAi]
    *** source: 19117990-Fig-6c
  *** SBE-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: FAO in BMS
    *** unaffected by: xMlk3 [addition]
    *** unaffected by: xMlk3(mnr)"DN" [addition]
    *** source: 15069087-Fig-6a
  *** SBE-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: mEFs<Smad2~null> in BMLS
    *** source: 16288034-Fig-2c
  *** SBE-reporter[Luc] is increased irt Tgfb1 (tnr)
    *** cells: HACAT in BMS
    *** unaffected by: xCtdsp1 [addition]
    *** source: 17035229-Fig-6a
  *** SBE-reporter[Luc] is increased irt Tgfb1 (tnr)
    *** cells: HACAT<Smad3~null><xSmad3> in BMS
    *** reqs: xSmad3 [omission]
    *** inhibited by: xSmad3(V356R) [substitution]
    *** inhibited by: xSmad3(W306R) [substitution]
    *** source: 12917407-Fig-7d
  *** SBE-reporter[Luc] is increased irt Tgfb2 (18 hr)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** does not req: IL1R1 [RNAi]
    *** reqs: TgfbR1 [RNAi]
    *** reqs: TgfbR2 [RNAi]
    *** unaffected by: xIkba(S32A/S36A)"SR" [addition]
    *** reqs: Smad2 [RNAi]
    *** source: 17360530-Fig-5d
  *** SBE-reporter[Luc] is increased irt Tgfb2 (24 hr)
    *** cells: AKR2B in BMLS
    *** source: 17440079-Fig-3d
  *** SBE-reporter[Luc] is increased irt Tgfb2 (24 hr)
    *** cells: AKR2B in BMLS
    *** unaffected by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-3c
  *** SBE-reporter[Luc] is unchanged irt Tgfb1 (18 hr)
    *** cells: MV1LU<xFoxh1> in BMLS
    *** source: 17420258-Fig-5d
  *** SBE-reporter[Luc] is unchanged irt Tgfb1 (24 hr)
    *** cells: mEFs<Smad3~null> in BMLS
    *** source: 16288034-Fig-2c
  *** SBE-reporter[Luc] is unchanged irt Tgfb2 (24 hr)
    *** cells: mEFs<Smad3~null><xSmad2(S467A)> in BMLS
    *** source: 17440079-Fig-3d
*** Shc1--
  *** Shc1p46[Ab]IP phos[32Pi] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5+ 10++ min
    *** source: 17673906-Fig-2a
  *** Shc1p46[Ab]IP Sphos[32Pi-PAA] is increased irt Tgfb1 (10 min)
    *** cells: SWISS3T3 in BMS
    *** source: 17673906-Fig-2b
  *** Shc1p46[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0 2++ 5++ 10++ 20+ 30 min
    *** comment: increase is not statistically significant (Supplemental Data)
    *** source: 17673906-Fig-1a
  *** Shc1p46[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5++ 10++ min
    *** source: 17673906-Fig-8a
  *** Shc1p46[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 10++ 20++ 30++ min
    *** comment: increase is not statistically significant (Supplemental Data)
    *** inhibited by: SB431542 [addition]
    *** source: 17673906-Fig-3b
  *** Shc1p46[Ab]IP Yphos[pYAb] is unchanged irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 2+ 5+ 10+ 20+ 30+ min
    *** comment: increase is not statistically significant (Supplemental Data)
    *** source: 17673906-Fig-1b
  *** Shc1p46[Ab]IP Yphos[pYAb] is unchanged irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5+ 10+ min
    *** comment: increase is not statistically significant (Supplemental Data)
    *** unaffected by: CHX [addition]
    *** source: 17673906-Fig-1c
  *** rShc1p52[32P] phos[32P-ATP] is increased by rEgfR
    *** cells: none
    *** source: 17673906-Fig-6a
  *** rShc1p52[32P] phos[32P-ATP] is increased by rTgfbR1(mnr)"Cyto-domain"
    *** cells: none
    *** comment: phosphorylation is on serine > threonine > tyrosine by PAA
    *** source: 17673906-Fig-6a
  *** rShc1p52[32P] phos[32P-ATP] is increased by rTgfbR2(mnr)"Cyto-domain"
    *** cells: none
    *** comment: phosphorylation mostly on serine by PAA
    *** source: 17673906-Fig-6a
  *** Shc1p52[Ab]IP phos[32Pi] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5+ 10++ min
    *** source: 17673906-Fig-2a
  *** Shc1p52[Ab]IP Sphos[32Pi-PAA] is increased irt Tgfb1 (10 min)
    *** cells: SWISS3T3 in BMS
    *** source: 17673906-Fig-2b
  *** Shc1p52[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0+ 2++ 5++ min
    *** inhibited by: xTgfbR1(mnr)"DN" [addition]
    *** source: 17673906-Fig-3a
  *** Shc1p52[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0+ 2+++ 5++ 10+++ 20+++ 30+ min
    *** comment: only 10,20 min increase is statistically significant (Supplemental Data)
    *** source: 17673906-Fig-1a
  *** Shc1p52[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 2+ 5++ 10++ 20++ 30++ min
    *** comment: only 5,10,20 min increase is statistically significant (Supplemental Data)
    *** source: 17673906-Fig-1b
  *** Shc1p52[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5+ 10++ min
    *** comment: increase is not statistically significant (Supplemental Data)
    *** unaffected by: CHX [addition]
    *** source: 17673906-Fig-1c
  *** Shc1p52[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5++ 10++ min
    *** source: 17673906-Fig-8a
  *** Shc1p52[Ab]IP Yphos[pYAb] is unchanged irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 10+ 20+ 30+ min
    *** comment: only 20 min increase is statistically significant (Supplemental Data)
    *** bkg inhibited by: SB431542 [addition]
    *** source: 17673906-Fig-3b
  *** rShc1p66[32P] phos[32P-ATP] is increased by (rTgfbR1(mnr)"Cyto-domain" + rTgfbR2(mnr)"Cyto-domain")
    *** cells: none
    *** inhibited by: rTgfbR1(mnr/K230R)"KD-cyto-domain" [substitution]
    *** inhibited by: rTgfbR2(mnr/K277R)"KD-cyto-domain" [substitution]
    *** comment: phosphorylation is on tyrosine > serine > threonine by PAA
    *** source: 17673906-Fig-6d
  *** rShc1p66[32P] phos[32P-ATP] is increased by rEgfR
    *** cells: none
    *** source: 17673906-Fig-6a
  *** rShc1p66[32P] phos[32P-ATP] is increased by rTgfbR1(mnr)"Cyto-domain"
    *** cells: none
    *** source: 17673906-Fig-6a
  *** rShc1p66[32P] phos[32P-ATP] is increased by rTgfbR2(mnr)"Cyto-domain"
    *** cells: none
    *** source: 17673906-Fig-6a
  *** Shc1p66[Ab]IP phos[32Pi] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5+ 10++ min
    *** source: 17673906-Fig-2a
  *** Shc1p66[Ab]IP Sphos[32Pi-PAA] is increased irt Tgfb1 (10 min)
    *** cells: SWISS3T3 in BMS
    *** source: 17673906-Fig-2b
  *** Shc1p66[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0 2++ 5+ 10++ 20+ 30 min
    *** comment: increase is not statistically significant (Supplemental Data)
    *** source: 17673906-Fig-1a
  *** Shc1p66[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 2+ 5+ 10++ 20++ 30 min
    *** comment: increase is not statistically significant (Supplemental Data)
    *** source: 17673906-Fig-1b
  *** Shc1p66[Ab]IP Yphos[pYAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5++ 10++ min
    *** source: 17673906-Fig-8a
  *** Shc1p66[Ab]IP Yphos[pYAb] is unchanged irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 10+ 20+ 30+ min
    *** comment: increase is not statistically significant (Supplemental Data)
    *** bkg inhibited by: SB431542 [addition]
    *** source: 17673906-Fig-3b
*** Skil--
  *** xSkil[tAb] prot-exp[WB] is decreased itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T<xSmad2><xSmurf2> in BMS
    *** inhibited by: xSmad2(del(221-225))"del-PY" [substitution]
    *** source: 11389444-Fig-6c
  *** xSkil[tAb] prot-exp[WB] is decreased itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T<xSmad2><xSmurf2> in BMS
    *** inhibited by: xSmurf2(C716A)"CIA" [substitution]
    *** source: 11389444-Fig-4b
  *** xSkil[tAb] prot-exp[WB] is decreased itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T<xSmad2><xSmurf2> in BMS
    *** inhibited by: xSmurf2(C716A)"CIA" [substitution]
    *** source: 11389444-Fig-4c
  *** xSkil[tAb] prot-exp[WB] is decreased itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T<xSmad2><xSmurf2> in BMS
    *** inhibited by: xTgfbR1(WT) [substitution]
    *** source: 11389444-Fig-4a
  *** xSkil[tAb] prot-exp[WB] is decreased itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T<xSmad2><xSmurf2> in BMS
    *** reqs: xSmad2 [omission]
    *** source: 11389444-Fig-4a
  *** xSkil[tAb] prot-exp[WB] is decreased itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T<xSmad2><xSmurf2> in BMS
    *** reqs: xSmad2 [omission]
    *** source: 11389444-Fig-4b
  *** xSkil[tAb] prot-exp[WB] is decreased itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T<xSmad2><xSmurf2> in BMS
    *** reqs: xSmurf2 [omission]
    *** source: 11389444-Fig-4a
  *** xSkil[tAb]IP ubiq[tUbAb] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T<xUbiq><xSmurf2><xSmad2> in BMS
    *** comment: IPs were boiled in 1% SDS and reIPed
    *** inhibited by: xSmad2(del(221-225))"del-PY" [substitution]
    *** source: 11389444-Fig-6d
  *** xSkil[tAb]IP ubiq[tUbAb] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T<xUbiq><xSmurf2><xSmad2> in BMS
    *** comment: IPs were boiled in 1% SDS and reIPed
    *** inhibited by: xSmurf2(C716A)"CIA" [substitution]
    *** source: 11389444-Fig-6d
*** Smad1--
  *** xSmad1[Gal4-DBD] Gal4-reporter[Luc] is unchanged irt Tgfb1 (12 hr)
    *** cells: MV1LU in BMS
    *** unaffected by: xJun [addition]
    *** unaffected by: xFos [addition]
    *** source: 9732876-Fig-1e
  *** Smad1[phosAb] phos(S206)[phosAb] is increased irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** source: 17085434-Fig-1b
  *** Smad1[phosAb] phos(S206)[phosAb] is unchanged irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** unaffected by: Ctdsp1 and/or Ctdsp2 [RNAi]
    *** source: 17085434-Fig-5b
  *** Smad1[phosAb] phos(S463/S425)[phosAb] is unchanged irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** source: 17085434-Fig-1b
  *** Smad1[phosAb] phos(S463/S425)[phosAb] is unchanged irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** unaffected by: Ctdsp1 and/or Ctdsp2 [RNAi]
    *** source: 17085434-Fig-5b
  *** Smad1[phosAb] phos(S463/S465)[phosAb] is unchanged irt Tgfb1 (45 min)
    *** cells: MA10 in BMS
    *** source: 10854429(D)
  *** Smad1[phosAb] phos(S463/S465)[phosAb] is unchanged irt Tgfb1 (45 min)
    *** cells: SMAT1 in BMS
    *** source: 10854429(D)
*** Smad2--
  *** Smad2-gene mRNA[Northern] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0+ 30+ 90+ 240+ 1440+ min
    *** source: 9335507-Fig-5a
  *** Smad2-gene mRNA[Northern] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: SW1736 in BMS
    *** times: 0+ 30+ 90+ 240+ 1440+ min
    *** source: 9335507-Fig-5a
  *** Smad2-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** reqs: Smad3 [RNAi]
    *** source: 18955504-Fig-7a
  *** rSmad2(1-185)"MH1"[tAb] nuc-import[IVnucImport] is detectable
    *** cells: none
    *** comment: performed in permeabilized HELA cells without additional cytosol
    *** source: 10934479-Fig-1a
  *** rSmad2(186-467)"LMH2"[tAb] nuc-import[IVnucImport] is detectable
    *** cells: none
    *** comment: performed in permeabilized HELA cells without additional cytosol
    *** source: 10934479-Fig-1a
  *** rSmad2(248-467)"MH2"[tAb] nuc-import[IVnucImport] is detectable
    *** cells: none
    *** comment: performed in permeabilized HELA cells without additional cytosol
    *** source: 10934479-Fig-1a
  *** rSmad2[Ab] boundby[WB] rSara(mnr)"SBD"[GST] is detectable
    *** cells: none
    *** inhibited by: rSmad2{phos} [substitution]
    *** comment: rSmad2 was phosed by coexpression with TgfbR1(T204D) in insect cells
    *** source: 10934479-Fig-3c
  *** Smad2[Ab] copptby[WB] Csnk1g2[Ab] is unchanged irt Tgfb1 (2 hr)
    *** cells: HACAT in BMS
    *** source: 18794808-Fig-1c
  *** Smad2[Ab] copptby[WB] Sara[Ab] is decreased irt Tgfb1 (30 min)
    *** cells: HEPG2 in BMS
    *** source: 9865696-Fig-2d
  *** Smad2[Ab] copptby[WB] Sptbn1[Ab] is unchanged irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** rSmad2[Ab] nuc-import[IVnucImport] is decreased by rSara(mnr)"SBD"
    *** cells: none
    *** comment: performed in permeabilized HELA cells without additional cytosol
    *** inhibited by: rSmad2{phos} [substitution]
    *** source: 10934479-Fig-3d
  *** rSmad2[Ab] nuc-import[IVnucImport] is detectable
    *** cells: none
    *** comment: performed in permeabilized HELA cells without additional cytosol
    *** inhibited by: xSara(mnr)"SBD" [addition]
    *** source: 10934479-Fig-3b
  *** rSmad2[Ab] nuc-import[IVnucImport] is detectable
    *** cells: none
    *** comment: performed in permeabilized HELA cells without additional cytosol
    *** source: 10934479-Fig-2a
  *** rSmad2[Ab] nuc-import[IVnucImport] is detectable
    *** cells: none
    *** comment: performed in permeabilized HELA cells without additional cytosol
    *** unaffected by: rSmad2(S464A/S465A/S267A) [substitution]
    *** source: 10934479-Fig-2b
  *** Smad2[Ab] prot-exp[WB] is decreased irt Tgfb1 (15 hr)
    *** cells: COS1 in BMS
    *** inhibited by: MG132 [addition]
    *** inhibited by: Lactacystin [addition]
    *** source: 10587642-Fig-2a
  *** Smad2[Ab] prot-exp[WB] is unchanged irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** source: 14555988-Fig-2a
  *** Smad2[Ab]IP prot-exp[WB] is unchanged irt Tgfb1 (times)
    *** cells: RGM1 in BMLS
    *** times: 0+ 5+ 15+ 30+ 60+ 120+ min
    *** source: 15326485-Fig-1b
  *** xSmad2[tAb] copptby[WB] CbpP300[Ab] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: bAECs in BMS
    *** source: 10085121-Fig-7b
  *** xSmad2[tAb] copptby[WB] xPdpk1[GST] is decreased irt Tgfb1 (20 hr)
    *** cells: HEK293T in BMS
    *** source: 17327236-Fig-3a
  *** xSmad2[tAb] copptby[WB] xSara[tAb] is decreased itpo xTgfb1(T204D)"CA"
    *** cells: COS1 in BMS
    *** inhibited by: xTgfbR1(WT) [substitution]
    *** source: 9865696-Fig-3b
  *** xSmad2[tAb] copptby[WB] xSara[tAb] is decreased itpo xTgfb1(T204D)"CA"
    *** cells: COS1 in BMS
    *** partially inhibited by: xSmad2(S464A/S465A/S467A) [substitution]
    *** source: 9865696-Fig-3b
  *** xSmad2[tAb] copptby[WB] xSkil[tAb] is detectable
    *** cells: HEK293T in BMS
    *** enhanced by: xTgfbR1(mnr)"CA" [addition]
    *** source: 11389444-Fig-6a
  *** xSmad2[tAb] copptby[WB] xSkil[tAb] is detectable
    *** cells: HEK293T in BMS
    *** unaffected by: xSmad2(del(221-225))"del-PY" [substitution]
    *** source: 11389444-Fig-6a
  *** xSmad2[tAb]IP prot-stability[35S-pulse-chase] is unchanged itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T in BMS
    *** unaffected by: xSmurf2 [addition]
    *** source: 11389444-Fig-2c
  *** xSmad2[tAb]IP upshift[WBMS] is increased irt Tgfb1 (6 hr)
    *** cells: COS1 in BMS
    *** enhanced by: Lactacystin [addition]
    *** source: 10587642-Fig-5b
  *** xSmad2[tAb]IP upshift[WBMS] is increased irt Tgfb1 (6 hr)
    *** cells: COS1 in BMS
    *** inhibited by: xSmad2(S464A/S465A/S467A) [substitution]
    *** source: 10587642-Fig-5b
  *** xSmad2[tAb]IP upshift[WBMS] is increased irt Tgfb1 (6 hr)
    *** cells: COS1 in BMS
    *** partially inhibited by: xUbiq(K48R) [addition]
    *** source: 10587642-Fig-5b
  *** rSmad2{phos}[Ab] nuc-import[IVnucImport] is unchanged by rSara(mnr)"SBD"
    *** cells: none
    *** comment: performed in permeabilized HELA cells without additional cytosol
    *** comment: rSmad2 was phosed by coexpression with TgfbR1(T204D) in insect cells
    *** source: 10934479-Fig-3d
*** Smad3--
  *** Smad3-gene mRNA[Northern] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0+ 30+ 90+ 240+ 1440+ min
    *** source: 9335507-Fig-5a
  *** Smad3-gene mRNA[Northern] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: SW1736 in BMS
    *** times: 0+ 30+ 90+ 240+ 1440+ min
    *** source: 9335507-Fig-5a
  *** Smad3-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** reqs: Smad2 [RNAi]
    *** source: 18955504-Fig-7a
  *** xSmad3(S418A)[Ab] prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: mEFs<xSmad3(S418A)> in BMS
    *** times: 0++ 1++ 4+ hr
    *** reversed by: MG132 [cotreatment]
    *** source: 18794808-Fig-6a
  *** Smad3[Ab] boundto(Col1a2-gene)[ChIP] is increased irt Tgfb1 (30 min)
    *** cells: mEFs in BMS
    *** repressed by: Smad2 [KO]
    *** source: 20595680-Fig-8d
  *** Smad3[Ab] copptby[WB] Smad2[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** Smad3[Ab] copptby[WB] Sptbn1[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** Smad3[Ab] prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: HACAT<xCsnk1g2> in BMS
    *** times: 0+ 1+ 2+ 4+ 6 hr
    *** source: 18794808-Fig-4d
  *** Smad3[Ab] prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: mEFs in BMS
    *** times: 0++ 2++ 4+ hr
    *** enhanced by: xCsnk1g2 [addition]
    *** unaffected by: xCsnk1g2(mnr)"KD" [addition]
    *** source: 18794808-Fig-3f
  *** Smad3[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0+ 1+ 2+ 4+ 6+ hr
    *** source: 18794808-Fig-4d
  *** xSmad3[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: mEFs<xSmad3> in BMS
    *** times: 0+ 1+ 4+ hr
    *** unaffected by: MG132 [cotreatment]
    *** source: 18794808-Fig-6a
  *** Smad3[Ab] prot-exp[WB] is unchanged irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** source: 14555988-Fig-2a
  *** Smad3[Ab]IP prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0++ 1+ 4 hr
    *** source: 11359933-Fig-1a
  *** Smad3[Ab]IP prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: RGM1 in BMLS
    *** times: 0++ 5++ 15++ 30++ 60+ 120+ min
    *** source: 15326485-Fig-1b
  *** xSmad3[Gal4-DBD] boundby[MamTwoHybrid] xFos[VP16] is increased irt Tgfb1 (tnr)
    *** cells: MV1LU in BMS
    *** source: 9732876-Fig-2a
  *** xSmad3[Gal4-DBD] boundby[MamTwoHybrid] xFos[VP16] is unchanged irt Tgfb1 (tnr)
    *** cells: F9 in BMS
    *** source: 9732876-Fig-2b
  *** xSmad3[Gal4-DBD] boundby[MamTwoHybrid] xJun[VP16] is increased irt Tgfb1 (tnr)
    *** cells: F9 in BMS
    *** source: 9732876-Fig-2b
  *** xSmad3[Gal4-DBD] boundby[MamTwoHybrid] xJun[VP16] is increased irt Tgfb1 (tnr)
    *** cells: MV1LU in BMS
    *** source: 9732876-Fig-2a
  *** xSmad3[tAb] copptby[WB] xPdpk1[GST] is decreased irt Tgfb1 (20 hr)
    *** cells: HEK293T in BMS
    *** source: 17327236-Fig-3a
*** Smad4--
  *** Smad4-gene mRNA[Northern] is unchanged irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0+ 30+ 90+ 240+ 1440+ min
    *** source: 9335507-Fig-5a
  *** Smad4-gene mRNA[Northern] is unchanged irt Tgfb1 (times)
    *** cells: SW1736 in BMS
    *** times: 0+ 30+ 90+ 240+ 1440+ min
    *** source: 9335507-Fig-5a
  *** xSmad4(266-562)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tgfb2 (16 hr)
    *** cells: ATDC5 in BMLS
    *** inhibited by: U0126 [addition]
    *** inhibited by: SB203580 [addition]
    *** inhibited by: SKF86002 [addition]
    *** source: 11278290-Fig-6b
  *** rSmad4[32P] phos[32P-ATP] is unchanged by xTgfbR2[tAb]IP
    *** cells: none
    *** IPfrom: COS1<xTgfbR1><xTgfbR2> in BMS "treated with Tgfb1 (30 min)"
    *** source: 8980228-Fig-3b
  *** Smad4[Ab] copptby[WB] Smad1[Ab] is unchanged irt Tgfb1 (45 min)
    *** cells: MA10 in BMS
    *** source: 10854429(D)
  *** Smad4[Ab] copptby[WB] Smad1[Ab] is unchanged irt Tgfb1 (45 min)
    *** cells: SMAT1 in BMS
    *** source: 10854429(D)
  *** Smad4[Ab] copptby[WB] Sptbn1[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** Smad4[Ab] copptby[WB] TgfbR1[Ab] is unchanged irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** Smad4[Ab] prot-exp[WB] is unchanged irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** source: 14555988-Fig-2a
  *** Smad4[Ab] snaggedby[WB] oligo[biotin] is increased irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** oligo: SBE 5-CTAGGATAGCGTCTAGACATAGTCTAGACTGAGTCCTAG-3
    *** source: 12904571-Fig-5b
  *** Smad4[Ab] snaggedby[WB] oligo[biotin] is increased irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** oligo: SBE sequence-not-reported
    *** source: 14993291-Fig-5d
  *** Smad4[Ab] snaggedby[WB] oligo[biotin] is increased irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS "nuclear-extract"
    *** oligo: SBE sequence-not-reported
    *** source: 14993291-Fig-5e
  *** Smad4[Ab]IP phos[32Pi] is unchanged irt Tgfb1 (tnr)
    *** cells: MV1LU in BMS
    *** source: 9311995-Fig-3a
  *** xSmad4[Gal4-DBD] boundby[MamTwoHybrid] xFos[VP16] is unchanged irt Tgfb1 (tnr)
    *** cells: MV1LU in BMS
    *** source: 9732876-Fig-2a
  *** xSmad4[Gal4-DBD] boundby[MamTwoHybrid] xJun[VP16] is unchanged irt Tgfb1 (tnr)
    *** cells: MV1LU in BMS
    *** source: 9732876-Fig-2a
  *** xSmad4[Gal4-DBD] Gal4-reporter[Luc] is unchanged irt Tgfb1 (12 hr)
    *** cells: MV1LU in BMS
    *** unaffected by: xJun [addition]
    *** unaffected by: xFos [addition]
    *** source: 9732876-Fig-1e
  *** xSmad4[tAb] copptby[WB] xPdpk1[GST] is decreased irt Tgfb1 (20 hr)
    *** cells: HEK293T in BMS
    *** source: 17327236-Fig-3a
  *** xSmad4[tAb] oligo-binding[EMSA] is increased irt Tgfb1 (1 hr)
    *** cells: NIH3T3<xFast3!Xenla><xSmad2> in BMS "nuclear-extracts"
    *** oligo: "activin-responsive Xenopus Mix.2 promoter" sequence-not-reported
    *** source: 12374795-Fig-3
  *** xSmad4[tAb] oligo-binding[EMSA] is increased irt Tgfb1 (1 hr)
    *** cells: NIH3T3<xFoxh1!Xenla><xSmad2> in BMS "nuclear-extracts"
    *** oligo: "activin-responsive Xenopus Mix.2 promoter" sequence-not-reported
    *** source: 12374795-Fig-2
  *** xSmad4[tAb] oligo-binding[EMSA] is increased irt Tgfb1 (1 hr)
    *** cells: NIH3T3<xSmad3> in BMS "nuclear-extracts"
    *** oligo: "5-UTR of Jun-gene" sequence-not-reported
    *** source: 12374795-Fig-4
  *** xSmad4[tAb] oligo-binding[EMSA] is increased irt Tgfb1 (30 min)
    *** cells: SW480<Smad4~null> in BMS
    *** unaffected by: xSmad4(L146A/L148A)"NES-mutant" [substitution]
    *** source: 11265759-Fig-3b
  *** xSmad4[tAb] oligo-binding[EMSA] is increased itpo xTgfbR1(T204D)"CA"
    *** cells: NIH3T3<xSmad2><xFoxh1> in BMS
    *** unaffected by: xSmad4(del(142-153)) [substitution]
    *** unaffected by: xSmad4(del(153-223)) [substitution]
    *** unaffected by: xSmad4(del(263-302)) [substitution]
    *** unaffected by: xSmad4(del(223-302)) [substitution]
    *** unaffected by: xSmad4(del(153-302)) [substitution]
    *** unaffected by: xSmad4(del(153-320)) [substitution]
    *** source: 11074002-Fig-3a
*** Smad7--
  *** xSmad7[Ab]IP phos[32Pi] is unchanged irt Tgfb1 (tnr)
    *** cells: COS1<xTgfbR1><xTgfbR2> in BMS
    *** source: 9335507-Fig-4a
  *** xSmad7[Ab]IP phos[32Pi] is unchanged itpo xTgfbR1(T204D)"CA"
    *** cells: COS1 in BMS
    *** source: 9335507-Fig-4a
  *** xSmad7[tAb] copptby[WB] xPdpk1[GST] is decreased irt Tgfb1 (20 hr)
    *** cells: HEK293T in BMS
    *** source: 17327236-Fig-3a
  *** Smad15s[Ab]IP phos[32Pi] is unchanged irt Tgfb1 (tnr)
    *** cells: MV1LU in BMS
    *** source: 9311995-Fig-3a
*** Smad23s--
  *** Smad23s[Ab] boundto(Bcat1-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Cdc45-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Dab2ip-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Dmtf1-gene)[ChIP] is unchanged irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Hprt1-gene)[ChIP] is unchanged irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-4d
  *** Smad23s[Ab] boundto(Hprt1-gene)[ChIP] is unchanged irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0 1 2 3 6 10 24 hr
    *** source: 18955504-Fig-1a
  *** Smad23s[Ab] boundto(Id1-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Id1-gene)[ChIP] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0 1++ 2+++ 3++ 6+ 10+ 24+ hr
    *** source: 18955504-Fig-1a
  *** Smad23s[Ab] boundto(Ing4-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Junb-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Mdc1-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Mnt-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Pmepa1-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Ptges-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Skil-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] copptby[WB] Ets1[Ab] is detectable-but unchanged irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-S5a
  *** Smad23s[Ab]IP ubiq[UbAb] is increased irt Tgfb1 (6 hr)
    *** cells: HACAT in BMS
    *** source: 10587642-Fig-5a
*** Smurf2--
  *** Smurf2[Ab] copptby[WB] Skil[Ab] is increased irt Tgfb1 (tnr)
    *** cells: U4A<Jak1~null><xJak1> in BMS "treated with LLNL"
    *** comment: phos(sitenr) Smad2 is found in coppt but total Smad2 was not performed
    *** source: 11389444-Fig-3a
  *** Snai1-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: PC3U<xTgfbR1> in BMS
    *** times: 0 30+ 360+ 720++ 1440++ min
    *** inhibited by: xTgfbR1(E161A) [substitution]
    *** source: 21629263-Fig-6d
*** Sos1--
  *** Sos1[Ab] copptby[WB] Shc1[Ab] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 1++ 2++ 5++ 10++ 20++ 30+ min
    *** source: 17673906-Fig-7b
*** Sptbn1--
  *** Sptbn1[Ab] copptby[WB] Smad3[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** Sptbn1[Ab] copptby[WB] Smad4[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** Sptbn1[Ab] copptby[WB] TgfbR1[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** Sptbn1[Ab]IP Sphos[pSAb] is increased irt Tgfb1 (times)
    *** cells: HEPG2 in BMS
    *** times: 0 2+++ 20++ 30+ 120+ 1080+ min
    *** source: 12543979-Fig-S2a
*** Tab2--
  *** Tab2[Ab] copptby[WB] Traf2[Ab] is unchanged irt Tgfb1 (18 hr)
    *** cells: CMT93 in BMS
    *** source: 17384642-Fig-6b
  *** Tab2[Ab] copptby[WB] Traf2[Ab] is unchanged irt Tgfb1 (18 hr)
    *** cells: mBMMs in BMS
    *** source: 17384642-Fig-6a
  *** Tab2[Ab] copptby[WB] xTak1[tAb] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: HEK293T<xTak1><xUbiq> in BMS
    *** times: 0+ 2+ 5+ min
    *** source: 18758450-Fig-1b
  *** Tab3[Ab] copptby[WB] Traf2[Ab] is unchanged irt Tgfb1 (18 hr)
    *** cells: CMT93 in BMS
    *** source: 17384642-Fig-6b
  *** Tab3[Ab] copptby[WB] Traf2[Ab] is unchanged irt Tgfb1 (18 hr)
    *** cells: mBMMs in BMS
    *** source: 17384642-Fig-6a
*** Tak1--
  *** Tak1[Ab] copptby[WB] Traf2[Ab] is unchanged irt Tgfb1 (18 hr)
    *** cells: CMT93 in BMS
    *** source: 17384642-Fig-6b
  *** Tak1[Ab] copptby[WB] Traf2[Ab] is unchanged irt Tgfb1 (18 hr)
    *** cells: mBMMs in BMS
    *** source: 17384642-Fig-6a
  *** Tak1[Ab] copptby[WB] Traf6[Ab] is decreased irt Tgfb1 (times)
    *** cells: HEK293T in BMS
    *** times: 0+ 2+ 5+ 15 min
    *** comment: decrease could be due to decrease in Traf6 in IP
    *** source: 18758450-Fig-3a
*** TgfbR1--
  *** xTgfbR1(K233R)[125I-Tgfb1-XL] copptby[WB] xSmad2[tAb] is decreased itpo xSmad7
    *** cells: COS1<xTgfbR2> in BMS
    *** inhibited by: xSmad7(1-408) [substitution]
    *** source: 9215638-Fig-6c
  *** xTgfbR1(K233R)[125I-Tgfb1-XL] copptby[WB] xSmad2[tAb] is decreased itpo xSmad7
    *** cells: COS1<xTgfbR2> in BMS
    *** source: 9215638-Fig-5c
  *** xTgfbR1(K233R)[125I-Tgfb1-XL] copptby[WB] xSmad2[tAb] is detectable
    *** cells: COS1<xTgfbR2> in BMS
    *** inhibited by: xTgfbR1(WT) [substitution]
    *** source: 9215638-Fig-5c
  *** xTgfbR1(K233R)[125I-Tgfb1-XL] copptby[WB] xSmad2[tAb] is detectable
    *** cells: COS1<xTgfbR2> in BMS
    *** inhibited by: xTgfbR1(WT) [substitution]
    *** source: 9215638-Fig-6c
  *** xTgfbR1(mnr)"KD"[125I-Tgfb1-XL] copptby[WB] xSmad4[tAb] is undetectable
    *** cells: COS1<xTgfbR1(mnr)"KD"><xTgfbR2> in BMS "treated with Tgfb1 (30 min)"
    *** source: 8980228-Fig-3a
  *** xTgfbR1(T204D)"CA"[tAb] copptby[WB] xSmad7[tAb] is detectable
    *** cells: COS1 in BMS
    *** inhibited by: xTgfbR2(WT) [substitution]
    *** source: 9215638-Fig-5b
  *** xTgfbR1[125I-Tgfb1-XL] copptby[WB] xSmad7[tAb] is detectable
    *** cells: COS1<xTgfbR1><xTgfbR2> in BMS
    *** reqs: xTgfbR1 [omission]
    *** enhanced by: xTgfbR1(K232R)"KD" [substitution]
    *** inhibited by: xTgfbR2(K277R)"KD" [substitution]
    *** source: 9335507-Fig-3
  *** xTgfbR1[125I-Tgfb1-XL] copptby[WB] xSmad7[tAb] is detectable
    *** cells: COS1<xTgfbR2> in BMS
    *** unaffected by: xTgfbR1(K232R)"KD" [substitution]
    *** inhibited by: xTgfbR2(K277R)"KD" [substitution]
    *** source: 9215638-Fig-5a
  *** xTgfbR1[125I-Tgfb1-XL] prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0++ 4+ 24 hr
    *** source: 11163210-Fig-5a
  *** xTgfbR1[125I-Tgfb1-XL] prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0++ 90++ 240+ 480 min
    *** partially inhibited by: Lactacystin [addition]
    *** partially inhibited by: Chloroquine [addition]
    *** source: 11163210-Fig-5b
  *** TgfbR1[Ab] boundto(Snai1-gene)[ChIP] is increased irt Tgfb1 (6 hr)
    *** cells: PC3U in BMS
    *** source: 21629263-Fig-6h
  *** TgfbR1[Ab] copptby[WB] Smad4[Ab] is unchanged irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** TgfbR1[Ab] copptby[WB] Sptbn1[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** TgfbR1[Ab] copptby[WB] xIL1R1[Ab] is increased irt Tgfb2 (15 min)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-6
  *** TgfbR1[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (6 hr)
    *** cells: A549 in BMS
    *** inhibited by: TAPI2 [cotreatment]
    *** inhibited by: PKCzPS [cotreatment]
    *** source: 21629263-Fig-7c
  *** TgfbR1[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (6 hr)
    *** cells: MDAMB231 in BMS
    *** inhibited by: TAPI2 [cotreatment]
    *** inhibited by: PKCzPS [cotreatment]
    *** source: 21629263-Fig-7a
  *** TgfbR1[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (6 hr)
    *** cells: PC3U in BMS
    *** inhibited by: PKCzPS [cotreatment]
    *** source: 21629263-Fig-5a
  *** TgfbR1[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (6 hr)
    *** cells: PC3U in BMS
    *** inhibited by: TAPI2 [cotreatment]
    *** source: 21629263-Fig-3c
  *** TgfbR1[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (6 hr)
    *** cells: PC3U in BMS
    *** source: 21629263-Fig-3a
  *** TgfbR1[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (30 min)
    *** cells: PC3U in BMS
    *** unaffected by: anti-Itgb1 [cotreatment]
    *** source: 21629263-Fig-S8
  *** TgfbR1[Ab] locatedin(nucleus)[IHC] is increased irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0 30+ 360+ min
    *** source: 21629263-Fig-6j
  *** TgfbR1[Ab] prot-exp[IHC] is increased irt Tgfb1 (6 hr)
    *** cells: PC3U in BMS
    *** source: 21629263-Fig-1a
  *** TgfbR1[Ab] prot-exp[IHC] is increased irt Tgfb1 (times)
    *** cells: hPRECs in BMS
    *** times: 0 30+ 360+ min
    *** comment: the staining was in the cytoplasm
    *** source: 21629263-Fig-6j
  *** TgfbR1[Ab] prot-exp[WB] is detectable-but unchanged irt Tgfb1 (times)
    *** cells: PC3U in BMS
    *** times: 0+ 30+ 360+ min
    *** source: 21629263-Fig-1a
  *** TgfbR1[Ab] Yphos[pYAb-ppt] is increased irt Tgfb1 (10 min)
    *** cells: MV1LU in BMS
    *** source: 17673906-Fig-6g
  *** TgfbR1[Ab]IP ubiq[UbAb] is increased irt Tgfb1 (30 min)
    *** cells: PC3U<xUbiq> in BMS
    *** inhibited by: xUbiq(K6R/K11R/K29R/K33R/K63R)"K48-only" [substitution]
    *** unaffected by: xUbiq(K6R/K11R/K29R/K33R/K48R)"K63-only" [substitution]
    *** comment: the antibody used for IP only sees full length Tgfb
    *** source: 21629263-Fig-2a
  *** xTgfbR1[tAb] cleavage[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U<xTgfbR1> in BMS
    *** times: 0 30+ 360+ min
    *** inhibited by: xTgfbR1(G120I) [substitution]
    *** source: 21629263-Fig-4a
  *** xTgfbR1[tAb] copptby[WB] Ep300[Ab] is increased irt Tgfb1 (times)
    *** cells: PC3U<xTgfbR1> in BMS
    *** times: 0 30 360+ min
    *** inhibited by: xTgfbR1(E161A) [substitution]
    *** source: 21629263-Fig-6d
  *** xTgfbR1[tAb] copptby[WB] Shc1[Ab] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0 5 10+ 20 min
    *** source: 17673906-Fig-4d
  *** xTgfbR1[tAb] copptby[WB] xSmad7[tAb] is detectable
    *** cells: COS1 in BMS
    *** inhibited by: xSmad7(1-408) [substitution]
    *** source: 9215638-Fig-6c
  *** xTgfbR1[tAb] infraction(nuclear)[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U<xTgfbR1> in BMS
    *** times: 0+ 30++ 360+ min
    *** source: 21629263-Fig-3b
  *** xTgfbR1[tAb] infraction(nuclear)[WB] is increased irt Tgfb1 (times)
    *** cells: PC3U<xTgfbR1> in BMS
    *** times: 0+ 30++ 360++ min
    *** source: 21629263-Fig-S1d
  *** xTgfbR1[tAb] locatedin(nucleus)[IHC] is increased irt Tgfb1 (30 min)
    *** cells: PC3U<xTgfbR1> in BMS
    *** inhibited by: xTgfbR1(E161A) [substitution]
    *** source: 21629263-Fig-2c
  *** xTgfbR1[tAb] locatedin(nucleus)[IHC] is increased irt Tgfb1 (30 min)
    *** cells: PC3U<xTgfbR1> in BMS
    *** inhibited by: xTgfbR1(G120I) [substitution]
    *** source: 21629263-Fig-4b
  *** xTgfbR1[XFP] locatedin(nucleus)[IHC] is increased irt Tgfb1 (6 hr)
    *** cells: PC3U<xTgfbR1> in BMS
    *** comment: unable to tell whether this is new protein or translocated from membrane
    *** source: 21629263-Fig-1a
*** TgfbR2--
  *** xTgfbR2[125I-Tgfb1-XL] copptby[WB] xShc1[tAb] is increased itpo xTgfbR1
    *** cells: COS in BMS
    *** source: 17673906-Fig-4b
  *** xTgfbR2[125I-Tgfb1-XL] prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0++ 4+ 24 hr
    *** source: 11163210-Fig-5a
  *** xTgfbR2[125I-Tgfb1-XL] prot-exp[WB] is decreased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0++ 90++ 240+ 480 min
    *** partially inhibited by: Lactacystin [addition]
    *** partially inhibited by: Chloroquine [addition]
    *** source: 11163210-Fig-5b
  *** TgfbR2[Ab] copptby[WB] xIL1R1[Ab] is increased irt Tgfb2 (15 min)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS
    *** source: 17360530-Fig-6
  *** TgfbR2[MW] boundby[Xlink] Tgfb2[125I] is detectable
    *** cells: RAT1 in BMLS
    *** source: 7693660-Fig-1b
  *** xTgfbR2[tAb] copptby[WB] Shc1[Ab] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0 5 10++ 20+ min
    *** source: 17673906-Fig-4c
*** TgfbR3--
  *** TgfbR3[125I-Tgfb1-XL] copptby[WB] xShc1[tAb] is increased itpo xTgfbR1
    *** cells: COS in BMS
    *** source: 17673906-Fig-4b
  *** TgfbR3[MW] boundby[Xlink] Tgfb1[125I] is detectable
    *** cells: DR27<TgfbR2~null><xTgfbR2> in BMLS
    *** inhibited by: Tgfb1 [addition]
    *** inhibited by: Tgfb2 [addition]
    *** inhibited by: Tgfb3 [addition]
    *** comment: Tgfb2 has a lower affinity for TgfbR3 than Tgfb1 or Tgfb3
    *** source: 1333888-Fig-6a
  *** TgfbR3[MW] boundby[Xlink] Tgfb1[125I] is detectable
    *** cells: MV1LU in BMLS
    *** inhibited by: Tgfb1 [addition]
    *** inhibited by: Tgfb2 [addition]
    *** inhibited by: Tgfb3 [addition]
    *** comment: Tgfb2 has a lower affinity for TgfbR3 than Tgfb1 or Tgfb3
    *** source: 1333888-Fig-6a
  *** TgfbR3[MW] boundby[Xlink] Tgfb1[125I] is detectable
    *** cells: RAT1 in BMLS
    *** source: 7693660-Fig-1a
  *** TgfbR3[MW] boundby[Xlink] Tgfb2[125I] is detectable
    *** cells: RAT1 in BMLS
    *** source: 7693660-Fig-1b
*** Tgif--
  *** Tgif[Ab] upshift[WBMS] is increased irt Tgfb2 (2 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-4b
  *** Tgif[Ab] upshift[WBMS] is increased irt Tgfb2 (2 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 17440079-Fig-4a
  *** Tgif[Ab] upshift[WBMS] is unchanged irt Tgfb2 (2 hr)
    *** cells: MV1LU in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** source: 17440079-Fig-4a
*** Tgm2--
  *** Tgm2[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** does not req: Smad2 [AntiSense]
    *** source: 14555988-Fig-2a
  *** Tgm2[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** partially reqs: Smad4 [AntiSense]
    *** source: 14555988-Fig-2c
  *** Tgm2[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** reqs: Smad3 [AntiSense]
    *** source: 14555988-Fig-2b
  *** Tgm2[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** reqs: Smad3 [AntiSense]
    *** source: 14555988-Fig-5a
  *** Tgm2[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: MCF10A in BMS
    *** reqs: Smad2 [AntiSense]
    *** source: 14555988-Fig-6a
  *** Tgm2[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: MCF10A in BMS
    *** reqs: Smad3 [AntiSense]
    *** source: 14555988-Fig-6b
  *** Tgm2[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: MCF10A in BMS
    *** reqs: Smad4 [AntiSense]
    *** source: 14555988-Fig-6c
  *** DNA-synthesis[3H-Thymidine] is decreased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** reversed by: xCsnk1g2 [addition]
    *** enhanced by: Csnk1g2 [RNAi]
    *** source: 18794808-Fig-3a
  *** DNA-synthesis[3H-Thymidine] is decreased irt Tgfb1 (36 hr)
    *** cells: BAF3 in BMS
    *** partially reversed by: xGfi1 [addition]
    *** source: 20190815-Fig-8a
*** TRE--
  *** TRE-reporter[Luc] is increased irt Tgfb1 (4 hr)
    *** cells: U4A<Jak1~null><xJak1> in BMS
    *** partially inhibited by: Ifng (1 hr) [pretreatment]
    *** does not req: Smurf2 [AntiSense]
    *** source: 11163210-Fig-6e
  *** TRE-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: MV1LU in BMS
    *** inhibited by: xJun(235-331)"DN" [addition]
    *** source: 9732876-Fig-4a
  *** TRE-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: MV1LU in BMS
    *** partially inhibited by: rSmad3(1-210)"LN-term" [addition]
    *** source: 9732876-Fig-4b
  *** TRE-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: MV1LU in BMS
    *** unaffected by: xSmad1 [addition]
    *** unaffected by: xSmad2 [addition]
    *** enhanced by: xSmad3 [addition]
    *** unaffected by: xSmad4 [addition]
    *** source: 9732876-Fig-1a
  *** TRE-reporter[Luc] is increased irt Tgfb1 (18 hr)
    *** cells: MV1LU in BMS
    *** enhanced by: xRhoa(Q63L)"CA" + xRac1(Q61L)"CA" [addition]
    *** partially inhibited by: xRhoa(T19N)"DN" + xRac1(T17N)"DN" [addition]
    *** partially inhibited by: xJnk?(mnr)"DN" [addition]
    *** source: 10601313-Fig-2c
  *** TRE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: C2C12<xSmad4> in BMS
    *** inhibited by: xSmad4(L146A/L148A)"NES-mutant" [substitution]
    *** source: 11265759-Fig-4
  *** TRE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HACAT in BMS
    *** enhanced by: xSenp1 [addition]
    *** source: 14750902-Fig-2b
  *** TRE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEPG2 in BMS
    *** inhibited by: xSmad7 [addition]
    *** unaffected by: xSmad7(Y211A) [addition]
    *** source: 11163210-Fig-6b
  *** TRE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEPG2<xSmad2> in BMS
    *** inhibited by: xSmad2(S464A) [substitution]
    *** inhibited by: xSmad2(S465A) [substitution]
    *** inhibited by: xSmad2(S467A) [substitution]
    *** inhibited by: xSmad2(S465A/S467A) [substitution]
    *** inhibited by: xSmad2(S464A/S465A/S467A) [substitution]
    *** source: 9346908-Fig-6
  *** TRE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MV1LU in BMS
    *** unaffected by: xSara [addition]
    *** inhibited by: xSara(665-1323) [addition]
    *** unaffected by: xSara(705-1323) [addition]
    *** source: 9865696-Fig-7e
  *** TRE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MV1LUL17 in BMS
    *** inhibited by: xPias4 [addition]
    *** source: 12904571-Fig-3
  *** TRE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MV1LUL17 in BMS
    *** unaffected by: xSumo1 [addition]
    *** partially inhibited by: xUbe2i [addition]
    *** partially inhibited by: xPias4 [addition]
    *** source: 14750902-Fig-2a
  *** TRE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: SW480<Smad4~null><xSmad4> in BMS
    *** partially inhibited by: xSmad4(L146A/L148A)"NES-mutant" [substitution]
    *** source: 11265759-Fig-4
  *** TRE-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: U4A<Jak1~null><xJak1> in BMS
    *** partially inhibited by: Ifng (1 hr) [pretreatment]
    *** source: 11163210-Fig-6d
  *** TRE-reporter[Luc] is increased irt Tgfb1 (22 hr)
    *** cells: MV1LU<xSmad2> in BMLS
    *** inhibited by: xSmad2(S464A) [substitution]
    *** inhibited by: xSmad2(S465A) [substitution]
    *** inhibited by: xSmad2(S465D) [substitution]
    *** inhibited by: xSmad2(S467A) [substitution]
    *** inhibited by: xSmad2(S467D) [substitution]
    *** inhibited by: xSmad2(S465A/S467A) [substitution]
    *** inhibited by: xSmad2(S465A/S467D) [substitution]
    *** inhibited by: xSmad2(S464A/S465A/S467A) [substitution]
    *** source: 9346966-Fig-4
  *** TRE-reporter[Luc] is increased irt Tgfb1 (30 hr)
    *** cells: HEPG2 in BMS
    *** enhanced by: xSara [addition]
    *** enhanced by: xPmlc [addition]
    *** source: 15356634-Fig-2i
  *** TRE-reporter[Luc] is increased irt Tgfb1 (tnr)
    *** cells: HEPG2 in BMS
    *** source: 11356828-Fig-4a
  *** TRE-reporter[Luc] is increased irt Tgfb1 (tnr)
    *** cells: HEPG2<xXiap> in BMS
    *** source: 11356828-Fig-4a
  *** TRE-reporter[Luc] is increased irt Tgfb2 (16 hr)
    *** cells: ATDC5 in BMLS
    *** inhibited by: xSmad4(del(275-322))"DN" [addition]
    *** source: 11278290-Fig-2b
  *** TRE-reporter[Luc] is increased itpo (xSara + xPmlc)
    *** cells: HEPG2 in BMS
    *** source: 15356634-Fig-2i
  *** TRE-reporter[Luc] is increased itpo xSmad3
    *** cells: SW480<Smad4~null> in BMS
    *** enhanced by: xSmad4 [addition]
    *** enhanced by: xSmad4(L146A/L148A)"NES-mutant" [addition]
    *** source: 11265759-Fig-4
  *** TRE-reporter[Luc] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: bAECs in BMS
    *** enhanced by: xMekk1(380-672)"CA" [addition]
    *** unaffected by: xMek1(del(32-51)/S218E/S222E)"CA" [addition]
    *** source: 10085121-Fig-1b
  *** TRE-reporter[Luc] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: bAECs in BMS
    *** inhibited by: xMekk1(mnr)"DN" [addition]
    *** inhibited by: xSmad7 [addition]
    *** source: 10085121-Fig-1c
  *** TRE-reporter[Luc] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: MV1LU in BMS
    *** inhibited by: xSmad7 [addition]
    *** source: 12519765-Fig-5
  *** TRE-reporter[Luc] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: MV1LU<TgfbR1~null> in BMS
    *** partially inhibited by: xSmad7 [addition]
    *** source: 12151385-Fig-5
  *** TRE-reporter[Luc] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: MV1LU<TgfbR1~null><xSmad7> in BMS
    *** partially inhibited by: xSmurf1 [addition]
    *** unaffected by: xSmurf1(del(22-37))"del-C2-domain" [addition]
    *** source: 12151385-Fig-5
  *** TRE-reporter[Luc] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: MV1LU<xSmad7> in BMS
    *** inhibited by: xSmurf1 [addition]
    *** unaffected by: xSmurf1(C710A)"CIA" [addition]
    *** enhanced by: xSmurf1(I638A/L640A)"NES-mut" [addition]
    *** source: 12519765-Fig-5
  *** TRE-reporter[Luc] is unchanged irt Tgfb1 (tnr)
    *** cells: MDAMB468 in BMS
    *** source: 10601313-Fig-4d
*** Tsc2--
  *** Tsc2[phosAb] phos(S939)[phosAb] is increased irt Tgfb1 (4 hr)
    *** cells: mEFs in BMLS
    *** does not req: Mlst8 [KO]
    *** source: 19117990-Fig-4a
  *** Tsc2[phosAb] phos(S939)[phosAb] is increased irt Tgfb1 (6 hr)
    *** cells: AKR2B in BMLS
    *** does not req: Raptor [RNAi]
    *** does not req: Rictor [RNAi]
    *** source: 19117990-Fig-4b
  *** Tsc2[phosAb] phos(S939)[phosAb] is increased irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 1+ 3++ 6++ 9+ 12+ hr
    *** source: 19117990-Fig-2b
*** Vim--
  *** Vim[Ab] prot-exp[IHC] is increased irt Tgfb1 (48 hr)
    *** cells: NMUMG in BMS
    *** comment: cells change from epithelial to fibroblastic
    *** unaffected by: xPak2(mnr)"DN" [addition]
    *** source: 19289088-Fig-S3a
*** Vps39--
  *** Vps39[Ab] copptby[WB] Smad4[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** source: 12941698-Fig-5c
*** Foxp3--
  *** Foxp3-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: mCD4TCs in BMS "containing anti-Cd3 and anti-Cd28"
    *** times: 0 24+ 48++ 72++ hr
    *** source: 18434325-Fig-1b
*** IL17a--
  *** IL17a-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: mCD4TCs in BMS "containing anti-Cd3 and anti-Cd28"
    *** times: 0 24 48+ 72+ hr
    *** source: 18434325-Fig-1b
