========
Cleavage
========

  *** xTgfbR1[tAb]IP cleavage[WB] is increased by xAdam17[tAb]IP
    *** cells: none
    *** IP1from: HEK293T<xTgfbR1> in BMLS
    *** IP1from: HEK293T<xAdam17> in BMLS
    *** source: 19595713-Fig-3c
  *** xTgfbR1[tAb]IP cleavage[WB] is increased itpo xAdam17
    *** cells: CHO<xTgfbR1> in BMLS
    *** inhibited by: xAdam17(E406A) [substitution]
    *** source: 19595713-Fig-3a
  *** xTgfbR1[tAb]IP cleavage[WB] is increased itpo xAdam17
    *** cells: CHO<xTgfbR1> in BMLS
    *** source: 19595713-Fig-3d

=========
Secretion
=========

  *** xTgfbR1[tAb]IP secretion[WB] is increased itpo xAdam17
    *** cells: CHO<xTgfbR1> in BMLS
    *** inhibited by: xAdam17(E406A) [substitution]
    *** source: 19595713-Fig-3b

============================================================================
Decrease in Surface Expression without decrease in Total Protein Expression
============================================================================

  *** TgfbR1[biotin]IP surface-exp[biotin-labeling] is increased itao Adam17 [RNAi]
    *** cells: HACAT in BMS
    *** source: 19595713-Fig-5a
  *** TgfbR1[Ab] prot-exp[WB] is detectable-but unchanged itao Adam17 [RNAi]
    *** cells: HACAT in BMS
    *** source: 19595713-Fig-5a

  *** TgfbR1[biotin]IP surface-exp[biotin-labeling] is increased itao Adam17 [RNAi]
    *** cells: T42 in BMS
    *** source: 19595713-Fig-5a
  *** TgfbR1[Ab] prot-exp[WB] is detectable-but unchanged itao Adam17 [RNAi]
    *** cells: T42 in BMS
    *** source: 19595713-Fig-5a

  *** TgfbR1[biotin]IP surface-exp[biotin-labeling] is increased itao Adam17 [RNAi]
    *** cells: MDAMB468 in BMS
    *** source: 19595713-Fig-5a
  *** TgfbR1[Ab] prot-exp[WB] is detectable-but unchanged itao Adam17 [RNAi]
    *** cells: MDAMB468 in BMS
    *** source: 19595713-Fig-5a

  *** TgfbR1[biotin]IP surface-exp[biotin-labeling] is increased itao Adam17 [RNAi]
    *** cells: HELA in BMS
    *** source: 19595713-Fig-5a
  *** TgfbR1[Ab] prot-exp[WB] is detectable-but unchanged itao Adam17 [RNAi]
    *** cells: HELA in BMS
    *** source: 19595713-Fig-5a

  *** TgfbR1[biotin]IP surface-exp[biotin-labeling] is increased itao Adam17 [RNAi]
    *** cells: A549 in BMS
    *** source: 19595713-Fig-5a
  *** TgfbR1[Ab] prot-exp[WB] is detectable-but unchanged itao Adam17 [RNAi]
    *** cells: A549 in BMS
    *** source: 19595713-Fig-5a

  *** TgfbR1[biotin]IP surface-exp[biotin-labeling] is increased itao Adam17 [RNAi]
    *** cells: HACAT in BMS
    *** source: 19595713-Fig-5b
  *** TgfbR1[Ab] prot-exp[WB] is detectable-but unchanged itao Adam17 [RNAi]
    *** cells: HACAT in BMS
    *** source: 19595713-Fig-5b
