==================================
Direct phosphorylation by Erk1-act
==================================

phos(S383)

  *** rElk1[phosAb] phos(S383)[phosAb] is increased by rErk1{act}
    *** cells: none
    *** source: 11896587-Fig-4b
  *** rElk1[phosAb] phos(S383)[phosAb] is increased by rErk2{act}
    *** cells: none
    *** unaffected by: rElk1(310-428) [substitution]
    *** inhibited by: rElk1((310-428)/S383A/S389A) [substitution]
    *** source: 12514134-Fig-3a

Total

  *** rElk1(307-428) phos[32P-ATP] is increased by rErk1{act}
    *** cells: none
    *** source: 9155018-Fig-8a

==================================
Direct phosphorylation by Erk2-act
==================================

S383

  *** rElk1[phosAb] phos(S383)[phosAb] is increased by rErk2{act}
    *** cells: none
    *** source: 11896587-Fig-4b

Total

  *** rElk1(307-428)[GST] phos[32P-ATP] is increased by rErk2{act}
    *** cells: none
    *** comment: rErk2 is activated with Mek1
    *** source: 16156666-Fig-3
  *** rElk1(205-428)[32P] phos[32P-ATP] is increased by rErk2{act}
    *** cells: none
    *** source: 16713578-Fig-3d
  *** rElk1(205-428)[32P] phos[32P-ATP] is increased by rErk2{act}
    *** cells: none
    *** inhibited by: rElk1(205-428/R314A/K316A)"M1" [substitution]
    *** inhibited by: rElk1(205-428/R317A/K319A)"M2" [substitution]
    *** unaffected by: rElk1(205-428/L323A/S324A)"M3" [substitution]
    *** unaffected by: rElk1(205-428/L327A/L328A)"M4" [substitution]
    *** inhibited by: rElk1(205-428/L319A/L321A)"M5" [substitution]
    *** source: 9501095-Fig-3b
  *** rElk1(205-428)[32P] phos[32P-ATP] is increased by rErk2{act}
    *** cells: none
    *** source: 9501095-Fig-1b
  *** rElk1[32P] phos[32P-ATP] is increased by rErk2{act}
    *** cells: none
    *** inhibited by: rElk1(del(310-334)) [substitution]
    *** source: 9501095-Fig-2b

====================================
Semi-Direct phosphorylation by Erks
====================================

  *** rElk1(307-428)[32P] phos[32P-ATP] is increased by xErks{act}[Ab]IP
    *** cells: none
    *** IPfrom: NIH3T3 in BMS "treated with serum for 10 min"
    *** unaffected by: rPea15 [addition]
    *** source: 11702783-Fig-1d
  *** rElk1(307-428)[32P] phos[32P-ATP] is increased by xErks{act}[Ab]IP
    *** cells: none
    *** IPfrom: NIH3T3 in BMS "treated with serum for 10 min"
    *** source: 11702783-Fig-6c


=======================================
Activation itpo over-expressed Erks
=======================================

Erk1--

  *** xElk1[Gal4-DBD] Gal4-reporter[Luc] is increased itpo xErk1
    *** cells: COS in BMLS
    *** enhanced by: xMek1(S218D/S222D) [addition]
    *** source: 9733512-Fig-5

Erk2--

  *** xElk1(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased itpo xErk2
    *** cells: HELA in BMLS
    *** partially inhibited by: xErk2(L198A) [substitution]
    *** partially inhibited by: xErk2(L232A) [substitution]
    *** inhibited by: xErk2(Y261A) [substitution]
    *** enhanced by: xErk2(D319N) [substitution]
    *** source: 16051177-Fig-3b



