=================
Required Proteins
=================

Erc1--

  *** Ikk1[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** reqs: Erc1 [RNAi]
    *** source: 16497931-Fig-5d

Nemo--  

  *** Nemo[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** reqs: Nemo [RNAi]
    *** source: 20932476-Fig-2f

  sites K277 K309 F312 Y308 L329

  *** xNemo[tAb]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (1 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(K277A/K309A) [substitution]
    *** source: 14651848-Fig-2c
  *** Nemo[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(F312A) [substitution]
    *** inhibited by: xNemo(Y308S) [substitution]
    *** bkg inhibited by: xNemo(L329P) [substitution]
    *** source: 20932476-Fig-5h
  *** Ikk1[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(S85A) [substitution]
    *** source: 16497931-Fig-1d

  phos site S68 or ubiquitination

  *** Ikk1[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** unaffected by: xNemo(ubiq/S85A) [substitution]
    *** source: 16497931-Fig-3c
  *** Atm[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(S85A) [substitution]
    *** source: 16497931-Fig-4f

Tab2-- and/or Tab3--

  *** Nemo[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** reqs: Tab2 and/or Tab3 [RNAi]
    *** source: 20932476-Fig-S1b

Tak1--

  *** Nemo[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: HEK293 in BMS
    *** partially reqs: Tak1 [RNAi]
    *** source: 20932476-Fig-S1b

no extras

  *** Nemo[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (times)
    *** cells: HEK293 in BMS
    *** times: 0+ 30+ 60++ 90++ 120++ min
    *** source: 20932476-Fig-1b
  *** Ikk1[Ab]IP IVKA(Ikba)[32P-ATP] is increased irt Etoposide (2 hr)
    *** cells: 70Z3 in BMS
    *** source: 12138192-Fig-1b

========
Location
========

must take place in cyto because Ikk1 is not in nucleus

  *** Ikk1[tAb] infraction(nuclear)[WB] is unchanged irt Etoposide (times)
    *** cells: 70Z3<Nemo~null><xNemo> in BMS
    *** times: 0+ 60++ 90++ 120++ min
    *** source: 14651848-Fig-3c

