======================
Direct phosphorylation
======================

  *** rIrf3(382-414)[32P] phos[32P-ATP] is increased by rTbk1
    *** cells: none
    *** inhibited by: rIrf3((382-414)/S402A/T404A/S405A) [substitution]
    *** source: 15367631-Fig-8a
  *** rIrf3(380-427)[32P] phos[32P-ATP] is increased by rTbk1
    *** cells: none
    *** unaffected by: rIrf3(S385A/S386A) [substitution]
    *** partially inhibited by: rIrf3(S396A/S398A/S402A/T404A/S405A) [substitution]
    *** inhibited by: rIrf3(S385A/S386A/S396A/S398A/S402A/T404A/S405A) [substitution]
    *** source: 14679297-Fig-1a

===================
Phosphorylation itpo
===================

  *** Irf3[phosAb] phos(S386)[phosAb] is increased itpo xTbk1
    *** cells: HEK293 in BMS
    *** comment: phos(S386) is seen only in the Irf3 dimer caused by xTbk1
    *** inhibited by: xTnfaip3 [addition]
    *** unaffected by: xTnfaip3(1-378)"Nterm" [addition]
    *** inhibited by: xTnfaip3(378-790)"Cterm" [addition]
    *** source: 15661910-Fig-3g

============
Dimerization
============

  *** Irf3[Ab] oligomerization[NativeWB] is increased itpo xTbk1
    *** cells: HEK293 in BMS
    *** comment: unaffected by expression of HCV NS3/4A protease
    *** source: 16301520-Fig-1d
  *** Irf3[Ab] oligomerization[NativeWB] is increased itpo xTbk1
    *** cells: HEK293 in BMS
    *** inhibited by: xTnfaip3 [addition]
    *** unaffected by: xTnfaip3(1-378)"Nterm" [addition]
    *** inhibited by: xTnfaip3(378-790)"Cterm" [addition]
    *** source: 15661910-Fig-3g


=============
Gal4-Reporter
=============

  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased itpo xTbk1
    *** cells: HEK293T in BMS
    *** source: 12692549-Fig-2a
  *** xIrf3[tAb] oligomerization[NativeWB] is increased itpo xTbk1
    *** cells: HEK293T in BMS
    *** source: 14703513-Fig-3a
  *** xIrf3[phosAb] phos(S386)[phosAb] is increased itpo xTbk1
    *** cells: HEK293T in BMS
    *** source: 14703513-Fig-3a
  *** xIrf3[phosAb] phos(S385/S386)[phosAb] is increased itpo xTbk1
    *** cells: HEK293T in BMS
    *** source: 14703513-Fig-4
  *** xIrf3(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased itpo xTbk1
    *** cells: HEK293 in BMS
    *** comment: unaffected by expression of HCV NS3/4A protease
    *** source: 16301520-Fig-1c

