=====================================================
Recruitment to the Pxn Complex requires Pxn phos(S83)
=====================================================

  *** Fak1[Ab] copptby[WB] xPxn[tAb] is increased irt Hgf (10 min)
    *** cells: MIMCD3<xPxn> in BMLS
    *** inhibited by: xPxn(S83A) [substitution]
    *** inhibited by: xPxn(Y118A/F120V/P121A) [substitution]
    *** source: 15494312-Fig-3e

=================================================================
Recruitment to the Pxn Complex requires Erk activity (drugs only)
=================================================================

  *** Fak1[Ab] copptby[WB] Pxn[Ab] is increased irt Hgf (10 min)
    *** cells: MIMCD3 in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 11784715-Fig-4a
  *** Fak1[Ab] copptby[WB] Pxn[Ab] is increased irt Hgf (10 min)
    *** cells: MIMCD3 in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 15494312-Fig-3c
  *** Pxn[Ab] copptby[WB] Fak1[Ab] is increased irt Hgf (10 min)
    *** cells: MIMCD3 in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 11784715-Fig-4b

===========================
Phosphorylation on Tyrosine
===========================

Effect of Src--

  *** Fak1[Ab]IP Yphos[pYAb] is increased irt Hgf (15 min)
    *** cells: HEK293 in BMLS
    *** enhanced by: xSrc [addition]
    *** source: 9748249-Fig-3a
  *** Fak1[Ab]IP Yphos[pYAb] is increased irt Hgf (15 min)
    *** cells: HEK293 in BMLS
    *** inhibited by: xSrc(mnr)"KD" [addition] no-bkg-control
    *** source: 9748249-Fig-3b

Fak1 features

  *** xFak1[tAb]IP Yphos[pYAb] is increased irt Hgf (15 min)
    *** cells: HEK293<xFak1> in BMLS
    *** bkg inhibited by: xFak1(mnr)"KD" [substitution]
    *** bkg inhibited by: xFak1(Y397F) [substitution]
    *** bkg inhibited by: xFak1(Y925F) [substitution]
    *** source: 9748249-Fig-4a

No extras

  *** Fak1[Ab]IP Yphos[pYAb] is detectable-but unchanged irt Hgf (10 min)
    *** cells: MIMCD3 in BMLS
    *** source: 11784715-Fig-1a
  *** Fak1[Ab]IP Yphos[pYAb] is increased irt Hgf (15 min)
    *** cells: HEK293 in BMLS
    *** source: 9748249-Fig-1a
  *** Fak1[Ab]IP Yphos[pYAb] is increased irt Hgf (15 min)
    *** cells: HEK293 in BMLS
    *** source: 9748249-Fig-1c
  *** Fak1[Ab]IP Yphos[pYAb] is increased irt Hgf (times)
    *** cells: HEK293 in BMLS
    *** times: 0 1 3+ 10++ 30++ 60++ 120+ 180+ min
    *** source: 9748249-Fig-1b

======================
Other Coprecipitations
======================

  *** Fak1[Ab] copptby[WB] Grb2[Ab] is increased irt Hgf (15 min)
    *** cells: HEK293 in BMLS
    *** source: 9748249-Fig-5b
