===============================
Ripk1 coppt with TnfR1 irt Tnf
===============================

not Ciap1-- or Ciap2--

  *** Ripk1[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 30+ min
    *** does not req: Ciap1 [KO]
    *** comment: coppt Ripk1 is ubiquitinated (UbAb on Ripk1[Ab]IP after dissociation from Tnf)
    *** source: 18621737-Fig-2b
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** does not req: Ciap1 [RNAi]
    *** does not req: Ciap2 [RNAi]
    *** does not req: Ciap1 and/or Ciap2 [RNAi]
    *** comment: slight changes in ubiq pattern was obsevered
    *** source: 18697935-Fig-4a
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mSkMFibros in BMS
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** does not req: Ciap1 [RNAi]
    *** does not req: Ciap2 [RNAi]
    *** source: 18697935-Fig-4b

not Fadd--

  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** does not req: Fadd [KO]
    *** source: 12887920(D)

not Traf2--

  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs in BMS
    *** does not req: Traf2 [KO]
    *** source: 10795740-Fig-3a

repressed by Tradd--

  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (10 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** repressed by: Tradd [RNAi]
    *** source: 16611992-Fig-5a
  *** Ripk1[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: H460 in BMS
    *** times: 0 1 5+ min
    *** repressed by: Tradd [RNAi]
    *** source: 16940186-Fig-1d
  *** Ripk1[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 1 5+ min
    *** repressed by: Tradd [RNAi]
    *** source: 16940186-Fig-1c

not Nemo--

  *** Ripk1[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+ 5+ min
    *** does not req: Nemo [KO]
    *** source: 16603398-Fig-5c
  *** Ripk1[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><xNemo> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is Ubiq [UbAb]
    *** unaffected by: xNemo(Y308S)"Ubiq-binding-mut" [substitution]
    *** source: 16603398-Fig-7g
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: mEFs<Nemo~null> in BMS
    *** unaffected by: xNemo [addition]
    *** unaffected by: xNemo(L320P) [addition]
    *** source: 16547522-Fig-5b

===========================================================
Ripk1 coppt with other components of TnfR1 complex irt Tnf
===========================================================

Itch--

  *** Ripk1[Ab] copptby[WB] Itch[Ab] is increased irt Tnf (30 min)
    *** cells: THP1 in BMS
    *** reqs: Rnf11 [RNAi]
    *** source: 19131965-Fig-5b

Nemo--

  *** Ripk1[Ab] copptby[WB] Nemo[Ab] is increased irt Tnf (times)
    *** cells: HELAS3 in BMS
    *** times: 0 1+ 5+++ 15++ 30+ min
    *** comment: coppt Ripk is ubiq [WBMS]
    *** source: 16547522-Fig-4d

Traf2--

  *** Ripk1[Ab] copptby[WB] Traf2[Ab] is increased irt Tnf (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0 15+ 30+ 60 120 min
    *** comment: decrease after 30 min reqs xTax1bp1 [omission]
    *** comment: decrease after 30 min inhibited by xTax1bp1(S593A/S666A) [substitution]
    *** source: 21765415-Fig-4a

Rnf11--

  *** Ripk1[Ab] copptby[WB] Rnf11[Ab] is increased irt Tnf (times)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** times: 0 15+ 60+ 120+ min
    *** reqs: xTax1bp1 [omission]
    *** inhibited by: xTax1bp1(S593A/S666A) [substitution]
    *** inhibited by: xTax1bp1(S593A) [substitution]
    *** inhibited by: xTax1bp1(S666A) [substitution]
    *** source: 21765415-Fig-5c
  *** Ripk1[Ab] copptby[WB] Rnf11[Ab] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** reqs: Itch [KO]
    *** source: 19131965-Fig-5c
  *** Ripk1[Ab] copptby[WB] Rnf11[Ab] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** reqs: Tnfaip3 [KO]
    *** source: 19131965-Fig-5c
  *** Ripk1[Ab] copptby[WB] Rnf11[Ab] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** source: 19131965-Fig-1b
  *** Ripk1[Ab] copptby[WB] Rnf11[Ab] is increased irt Tnf (30 min)
    *** cells: THP1 in BMS
    *** source: 19131965-Fig-6c
  *** Ripk1[Ab] copptby[WB] Rnf11[Ab] is increased irt Tnf (30 min)
    *** cells: THP1<Rnf11~null><xRnf11> in BMS
    *** inhibited by: xRnf11(C99A) [substitution]
    *** inhibited by: xRnf11(Y40A) [substitution]
    *** source: 19131965-Fig-6c
  *** Ripk1[Ab] copptby[WB] Rnf11[Ab] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 30+ 60+ min
    *** source: 19131965-Fig-1c
  *** Ripk1[Ab] copptby[WB] Rnf11[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30+ 60+ 120+ min
    *** source: 19131965-Fig-1d

=====================================
Ripk1 coppt by TnfR1 is ubiquitinated
=====================================

  *** Ripk1[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 30+ 60 min
    *** comment: coppt Ripk1 is Ubiq unless Tradd is KO
    *** source: 18641654-Fig-1d
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10+ 25+ min
    *** comment: coppt Ripk1 is Ubiq [WBMS]
    *** comment: KO of Tnfaip3 changes Ubiq pattern of Ripk1
    *** source: 15258597-Fig-4d
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: mEFs<Tnfaip3~null><xTnfaip3> in BMS
    *** times: 0 2++ 15++ 20+ 25+ min
    *** comment: coppt Ripk1 is Ubiq [WBMS]
    *** source: 15258597-Fig-4e
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ min
    *** comment: coppt Ripk1 is ubiq [WBMS]
    *** source: 15175328-Fig-5,6a
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** comment: coppt Ripk1 is ubiq [WBMS]
    *** source: 11864612-Fig-6c
  *** Ripk1[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 30+ 60 min
    *** comment: coppt Ripk1 is ubiq [WBMS]
    *** source: 18641654-Fig-1d
  *** Ripk1[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 2+++ 5++ 10+ min
    *** comment: coppt Ripk1 is ubiq [UbAb]
    *** source: 16603398-Fig-1a
  *** xRipk1[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null><Ripk1~null> in BMS
    *** times: 0 5+ 10+ min
    *** comment: coppt Ripk1 is ubiq [WBMS]
    *** unaffected by: xRipk1(K305R/K306R) [substitution]
    *** inhibited by: xRipk1(K377R)"Ubiq-deficient-mut" [substitution]
    *** unaffected by: xRipk1(K396R) [substitution]
    *** unaffected by: xRipk1(K565R) [substitution]
    *** source: 16603398-Fig-1a
  *** Ripk1[Ab] copptby[WB] Tnf[GST] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 5+ 10++ min
    *** reqs: Ube2ds [RNAi]
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 19854138-Fig-S4b
  *** Ripk1[Ab] copptby[WB] Tnf[biotin] is increased irt Tnf (times)
    *** cells: NotReported in BMS
    *** times: 0 2+ 5+ 20+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** source: 18178551-Fig-6b

=========
chemicals
=========

  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** inhibited by: Geldanamycin [addition]
    *** source: 11864612-Fig-6c
  *** Ripk1[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: HT1080 in BMS
    *** times: 0 5+ 30+ min
    *** comment: coppt Ripk1 is ubiquitinated [WBMS]
    *** unaffected by: BV6 [addition]
    *** comment: coppt Ripk1 in BV6 treated cells is not ubiquitinated [WBMS]
    *** source: 18621737-Fig-2a

=====
????
=====

  *** Ripk1[Ab] copptby[WB] Tnf[biotin] is increased itpo xCezanne
    *** cells: NotReported in BMS
    *** unaffected by: xCezanne(C209S) [substitution]
    *** comment: coppt Ripk1 is ubiquitinated [WBMS] after 2 min Tnf
    *** source: 18178551-Fig-6b

=========
no extras
=========

  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2++ 5++ 10+ 20 min
    *** source: 10356400-Fig-8
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: U937 in BMS
    *** times: 0 15+ 30+ min
    *** source: 8612133-Fig-7
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (10 min)
    *** cells: HEK293 in BMS
    *** source: 16115877-Fig-7a
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: HELAS3 in BMS
    *** times: 0 2+++ 5+++ 10+++ 15++ 30+ min
    *** source: 10755617(D)
  *** Ripk1[Ab] copptby[WB] rTnf[tAb] is increased irt Tnf (times)
    *** cells: HT1080 in BMS
    *** times: 0 5++ 20+ min
    *** source: 18439848-Fig-S3
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (5 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** source: 10795740-Fig-3c
  *** Ripk1[Ab] copptby[WB] TnfR1[Ab] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 5+ 10+ min
    *** source: 10795740-Fig-6b

