=======================
Phosphorylation on S403
=======================

Atm--

  *** Mdm4[Ab]IP phos(S403)[phosAb] is unchanged irt NCS (15 min)
    *** cells: AT59<Atm~fmut> in BMS
    *** source: 15788536-Fig-2b
  *** xMdm4[Ab]IP phos(S403)[phosAb] is unchanged irt NCS (1 hr)
    *** cells: AT2RO<Atm~fmut><xMdm4> in BMS
    *** source: 15788536-Fig-3b
  *** Mdm4[Ab]IP phos(S403)[phosAb] is increased irt NCS (15 min)
    *** cells: L3AT<Atm~fmut> in BMS
    *** comment: bkg and increase is less than seen in C3ABR
    *** source: 15788536-Fig-2b

chemicals--

  *** xMdm4[phosAb] phos(S403)[phosAb] is increased irt NCS (15 min)
    *** cells: U2OS<xMdm4> in BMS
    *** inhibited by: Wortmannin [pretreatment]
    *** inhibited by: KU55933 [pretreatment]
    *** source: 15788536-Fig-9

no extras

  *** xMdm4[phosAb] phos(S403)[phosAb] is increased irt NCS (1 hr)
    *** cells: U2OS<xMdm4> in BMS
    *** source: 15788536-Fig-2b
  *** xMdm4[Ab]IP phos(S403)[phosAb] is increased irt NCS (1 hr)
    *** cells: VH25<xMdm4> in BMS
    *** source: 15788536-Fig-3b
  *** Mdm4[Ab]IP phos(S403)[phosAb] is increased irt NCS (15 min)
    *** cells: C3ABR in BMS
    *** source: 15788536-Fig-2b

=====================
Total Phosphorylation
=====================

  *** xMdm4[Ab] phos[WBMS] is increased irt NCS (1 hr)
    *** cells: U2OS<xMdm4> in BMS
    *** inhibited by: xMdm4(S403A) [substitution]
    *** source: 15788536-Fig-2a
  *** Mdm4[Ab] phos[WBMS] is increased irt NCS (5 hr)
    *** cells: U2OS in BMS "pretreated with MG132"
    *** source: 15788536-Fig-6b

