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Smad3 Smad4 coppt requires Smad3 nucleoporin binding-sites
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  *** xSmad4[tAb] copptby[WB] xSmad3[tAb] is increased itpo xTgfbR1(T402D)"CA"
    *** cells: R1BL17 in BMS
    *** inhibited by: xSmad3(V356R)"nucleoporin-BS" [substitution]
    *** inhibited by: xSmad3(W406A)"nucleoporin-BS" [substitution]
    *** source: 12917407-Fig-7c

  *** Smad4[Ab] copptby[WB] Smad3[Ab] is increased itpo xTgfbR1
    *** cells: HACAT in BMS
    *** inhibited by: xPpm1a [addition]
    *** unaffected by: xPpm1a(D239M)"CIA" [addition]
    *** source: 16751101-Fig-4f

  *** xSmad4[35S] copptby[WB] xSmad3[35S] is increased irt Tgfb1 (tnr)
    *** cells: COS<xTgfbR1><xTgfbR2> in BMS
    *** source: 9311995-Fig-6c
  *** xSmad4[tAb] copptby[WB] xSmad3[tAb] is increased irt Tgfb1 (tnr)
    *** cells: COS<xTgfbR1><xTgfbR2> in BMS
    *** reqs: xTgfbR1 and/or xTgfbR2 [omission]
    *** source: 9311995-Fig-5a
  *** xSmad3[tAb] copptby[WB] xSmad4[tAb] is increased irt Tgfb1 (1 hr)
    *** cells: C2C12 in BMS
    *** source: 11265759-Fig-5c

  *** Smad4[Ab] copptby[WB] Smad23s[Ab] is increased irt Tgfb1 (40 min)
    *** cells: RGM1 in BMLS
    *** source: 15326485-Fig-5a
  *** Smad4[Ab] copptby[WB] Smad3{phos(S208/S213)}[phosAb] is increased irt Tgfb1 (40 min)
    *** cells: RGM1 in BMLS
    *** source: 15326485-Fig-5a
  *** Smad4[Ab] copptby[WB] Smad23s[Ab] is increased irt Tgfb1 (40 min)
    *** cells: RGM1 in BMLS "treated with SP600125"
    *** source: 15326485-Fig-5b
  *** Smad4[Ab] copptby[WB] Smad3{phos(S208/S213)}[phosAb] is increased irt Tgfb1 (40 min)
    *** cells: RGM1 in BMLS "treated with SP600125"
    *** source: 15326485-Fig-5b
  *** Smad4[Ab] copptby[WB] Smad3{phos(S423/S425)}[phosAb] is increased irt Tgfb1 (40 min)
    *** cells: RGM1 in BMLS
    *** source: 15326485-Fig-5a
  *** Smad4[Ab] copptby[WB] Smad3{phos(S423/S425)}[phosAb] is increased irt Tgfb1 (40 min)
    *** cells: RGM1 in BMLS "treated with SP600125"
    *** source: 15326485-Fig-5b

why would this happen?

  *** Smad4[Ab] copptby[WB] Smad3[Ab] is increased irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
  *** Smad3[Ab] copptby[WB] Smad4[Ab] is unchanged irt Tgfb1 (1 hr)
    *** cells: HEPG2 in BMS
    *** source: 12543979-Fig-2
