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Phosphorylation on S133
=======================

Msk1-- and/or Msk2--

  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (times)
    *** cells: mEFs in BMLS
    *** times: 0 15+ 30+ min
    *** partially reqs: Msk1 [KO]
    *** partially reqs: Msk2 [KO]
    *** partially reqs: Msk1 or Msk2 [DKO]
    *** source: 11909979-Fig-7b
  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (times)
    *** cells: mESCs in BMLS
    *** times: 0 5+ 10 20 min
    *** partially reqs: Msk1 [KO]
    *** source: 11018520-Fig-5c

not P38s

  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (5 min)
    *** cells: mEFs in BMLS
    *** partially inhibited by: PD184352 [addition] no-bkg-control
    *** unaffected by: SB203580 [addition] no-bkg-control
    *** inhibited by: PD184352 + SB203580 [addition] no-bkg-control
    *** source: 11909979-Fig-5d

Chemicals

  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (10 min)
    *** cells: RAT2 in BMS
    *** inhibited by: H89 [addition]
    *** source: 11297520-Fig-7a
  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (10 min)
    *** cells: RAT2 in BMS
    *** unaffected by: Rapamycin [addition]
    *** unaffected by: Wortmannin [addition]
    *** inhibited by: Ro318220 [addition]
    *** source: 11297520-Fig-6b
  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (15 min)
    *** cells: HEK293 in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** unaffected by: SB203580 [pretreatment]
    *** source: 9687510-Fig-10e
  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (15 min)
    *** cells: HEK293 in BMLS
    *** inhibited by: Ro318220 [pretreatment]
    *** source: 9687510-Fig-10b
  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (tnr)
    *** cells: mESCs in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 11018520-Fig-5a
  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (10 min)
    *** cells: RAT2 in BMS
    *** inhibited by: PD98059 [addition]
    *** inhibited by: PD184352 [addition]
    *** inhibited by: U0126 [addition]
    *** source: 11297520-Fig-6b
  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (5 min)
    *** cells: mEFs in BMLS
    *** partially inhibited by: PD184352 [addition] no-bkg-control
    *** inhibited by: PD184352 + SB203580 [addition] no-bkg-control
    *** source: 11909979-Fig-5d

no extras

  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (times)
    *** cells: MDAMB361 in BMLS
    *** times: 0 5++ 10++ 20++ 30++ 45++ 60+ min
    *** source: 11297548(D)
  *** Creb1[phosAb] phos(S133)[phosAb] is increased irt Egf (25 min)
    *** cells: COS7 in BMLS
    *** source: 10856237-Fig-12b


=========================================
Cells containing the Braf(V600E) mutation
=========================================

  *** Creb1[phosAb] phos(S133)[phosAb] is detectable-but unchanged irt Egf (4 hr)
    *** cells: A375 in BMLS "containing low-glucose"
    *** source: 19274086-Fig-3d
  *** Creb1[phosAb] phos(S133)[phosAb] is detectable-but unchanged irt Egf (4 hr)
    *** cells: SKMEL28 in BMLS "containing low-glucose"
    *** source: 19274086-Fig-3d
  *** Creb1[phosAb] phos(S133)[phosAb] is detectable-but unchanged irt Egf (4 hr)
    *** cells: UACC903 in BMLS "containing low-glucose"
    *** source: 19274086-Fig-3d

  *** Creb1[phosAb] phos(S133)[phosAb] is decreased irt Egf (4 hr)
    *** cells: UACC903 in BMLS "containing low-glucose"
    *** source: 19274086-Fig-3e
  *** Creb1[phosAb] phos(S133)[phosAb] is detectable-but unchanged irt Egf (4 hr)
    *** cells: A375 in BMLS "containing low-glucose"
    *** source: 19274086-Fig-3e
  *** Creb1[phosAb] phos(S133)[phosAb] is detectable-but unchanged irt Egf (4 hr)
    *** cells: SKMEL28 in BMLS "containing low-glucose"
    *** source: 19274086-Fig-3e
