===============
Phosphorylation
===============

Hras--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb2 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-2b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb2 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb2 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-5a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb2 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: Hras(S17N)"DN" [addition]
    *** source: 17440079-Fig-5b

Pak2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb2 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: Pak2(K278R)"DN" [addition]
    *** source: 17440079-Fig-5b


chemicals

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (9 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: AG1295 [cotreatment]
    *** source: 23913859-Fig-S2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (9 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: Imatinib [cotreatment]
    *** source: 23913859-Fig-S2b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (9 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: U0126 [cotreatment]
    *** source: 23913859-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb2 (2 hr)
    *** cells: AKR2B in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 17440079-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb2 (45 min)
    *** cells: AKR2B in BMLS
    *** inhibited by: LY294002 [cotreatment]
    *** source: 17440079-Fig-5b

no extras

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb2 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 20 40+ 60+ 120+ min
    *** source: 17440079-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: FAO in BMS
    *** times: 0 1 4 8+ 12++ 16++ 20++ 24++ hr
    *** source: 15069087-Fig-7a


  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (1 hr)
    *** cells: NIH3T3 in BMS
    *** unaffected by: xPpm1a [addition]
    *** source: 16751101-Fig-S8b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (24 hr)
    *** cells: FAO in BMS
    *** enhanced by: xMlk3 [addition]
    *** partially inhibited by: xMlk3(mnr)"DN" [addition]
    *** source: 15069087-Fig-7b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: RGM1 in BMLS
    *** times: 0 5+++ 15++ 30+ 60 120 min
    *** source: 15326485-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 1++ 2++ 5++ 10++++ 20+++ 30+++ min
    *** source: 17673906-Fig-7c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (times)
    *** cells: SWISS3T3 in BMS
    *** times: 0+ 5+ 10++ min
    *** inhibited by: xShc1(mnr)"CH1/SH2-domains" [substitution]
    *** inhibited by: xShc1(mnr)"PTP/CH1-domains" [substitution]
    *** source: 17673906-Fig-8d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb1 (4 hr)
    *** cells: AKR2B in BMLS
    *** source: 19117990-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt Tgfb2 (times)
    *** cells: ATDC5 in BMLS
    *** times: 0 5+ 15+ 60++ 120+ 240 min
    *** source: 11278290-Fig-3a

=========================================
does not occur in epithelial type cells?  FAO???  RGM1
=========================================

  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tgfb1 (1 hr)
    *** cells: HACAT in BMS
    *** source: 17085434-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tgfb1 (30 min)
    *** cells: CHO in BMLS
    *** source: 19595713-Fig-1a
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tgfb2 (2 hr)
    *** cells: MV1LU in BMLS
    *** unaffected by: PD98059 [pretreatment]
    *** source: 17440079-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt Tgfb2 (times)
    *** cells: MV1LU in BMLS
    *** times: 0 20 40+ 60+ 120+ min
    *** source: 17440079-Fig-1b


====================
Kinase Activation???
====================

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0 5 10 15 30+ 60 120 240 360 480 720 960 1440 min
    *** source: 10601313-Fig-1a
  *** Erks[Ab]IP IVKA(Smad3)[32P-ATP] is unchanged irt Tgfb1 (tnr)
    *** cells: MV1LU in BMLS
    *** source: 10601313-Fig-4a
  *** Erk1[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Tgfb1 (10 min)
    *** cells: IEC18C41 in BMS
    *** partially inhibited by: xHras(S17N) [addition]
    *** source: 8798398-Fig-4b
  *** Erk2[Ab]IP IVKA(MBP)[32P-ATP] is increased irt Tgfb1 (10 min)
    *** cells: IEC18C41 in BMLS
    *** source: 7706248-Fig-2b
  *** Erks[Ab]IP IVKA(Elk1)(sitenr)[phosAb] is increased irt Tgfb2 (15 min)
    *** cells: ATDC5 in BMLS
    *** source: 11278290-Fig-3a

