======================
Direct Phosphorylation
======================

phos(S536)

  *** rRela[phosAb] phos(S536)[phosAb] is increased by rIkk2
    *** cells: none
    *** source: 16135789-Fig-4c
  *** rRela(354-551)[phosAb] phos(S536)[phosAb] is increased by rIkk2
    *** cells: none
    *** source: 12842894-Fig-7a
  *** rRela(354-551)[phosAb] phos(S536)[phosAb] is increased by rIkk2
    *** cells: none
    *** inhibited by: rRela(S536A) [substitution]
    *** source: 10521409-Fig-4d
  *** rRela(354-551)[phosAb] phos(S536)[phosAb] is increased by rIkk2
    *** cells: none
    *** unaffected by: rRela((354-551)/T464A) [substitution]
    *** unaffected by: rRela((354-551)/S468A) [substitution]
    *** unaffected by: rRela((354-551)/T472A) [substitution]
    *** source: 16046471-Fig-2c
  *** rRela(354-551)[phosAb] phos(S536)[phosAb] is increased by rIkk2
    *** cells: none
    *** source: 16046471-Fig-2d

phos(S468)

  *** rRela((354-551)/S536A)[32P] phos[32P-ATP] is increased by rIkk2
    *** cells: none
    *** unaffected by: rRela((354-551)/S536A/S437A) [substitution]
    *** unaffected by: rRela((354-551)/S536A/S457A) [substitution]
    *** unaffected by: rRela((354-551)/S536A/S457A) [substitution]
    *** partially inhibited by: rRela((354-551)/S536A/S468A) [substitution]
    *** unaffected by: rRela((354-551)/S536A/S472A) [substitution]
    *** source: 16046471-Fig-2a
  *** rRela(354-520)[32P] phos[32P-ATP] is increased by rIkk2
    *** cells: none
    *** unaffected by: rRela((354-520)/S437A) [substitution]
    *** unaffected by: rRela((354-520)/S457A) [substitution]
    *** partially inhibited by: rRela((354-520)/S468A) [substitution]
    *** unaffected by: rRela((354-520)/S472A) [substitution]
    *** source: 16046471-Fig-2b
  *** rRela(354-551)[32P] phos[32P-ATP] is increased by rIkk2
    *** cells: none
    *** partially inhibited by: rRela((354-551)/S536A) [substitution]
    *** partially inhibited by: rRela(354-520) [substitution]
    *** inhibited by: rRela(354-430) [substitution]
    *** inhibited by: rRela(354-360) [substitution]
    *** source: 16046471-Fig-1b
  *** rRela(354-551)[phosAb] phos(S468)[phosAb] is increased by rIkk2
    *** cells: none
    *** unaffected by: rRela((354-551)/T464A) [substitution]
    *** inhibited by: rRela((354-551)/S468A) [substitution]
    *** unaffected by: rRela((354-551)/T472A) [substitution]
    *** source: 16046471-Fig-2c
  *** rRela(354-551)[phosAb] phos(S468)[phosAb] is increased by rIkk2
    *** cells: none
    *** source: 16046471-Fig-2d
  *** rRela(354-551)[phosAb] phos(S468)[phosAb] is unchanged by rIkk2
    *** cells: none
    *** source: 16046471-Fig-2d




==========================================
Phosphorylation Due to Ikk2 overexpression
==========================================


  *** xRela[phosAb] phos(S536)[phosAb] is increased itpo (xIkk1 + xIkk2)
    *** cells: HEK293<xIL1R1> in BMS
    *** unaffected by: xIkk1(mnr)"KD" + xIkk2(mnr)"KD" [substitution]
    *** source: 15489227-Fig-3c
  *** Rela[phosAb] phos(S536)[phosAb] is increased itpo xIkk2
    *** cells: HEK293 in BMS
    *** enhanced by: xIkk1 [addition]
    *** source: 12842894-Fig-7b

