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Phosphorylation on T184/T187/S192
=================================

Ciap1-- or Ciap2--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: KMS28BM in BMS
    *** times: 0 10+ 30+ min
    *** partially reqs: Ciap1 and/or Ciap2 [fmut]
    *** source: 19898473-Fig-S2b
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5+ 10++ 30++ min
    *** partially reqs: Ciap1 and/or Ciap2 [RNAi]
    *** source: 19898473-Fig-S2a

Myd88--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30+ min
    *** reqs: Myd88 [KO]
    *** source: 19898473-Fig-1b

not Trif--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30+ min
    *** unaffected by: Trif [fmut]
    *** source: 19898473-Fig-1b

not Traf3--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5 10+ 30++ min
    *** does not req: Traf3 [RNAi]
    *** source: 19898473-Fig-3a
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** times: 0 5 10+ min
    *** does not req: xTraf3 [omission]
    *** unaffected by: xTraf3(C68A/H70A) [substitution]
    *** source: 19898473-Fig-5b
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** times: 0 10++ 30++ 60+ min
    *** unaffected by: xTraf3(K107R/K156R) [substitution]
    *** source: 19898473-Fig-5e

Traf6--

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5 10+ 30++ min
    *** reqs: Traf6 [RNAi]
    *** source: 19898473-Fig-3a

Tak1 features

  *** xTak1[phosAb] phos(T187/S192)[phosAb] is increased irt Lps (20 min)
    *** cells: RAW2647<xTak1> in BMLS
    *** unaffected by: xTak1(K34R) [substitution]
    *** source: 22069318-Fig-9a

chemicals

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 5 10 30+ 60++ min
    *** inhibited by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-1a
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5+ 10++ 30++ min
    *** inhibited by: MG132 [pretreatment]
    *** source: 19898473-Fig-S2c
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 30+ 60+ min
    *** partially inhibited by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S1
  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647<Traf3~kd> in BMS
    *** times: 0 5+ 10++ 30++ min
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S2d
  *** Tak1[phosAb] phos(T182/T187)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 5 15+ 30+ 60+  min
    *** inhibited by: Lps [preconditioning]
    *** source: 21220427-Fig-5b
  *** Tak1[phosAb] phos(T187/S192)[phosAb] is increased irt Lps (20 min)
    *** cells: RAW2647 in BMLS
    *** inhibited by: Cl-Radicicol-A [pretreatment] no-bkg-control
    *** source: 22069318-Fig-9c

no extras

  *** Tak1[phosAb] phos(T184/T187)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5 10+ min
    *** source: 19898473-Fig-5b
  *** Tak1[phosAb] phos(T187)[phosAb] is detectable-but unchanged irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0+ 5+ 15+ 30+ 45+ 60+ min
    *** source: 22833096-Fig-2g
  *** Tak1[phosAb] phos(T187)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0+ 30++ 60++ min
    *** source: 22833096-Fig-2f


===============
Kinase Activity
===============

  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Lps (15 min)
    *** cells: hPBMonos in BMS
    *** inhibited by: Lps [preconditioning]
    *** source: 21220427-Fig-5c
  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 5+ 15+ 30 min
    *** inhibited by: Lps [preconditioning]
    *** source: 21220427-Fig-5a
  *** Tab1[Ab]IP IVKA(Mkk6,P38a)[32P-ATP] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5 10 15++ 30 min
    *** enhanced by: SB203580 [addition] no-bkg-control
    *** source: 14592977-Fig-8a
  *** Tab1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt Lps (15 min)
    *** cells: RAW2647 in BMS
    *** enhanced by: SB203580 [addition] no-bkg-control
    *** source: 14592977-Fig-8b
  *** Tab2[Ab]IP IVKA(Mkk6/P38a/MBP)[32P-ATP] is increased irt Lps (15 min)
    *** cells: RAW2647 in BMS
    *** enhanced by: SB203580 [addition]
    *** source: 14670075-Fig-4d
  *** Tab3[Ab]IP IVKA(Mkk6/P38a/MBP)[32P-ATP] is increased irt Lps (15 min)
    *** cells: RAW2647 in BMS
    *** enhanced by: SB203580 [addition]
    *** source: 14670075-Fig-4d
