===============
Kinase Activity
===============

  *** Jak3[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (times)
    *** cells: hEBVBCs in BMS
    *** times: 0+ 1+ 5++ 10+ min
    *** source: 10825200-Fig-5b
  *** Jak3[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7973658-Fig-1f
  *** Jak3[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: BAFB03<IL2Rb~null><xIL2Rb> in BMS "Growth-factor-deprived"
    *** source: 7973659-Fig-2a

====================================
Jak3 coppt with IL2R complex irt IL2
====================================

IL2Rb--

  *** Jak3[Ab] copptby[WB] IL2Rb[Ab] is increased irt IL2 (15 min)
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3b
  *** Jak3[Ab] copptby[WB] IL2Rb[Ab] is increased irt IL2 (tnr)
    *** cells: YT in BMS
    *** source: 7973658-Fig-2

IL2Rg--

  *** Jak3[Ab] copptby[WB] IL2Rg[Ab] is increased irt IL2 (15 min)
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3a
  *** Jak3[Ab] copptby[WB] IL2Rg[Ab] is detectable-but unchanged irt IL2 (15 min)
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3c
  *** Jak3[Ab] copptby[WB] IL2Rg[Ab] is increased irt IL2 (tnr)
    *** cells: YT in BMS
    *** source: 7973658-Fig-2

============
Other coppts
============

  *** Jak3[Ab] copptby[WB] Fak2[Ab] is unchanged irt IL2 (60 min)
    *** cells: BAFB03<xIL2Rb> in BMS "IL2-deprived"
    *** source: 9512511-Fig-3d
  *** Jak3[Ab] copptby[WB] Irs1[Ab] is detectable
    *** cells: hPHAblasts in BMLS
    *** comment: Yphos of coppt Jak3 is increased irt IL2 (15 min)
    *** source: 7499365-Fig-2a
  *** Jak3[Ab] copptby[WB] Stam[Ab] is increased irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 9133424-Fig-4
  *** Jak3[Ab] copptby[WB] Stam2[Ab] is unchanged irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 10899310-Fig-2a

=====
Yphos
=====

IL2Rg--

  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: ED40515<xIL2Rg> in BMS
    *** inhibited by: xIL2Rg(1-290)"M1" [substitution]
    *** inhibited by: xIL2Rg(1-321)"M2" [substitution]
    *** source: 10421845-Fig-2a

  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (5 min)
    *** cells: BAFB03 in BMS "IL3-deprived"
    *** unaffected by: xJak3 [addition]
    *** inhibited by: xJak3(mnr)"del-kinase-domain" [addition]
    *** source: 7568005-Fig-2b
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (5 min)
    *** cells: hPBTCs in BMLS
    *** source: 10849428-Fig-1d
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: ILTMAT in BMS
    *** source: 10899310-Fig-2a
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7973658-Fig-1b

=========
Chemicals
=========

CP118556--

  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: YT in BMS
    *** unaffected by: CP118556 [pretreatment]    
    *** source: 10825200-Fig-2b

Staurosporine--

  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: YT in BMS
    *** inhibited by: Staurosporine [pretreatment] no-bkg-control
    *** source: 10825200-Fig-2c

=========
No Extras
=========

  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: BAFB03<xIL2Rb> in BMS "IL2-deprived"
    *** times: 0 10+ 30+ 60+ min
    *** source: 9512511-Fig-1a
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: ED40515<xIL2Rg> in BMS
    *** times: 0 10+ 30+ 60+ min
    *** source: 9512511-Fig-1a
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: hIL2RTCs in BMS "IL2-deprived"
    *** times: 0 10+ 30+ 60+ min
    *** source: 9512511-Fig-1a
  *** xJak3[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: NIH3T3<xIL2Ra><xIL2Rb><xIL2Rg><Jak3~null><Lck~null><xLck(mnr)"CA"> in BMS
    *** times: 0 1+ 5+ 15+ min
    *** source: 10825200-Fig-3b
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: NK33 in BMS
    *** times: 0 1+ 5+ 15+ min
    *** source: 10825200-Fig-3b
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3c
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: KIT225 in BMS
    *** source: 7988557-Fig-1a
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7568001-Fig-1a
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: BAFB03<IL2Rb~null><xIL2Rb(1-379)"H4"> in BMS
    *** source: 7777534-Fig-3c
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** source: 7760829-Fig-4c
  *** Jak3[Ab] Yphos[pYAb-ppt] is increased irt IL2 (10 min)
    *** cells: hPHAblasts in BMS
    *** source: 7528775-Fig-2d
  *** Jak3[Ab] Yphos[pYAb-ppt] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7528775-Fig-3a
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7528775-Fig-2c
  *** Jak3[Ab]IP Yphos[pYAb] is increased irt IL2 (20 min)
    *** cells: hPHAblasts in BMS
    *** source: 9454765-Fig-3


