=================
Required Proteins
=================

not Ciap1-- Ciap2--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: KMS28BM in BMS
    *** does not req: Ciap1 and/or Ciap2 [fmut]
    *** source: 19898473-Fig-S9c
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: RAW2647 in BMS
    *** does not req: Ciap1 and/or Ciap2 [RNAi]
    *** source: 19898473-Fig-S9b

not Hmgb1-- Hmgb2-- Hmgb3--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mEFs in BMS
    *** does not req: Hmgb1 [KO]
    *** source: 19890330-Fig-S2b
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mEFs in BMS
    *** does not req: Hmgb1 and/or Hmgb2 and/or Hmgb3 [KO]
    *** source: 19890330-Fig-1d
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mEFs in BMS
    *** does not req: Hmgb1 and/or Hmgb2 and/or Hmgb3 [RNAi]
    *** source: 19890330-Fig-S2j
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: NIH3T3 in BMS
    *** does not req: Hmgb1 and/or Hmgb2 and/or Hmgb3 [RNAi]
    *** source: 19890330-Fig-S2q
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: RAW2647 in BMS
    *** does not req: Hmgb1 and/or Hmgb2 and/or Hmgb3 [RNAi]
    *** source: 19890330-Fig-S2o
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mEFs in BMS
    *** does not req: Hmgb2 [KO]
    *** source: 19890330-Fig-S2d
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2++ 4+ hr
    *** does not req: Hmgb1 [KO]
    *** source: 19890330-Fig-1a
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2++ 4+ hr
    *** does not req: Hmgb2 [KO]
    *** source: 19890330-Fig-1b

not IfnaR1--

  *** Ifnb1-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1+ 2+ 4 hr
    *** does not req:  IfnaR1 [KO]
    *** source: 12356687-Fig-1

Ikba--  ????

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 1+ 2++ hr
    *** inhibited by: xIkba(mnr)"ER" [addition]
    *** source: 12354379-Fig-4b
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: U373<xCd14> in BMS
    *** unaffected by: xIkba(S32A/S36A)"DN" [addition]
    *** source: 22065573-Fig-1e

not Ikke--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2++ 4+ 8 hr
    *** does not req: Ikke [KO]
    *** source: 15210742-Fig-2a

Irak4--

  *** Ifnb1-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 3+ 8 hr
    *** reqs: Irak4 [KO]
    *** source: 14634120-Fig-1a

Irf1--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1 2+ 4++ 8+++ 16++ hr
    *** partially reqs: Irf1 [KO]
    *** source: 17018642-Fig-3a

Irf3--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMS
    *** enhanced by: xIrf3 [addition]
    *** inhibited by: xIrf3(mnr)"DN" [addition]
    *** source: 12354379-Fig-4d
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 2 4+ 6 12 hr
    *** reqs: Irf3 [KO]
    *** source: 12821121(D)
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMDCs in BMS "primed with Ifnb for 16 hr"
    *** times: 0 2++ 4+++ 6+ 12+ hr
    *** partially reqs: Irf3 [KO]
    *** source: 12821121(D)
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1 2+ 4++ 8+++ 16++ hr
    *** reqs: Irf3 and/or Irf7 [DKO]
    *** source: 17018642-Fig-3a
  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** enhanced by: xIrf3 [addition]
    *** source: 12821121(D)
  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 2+ 6 12 24 hr
    *** reqs: Irf3 [KO]
    *** source: 12821121(D)

Irf7--  ???

  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** enhanced by: xIrf7 [addition]
    *** source: 12821121-Fig-2b
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMMs in BMS "immortalized"
    *** times: 0 2+ 4++ hr
    *** does not req: Irf7 [RNAi]
    *** source: 22065573-Fig-7c

not Mavs--

  *** Ifnb1[Ab] secretion[ELISA] is increased irt Lps (16 hr)
    *** cells: mBMMs in BMS
    *** does not req: Mavs [KO]
    *** source: 16713980-Fig-3c

not Myd88--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** does not req: Myd88 [KO]
    *** source: 19898473-Fig-6b
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: mBMDCs in BMS
    *** does not req: Myd88 [RNAi]
    *** source: 12539043-Fig-S1
  *** Ifnb1-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1+ 2+ 4 hr
    *** partially reqs: Myd88 [KO]
    *** source: 12356687-Fig-1
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1++ 5+ hr
    *** does not req: Myd88 [KO]
    *** source: 11896392-Fig-7b
  -------------------------------------------------------
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: hMDMacs in BMS
    *** inhibited by: xMyd88(del(1-53)/F56N)"DN" [addition]
    *** source: 14630816(D)
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xMyd88(del(1-53)/F56N)"DN" [addition]
    *** source: 14630816(D)
  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (tnr)
    *** cells: HEK293<xTLR4><xCd14><xMd2> in BMS
    *** inhibited by: xMyd88(mnr)"DN" [addition]
    *** source: 12539043-Fig-1b

not Pkr--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mPECs in BMS
    *** does not req: Pkr [KO]
    *** source: 11896392-Fig-8c

Stat1--

  *** Ifnb1-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1+ 2+ 4 hr
    *** partially reqs: Stat1 [KO]
    *** source: 12356687-Fig-1

Tbk1--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 1+ 4 hr
    *** reqs: Tbk1 and/or TnfR1 [DKO]
    *** source: 15210743-Fig-1c
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2++ 4+ 8 hr
    *** reqs: Tbk1 [KO]
    *** source: 15210742-Fig-2a
  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (12 hr)
    *** cells: mEFs in BMS
    *** reqs: Tbk1 [KO]
    *** source: 15210742-Fig-3c
  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (16 hr)
    *** cells: mEFs in BMS
    *** reqs: Tbk1 [KO]
    *** source: 14679297-Fig-2a

Ticam2--

  *** Ifnb1-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1++ 2+ 4++ hr
    *** reqs: Ticam2 [KO]
    *** source: 14556004-Fig-4a
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** partially reqs: Ticam2 [RNAi]
    *** source: 14519765-Fig-6d
  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR4><xMd2><xCd14> in BMS
    *** inhibited by: Ticam2(C117H)"DN" [addition]
    *** source: 14519765-Fig-4e

Tirap--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: RAW2647 in BMS
    *** reqs: Tirap [blocking-peptide]
    *** source: 11896392-Fig-8b
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: hMDMacs in BMS
    *** inhibited by: xTirap(P125H)"DN" [addition]
    *** inhibited by: xTirap(del(1-70)) [addition]
    *** source: 14630816(D)
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xTirap(P125H)"DN" [addition]
    *** inhibited by: xTirap(del(1-70)) [addition]
    *** source: 14630816(D)
  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (5 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xTirap(mnr)"DN" [addition]
    *** source: 11896392-Fig-8a
  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (tnr)
    *** cells: HEK293<xTLR4><xCd14><xMd2> in BMS
    *** inhibited by: xTirap(P125H)"DN" [addition]
    *** source: 12539043-Fig-1b

not TLR3--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: mBMMs in BMS
    *** does not req: TLR3 [KO]
    *** source: 11607032-Fig-3e
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** does not req: TLR3 [RNAi]
    *** source: 14519765(D)

TLR4--

  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (tnr)
    *** cells: HEK293<xTLR4><xCd14><xMd2> in BMS
    *** reqs: xTLR4 and/or xCd14 and/or xMd2 [omission]
    *** source: 12539043-Fig-1b

Traf3--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (90 min)
    *** cells: mBMMs in BMS
    *** reqs: Traf3 [KO]
    *** source: 16306937-Fig-S3e
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: mBMMs in BMS
    *** reqs: Traf3 [KO]
    *** source: 16306936-Fig-1a

not Traf6--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** repressed by: Traf6 [KO]
    *** source: 16306937-Fig-S5c

Trif--

  *** Ifnb1-gene mRNA[Northern] is increased irt Lps (1 hr)
    *** cells: mPECs in BMS
    *** reqs: Trif [KO]
    *** source: 12872135-Fig-2c
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** reqs: Trif [RNAi]
    *** source: 14519765(D)
  *** Ifnb1-gene promo-reporter[Luc] is increased irt Lps (6 hr)
    *** cells: HEK293<xTLR4><xMd2><xCd14> in BMS
    *** inhibited by: Trif(P434H)"DN" [addition]
    *** source: 14519765(D)
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS "immortalized"
    *** reqs: Trif [KO]
    *** source: 22065573-Fig-1a
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** reqs: Trif [fmut]
    *** source: 19898473-Fig-6b

not Yy1--

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS "immortalized"
    *** unaffected by: Yy1 [RNAi]
    *** source: 22065573-Fig-2d

Chemicals

  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: mBMMs in BMS
    *** inhibited by: Dynasore [addition]
    *** source: 18297073-Fig-1d
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS "immortalized"
    *** inhibited by: JSH23 [pretreatment]
    *** unaffected by: CHX [pretreatment]
    *** source: 22065573-Fig-2a
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS "immortalized"
    *** unaffected by: JSH23 [pretreatment]
    *** source: 22065573-Fig-1a
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: THP1 in BMS "differentiated with Csf1"
    *** partially inhibited by: JSH23 [pretreatment]
    *** source: 22065573-Fig-1c
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-6b
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-6a

no extras

  *** Ifnb1-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 3++ 6+ 24 hr
    *** source: 12356687-Fig-2
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mAMCs in BMS
    *** source: 15240691-Fig-5b
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mPECs in BMS
    *** source: 15240691-Fig-5a
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: RAW2647 in BMS
    *** source: 11896392-Fig-5b
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: mPECs in BMS
    *** source: 16709849(D)
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** source: 18297073-Fig-5e
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (24 hr)
    *** cells: mPECs in BMS
    *** source: 16709849(D)
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 1+++ 2+++ 4++ 6+ hr
    *** source: 12354379-Fig-5b
  *** Ifnb1-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1+ 2+ 4 6 hr
    *** source: 11896392-Fig-5a
  *** Ifnb1[Ab] secretion[ELISA] is increased irt Lps (3 hr)
    *** cells: mPECs in BMS
    *** source: 15240691-Fig-5d
  *** Ifnb1[Ab] secretion[ELISA] is unchanged irt Lps (3 hr)
    *** cells: mAMCs in BMS
    *** source: 15240691-Fig-5d

