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Transcription
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Ets1--

  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** reqs: Ets1 [RNAi]
    *** source: 18955504-Fig-4e
  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** reqs: Ets1 [RNAi]
    *** source: 18955504-Fig-4c
  *** Pai1-gene promo-reporter[Luc] is unchanged itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T in BMS
    *** enhanced by: xEts1 [addition]
    *** source: 18955504-Fig-4f
  *** Smad23s[Ab] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** reqs: Ets1 [RNAi]
    *** source: 18955504-Fig-4d

not Fak1--

  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (10 min)
    *** cells: mEFs<Fak1~null><xFak1><Foxh1> in BMLS
    *** does not req: xFak1 [omission]
    *** source: 21454615-Fig-3b

inhibited by Jun--

  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** repressed by: Jun [RNAi]
    *** source: 18955504-Fig-4e
  *** Pai1-gene promo-reporter[Luc] is unchanged itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T in BMS
    *** unaffected by: xJun [addition]
    *** source: 18955504-Fig-4f
  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** repressed by: Jun [RNAi]
    *** source: 18955504-Fig-4c
  *** Smad23s[Ab] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** repressed by: Jun [RNAi]
    *** source: 18955504-Fig-4d

Max-- ???

  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEPG2 in BMLS
    *** unaffected by: xMax [addition]
    *** source: 12551947-Fig-7a

Mekk1--  ???

  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: RGM1 in BMLS
    *** inhibited by: xMekk1(mnr)"DN" [addition]
    *** source: 15326485-Fig-8b
  *** Pai1-gene promo-reporter[Luc] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: bAECs in BMS
    *** enhanced by: xMekk1(380-672)"CA" [addition]
    *** source: 10085121-Fig-1a
  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MV1LU in BMS
    *** unaffected by: xMekk1(mnr)"CA" [addition]
    *** source: 8533096-Fig-3b

not Mek1--

  *** Pai1-gene promo-reporter[Luc] is increased itpo xTgfbR1(mnr)"CA"
    *** cells: bAECs in BMS
    *** unaffected by: xMek1(del(32-51)/S218E/S222E)"CA" [addition]
    *** source: 10085121-Fig-1a

inhibited by Pias4--

  *** Pai1-gene mRNA[Northern] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0 1+ 2+ 4+ 8+ hr
    *** partially inhibited by: xPias4 [addition]
    *** source: 12904571-Fig-3

Pml--

  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (30 hr)
    *** cells: mEFs<xSmad3> in BMS
    *** reqs: Pml [KO]
    *** source: 15356634-Fig-1a

inhibited by Ppm1a--

  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0 4+ 8+ 24 hr
    *** comment: decrease at 24 hr reqs Ppm1a [RNAi]
    *** source: 16751101-Fig-5h

Raf1--  ???

  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MV1LU in BMS
    *** unaffected by: xRaf1(mnr)"CA" [addition]
    *** source: 8533096-Fig-3b

Smad2--

  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** partially reqs: Smad2 [RNAi]
    *** source: 18955504-Fig-7a
  *** Pai1[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: MCF10A in BMS
    *** partially reqs: Smad2 [AntiSense]
    *** source: 14555988-Fig-6a

Smad3--

  *** Pai1-gene mRNA[RPA] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0 2+ 4+ 8++ hr
    *** inhibited by: xSmad3(D408E)"DN" [addition]
    *** source: 14993291-Fig-2c
  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: RGM1<xSmad3> in BMLS
    *** unaffected by: xSmad3(T179V/S204A/S208A/S213A) [substitution]
    *** partially inhibited by: xSmad3(S416A/S422A/S425A) [substitution]
    *** source: 15326485-Fig-8c
  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** reqs: Smad3 [RNAi]
    *** source: 18955504-Fig-7a
  *** Pai1[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: HACAT in BMS
    *** reqs: Smad3 [AntiSense]
    *** source: 14555988-Fig-5a
  *** Pai1[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: MCF10A in BMS
    *** partially reqs: Smad3 [AntiSense]
    *** source: 14555988-Fig-6b

Smad4--  ???

  *** Pai1[Ab] prot-exp[WB] is increased irt Tgfb1 (18 hr)
    *** cells: MCF10A in BMS
    *** partially reqs: Smad4 [AntiSense]
    *** source: 14555988-Fig-6c

Tak1--

  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MV1LU in BMS
    *** unaffected by: xTak1 [addition]
    *** inhibited by: xTak1(K63W) [addition]
    *** source: 8533096-Fig-3b
  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: MV1LU in BMS
    *** unaffected by: xTak1 [addition]
    *** source: 8533096-Fig-3c

inhibited by Tfap2a--

  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** repressed by: Tfap2a [RNAi]
    *** source: 18955504-Fig-4e
  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** repressed by: Tfap2a [RNAi]
    *** source: 18955504-Fig-4c
  *** Pai1-gene promo-reporter[Luc] is unchanged itpo xTgfbR1(mnr)"CA"
    *** cells: HEK293T in BMS
    *** unaffected by: xTfap2a [addition]
    *** source: 18955504-Fig-4f
  *** Smad23s[Ab] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** unaffected by: Tfap2a [RNAi]
    *** source: 18955504-Fig-4d

Tfeb--  ???

  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEPG2 in BMLS
    *** enhanced by: xTfeb [addition]
    *** source: 12551947-Fig-7b

TgfbR1--

  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (times)
    *** cells: PC3U<xTgfbR1> in BMS
    *** times: 0 30 360+ 720++ 1440++ min
    *** inhibited by: xTgfbR1(E161A) [substitution]
    *** source: 21629263-Fig-6d

Zfyve16--

  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (20 hr)
    *** cells: HEP3B in BMS
    *** partially reqs: Zfyve16 [RNAi]
    *** source: 17272273-Fig-3c

Chemicals

  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (15 hr)
    *** cells: COS1 in BMS
    *** inhibited by: Thapsigargin [addition]
    *** source: 11027280(D)

no extras

  *** Pai1-gene mRNA[Northern] is increased irt Tgfb1 (times)
    *** cells: MV1LU in BMS
    *** times: 0 15 30 90++ 240++ 1440+ min
    *** source: 9335507-Fig-5c
  *** Pai1-gene mRNA[Northern] is increased irt Tgfb1 (2 hr)
    *** cells: MV1LU in BMS
    *** source: 9786930-Fig-3d
  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1 (3 hr)
    *** cells: RGM1 in BMLS
    *** source: 15326485-Fig-8a
  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (12 hr)
    *** cells: RGM1 in BMLS
    *** source: 15326485-Fig-8c
  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (20 hr)
    *** cells: HEP3B in BMLS
    *** source: 12551947-Fig-7c
  *** Pai1-gene mRNA[RTPCR] is increased irt Tgfb1
    *** cells: HACAT in BMLS
    *** times: 0 1+ 2++ 8++ 12+++ 24++ hr
    *** source: 19595713-Fig-5d
  *** Pai1-gene promo-reporter[Luc] is increased irt Tgfb1 (24 hr)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1d
  *** Smad23s[Ab] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (90 min)
    *** cells: HACAT in BMS
    *** source: 18955504-Fig-1c
  *** Smad23s[Ab] boundto(Pai1-gene)[ChIP] is increased irt Tgfb1 (times)
    *** cells: HACAT in BMS
    *** times: 0 1+ 2++ 3++ 6+ 10+ 24+ hr
    *** source: 18955504-Fig-1a
  *** Pak1[Ab]IP IVKA(MBP)[phosAb] is unchanged irt Tgfb1 (times)
    *** cells: AKR2B in BMLS
    *** times: 0 5 15 30 60 120 min
    *** source: 14612425-Fig-1a
  *** Pak1[Ab]IP IVKA(MBP)[phosAb] is unchanged irt Tgfb1 (times)
    *** cells: MV1LU in BMLS
    *** times: 0 5 15 30 60 120 min
    *** source: 14612425-Fig-1b

===========
Translation
===========

  *** Pai1[Ab] prot-exp[WB] is increased irt Tgfb1 (20 hr)
    *** cells: HACAT in BMS
    *** source: 17327236-Fig-7d
  *** Pai1[Ab] prot-exp[WB] is increased irt Tgfb1 (20 hr)
    *** cells: HELA in BMS
    *** source: 17327236-Fig-7d


