===========================================
GTP binding is increased in response to Egf
===========================================

  *** Cdc42[Ab] GTP-association[BDPD] is increased irt Egf (tnr)
    *** cells: COS7 in BMLS
    *** source: 15034142-Fig-S3a
  *** Cdc42[Ab] GTP-association[BDPD] is increased irt Egf (3 min)
    *** cells: COS1 in BMLS
    *** source: 14699061-Fig-7d
  *** Cdc42[Ab] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: COS1 in BMLS
    *** times: 0+ 1+ 3++ 5+ 15+ min
    *** source: 14699061-Fig-3a
  *** xCdc42[tAb] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: COS7 in BMLS
    *** times: 0 5+ 10+ min
    *** source: 14506284-Fig-9

========================
GTP binding requires Src
========================

  *** xCdc42[tAb] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: COS7 in BMLS
    *** times: 0 3+ 5+ 10+ 15+ 30+ min
    *** inhibited by: xSrc(K297R)"DN" [addition]
    *** source: 14506284-Fig-6

======================================
GTP binding partially requires ArhGef4
======================================

  *** xCdc42(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431 in BMLS
    *** partially reqs: ArhGef4 [RNAi]
    *** source: 18653540-Fig-3a
  *** xCdc42(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431 in BMLS
    *** partially reqs: ArhGef4 [RNAi]
    *** source: 18653540-Fig-8b
  *** xCdc42(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431<ArhGef4~null><xArhGef4> in BMLS
    *** inhibited by: xArhGef4(Y94F) [substitution]
    *** source: 18653540-Fig-8b
  *** xCdc42(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: HELA in BMLS
    *** partially reqs: ArhGef4 [RNAi]
    *** source: 18653540-Fig-S4
  *** Cdc42[Ab] GTP-association[BDPD] is increased irt Egf (2 min)
    *** cells: A431 in BMLS
    *** partially reqs: ArhGef4 [RNAi]
    *** source: 18653540-Fig-3b

======================================
GTP binding partially requires ArhGef7
======================================

  *** Cdc42[Ab] GTP-association[BDPD] is increased irt Egf (times)
    *** cells: NIH3T3 in BMLS
    *** times: 0 10++ 45+ min
    *** partially reqs: ArhGef7 [RNAi]
    *** source: 16892055-Fig-3b

  *** xCdc42[tAb] copptby[WB] ArhGef7[Ab] is decreased itpo xEgfR
    *** cells: NIH3T3 in BMLS
    *** source: 16892055-Fig-4b

========================================================
Tyrosine phosphorylation is increased in response to Egf
========================================================
=====================================
Tyrosine phosphorylation requires Src
=====================================

  *** xCdc42[tAb]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: COS7 in BMLS
    *** times: 0 5+ 10++ min
    *** inhibited by: PP2 [addition]
    *** inhibited by: xSrc(K297R)"DN" [addition]
    *** source: 14506284-Fig-1a
  *** xCdc42[tAb]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: HEK293 in BMLS
    *** times: 0 5+ 10++ min
    *** inhibited by: PP2 [addition]
    *** inhibited by: xSrc(K297R)"DN" [addition]
    *** source: 14506284-Fig-1b

==========
other info
==========

  *** Cdc42[Ab] GTP-association[BDPD] is increased irt Egf (2 min)
    *** cells: A431 in BMLS
    *** does not req: Tiam1 [RNAi]
    *** does not req: Vav2 [RNAi]
    *** source: 18653540-Fig-3b
  *** xCdc42(Raichu)[XFP] GTP-association[FRET] is increased irt Egf (tnr)
    *** cells: A431 in BMLS
    *** does not req: Tiam1 [RNAi]
    *** partially reqs: Vav2 [RNAi]
    *** source: 18653540-Fig-3a

=============
contradiction
=============

  *** Cdc42[Ab] GTP-association[BDPD] is unchanged irt Egf (times)
    *** cells: rVSMCs in BMLS
    *** times: 0 1 5 30 min
    *** source: 17350025-Fig-1b
