===============
Kinase Activity
===============

not Irak1--

  *** P38a[Ab]IP IVKA(Mapkapk2)[32P-ATP] is increased irt Tnf (10 min)
    *** cells: mEFs in BMLS
    *** does not req: Irak1 [KO]
    *** source: 9625767(D)

not Mekk4--

  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (15 min)
    *** cells: HELA in BMLS
    *** unaffected by: xMekk4(K1371R)"DN" [addition]
    *** source: 9305639-Fig-11a

Mlk3-- ???

  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 8++ 10++ 12++ 15++ 30 60 min
    *** does not req: Mlk3 [KO]
    *** source: 15831472-Fig-5b

Ripk1--

  *** P38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30 60 min
    *** reqs: Ripk1 [KO]
    *** source: 14585994-Fig-1a

No extras

  *** P38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 15+ 30++ 60++ 120+ min
    *** source: 7535770-Fig-7
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (15 min)
    *** cells: HELA in BMS
    *** source: 9430721-Fig-5
  *** xP38b[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 15 45+ min
    *** source: 9430721-Fig-5
  *** xP38g[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (15 min)
    *** cells: HELA in BMS
    *** source: 9430721-Fig-5
  *** P38s[Ab]IP IVKA(Hspb1)[32P-ATP] is increased irt Tnf (10 min)
    *** cells: CT6 in BMS
    *** source: 9169478-Fig-2a
  *** P38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (tnr)
    *** cells: HEK293 in BMS
    *** source: 9712898-Fig-5a
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (20 min)
    *** cells: HELA in BMS
    *** source: 8663524-Fig-5
  *** xP38a[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5++ 15+++ 30++ 60+ 120 min
    *** source: 8663524-Fig-6
  *** xP38b[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (20 min)
    *** cells: HELA in BMS
    *** source: 8663524-Fig-5
  *** xP38b[tAb]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5 15+ 30++ 60++ 120+ min
    *** source: 8663524-Fig-6

===========================
Phosphorylation on TGY site
===========================

not Cltc--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (10 min)
    *** cells: HELA in BMS
    *** does not req: Cltc [RNAi]
    *** source: 19687304-Fig-5d

not EgfR--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5+ 10++ min
    *** does not req: EgfR [RNAi]
    *** source: 19687304-Fig-7b

not Erk2--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (10 min)
    *** cells: HELA in BMS
    *** does not req: Erk2 [RNAi]
    *** source: 19687304-Fig-4d

not Ikk1-- and/or Ikk2--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 min
    *** does not req: Ikk1 [KO]
    *** does not req: Ikk2 [KO]
    *** comment: decrease in phos at 30 min is not seen in Ikk-null cells
    *** source: 11733537-Fig-2

not Irak3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 20++ 60 min
    *** does not req: Irak3 [KO]
    *** source: 12150927-Fig-4c

not Irak4--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 min
    *** unaffected by: xIrak4(K213A/K214A)"KD" [addition]
    *** source: 17337443-Fig-3c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30 60 min
    *** does not req: Irak4 [KO]
    *** source: 11923871(D)

Mekk1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mESCs in BMS
    *** times: 0 10+ 30+ 60 min
    *** inhibited by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 10805784-Fig-2

not Mekk3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5 10++ 30++ 60+ min
    *** does not req: Mekk3 [KO]
    *** source: 14585994-Fig-4f
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMLS
    *** times: 0 10++ 15++ 30+ min
    *** does not req: Mekk3 [KO]
    *** source: 18021073-Fig-8b

Mlk3-- ???

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 8++ 10++ 12+ 15+ 30 60 min
    *** comment: reqs Mlk3 [KO] for the decreased at later times
    *** source: 15831472-Fig-6a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (10 min)
    *** cells: JURKAT<Pten~null> in BMLS
    *** partially reqs: Mlk3 [RNAi]
    *** source: 15258589-Fig-2e
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (10 min)
    *** cells: CCD18CO in BMLS
    *** reqs: Mlk3 [RNAi]
    *** source: 15258589-Fig-2a

not Rela--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 10+ 60 min
    *** does not req: Rela [RNAi]
    *** source: 19687304-Fig-7c

Ripk1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ 60+ min
    *** reqs: Ripk1 [KO]
    *** source: 15175328-Fig-2b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 30+ 60+ min
    *** reqs: Ripk1 [KO]
    *** source: 14585994-Fig-3d
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs<Ripk1~null><xRipk1> in BMS
    *** times: 0 10+ 30+ 60+ min
    *** unaffected by: xRipk1(D138N)"KD" [substitution]
    *** source: 15175328-Fig-2a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10+ 15 min
    *** partially reqs: Ripk1 [KO]
    *** source: 12776182-Fig-1a

Syk--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (15 min)
    *** cells: JURKAT<Pten~null> in BMS
    *** enhanced by: xSyk [addition]
    *** reqs: Syk [RNAi]
    *** source: 15240695-Fig-7b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: JURKAT<Pten~null> in BMS
    *** times: 0 5+ 10++ 15++ 30+ min
    *** inhibited by: Piceatannol [addition]
    *** source: 15240695-Fig-2d
  *** P38s[phosAb] phos(TGY)[phosAb] is unchanged irt Tnf (times)
    *** cells: JCam1 in BMS "Syk and Lck deficient"
    *** times: 0 5 10 15 30 min
    *** unaffected by: xLck [addition]
    *** source: 15240695-Fig-3d

Tab1-- ???

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** partially reqs: Tab1 [RNAi]
    *** source: 15590691-Fig-6a

Tab2-- ???

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** partially reqs: Tab2 [RNAi]
    *** source: 15590691-Fig-6b

Tab3-- ???

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (10 min)
    *** cells: HELA in BMS
    *** partially reqs: Tab2 [RNAi]
    *** partially reqs: Tab3 [RNAi]
    *** reqs: Tab2 and/or Tab3 [DRNAi]
    *** source: 14633987-Fig-7d
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 60 min
    *** does not req: Tab1 [KO]
    *** does not req: Tab2 [KO]
    *** source: 16260493(D)

Tak1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30 60 min
    *** reqs: Tak1 [KO]
    *** source: 16260493(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 20++ 30+ min
    *** reqs: Tak1 [KO]
    *** source: 16186825(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs<Tak1~null> in BMS
    *** times: 0+ 5++ 10++ 15++ 30+ min
    *** enhanced by: xTak1 [addition]
    *** partially inhibited by: xTak1(K158R) [addition]
    *** source: 20038579-Fig-7a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** partially reqs: Tak1 [RNAi]
    *** source: 19393267-Fig-1b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (5 min)
    *** cells: HELA in BMS
    *** reqs: Tak1 [RNAi]
    *** source: 15590691-Fig-5d
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (10 min)
    *** cells: HELA in BMS
    *** reqs: Tak1 [RNAi]
    *** source: 19687304-Fig-4a

TnfR1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 5++ 15++ 30+ 45+ min
    *** reqs: TnfR1 [KO]
    *** source: 18641654-Fig-1b

not Tpl2--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 10++ 20++ 30+ 40 60 min
    *** does not req: Tpl2 [KO]
    *** source: 15833743-Fig-1a

Tradd--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mBMMs in BMS
    *** times: 0 5++ 15++ 30+ 45+ min
    *** partially reqs: Tradd [KO]
    *** source: 18641654-Fig-1b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15++ 30++ 45+ min
    *** reqs: Tradd [KO]
    *** source: 18641654-Fig-1a

not Traf2--

  *** P38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Tnf (10 min)
    *** cells: mEFs in BMS
    *** does not req: Traf2 [KO]
    *** source: 14585994-Fig-2a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: mEFs in BMS
    *** times: 0 5++ 10+ 15 min
    *** partially reqs: Traf2 [KO]
    *** source: 12776182-Fig-1a

not Traf6--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (15 min)
    *** cells: mEFs in BMS
    *** does not req: Traf6 [KO]
    *** source: 16260598-Fig-6d

not Ubc13--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (10 min)
    *** cells: HELA in BMS
    *** does not req: Ubc13 [RNAi]
    *** source: 14713952-Fig-4e

Chemicals

  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt Tnf (15 min)
    *** cells: hUVECs in BMS
    *** unaffected by: Ebselen [pretreatment]
    *** source: 14720501-Fig-2
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 15+ 60 min
    *** unaffected by: SB203580 [pretreatment]
    *** source: 19687304-Fig-5e,5f

No extras

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (20 min)
    *** cells: HEK293T in BMS
    *** source: 10755617(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (3 min)
    *** cells: HELA in BMS
    *** unaffected by: Bay117082 [addition]
    *** source: 12842894-Fig-6
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: 3T3L1 in BMS "differentiated into adipocytes"
    *** times: 0 5++ 10++ 15+ 30+ 60+ 120+ 360+ 720 min
    *** source: 17500068-Fig-4b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: 3T3L1 in BMS "differentiated into adipocytes"
    *** times: 0 5++ 15++ 30++ 60++ 120++ 360+ 720 min
    *** source: 17500068-Fig-8b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt anti-TnfR1 (times)
    *** cells: 3T3L1 in BMS "differentiated into adipocytes"
    *** times: 0 5++ 15++ 30++ 60++ 120++ 360+ 720 min
    *** source: 17500068-Fig-8b
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt Tnf (15 min)
    *** cells: hUVECs in BMS
    *** source: 14720501-Fig-1c
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt Tnf (times)
    *** cells: hUVECs in BMS
    *** times: 0 5 10+ 15+ 30+ 60 min
    *** source: 14720501-Fig-1a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 5+ 10++ min
    *** source: 15590691-Fig-7c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 2 4+ 6++ 8++ 10++ min
    *** source: 19687304-Fig-4e
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 10+ 30 60 min
    *** source: 19687304-Fig-3a

Contradictions

  *** P38s[phosAb] phos(TGY)[phosAb] is unchanged irt Tnf (times)
    *** cells: MDAMB453 in BMLS
    *** times: 0 5 10 20 30 min
    *** source: 17693255-Fig-S1c
  *** P38s[phosAb] phos(TGY)[phosAb] is unchanged irt Tnf (30 min)
    *** cells: MCF7 in BMLS
    *** source: 17693255-Fig-S1b
