=============
Transcription
=============


Cd14--

  *** CxcL10[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: hMDDCs in BMS "contining IL4 and Csf2"
    *** reqs: Cd14 [blocking-Ab]
    *** source: 17163980(D)

not Ciap1-- or Ciap2--

  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: KMS28BM in BMS
    *** does not req: Ciap1 and/or Ciap2 [fmut]
    *** source: 19898473-Fig-S9c
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: RAW2647 in BMS
    *** does not req: Ciap1 and/or Ciap2 [RNAi]
    *** source: 19898473-Fig-S9b

Ikba--

  *** CxcL10-gene promo-reporter[CAT] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xIkba(mnr)"DN" [addition]
    *** source: 12354379-Fig-3c
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 1+ 2++ hr
    *** inhibited by: xIkba(mnr)"DN" [addition]
    *** source: 12354379-Fig-4b

Ikke--  ???

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 1+ 2++ 5+ hr
    *** reqs: Ikke [KO]
    *** source: 12736252-Fig-4a
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4+++ 8++ hr
    *** does not req: Ikke [KO]
    *** source: 15210742-Fig-2b

Irak4--

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 3+ 8 hr
    *** partially reqs: Irak4 [KO]
    *** source: 14634120-Fig-3
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2 6+ 12 24 hr
    *** reqs: Irak4 [KO]
    *** source: 14634120-Fig-1a

Irf3--

  *** CxcL10-gene promo-reporter[CAT] is increased irt Lps (6 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: xIrf3(mnr)"DN" [addition]
    *** source: 12354379-Fig-3c
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMS
    *** enhanced by: xIrf3 [addition]
    *** inhibited by: xIrf3(mnr)"DN" [addition]
    *** source: 12354379-Fig-4d
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 2++ 6+ 12 24 hr
    *** reqs: Irf3 [KO]
    *** source: 12821121-Fig-3a

not Mavs--

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2 4+ 6++ hr
    *** does not req: Mavs [KO]
    *** source: 16785313-Fig-2f

not Myd88--

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (2 hr)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4++ hr
    *** does not req: Myd88 [KO]
    *** source: 15241416-Fig-1b
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1+ 2++ 4+++ hr
    *** does not req: Myd88 [KO]
    *** source: 12356687-Fig-1
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2 6+ 12 24 hr
    *** does not req: Myd88 [KO]
    *** source: 14634120-Fig-1a
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1 2+ 4++ hr
    *** does not req: Myd88 [KO]
    *** source: 15694359-Fig-1
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1 2+ 4++ hr
    *** does not req: Myd88 [KO]
    *** does not req: Tirap or Myd88 [DKO]
    *** source: 12447441-Fig-5a
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mPECs in BMLS
    *** does not req: Myd88 [KO]
    *** source: 16143103-Fig-5d
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** does not req: Myd88 [KO]
    *** source: 19898473-Fig-S9d

IfnaR1--           !!!!!!!!!!!!!!

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1+ 2++ 4+++ hr
    *** reqs:  IfnaR1 [KO]
    *** source: 12356687-Fig-1


Stat1--

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 1+ 2++ 4+++ hr
    *** reqs: Stat1 [KO]
    *** source: 12356687-Fig-1

not Pkr--

  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mPECs in BMS
    *** does not req: Pkr [KO]
    *** source: 11896392-Fig-8c

Rela--

  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mHMCs<Tnf~null><Rel~null> in BMLS
    *** reqs: Rela [KO]
    *** source: 16143103-Fig-S1

not Rig1--

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2 4+ hr
    *** does not req: Rig1 [KO]
    *** source: 16039576-Fig-2c

Tbk1--

  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4+++ 8++ hr
    *** reqs: Tbk1 [KO]
    *** source: 15210742-Fig-2b
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 1 4+ hr
    *** reqs: Tbk1 and/or TnfR1 [DKO]
    *** source: 15210743-Fig-1c
  *** CxcL10-gene promo-reporter[Luc] is increased irt Lps (16 hr)
    *** cells: mEFs in BMS
    *** reqs: Tbk1 [KO]
    *** source: 14679297-Fig-2c
  ---------------------------------------------------------------
  *** CxcL10[Ab] secretion[ELISA] is increased irt Lps (16 hr)
    *** cells: mEFs in BMS
    *** reqs: Tbk1 [KO]
    *** source: 14679297-Fig-6c

Trif--

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4++ 6+ hr
    *** reqs: Trif [KO]
    *** source: 12855817-Fig-2a
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 2+ 4++ 6+ hr
    *** reqs: Trif and/or Myd88 [DKO]
    *** source: 12855817-Fig-3f
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1 2+ 4++ hr
    *** reqs: Trif [KO]
    *** source: 15694359-Fig-1
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** reqs: Trif [fmut]
    *** source: 19898473-Fig-S9d

Ticam2--

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1 2 4+ hr
    *** reqs: Ticam2 [KO]
    *** source: 14556004(D)

not Tirap--  ???

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 1 2+ 4++ hr
    *** does not req: Tirap [KO]
    *** does not req: Tirap or Myd88 [DKO]
    *** source: 12447441-Fig-5a
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: RAW2647 in BMS
    *** reqs: Tirap [blocking-peptide]
    *** source: 12421970-Fig-7

Traf3--

  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (90 min)
    *** cells: mBMMs in BMS
    *** reqs: Traf3 [KO]
    *** source: 16306937-Fig-S3e

not Traf6--

  *** CxcL10-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mSMacs in BMS
    *** times: 0 1+ 4++ hr
    *** does not req: Traf6 [KO]
    *** source: 15322147-Fig-3c

TLR4--

  *** CxcL10-gene mRNA[RPA] is increased irt Lps (5 hr)
    *** cells: HENC2 in BMS
    *** reqs: TLR4 [KO]
    *** source: 16895974(D)

=================================
Requirement for Protein Synthesis
=================================

  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 2++ 6+ hr
    *** unaffected by: CHX [addition]
    *** source: 12821121-Fig-3b

=========
Chemicals
=========

  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mPECs in BMLS
    *** partially inhibited by: Dexamethasone [addition]
    *** source: 16143103-Fig-5d
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (6 hr)
    *** cells: mPECs in BMLS
    *** partially inhibited by: Dexamethasone [addition]
    *** partially inhibited by: GW7845 [addition]
    *** unaffected by: T1317 [addition]
    *** unaffected by: ATRA [addition]
    *** unaffected by: Calcitrol [addition]
    *** unaffected by: Estradiol [addition]
    *** source: 16143103-Fig-1d
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (6 hr)
    *** cells: mPECs in BMLS
    *** partially inhibited by: Dexamethasone [addition]
    *** unaffected by: GW7845 [addition]
    *** partially inhibited by: GW3965 [addition]
    *** source: 16143103-Fig-2d
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (6 hr)
    *** cells: mPECs in BMLS
    *** partially inhibited by: Dexamethasone [addition]
    *** unaffected by: GW7845 [addition]
    *** inhibited by: Dexamethasone + GW7845 [addition]
    *** source: 16143103-Fig-6b
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S9d
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S9a

no extras

  *** CxcL10-gene mRNA[MicroArray] is increased irt Lps (times)
    *** cells: mSpBCs in BMS
    *** times: 0 4+++ 12++ 24+ 72 168 hr
    *** source: 12354379-Fig-1b
  *** CxcL10-gene mRNA[Northern] is increased irt Lps (4 hr)
    *** cells: mPECs in BMS
    *** source: 12096038-Fig-1b
  *** CxcL10-gene mRNA[RPA] is increased irt Lps (3 hr)
    *** cells: THP1 in BMS
    *** source: 16574669(D)
  *** CxcL10-gene mRNA[RPA] is increased irt Lps (5 hr)
    *** cells: hMDMacs in BMS
    *** source: 16895974(D)
  *** CxcL10-gene mRNA[RPA] is increased irt Lps (5 hr)
    *** cells: hMDDCs in BMS
    *** source: 16895974(D)
  *** CxcL10-gene mRNA[RPA] is unchanged irt Lps (3 hr)
    *** cells: hPBMCs in BMS "adherent"
    *** source: 16574669(D)
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: mPECs in BMS
    *** source: 16709849(D)
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: mPECs in BMS
    *** times: 0 3+ hr
    *** source: 11896392-Fig-1,6
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: mPECs in BMS
    *** times: 0 1 2 4+ 6++ hr
    *** source: 11896392-Fig-6
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (24 hr)
    *** cells: mPECs in BMS
    *** source: 16709849(D)
  *** CxcL10-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0+ 2++ 4++ 6++ 8++ 10++ hr
    *** source: 11179315(D)
