==========================
Coprecipitation with Axin1
===========================

does not req Dvl1--

  *** xAxin1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: COS<xAxin1><xCsnk1e> in BMS
    *** unaffected by: xDvl1 [addition]
    *** source: 11425858-Fig-6
  *** xCsnk1e[Ab] copptby[WB] xAxin1[tAb] is detectable
    *** cells: COS<xCsnk1e><xAxin1> in BMS
    *** unaffected by: xDvl1 [addition]
    *** source: 11425858-Fig-6

Axin1 reauired features

  *** Csnk1e[Ab] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293<xAxin1> in BMS
    *** inhibited by: xAxin1(284-500) [substitution]
    *** unaffected by: xAxin1(284-712) [substitution]
    *** unaffected by: xAxin1(475-676) [substitution]
    *** inhibited by: xAxin1(712-827) [substitution]
    *** source: 11487578-Fig-6
  *** xCsnk1e[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: COS<xCsnk1e><xAxin1> in BMS
    *** partially inhibited by: xAxin1(298-713) [substitution]
    *** partially inhibited by: xAxin1(1-529) [substitution]
    *** inhibited by: xAxin1(1-437) [substitution]
    *** inhibited by: xAxin1(1-229) [substitution]
    *** unaffected by: xAxin1(1-713) [substitution]
    *** inhibited by: xAxin1(298-506) [substitution]
    *** inhibited by: xAxin1(508-832) [substitution]
    *** source: 11425858-Fig-5b
  *** xAxin1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** unaffected by: xAxin1(198-832)"N1" [substitution]
    *** inhibited by: xAxin1(del(210-352))"M2" [substitution]
    *** inhibited by: xAxin1(1-509)"C1" [substitution]
    *** inhibited by: xAxin1(509-832)"N3" [substitution]
    *** unaffected by: xAxin1((198-353)/(509-832))"M3" [substitution]
    *** source: 11884395-Fig-4b
  *** xCsnk1e[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** partially inhibited by: xAxin1(198-832)"N1" [substitution]
    *** inhibited by: xAxin1(del(210-352))"M2" [substitution]
    *** inhibited by: xAxin1(1-509)"C1" [substitution]
    *** inhibited by: xAxin1(509-832)"N3" [substitution]
    *** unaffected by: xAxin1((198-353)/(509-832))"M3" [substitution]
    *** source: 11884395-Fig-4b

Csnk1e required features: not kinase activity

  *** xAxin1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: COS<xAxin1><xCsnk1e> in BMS
    *** unaffected by: xCsnk1e(mnr)"KD" [substitution]
    *** source: 11425858-Fig-6
  *** xCsnk1e[Ab] copptby[WB] xAxin1[tAb] is detectable
    *** cells: COS<xCsnk1e><xAxin1> in BMS
    *** unaffected by: xCsnk1e(mnr)"KD" [substitution]
    *** source: 11425858-Fig-6
  *** xCsnk1e[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: COS<xCsnk1e><xAxin1> in BMS
    *** unaffected by: xCsnk1e(mnr)"KD" [substitution]
    *** source: 11425858-Fig-5a
  *** xAxin1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** unaffected by: xCsnk1e(1-370)"C1" [substitution]
    *** unaffected by: xCsnk1e(1-295)"C2" [substitution]
    *** inhibited by: xCsnk1e(1-248)"C3" [substitution]
    *** source: 11884395-Fig-5b
  *** xCsnk1e[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** partially inhibited by: xCsnk1e(1-370)"C1" [substitution]
    *** partially inhibited by: xCsnk1e(1-295)"C2" [substitution]
    *** inhibited by: xCsnk1e(1-248)"C3" [substitution]
    *** source: 11884395-Fig-5b
  *** xAxin1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** unaffected by: xCsnk1e(K38R)"KD" [substitution]
    *** source: 11884395-Fig-6b
  *** xCsnk1e[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** unaffected by: xCsnk1e(K38R)"KD" [substitution]
    *** source: 11884395-Fig-6b

No extras

  *** xAxin1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** source: 11408485-Fig-3a
  *** xCsnk1e[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** source: 11408485-Fig-3a
  *** Csnk1e[Ab] copptby[WB] Axin1[Ab] is detectable
    *** cells: Lcells in BMS
    *** source: 11425858-Fig-2
  *** xAxin1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** source: 11884395-Fig-2a
  *** xAxin1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e><xMekk1(mnr)"C"> in BMS
    *** source: 11884395-Fig-2a
  *** xAxin1[tAb] copptby[WB] xCsnk1e[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** source: 11884395-Fig-3
  *** xCsnk1e[tAb] copptby[WB] xAxin1[tAb] is detectable
    *** cells: HEK293T<xAxin1><xCsnk1e> in BMS
    *** source: 11884395-Fig-3

=======================================================
Coprecipitation with other members of the Axin complex
=======================================================

Apc--

  *** xCsnk1e[tAb] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xCsnk1e><xApc> in BMS
    *** enhanced by: xAxin1 [addition]
    *** source: 11425858-Fig-7
  *** xCsnk1e[tAb] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xCsnk1e><xApc> in BMS
    *** unaffected by: xCsnk1e(mnr)"KD" [substitution]
    *** source: 11425858-Fig-7
  *** xCsnk1e[tAb] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xCsnk1e><xApc> in BMS
    *** unaffected by: xDvl1 [addition]
    *** source: 11425858-Fig-7
  *** xCsnk1e[tAb] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xCsnk1e><xApc><xAxin1> in BMS
    *** unaffected by: xCsnk1e(mnr)"KD" [substitution]
    *** source: 11425858-Fig-7
  *** xCsnk1e[tAb] copptby[WB] xApc[tAb] is detectable
    *** cells: COS<xCsnk1e><xApc><xAxin1> in BMS
    *** unaffected by: xDvl1 [addition]
    *** source: 11425858-Fig-7

Dvl1--

  *** Csnk1e[Ab] copptby[WB] Dvl1[Ab] is detectable
    *** cells: Lcells in BMS
    *** source: 11425858-Fig-2
  *** xCsnk1e[tAb] copptby[WB] xDvl1[tAb] is detectable
    *** cells: COS<xCsnk1e><xDvl1> in BMS
    *** unaffected by: xCsnk1e(mnr)"KD" [substitution]
    *** source: 11425858-Fig-4a
  *** xCsnk1e[tAb] copptby[WB] xDvl1[tAb] is detectable
    *** cells: COS<xCsnk1e><xDvl1> in BMS
    *** unaffected by: xDvl1(del(282-336))"delPDZ" [substitution]
    *** inhibited by: xDvl1(201-371) [substitution]
    *** inhibited by: xDvl1(1-378) [substitution]
    *** inhibited by: xDvl1(1-432) [substitution]
    *** unaffected by: xDvl1(1-519) [substitution]
    *** unaffected by: xDvl1(140-670) [substitution]
    *** source: 11425858-Fig-4b
  *** xCsnk1e[tAb] copptby[WB] xDvl1[tAb] is detectable
    *** cells: COS<xCsnk1e><xDvl1><xAxin1> in BMS
    *** unaffected by: xCsnk1e(mnr)"KD" [substitution]
    *** source: 11425858-Fig-6

