===============
Kinase Activity
===============

Cd56--

  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** unaffected by: xCd56 [addition]
    *** source: 12393431-Fig-2d
  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** unaffected by: xCd56 [addition]
    *** source: 12393431-Fig-4b

Pik3r--

  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: xPik3r?(mnr)"DN" [addition]
    *** source: 12393431-Fig-2d

Rac1--

  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** unaffected by: xRac1(G12V) [addition]
    *** source: 12393431-Fig-5c

Syk--

  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: hNKCs in BMS "IL2-deprived"
    *** inhibited by: xSyk(mnr)"KD" [addition] no-bkg-control
    *** source: 12393431-Fig-5c
  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: xSyk(mnr)"KD" [addition] no-bkg-control
    *** source: 12393431-Fig-4b
  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** partially inhibited by: xSyk(mnr)"KD" [addition]
    *** source: 12393431-Fig-2d

Chemicals--

  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: LY294002 [pretreatment] no-bkg-control
    *** source: 12393431-Fig-2c
  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: hNKCs in BMS "IL2-deprived"
    *** inhibited by: Piceatannol [pretreatment] no-bkg-control
    *** source: 12393431-Fig-5c
  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: Piceatannol [pretreatment] no-bkg-control
    *** source: 12393431-Fig-2c
  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: Piceatannol [pretreatment] no-bkg-control
    *** source: 12393431-Fig-4b
  *** Akt1[Ab]IP IVKA(HistH2B)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: Wortmannin [pretreatment] no-bkg-control
    *** source: 12393431-Fig-2c

No extras--

  *** Akt1[Ab]IP IVKA(Gsk3?)(SFAE)[phosAb] is increased irt IL2 (48 hr)
    *** cells: NK92 in BMS "IL2-deprived"
    *** source: 15843522-Fig-1a
  *** Akt1[Ab]IP IVKA(Gsk3?)[32P-ATP] is increased irt IL2 (30 min)
    *** cells: NK92 in BMS "IL2-deprived"
    *** source: 15843522-Fig-1a

====================
S473 phosphorylation
====================

Cd56--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** unaffected by: xCd56 [addition]
    *** source: 12393431-Fig-2d
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** unaffected by: xCd56 [addition]
    *** source: 12393431-Fig-4a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** unaffected by: xCd56 [addition]
    *** source: 12393431-Fig-5b

Pik3r--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: xPik3r?(mnr)"DN" [addition]
    *** source: 12393431-Fig-2d

Rac1--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: xRac1(T17N) [addition]
    *** unaffected by: xRac1(G12V) [addition]
    *** source: 12393431-Fig-5b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** unaffected by: xRac1(G12V) [addition]
    *** source: 12393431-Fig-5c

Syk--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: xSyk(mnr)"KD" [addition]
    *** source: 12393431-Fig-2d

Chemicals--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: LY294002 [pretreatment] no-bkg-control
    *** source: 12393431-Fig-2c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: Piceatannol [pretreatment] no-bkg-control
    *** source: 12393431-Fig-2b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: Piceatannol [pretreatment] no-bkg-control
    *** source: 12393431-Fig-2c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: Piceatannol [pretreatment] no-bkg-control
    *** source: 12393431-Fig-4a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: Wortmannin [pretreatment] no-bkg-control
    *** source: 12393431-Fig-2c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (times)
    *** cells: KHYG1 in BMS "IL2-deprived"
    *** times: 0+ 5+++ 15+ 30+ min
    *** inhibited by: LY294002 [pretreatment]
    *** source: 15271800-Fig-3a

No Extras--

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt IL2 (5 min)
    *** cells: hNKCs in BMS "IL2-deprived"
    *** source: 12393431-Fig-5b
