not Akt1-- or Akt2--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<xTax1bp1> in BMS
    *** times: 0+ 15 30+ min
    *** does not req: Akt1 or Akt2 [DKO]
    *** source: 21765415-Fig-S3

Erc1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: HELA in BMS
    *** times: 0+ 30 60 min
    *** reqs: Erc1 [RNAi]
    *** source: 15218148-Fig-2b

Ikk1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30+ 60++ min
    *** does not req: Ikk1 [KO]
    *** source: 11733537-Fig-3a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs<Ikk1~null><xIkk1> in BMS
    *** unaffected by: xIkk1(K44M)"KD" [substitution]
    *** source: 21765415-Fig-1g
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs<Ikk1~null><xIkk1><xTax1bp1> in BMS
    *** does not req: xIkk1 [omission]
    *** unaffected by: xIkk1(K44M)"KD" [substitution]
    *** source: 21765415-Fig-1h
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs<xTax1bp1> in BMS
    *** does not req: Ikk1 [KO]
    *** source: 21765415-Fig-S1
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0++ 5+ 15 60++ min
    *** does not req: Ikk1 [KO]
    *** source: 11297557-Fig-1a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0++ 5+ 10+ 20 30+ 60++ min
    *** does not req: Ikk1 [KO]
    *** source: 19666475-Fig-5a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs<Ikk1~null><xIkk1> in BMS
    *** times: 0++ 5+ 10 20 30+ 60++ min
    *** does not req: xIkk1 [omission]
    *** unaffected by: xIkk1(1-737)"delNBD" [substitution]
    *** source: 19666475-Fig-5a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 30 60+ min
    *** does not req: Ikk1 [KO]
    *** source: 17244613-Fig-1c
  ----- required in the absence of Ikk2 -----------------
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs<Ikk1~null><Ikk2~null><xIkk1> in BMS
    *** times: 0++ 15 30+ 60++ min
    *** reqs: xIkk1 [omission]
    *** source: 17244613-Fig-5c

Ikk2--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** reqs: Ikk2 [KO]
    *** source: 17197697-Fig-7b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs<Ikk2~null><xIkk2> in BMS
    *** reqs: xIkk2 [omission]
    *** inhibited by: xIkk2(mnr)"KD" [substitution]
    *** source: 17197697-Fig-7b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 5+ 15 30+ 60+ min
    *** reqs: Ikk2 [KO]
    *** source: 17197697-Fig-7a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Ikk2~null><xIkk2> in BMS
    *** times: 0+ 5+ 15 30+ 60+ min
    *** reqs: xIkk2 [omission]
    *** source: 17197697-Fig-7a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs<xTax1bp1> in BMS
    *** reqs: Ikk2 [KO]
    *** source: 21765415-Fig-S1
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0++ 5+ 15 60++ min
    *** partially reqs: Ikk2 [KO]
    *** source: 11297557-Fig-1b
  ---- contradictions -----------
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0++ 5++ 10+ 20 30 60++ min
    *** does not req: Ikk2 [KO]
    *** source: 19666475-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs<Ikk2~null><xIkk2> in BMS
    *** times: 0++ 5+ 10 20 30+ 60++ min
    *** does not req: xIkk2 [omission]
    *** unaffected by: xIkk2(1-733)"delNBD" [substitution]
    *** source: 19666475-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30+ 60++ min
    *** partially reqs: Ikk2 [KO]
    *** source: 11733537-Fig-3a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 30 60+ min
    *** partially reqs: Ikk2 [KO]
    *** source: 17244613-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 60+ min
    *** does not req: Ikk2 [KO]
    *** source: 17244613-Fig-3b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30+ 60++ min
    *** partially reversed by: xIkk2(K44M) [addition]
    *** source: 17244613-Fig-4c

Ikk1 or Ikk2--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HELA in BMS
    *** times: 0++ 2++ 5+ 10+ 20 60+ min
    *** partially reqs: Ikk1 [RNAi]
    *** partially reqs: Ikk2 [RNAi]
    *** partially reqs: Ikk1 and/or Ikk2 [RNAi]
    *** source: 12547194(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 60+ min
    *** reqs: Ikk1 and/or Ikk2 [DKO]
    *** source: 10898787-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30+ 60++ min
    *** reqs: Ikk1 and/or Ikk2 [DKO]
    *** source: 17244613-Fig-5c

Irak1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs in BMLS
    *** partially reqs: Irak1 [KO]
    *** source: 9625767(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMLS
    *** times: 0+++ 5+++ 15+ 30+ 45++ 60++ min
    *** reqs: Irak1 [KO]
    *** source: 19754427-Fig-1a
  *** Ikks[phosAb] phos(S176/S180)[phosAb] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMLS
    *** times: 0 5++ 15++ 30++ 45+ 60+ min
    *** reqs: Irak1 [KO]
    *** source: 19754427-Fig-1a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS "pretreated with CHX"
    *** times: 0+++ 30++ 60 120 240+ 480+ 960++ 1440++ min
    *** reqs: Irak1 [RNAi]
    *** source: 17360530-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is unchanged irt IL1b (times)
    *** cells: HEK293I1A<Irak1~null><xIL1R1> in BMS
    *** times: 0+ 5+ 15+ 30+ 45+ 60+ min
    *** source: 19675569-Fig-S5b
  *** Ikba[Ab] prot-exp[WB] is unchanged irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null> in BMS
    *** times: 0+ 10+ 30+ 120+ min
    *** source: 17197697-Fig-3c
  *** Ikba[Ab] prot-exp[WB] is unchanged irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null><xIrak1(K239A/K32R/K134R/K179R)> in BMS
    *** times: 0+ 5+ 15+ 30+ 60+ min
    *** source: 17197697-Fig-3c
  -------------contradiction --------------------------------------------
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null><xIrak1(K239A)"KD"> in BMS
    *** times: 0++ 5+ 15 30 60+ min
    *** source: 17197697-Fig-3c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: HEK293I1A<Irak1~null><xIrak1(K239A/S131A/S137A/S138A/S140A/T141A/S144A)> in BMS
    *** times: 0+++ 5++ 15+ 30+ 60++ min
    *** source: 17197697-Fig-3c


Irak4

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0+ 30 60 min
    *** reqs: Irak4 [KO]
    *** source: 11923871(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 30 min
    *** inhibited by: kIrak4(K213A/K214A)"KD" [substitution]
    *** source: 17337443-Fig-3a

not Mekk2

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0++ 15 60+ 120++ min
    *** does not req: Mekk2 [RNAi]
    *** source: 14636585-Fig-6d

Mekk3

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10+ 20 40 60+ min
    *** reqs: Mekk3 [KO]
    *** source: 14661019-Fig-3f
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMLS
    *** times: 0++ 10 15 30+ min
    *** does not req: Mekk3 [KO]
    *** source: 18021073-Fig-8b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS "on gelatin"
    *** times: 0++ 15 60+ 120++ min
    *** reqs: Mekk2 [RNAi] and/or Mekk3 [KO]
    *** source: 14636585-Fig-6d
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<xTLR8> in BMS
    *** times: 0+ 15 30 min
    *** does not req: Mekk3 [KO]
    *** source: 16737960-Fig-4b

Myd88--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (15 min)
    *** cells: mEFs in BMS
    *** reqs: Myd88 [KO]
    *** source: 16428431(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (45 min)
    *** cells: hMDMacs in BMS
    *** inhibited by: xMyd88(del(1-53)/F56N)"DN" [addition]
    *** source: 14630816(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<Myd88~null><xMyd88> in BMS
    *** times: 0+ 2 30 min
    *** reqs: xMyd88 [omission]
    *** source: 12538665-Fig-1b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xIL1Rap> in BMS "pretreated with CHX"
    *** times: 0+++ 30++ 60 120 240+ 480+ 960++ 1440++ min
    *** reqs: Myd88 [RNAi]
    *** source: 17360530-Fig-2b

Nemo--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 30 60+ min
    *** reqs: Nemo [KO]
    *** source: 17244613-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<Nemo~null><xNemo> in BMS
    *** times: 0++ 5 15 30+ min
    *** reqs: xNemo [omission]
    *** inhibited by: xNemo(L329P)"impaired-K63-Ubiq-binding-mut" [substitution]
    *** source: 18347055-Fig-2c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (10 min)
    *** cells: mEFs<Nemo~null><xNemo> in BMS
    *** inhibited by: xNemo(L329P)"impaired-K63-Ubiq-binding-mut" [substitution]
    *** source: 18347055-Fig-2d
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<Nemo~null><xNemo> in BMS
    *** times: 0++ 5+ 20 min
    *** reqs: xNemo [omission]
    *** unaffected by: xNemo(K285R) [substitution]
    *** source: 19112497-Fig-6a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs<xTax1bp1> in BMS
    *** reqs: Nemo [KO]
    *** source: 21765415-Fig-S1
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: mEFs in BMS
    *** times: 0++ 5+ 15 60++ min
    *** reqs: Nemo [KO]
    *** source: 11297557-Fig-1c

not Nfkb1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: HELA<xNfkb1> in BMS
    *** times: 0+ 15+ 30 60 min
    *** unaffected by: xNfkb1(S927A) [substitution]
    *** source: 11297557-Fig-4b

Pin1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 30+ 60+ 90+ 120+ min
    *** comment: degradation was delayed in Pin1-null cells
    *** comment: feedback upreg was prevented in Pin1-null cells
    *** source: 14690596-Fig-5c

not Ripk1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0+ 5+ 15 30+ min
    *** does not req: Ripk1 [KO]
    *** source: 12654725-Fig-1c

not Tab2 or Tab3

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 30+ min
    *** does not req: Tab2 [KO]
    *** source: 12556483-Fig-4a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30+ 60++ 120++ 240++ min
    *** does not req: Tab2 [KO]
    *** source: 16260493(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HELA in BMS
    *** times: 0++ 2+ 6 min
    *** partially reqs: Tab2 [RNAi]
    *** partially reqs: Tab3 [RNAi]
    *** partially reqs: Tab2 and/or Tab3 [DRNAi]
    *** source: 14633987-Fig-7a

not Tab1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30+ 60++ 120++ 240++ min
    *** does not req: Tab1 [KO]
    *** source: 16260493(D)

Tak1--        protein expression

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HELA in BMS
    *** times: 0++ 2++ 5+ 10+ 20 60+ min
    *** partially reqs: Tak1 [RNAi]
    *** source: 12547194(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0+ 5+ 10 15 30+ min
    *** partially reqs: xTak1 [omission]
    *** source: 18617512-Fig-4d
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30+ min
    *** reqs: Tak1 [KO]
    *** source: 16186825(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0++ 15 30+ 60++ 120++ 240++ min
    *** reqs: Tak1 [KO]
    *** source: 16260493(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs in BMS
    *** times: 0++ 5++ 15+ 30 min
    *** reqs: Tak1 [KO]
    *** source: 17197697-Fig-8a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0++ 10+ 30+ 120+ min
    *** reqs: Tak1 [KO]
    *** enhanced by: CHX [addition]
    *** source: 17197697-Fig-5b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+++ 10++ 30+ 120+ min
    *** reqs: Tak1 [KO]
    *** source: 17197697-Fig-5a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0++ 5++ 20 min
    *** partially reqs: xTak1 [omission]
    *** source: 19112497-Fig-S2
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0+++ 5++ 15+ min
    *** reqs: xTak1 [omission]
    *** source: 19843958-Fig-2a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0+++ 5+ 15+ min
    *** reqs: xTak1 [omission]
    *** source: 19843958-Fig-2f
  *** Ikba[Ab] copptby[WB] Rela[Ab] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+++ 5++ 15+ 30 min
    *** partially reqs: Tak1 [KO]
    *** comment: the decrease in Ikba in ppt corresponds with decrease in total protein
    *** source: 17197697-Fig-8a

  --- requires Tak1 kinase activity

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMLS
    *** times: 0++ 2++ 5+ 10 30+ min
    *** inhibited by: xTak1(mnr)"KD" [addition]
    *** source: 18180283-Fig-6a

  --- requires Tak1 T178 T184 phos sites

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0+ 5+ 10 15 30+ min
    *** partially inhibited by: xTak1(T178A/T184A) [substitution]
    *** source: 18617512-Fig-4d

  --- requires Tak1 K209 K63 ubiq site

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0+++ 5++ 15+ min
    *** inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-2a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0++ 5++ 15+ 30+ min
    *** inhibited by: xTak1(K209R) [substitution]
    *** source: 19843958-Fig-2d

  --- does not req Tak1 T187 K172 K34

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0++ 5++ 20 min
    *** unaffected by: xTak1(T187A) [substitution]
    *** source: 19112497-Fig-S2
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0+++ 5++ 15+ min
    *** unaffected by: xTak1(K172R) [substitution]
    *** source: 19843958-Fig-2a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0+++ 5+ 15+ min
    *** unaffected by: xTak1(K34R) [substitution]
    *** source: 19843958-Fig-2f

  --- requires Tak1 K158

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<Tak1~null><xTak1> in BMS
    *** times: 0++ 5+ 10+ 15 30+ min
    *** reqs: xTak1 [omission]
    *** inhibited by: xTak1(K158R) [addition]
    *** source: 20038579-Fig-7b

not Tax1bp1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: mEFs<Tax1bp1~null><xTax1bp1> in BMS
    *** unaffected by: xTax1bp1(S593A) [substitution]
    *** unaffected by: xTax1bp1(S593A/S666A) [substitution]
    *** unaffected by: xTax1bp1(S666A) [substitution]
    *** source: 21765415-Fig-2f

not Tbk1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0++ 1+ 3+ 9 27++ 90++ min
    *** does not req: Tbk1 [KO]
    *** source: 10990461-Fig-5a

not Tirap--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (45 min)
    *** cells: hMDMacs in BMS
    *** unaffected by: xTirap(P125H)"DN" [addition]
    *** source: 14630816(D)

not Tnfaip3--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10 20 30 60++ 90++ 120++ 180+ min
    *** comment: return of signal after 60 min does not req Tnfaip3 [KO]
    *** source: 11009421-Fig-3f

not Tollip--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs in BMS
    *** times: 0++ 5+ 15 30+ 60++ 180++ min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)

not Traf2-- or Traf5--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 10 min
    *** does not req: Traf2 or Traf5 [DKO]
    *** source: 11479302-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (10 min)
    *** cells: mEFs in BMS
    *** does not req: Traf2 or Traf5 [DKO]
    *** source: 12842894-Fig-4
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (20 min)
    *** cells: EJ in BMS
    *** does not req: Traf2 [RNAi]
    *** source: 16260598-Fig-3e
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (20 min)
    *** cells: mEFs in BMS
    *** does not req: Traf2 [KO]
    *** source: 16260598-Fig-4d

Traf6--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0++ 5+ 20 min
    *** reqs: xTraf6 [omission]
    *** inhibited by: xTraf6(C70A) [substitution]
    *** unaffected by: xTraf6(mnr)"K32-518R" [substitution]
    *** unaffected by: xTraf6(K124R) [substitution]
    *** source: 19112497-Fig-S3
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs<Traf6~null><xTraf6> in BMS
    *** times: 0++ 5+ 15+ 30+ min
    *** inhibited by: xTraf6(110-522)"T6dR" [substitution]
    *** inhibited by: xTraf6(260-522)"T6dRZ" [substitution]
    *** source: 19843958-Fig-S9a

Ube1--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: U2OS in BMS
    *** times: 0+ 5+ 10 min
    *** reqs: Ube1 [RNAi]
    *** source: 19854138-Fig-S3c

not Ube2ds--

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: U2OS in BMS
    *** times: 0+ 5+ 15 min
    *** does not req: Ube2ds [RNAi]
    *** source: 19854138-Fig-4a

Ubc13-- ???

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: U2OS in BMS
    *** times: 0+ 10+ 20 min
    *** reqs: Ubc13 [RNAi]
    *** source: 19854138-Fig-3a,3b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: U2OS<Ubc13~null><xUbc13> in BMS
    *** times: 0+ 5+ 15 min
    *** inhibited by: xUbc13(C87A) [substitution]
    *** source: 19854138-Fig-3b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0++ 5+ 15+ min
    *** reqs: Ubc13 [KO]
    *** source: 19843958-Fig-4c
 --- contradiction within same paper -----------
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0++ 5+ 15 min
    *** does not req: Ubc13 [KO]
    *** source: 19843958-Fig-S8a

Ubiq--  K63-linked

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: U2OS in BMS
    *** times: 0+ 5+ 15 min
    *** reqs: Ubiq [RNAi]
    *** source: 19854138-Fig-2a,2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: U2OS<Ubiq~null><xUbiq> in BMS
    *** times: 0+ 5+ 15 min
    *** inhibited by: xUbiq(K63R) [substitution]
    *** source: 19854138-Fig-2b

===============
Ikba features--
===============

  *** xIkba[Ab] prot-exp[WB] is decreased irt IL1a (25 min)
    *** cells: HELA in BMS
    *** inhibited by: xIkba(S36A) [substitution]
    *** inhibited by: xIkba(S32A) [substitution]
    *** inhibited by: xIkba(S32A/S36A) [substitution]
    *** inhibited by: xIkba(D31A) [substitution]
    *** inhibited by: xIkba(D31A/D35A) [substitution]
    *** partially inhibited by: xIkba(S32T) [substitution]
    *** unaffected by: xIkba(S234A) [substitution]
    *** source: 8657102-Fig-2b

===========
chemicals--
===========

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMLS
    *** times: 0+ 10 30+ min
    *** inhibited by: MG132 [addition]
    *** source: 18180283-Fig-4a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMLS
    *** times: 0++ 2++ 5++ 10+ 20 30+ 40++ 50++ 60++ min
    *** source: 18180283-Fig-5c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: MRC5 in BMLS
    *** times: 0++ 2+ 5 12 30 60++ 120++ min
    *** inhibited by: LLL [addition]
    *** source: 9261174-Fig-5,7
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: MRC5 in BMLS
    *** times: 0++ 2++ 5+ 10 20 40 min
    *** inhibited by: LLL [addition]
    *** inhibited by: IEAL [addition]
    *** inhibited by: LLNV [addition]
    *** source: 9261174-Fig-5,7
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0++ 10+ 30+ 60++ min
    *** inhibited by: 5Z7Oxozeaenol [addition]
    *** source: 17197697-Fig-5c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** inhibited by: PS1145 [addition]
    *** source: 19754427-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (15 min)
    *** cells: HEK293<xIL1R1> in BMLS
    *** unaffected by: PP2 [addition]
    *** source: 19754427-Fig-3b
  *** Ikba[Ab] prot-exp[WB] is unchanged irt IL1b (15 min)
    *** cells: HEK293<xIL1R1><Irak1~null><xTpl2> in BMLS
    *** unaffected by: PS1145 [addition]
    *** source: 19754427-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (20 min)
    *** cells: HELA in BMS
    *** unaffected by: PP1 [addition]
    *** source: 16371247-Fig-5a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (20 min)
    *** cells: HELA in BMS
    *** unaffected by: SC514 [addition]
    *** source: 16371247-Fig-3c

=========
no extras
=========

  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: MRC5 in BMLS
    *** times: 0++ 1+ 2 4 10 min
    *** source: 9261174-Fig-3
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: MRC5 in BMLS
    *** times: 0++ 5+ 20 min
    *** source: 9261174-Fig-4
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (15 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** source: 10882101(D)
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0++ 2++ 5+ 15 30 min
    *** source: 11259596-Fig-8a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1><xTLR8> in BMS
    *** times: 0+ 15 30 min
    *** source: 16737960-Fig-1c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: mKidneyCells in BMS
    *** times: 0+ 15 30 min
    *** source: 16737960-Fig-1d
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: 3T3L1 in BMS "differentiated into adipocytes"
    *** times: 0++ 5 10 15 30+ 60++ min
    *** source: 17500068-Fig-4a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: EL4 in BMS
    *** times: 0++ 1++ 2++ 5+ 10+ min
    *** source: 10854325-Fig-2b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HELA in BMS
    *** times: 0++ 5+ 10 20 40+ 60++ min
    *** source: 11460167-Fig-4a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1a (times)
    *** cells: HEK293<xCd40> in BMS
    *** times: 0+ 30 300+ min
    *** source: 12374738-Fig-1d
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: HEK293 in BMS
    *** times: 0++ 10 30 120+ min
    *** source: 17197697-Fig-3c
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 15 30+ min
    *** source: 17197697-Fig-9a
  *** Ikba[Ab] prot-exp[WB] is decreased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0++ 15 30+ min
    *** source: 17197697-Fig-9a
  *** Ikba[Ab] prot-exp[WB] is unchanged irt IL1 (times)
    *** cells: mCECs in BMS
    *** times: 0+ 15+ 30+ min
    *** source: 17197697-Fig-9b
  *** Ikba[Ab] prot-exp[WB] is unchanged irt Lps (times)
    *** cells: mCECs in BMS
    *** times: 0+ 10+ 30+ min
    *** source: 17197697-Fig-9b
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0++ 5+ 15 30 45+ 60+ min
    *** source: 19675569-Fig-S5b
  *** Irak1[Ab] prot-exp[WB] is decreased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMLS
    *** times: 0+++ 5+ 15+ 30+ 45+ 60+ min
    *** source: 19754427-Fig-1a
  *** Ikba[Ab] prot-exp[WB] is decreased irt IL1 (times)
    *** cells: mEFs in BMS
    *** times: 0+ 15 30 60+ min
    *** source: 20185725-Fig-1b

===========
later times
===========

  *** Ikba[Ab] prot-exp[WB] is unchanged irt IL1 (times)
    *** cells: mBMDCs in BMS
    *** times: 0+ 2+ 4+ 6+ hr
    *** source: 20185725-Fig-3c
