===============
Kinase Activity
===============

IL2Rb--  ???

  *** S6ks[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (45 min)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS "IL3-deprived"
    *** unaffected by: xIL2Rb(del(264-322))"SD-1" [substitution]
    *** source: 7528328-Fig-3

Tsc2--  ???

  *** xS6k1[tAb]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (15 min)
    *** cells: HEK293<xTsc2> in BMS
    *** partially inhibited by: xTsc2(S1798A) [substitution]
    *** partially inhibited by: xTsc2(S939A/T1462A) [substitution]
    *** partially  inhibited by: xTsc2(S939A/T1462A/S1798A) [substitution]
    *** source: 15342917-Fig-5c

Chemicals

  *** xS6k1[tAb]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (15 min)
    *** cells: HEK293<xS6k1> in BMLS
    *** unaffected by: Wortmannin [pretreatment]
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** partially inhibited by: U0126 [pretreatment]
    *** source: 15342917-Fig-1a
  *** xS6k1[tAb]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (15 min)
    *** cells: HEK293<xTsc1><xTsc2><xS6k1> in BMLS
    *** unaffected by: Wortmannin [pretreatment]
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** inhibited by: U0126 [pretreatment]
    *** source: 15342917-Fig-1a
  *** S6ks[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (45 min)
    *** cells: BAF3<IL2Rb~null><xIL2Ra><xIL2Rb> in BMS "IL3-deprived"
    *** unaffected by: Wortmannin [pretreatment] no-bkg-control
    *** source: 7528328-Fig-5a
  *** S6ks[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (45 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** inhibited by: PMA (15 hr) [pretreatment]
    *** source: 7528328-Fig-2
  *** S6ks[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (45 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** unaffected by: Wortmannin [pretreatment] no-bkg-control
    *** inhibited by: Rapamycin [pretreatment] no-bkg-control
    *** source: 7528328-Fig-5b
  *** S6ks[Ab]IP IVKA(snr)[32P-ATP] is increased irt PMA (20 min)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** partially inhibited by: Wortmannin [pretreatment]
    *** source: 7760801-Fig-3

no extras

  *** S6k1[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (times)
    *** cells: SWISS3T3 in BMLS
    *** times: 0 5++ 10++ 15+++ 20++ 30++ 45+ 60+ 75+ 90+ 120+ 240+ min
    *** source: 1848664-Fig-2
  *** xS6k1[tAb]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (15 min)
    *** cells: HEK293 in BMS
    *** source: 15342917-Fig-5c
  *** S6ks[Ab]IP IVKA(Rps6)[32P-ATP] is increased irt PMA (45 min)
    *** cells: CTLL20 in BMS "IL2-deprived"
    *** source: 7528328-Fig-1c
  *** S6ks[Ab]IP IVKA(snr)[32P-ATP] is increased irt PMA (20 min)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** bkg inhibited by: Rapamycin [pretreatment]
    *** source: 7760801-Fig-3


===============
Phosphorylation
===============

Chemicals

  *** S6k1[phosAb] phos(T412)[phosAb] is increased irt PMA (15 min)
    *** cells: HEK293 in BMS
    *** inhibited by: U0126 [pretreatment]
    *** inhibited by: Bisindolylmaleimide-I [pretreatment]
    *** partially inhibited by: Wortmannin [pretreatment]
    *** inhibited by: Rapamycin [pretreatment]
    *** source: 15342917-Fig-1b
  *** xS6k1[phosAb] phos(T412)[phosAb] is increased irt PMA (30 min)
    *** cells: HEK293<xS6k1> in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 15851026-Fig-5a
  *** S6k1[phosAb] phos(T412)[phosAb] is unchanged irt PMA (5 min)
    *** cells: 3T3L1 in BMLS "AminoAcid deprived" "differentiated into adipocytes"
    *** source: 16541103-Fig-8c

no extras

  *** S6k1[phosAb] phos(T444/S447)[phosAb] is increased irt PMA (45 min)
    *** cells: HEK293 in BMLS
    *** source: 12777372-Fig-3b

