===============
Kinase Activity
===============

  *** Jak2[Ab]IP IVKA(auto)[32P-ATP] is increased irt (IL6 + IL6Rsol) (10 min) 
    *** cells: BAFB03<xGp130> in BMLS
    *** partially inhibited by: xGp130(1-707)"IC65" [substitution]
    *** inhibited by: xGp130(1-693)"IC51" [substitution]
    *** inhibited by: xGp130(P656S/P658S) [substitution]
    *** source: 8134389-Fig-3c
  *** Jak2[Ab]IP IVKA(auto)[32P-ATP] is increased irt (IL6 + IL6Rsol) (10 min) 
    *** cells: BAFB03<xGp130> in BMLS
    *** source: 8134389-Fig-2c
  *** Jak2[Ab]IP IVKA(auto)[32P-ATP] is increased irt (IL6 + IL6Rsol) (10 min) 
    *** cells: M1 in BMLS
    *** source: 8134389-Fig-2c
  *** Jak2[Ab]IP IVKA(auto)[32P-ATP] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: 2FTGH in BMS
    *** source: 7537214-Fig-3
  *** Jak2[Ab]IP IVKA(auto)[32P-ATP] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: U4A<Jak1~null> in BMS
    *** source: 7537214-Fig-3

===========================
Phosphorylation on Tyrosine
===========================

not Jak1--

  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: U4A<Jak1~null> in BMS
    *** source: 7537214-Fig-2a
  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: U4A<Jak1~null><xJak1> in BMS
    *** source: 7537214-Fig-2a

not Tyk2--

  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: U1D<Tyk2~null> in BMS
    *** source: 7537214-Fig-2a

Jak2 features

  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: 2C4 in BMS
    *** unaffected by: xJak2(mnr)"KD" [addition]
    *** source: 7537214-Fig-7c

chemicals

  *** Jak2[Ab]IP Yphos[pYAb] is increased irt IL6 (10 min)
    *** cells: KAS61 in BMS "IL6 deprived for 24 hr"
    *** unaffected by: 15dPGJ2 [pretreatment]
    *** unaffected by: Troglitazone [pretreatment]
    *** unaffected by: Troglitazone + GW9662 [pretreatment]
    *** unaffected by: WY14643 [pretreatment]
    *** source: 14975242-Fig-3b

No extras

  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (5 min)
    *** cells: EW1 in BMLS
    *** source: 8272873-Fig-2a
  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (5 min)
    *** cells: SKMES in BMLS
    *** source: 8272873-Fig-2c
  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (10 min)
    *** cells: BAFB03<xGp130> in BMLS
    *** source: 8134389-Fig-2a
  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (10 min)
    *** cells: M1 in BMLS
    *** source: 8134389-Fig-2a
  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (15 min)
    *** cells: 2FTGH in BMS
    *** source: 7537214-Fig-2a
  *** Jak2[Ab]IP Yphos[pYAb] is increased irt (IL6 + IL6Rsol) (times)
    *** cells: M1 in BMLS
    *** times: 0 2+ 5+ 15+ 30 min
    *** source: 8134389-Fig-2b
  *** Jak2[Ab]IP Yphos[pYAb] is increased irt IL6 (15 min)
    *** cells: 2FTGH in BMS
    *** source: 7537214-Fig-1c


================
Coprecipitations
================

  *** xJak2[Ab] copptby[WB] xShp2[Ab] is detectable-but unchanged irt (IL6 + IL6Rsol) (15 min)
    *** cells: GAMMA2A<Jak2~null><xJak2> in BMS
    *** source: 9794795-Fig-4b
