==========================
RapGef1 is a Gef for Rap1a
==========================

  *** rRap1a GDP-dissociation[3H-GDP] is increased by rRapGef1
    *** cells: none
    *** source: 8524240-Fig-1a,2a
  *** rRap1a GDP-dissociation[3H-GDP] is increased by rRapGef1
    *** cells: none
    *** unaffected by: rCrkL [addition]
    *** source: 9268367-Fig-5a
  *** rRap1a GDP-dissociation[Mant-GDP] is increased by rRapGef1
    *** cells: none
    *** source: 10913189-Fig-2b
  *** rRap1a GDP-dissociation[3H-GDP] is increased by xRapGef1[tAb]IP
    *** cells: none
    *** source: 11309621-Fig-4a

=================================================
Rap1a{GTP} is increased in the presence of RapGef1
=================================================

  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: COS7 in BMS
    *** source: 8524240-Fig-4
  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: HEK293T in BMS
    *** source: 9789079-Fig-2c
  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: HEK293T in BMS
    *** source: 9856955-Fig-2a
  *** xRap1a[tAb]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: HEK293 in BMS
    *** source: 10896938-Fig-1c
  *** xRap1a[tAb]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: HEK293T in BMS
    *** source: 10835426-Fig-3a
  *** xRap1a[tAb]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: HEK293T in BMS
    *** source: 10913189-Fig-2a
  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: COS1 in BMS
    *** enhanced by: xCrkI [addition]
    *** source: 10318861-Fig-6a
  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: COS1 in BMS
    *** enhanced by: xCrkI [addition]
    *** unaffected by: xRapGef1(mnr)"farnesylated" [substitution]
    *** source: 10318861-Fig-1a
  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: COS1 in BMS
    *** unaffected by: xRapGef1(62-1077) [substitution]
    *** unaffected by: xRapGef1(391-1077) [substitution]
    *** enhanced by: xRapGef1(580-1077) [substitution]
    *** source: 10318861-Fig-6a
  -------------------------------------------------------------
  *** xRap1a[tAb] GTP-association[BDPD] is increased itpo xRapGef1
    *** cells: HEK293T in BMS
    *** source: 10913189-Fig-1b
  *** xRap1a[tAb] GTP-association[BDPD] is increased itpo xRapGef1
    *** cells: HEK293T in BMS
    *** source: 12432078-Fig-2a
  *** xRap1a[tAb] GTP-association[BDPD] is increased itpo xRapGef1
    *** cells: HEK293T in BMLS
    *** source: 10934204-Fig-3b
  *** xRap1a[tAb] GTP-association[BDPD] is increased itpo xRapGef1
    *** cells: COS7 in BMS
    *** source: 10608883-Fig-3b
  *** xRap1a[tAb] GTP-association[BDPD] is increased itpo xRapGef1
    *** cells: HEK293T in BMLS
    *** source: 10747847-Fig-3b
  *** xRap1a[tAb] GTP-association[BDPD] is increased itpo xRapGef1
    *** cells: COS7 in BMS
    *** source: 10889189-Fig-4b
  -------------------------------------------------------------
  *** Rap1s[Ab] GTP-association[BDPD] is increased itpo xRapGef1
    *** cells: NIH3T3 in BMS
    *** source: 12734187-Fig-5g

enhanced by Crk

  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: COS1 in BMS
    *** enhanced by: xCrk [addition]
    *** unaffected by: xCrk(W169L) [addition]
    *** source: 9268367-Fig-2a

enhanced by CrkI

  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: COS1 in BMS
    *** enhanced by: xCrkI [addition]
    *** unaffected by: xCrkI(R38V) [addition]
    *** source: 9268367-Fig-2a
  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xCrkI
    *** cells: COS1<xRapGef1> in BMS
    *** inhibited by: xRapGef1(Y504F) [substitution]
    *** unaffected by: xRapGef1(Y554F/Y561F/Y570F) [substitution]
    *** unaffected by: xRapGef1(Y478F/Y485F/Y579F) [substitution]
    *** source: 10318861-Fig-7b

enhanced by CrkL

  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: COS1 in BMS
    *** enhanced by: xCrkL [addition]
    *** source: 9268367-Fig-3a
  *** xRap1a[tAb]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: PC12 in BMLS
    *** enhanced by: xCrkL [addition]
    *** source: 9560161-Fig-4d

enhanced by Grb2

  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: COS1 in BMS
    *** enhanced by: xGrb2 [addition]
    *** source: 9268367-Fig-3a

inhibited by Rap1Gap2

  *** xRap1a[tAb]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: HEK293T in BMS
    *** inhibited by: xRap1Gap2 [addition]
    *** source: 10913189-Fig-4a

inhibited by Sip1a

  *** xRap1a[tAb]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: HEK293T in BMS
    *** inhibited by: xSipa1 [addition]
    *** source: 10913189-Fig-4a
  *** xRap1a[tAb] GTP-association[BDPD] is increased itpo xRapGef1(mnr)"CAAX"
    *** cells: HEK293T in BMS
    *** inhibited by: xSipa1 [addition]
    *** source: 10373454(D)

==================
RapGef1 attributes: requires RapGef1-phos(Y504)
==================

  *** xRap1a[GST]IP GTP-association[TLC] is increased itpo xRapGef1
    *** cells: COS1 in BMS
    *** enhanced by: xRapGef1(619-1077)"CatDom" [substitution]
    *** source: 9268367-Fig-4a
  *** Rap1s[Ab] GTP-association[BDPD] is increased itpo xRapGef1
    *** cells: NIH3T3 in BMS
    *** inhibited by: xRapGef1(Y504F) [addition]
    *** source: 12734187-Fig-5g


