===============
Tak1 activation
===============

  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 1 2++ 5++ 15 30 min
    *** source: 11259596-Fig-8a
  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt IL1b (5 min)
    *** cells: HEK293 in BMS
    *** source: 11259596-Fig-2
  *** Tak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL1b (5 min)
    *** cells: HEK293 in BMS
    *** source: 11259596-Fig-2
  *** Tak1[Ab]IP IVKA(snr)[32P-ATP] is increased irt IL1b (30 min)
    *** cells: HEK293 in BMS
    *** source: 11518704-Fig-6a
  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt IL1b (times)
    *** cells: HELA in BMS
    *** times: 0 2+++ 5++ 10++ 20 min
    *** source: 15327770(D)
  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt IL1 (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 3+ 6++ min
    *** source: 10094049-Fig-1a
  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt IL1 (10 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** source: 10702308-Fig-1

  *** Tak1[Ab]IP IVKA(Mkk6,P38a,MBP)[32P-ATP] is increased irt IL1a (times)
    *** cells: mEFs in BMLS
    *** times: 0 5++ 10+ min
    *** bkg reqs: Tab1 [KO]
    *** source: 18021073-Fig-7a

============
Tab1-IP-IVKA
============

  *** Tab1[Ab]IP IVKA(Mkk6,P38a)[32P-ATP] is increased irt IL1a (20 min)
    *** cells: mEFs in BMS
    *** enhanced by: SB203580 [addition] no-bkg-control
    *** source: 14592977-Fig-9a
  *** Tab1[Ab]IP IVKA(Mkk6,P38a)[32P-ATP] is increased irt IL1a (20 min)
    *** cells: mEFs in BMS
    *** repressed by: P38a [KO]
    *** source: 14592977-Fig-9a
  *** Tab1[Ab]IP IVKA(Mkk6,P38a)[32P-ATP] is increased irt IL1a (times)
    *** cells: KB in BMS
    *** times: 0 5 10+ 20++ 30+ min
    *** enhanced by: SB203580 [addition] no-bkg-control
    *** source: 14592977-Fig-8a

============
Tab2-IP-IVKA  Tab2 is constitutively bound to Tak1
============

  *** Tab2[Ab]IP IVKA(Mkk6/P38a/MBP)[32P-ATP] is increased irt IL1a (20 min)
    *** cells: KB in BMLS
    *** enhanced by: SB203580 [addition]
    *** source: 14670075-Fig-4a
  --------------------------------------------------------------------------
  *** Tak1[Ab] copptby[WB] Tab2[Ab] is unchanged irt IL1b (times)
    *** cells: KB in BMLS
    *** times: 0+ 20+ min
    *** comment: coppt Tak1 phos[WBMS] increases with time
    *** source: 14670075-Fig-4a
  *** Tak1[Ab] copptby[WB] Tab2[Ab] is unchanged irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0+ 3+ 15+ min
    *** comment: coppt Tak1 phos[WBMS] increases with time
    *** source: 14633987-Fig-5a
  *** Tak1[Ab] copptby[WB] Tab2[Ab] is unchanged irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMLS
    *** times: 0+ 2+ 5+ 10+ 20+ 30+ 40+ 50+ 60+ min
    *** source: 18180283-Fig-5a
  *** Tak1[Ab] copptby[WB] Tab2[Ab] is unchanged irt IL1b (times)
    *** cells: HEK293 in BMS
    *** times: 0+ 10+ min
    *** source: 12242293-Fig-5a
  --------------------------------------------------------------------------
  *** xTak1[Ab] copptby[WB] Tab2[Ab] is increased irt IL1 (10 min)
    *** cells: mEFs<Tak1~null> in BMS
    *** source: 19843958-Fig-S3

============
Tab3-IP-IVKA  Tab3 is constitutively bound to Tak1
============

  *** Tab3[Ab]IP IVKA(Mkk6,P38a,MBP)[32P-ATP] is increased irt IL1a (20 min)
    *** cells: KB in BMLS
    *** enhanced by: SB203580 [addition]
    *** source: 14670075-Fig-4a
  ----------------------------------------------------------------------
  *** Tak1[Ab] copptby[WB] Tab3[Ab] is unchanged irt IL1b (times)
    *** cells: KB in BMLS
    *** times: 0+ 20+ min
    *** comment: coppt Tak1 phos[WBMS] increases with time
    *** source: 14670075-Fig-4a
  *** Tak1[Ab] copptby[WB] Tab3[Ab] is unchanged irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0+ 3+ 15++ min
    *** comment: coppt Tak1 phos[WBMS] increases with time
    *** source: 14633987-Fig-5a

===================
effect of chemicals
===================

  *** Tak1[Ab]IP IVKA(Mkk6)[32P-ATP] is increased irt IL1b (times)
    *** cells: HEK293<xIL1R1> in BMS
    *** times: 0 1++ 2+ 5 min
    *** inhibited by: Okadaic-acid [addition]
    *** source: 17079228(D)

