=================
Direct Activation
=================

  *** rJnk1 IVKA(Jun)[32P-ATP] is increased by rMkk4
    *** cells: none
    *** source: 9384583-Fig-1b

  *** rJnk3[32P] phos[32P-ATP] is increased by (rTaok1(1-416)"CA" + rMkk4)
    *** cells: none
    *** reqs: both [omissions]
    *** source: 9786855-Fig-4b

======================
Direct Phosphorylation
======================

  *** rJnk3[32P] phos[32P-ATP] is increased by rMkk4
    *** cells: none
    *** enhanced by: rTaok2(1-320)"CA" [addition]
    *** source: 10497253-Fig-2a

====================
Protein Association
====================

  *** xJnk1[tAb] copptby[WB] xMkk4[tAb] is detectable
    *** cells: COS1 in BMS
    *** inhibited by: xMkk4(mnr) [substitution]
    *** inhibited by: xMekk1(CatDom)"CA" [addition]
    *** source: 9808624-Fig-6a,6d

===============
Activation itpo
===============

  *** xJnk1[Ab]IP IVKA(Jun)[32P-ATP] is increased itpo xMkk4
    *** cells: COS in BMS
    *** source: 11390361-Fig-2
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased itpo xMkk4
    *** cells: COS7 in BMS
    *** source: 9384583-Fig-1a

requires Mkk4 kinase activity

  *** xJnk3[tAb]IP IVKA(Jun)[32P-ATP] is decreased itpo xMkk4(S220A/T224L)
    *** cells: COS in BMS
    *** source: 8702571-Fig-2b

contradiction

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is unchanged itpo xMkk4
    *** cells: HEK293T<xJnk1> in BMS
    *** source: 10575011-Fig-1c
