not Jnks

  *** Irs1[Ab]IP Yphos[pYAb] is increased irt Ins (times)
    *** cells: mEFs in BMLS
    *** times: 0 2+ 10+ 20+ 40+ min
    *** does not req: Jnk1 or Jnk2 [DKO]
    *** source: 12417588-Fig-3

Yphos

  *** Irs1[Ab]IP Yphos[pYAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** partially inhibited by: xInsR(Y1158F) [substitution]
    *** partially inhibited by: xInsR(Y1162F/T1163F) [substitution]
    *** inhibited by: xInsR(Y1158F/T1162F) [substitution]
    *** source: 7806540-Fig-3
  *** Irs1[Ab]IP Yphos[pYAb] is increased irt Ins (times)
    *** cells: FAO in BMLS
    *** times: 0 1++ 10+ min
    *** source: 10688912(D)
  *** Irs1[Ab]IP Yphos[pYAb] is increased irt Ins (2 min)
    *** cells: NIH3T3 in BMS
    *** source: 8995447-Fig-1
  *** xIrs1[Ab]IP Yphos[pYAb] is increased irt Ins (times)
    *** cells: 32D<xInsR><xIrs1> in BMS
    *** times: 0 1+ 5+ 10+ 20+ min
    *** unaffected by: xIrs1(L856G/L858G) [substitution]
    *** source: 12417588-Fig-5a
  *** Irs1[Ab]IP Yphos[pYAb] is increased irt Ins (times)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** times: 0 2+ 5++ 10++ 20+ min
    *** source: 12417588-Fig-6
  *** Irs1[Ab]IP Yphos[pYAb] is increased irt Ins (1 min)
    *** cells: rHepatocytes in BMLS
    *** unaffected by: PP1 [addition] no-bkg-control
    *** source: 12464621-Fig-1b
  *** Irs1[Ab]IP Yphos[pYAb] is increased irt Ins (30 min)
    *** cells: MDAMB453 in BMLS
    *** enhanced by: xTsc1 [addition]
    *** enhanced by: xTsc1(mnr)"SSAA" [addition]
    *** unaffected by: xTsc1(mnr)"SSDD" [addition]
    *** source: 18949383-Fig-2a

phos(S307)

  *** Irs1[Ab]IP phos(S307)[phosAb] is increased irt Ins (times)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** times: 0 2+ 5++ 10++ 20+ min
    *** source: 12417588-Fig-6
  *** xIrs1[phosAb] phos(S307)[phosAb] is increased irt Ins (15 min)
    *** cells: 32D<xInsR><xIrs1> in BMS
    *** partially inhibited by: PD98059 [addition]
    *** source: 12417588-Fig-2a
  *** xIrs1[phosAb] phos(S307)[phosAb] is increased irt Ins (15 min)
    *** cells: 32D<xInsR><xIrs1> in BMS
    *** partially inhibited by: LY294002 [addition]
    *** source: 12417588-Fig-2a
  *** Irs1[phosAb] phos(S307)[phosAb] is increased irt Ins (times)
    *** cells: 32D<xInsR><xIrs1> in BMS
    *** times: 0+ 1+ 5++ 10++ 20++ min
    *** source: 12417588-Fig-5a

phos(S636/S639)

  *** Irs1[phosAb] phos(S636/S639)[phosAb] is increased irt Ins (10 min)
    *** cells: 3T3L1 in BMLS
    *** does not req: Pras40 [RNAi]
    *** source: 17277771-Fig-3d
  *** Irs1[phosAb] phos(S636/S639)[phosAb] is increased irt Ins (10 min)
    *** cells: 3T3L1<xPras40> in BMLS
    *** inhibited by: xPras40(T246A) [substitution]
    *** source: 17277771-Fig-3d


Grb10  inhibition

  *** Irs1[Ab]IP Yphos[pYAb] is increased irt Ins (5 min)
    *** cells: 3T3L1 in BMLS "differentiated into adipocytes"
    *** inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-3a
  *** xIrs1[tAb]IP Yphos[pYAb] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-6b
  *** xIrs1[tAb]IP Yphos[pYAb] is increased irt Ins (10 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-2a
  *** xIrs1[tAb]IP Yphos[pYAb] is increased irt Ins (10 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-2b
  *** xIrs1[tAb]IP Yphos[pYAb] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMLS
    *** times: 0 1+ 3+ 5+ 10+ 30+ 60+ min
    *** inhibited by: xGrb10 [addition]
    *** source: 12493740-Fig-4a




