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Irak1 kinase-activity is increased in response to IL1
=====================================================

  *** Irak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL1a (1 min)
    *** cells: MRC5 in BMLS
    *** source: 9261174-Fig-1c
  *** xIrak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL1b (times)
    *** cells: EL4 in BMS
    *** times: 0 5+ 90++ 120++ min
    *** source: 15896328-Fig-1b
  *** xIrak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL1b (times)
    *** cells: EL4 in BMS
    *** times: 0 5+ 90++ 120+++ min
    *** source: 15896328-Fig-1c
  *** xIrak1[Ab]IP IVKA(HistH1)[32P-ATP] is increased irt IL1b (times)
    *** cells: EL4 in BMS
    *** times: 0 5+ 90++ 120++ min
    *** source: 15896328-Fig-1c
  *** xIrak1[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL1b (times)
    *** cells: EL4 in BMS
    *** times: 0 5+ 90++ 120++ min
    *** source: 15896328-Fig-1c
  *** xIrak1[tAb]IP IVKA(auto)[32P-ATP] is increased irt IL1b (times)
    *** cells: EL4 in BMS
    *** times: 0 5 90+ 120+ min
    *** source: 15896328-Fig-1b
  *** Irak1[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL1b (times)
    *** cells: EL4 in BMS
    *** times: 0 10++ 60+ min
    *** unaffected by: xIrak1(K239S)"KD" [addition]
    *** source: 10217414-Fig-1a
  *** xIrak1[Ab]IP IVKA(MBP)[32P-ATP] is increased irt IL1b (times)
    *** cells: EL4 in BMS
    *** times: 0 10++ 60++ min
    *** source: 10217414-Fig-1a

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Irak1 phos is increased in response to IL1
==============================================

  *** Irak1[Ab] phos[WBMS-PPase] is increased irt IL1b (times)
    *** cells: HEK293<xTLR8> in BMS
    *** times: 0 5+ 15+ 30+ 60+ 120+ min
    *** source: 16737960-Fig-2e
  *** Irak1[Ab] upshift[WBMS] is increased irt IL1b (30 min)
    *** cells: HEK293<xIL1R1> in BMS
    *** comment: upshift inhibited by treatment of lysates with ProteinPhosphatase1
    *** source: 14625308-Fig-6b
  *** Irak1[Ab]IP phos[32Pi] is increased irt IL1b (15 min)
    *** cells: HEK293 in BMS
    *** source: 11518704-Fig-1b

phos occurs in Irak1 hyperphos region (104-198)

  *** Irak1[Ab]IP phos[32Pi] is unchanged irt IL1b (15 min)
    *** cells: HEK293I1A<Irak1~null><xIrak1(del(104-198))"dUD"> in BMS
    *** source: 11518704-Fig-1b


xxxx leave out fractionation evidence until someone confirms with IHC xxxxx


