phos(Y221)

  *** xCrk[phosAb] phos(Y221)[phosAb] is increased irt Egf (times)
    *** cells: HEK293T<xEgfR> in BMLS
    *** times: 0 1+ 3+ 10+ min
    *** source: 9642287-Fig-6c
  *** xCrk[phosAb] phos(Y221)[phosAb] is increased irt Egf (3 min)
    *** cells: HEK293T<xEgfR> in BMLS
    *** source: 9642287-Fig-3a
  *** Crk[Ab] phos(Y221)[phosAb-ppt] is increased irt Egf  (3 min)
    *** cells: mEFs<Abl1~null> in BMLS
    *** source: 9642287-Fig-3b
  *** xCrk[phosAb] phos(Y221)[phosAb] is increased irt Egf (3 min)
    *** cells: HEK293T<xEgfR> in BMLS
    *** inhibited by: xCrk(Y221F) [substitution]
    *** inhibited by: xCrk(R38V)"SH2-domain-mut" [substitution]
    *** unaffected by: xCrk(W169L)"SH3-domain-mut" [substitution]
    *** source: 9642287-Fig-5

Yphos

  *** xCrk[Ab]IP Yphos[pYAb] is increased irt Egf (times)
    *** cells: HEK293T<xEgfR> in BMLS
    *** times: 0+ 1++ 3++ 10++ min
    *** source: 9642287-Fig-6c

EgfR coppt

  *** xEgfR[Ab] copptby[WB] xCrk[Ab] is increased irt Egf (times)
    *** cells: HEK293T in BMLS
    *** times: 0 1++ 3++ 10+ min
    *** source: 9642287-Fig-6c
  *** Crk[Ab] copptby[WB] EgfR[Ab] is increased irt Egf (times)
    *** cells: HELA in BMLS
    *** times: 0 2+ 10++ min
    *** source: 16729043-Fig-5b
  *** EgfR[Ab] copptby[WB] Crk[Ab] is decreased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0++ 2++ 5++ 15++ 30+ 60 min
    *** comment: total EgfR was not shown so decrease could be due to decreased protein levels
    *** source: 11278445-Fig-6


================================================
Coprecipitation with other EgfR binding proteins
================================================

  *** Crk[Ab] copptby[WB] Bcar1[Ab] is increased irt Egf (5 min)
    *** cells: RAT1<xEgfR> in BMLS
    *** source: 9325334-Fig-5
  *** Bcar1[Ab] copptby[WB] Crk[Ab] is decreased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0++ 2 5+ 15+ 30++ 60++ min
    *** source: 11278445-Fig-5c
  *** Bcar1[Ab] copptby[WB] Crk[Ab] is decreased irt Egf (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0+ 5+ 10 20 min
    *** source: 9348226-Fig-1b


  *** Crk[Ab] copptby[WB] RapGef1[Ab] is decreased irt Egf (times)
    *** cells: CHO<xInsR><xEgfR> in BMLS
    *** times: 0+++ 1++ 2++ 5+ 15+ 30+ min
    *** source: 9353263-Fig-3b

  *** Efs[Ab] copptby[WB] Crk[Ab] is decreased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0++ 10 30+ min
    *** source: 11278445-Fig-5d
