=================
Required Proteins
=================

Gnai1-- and/or Gnai3--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (15 min)
    *** cells: mEFs in BMLS
    *** reqs: Gnai1 and/or Gnai3 [KO]
    *** source: 19401591-Fig-1a
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (times)
    *** cells: mEFs in BMLS
    *** times: 0 2 5+ 15++ 30++ min
    *** reqs: Gnai1 and/or Gnai3 [KO]
    *** source: 19401591-Fig-1b
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (times)
    *** cells: mEFs in BMLS
    *** times: 0 10+ 20+ min
    *** inhibited by: xGnai1(G202T)"DN" + xGnai3(G202T)"DN" [addition]
    *** source: 19401591-Fig-3c
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (times)
    *** cells: mEFs in BMLS
    *** times: 0 10+ 20+ min
    *** partially reqs: Gnai3 [KO]
    *** reqs: Gnai1 and/or Gnai3 [KO]
    *** source: 19401591-Fig-1c
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (times)
    *** cells: mEFs<Gnai1~null><Gnai3~null><xGnai1> in BMLS
    *** times: 0 10+ 20++ min
    *** reqs: xGnai1 [omission]
    *** source: 19401591-Fig-3b
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (times)
    *** cells: mEFs<Gnai1~null><Gnai3~null><xGnai3> in BMLS
    *** times: 0 10+ 20++ min
    *** reqs: xGnai3 [omission]
    *** source: 19401591-Fig-3b

not Gnai2--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (times)
    *** cells: mEFs in BMLS
    *** times: 0 2 5+ 15++ 30++ min
    *** does not req: Gnai2 [KO]
    *** source: 19401591-Fig-1d

not Rictor--

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (5 min)
    *** cells: mEFs in BMLS
    *** does not req: Rictor [KO]
    *** source: 21464307-Fig-S4a

chemicals

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (30 min)
    *** cells: HEK293E in BMLS
    *** inhibited by: Rapamycin [addition]
    *** source: 16286006-Fig-1d
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (times)
    *** cells: HC11 in BMLS
    *** times: 0 7+ 15+ min
    *** bkg inhibited by: LY294002 [addition]
    *** bkg inhibited by: Rapamycin [addition]
    *** source: 16984645-Fig-5
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (15 min)
    *** cells: HEK293E in BMLS
    *** partially inhibited by: FMK [pretreatment]
    *** source: 17360704-Fig-4b
  *** Rps6[phosAb] phos(S240/S244)[phosAb] is increased irt Egf (15 min)
    *** cells: HEK293E in BMLS
    *** partially inhibited by: FMK [pretreatment]
    *** source: 17360704-Fig-4b

special cases

  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (times)
    *** cells: HC11 in BMLS "containing Ins"
    *** times: 0 7+ 15+ min
    *** inhibited by: LY294002 [addition]
    *** unaffected by: PD98059 [addition]
    *** source: 16984645-Fig-4c
  *** Rps6[phosAb] phos(S235/S236)[phosAb] is increased irt Egf (times)
    *** cells: HC11 in BMLS "containing Ins"
    *** times: 0+ 7++ 15+ min
    *** bkg inhibited by: LY294002 [addition]
    *** bkg inhibited by: Rapamycin [addition]
    *** source: 16984645-Fig-4b

