===========================
Phosphorylation on Tyrosine
===========================

IL4R--

  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL4 (30 min)
    *** cells: 32D<xIrs2><xIL4R> in BMS "IL3-deprived"
    *** reqs: xIL4R [omission]
    *** unaffected by: xIL4R(Y713F) [substitution]
    *** source: 11714803-Fig-5a
  *** Jak1[phosAb] phos(Y1022/Y1023)[phosAb] is increased irt IL4 (times)
    *** cells: mSpCs in BMS "blasted with anti-TcRb/IL2"
    *** times: 0 1+ 5+ min
    *** unaffected by: kIL4R(Y500F) [knockin]
    *** source: 14557412-Fig-2a

inhibited by xSocs1--

  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL4 (10 min)
    *** cells: M1241 in BMLS
    *** partially inhibited by: xSocs1 [addition]
    *** source: 10201892-Fig-3a

Unaffected by xSocs2--

  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL4 (10 min)
    *** cells: M1241 in BMLS
    *** unaffected by: xSocs2 [addition]
    *** source: 10201892-Fig-3b

Unaffected by xSocs3--

  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL4 (10 min)
    *** cells: M1241 in BMLS
    *** unaffected by: xSocs3 [addition]
    *** source: 10201892-Fig-3c

No extras

  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL4 (5 min)
    *** cells: HT29 in BMS
    *** source: 8609418-Fig-2a
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL4 (5 min)
    *** cells: WIDR in BMS
    *** source: 8609418-Fig-2a
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL4 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7568001-Fig-1b
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL4 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7973658-Fig-1a
  *** Jak1[Ab]IP Yphos[pYAb] is increased irt IL4 (15 min)
    *** cells: KIT225 in BMLS "IL2-deprived"
    *** source: 7760829-Fig-4c
  *** Jak1[phosAb] phos(sitenr)[phosAb] is increased irt IL4 (times)
    *** cells: mSpCs<Cd4~neg><Cd45~neg><Cd8~pos> in BMS "treated with anti-Cd3,anti-Cd28/IL2"
    *** times: 0 5++ 15++ 30+ min
    *** source: 17200144-Fig-3

===============
Kinase Activity
===============

  *** Jak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL4 (10 min)
    *** cells: M1241 in BMLS
    *** inhibited by: xSocs1 [addition]
    *** source: 10201892-Fig-3d
  *** Jak1[Ab]IP IVKA(auto)[32P-ATP] is increased irt IL4 (15 min)
    *** cells: hPHAblasts in BMS
    *** source: 7973658-Fig-1f

================================
Recruitment to IL4R complex ???
================================

  *** Jak1[Ab] copptby[WB] IL2Rb[Ab] is unchanged irt IL4 (15 min)
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3b
  *** Jak1[Ab] copptby[WB] IL2Rg[Ab] is unchanged irt IL4 (15 min)
    *** cells: hIL2RTCs in BMLS "IL2-deprived"
    *** source: 7973657-Fig-3a
  *** Jak1[Ab] copptby[WB] IL4R[Ab] is unchanged irt IL4 (5 min)
    *** cells: HT29 in BMS
    *** comment: anti-IL4R Ab "P7" sees wrong size protein (140 kD)
    *** source: 8609418-Fig-3b

============================================
Coppt with other members of IL4R complex ???
============================================

  *** Jak1[Ab] copptby[WB] Irs1[Ab] is unchanged irt IL4 (times)
    *** cells: hPBMCs in BMLS
    *** times: 0+ 15+ min
    *** source: 7499365-Fig-2b
  *** Jak1[Ab] copptby[WB] xFes[tAb] is unchanged irt IL4 (times)
    *** cells: M1241 in BMS
    *** times: 0+ 1+ 5+ 15+ 30+ 60+ min
    *** source: 11160325-Fig-2c
