Ampka1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 5+ 15+ 30+ 45+ 60+ min
    *** reqs: Ampka1 [RNAi]
    *** source: 22833096-Fig-2g

Casp1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 5+ 15++ 30++ min
    *** reqs: Casp1 [KO]
    *** source: 17360653(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 5++ 15++ 30+ min
    *** reqs: Casp1 [KO]
    *** source: 17360653(D)

Ciap1-- Ciap2--  ???

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: KMS28BM in BMS
    *** times: 0 10+ 30+ min
    *** partially reqs: Ciap1 and/or Ciap2 [fmut]
    *** source: 19898473-Fig-S2b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5+ 10++ 30++ min
    *** partially reqs: Ciap1 and/or Ciap2 [RNAi]
    *** source: 19898473-Fig-S2a

not Ikke--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS "immortalized"
    *** times: 0 20+ 40 min
    *** does not req: Tbk1 or Ikke [DKO]
    *** source: 15210742-Fig-6c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 20++ 40+ min
    *** does not req: Ikke [KO]
    *** source: 15210742-Fig-3b

Irak1--

  *** P38s[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 7 15+ 30+ 60 90 min
    *** partially reqs: Irak1 [KO]
    *** source: 10754329-Fig-3b

not Irak3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10 20+ 60 min
    *** does not req: Irak3 [KO]
    *** source: 12150927-Fig-4b

not Irak4--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30 min
    *** unaffected by: kIrak4(K213M/K214M)"KD" [knockin]
    *** source: 17470642-Fig-6b

Mekk1-- ???

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mESCs in BMS
    *** times: 0 30+ 60 120 min
    *** inhibited by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 10805784-Fig-2
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mSpBCs in BMS
    *** times: 0 10++ 30+ 60 min
    *** unaffected by: kMekk1(1-1188)"del-kinase-domain" [addition]
    *** source: 17143273-Fig-3

Mekk3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 10+ 20+ 40+ 60+ min
    *** reqs: Mekk3 [KO]
    *** source: 14661019(D)

Myd88--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 20+ 60+ min
    *** comment: reqs Myd88 [KO] at 10 min only
    *** source: 12447442(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15+ 30++ 45++ 90++ min
    *** partially reqs: Myd88 [KO]
    *** source: 11607032-Fig-6b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40++ 60+ min
    *** reqs: Trif and/or Myd88 [DKO]
    *** source: 12855817-Fig-3e
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 30++ 60+ min
    *** partially reqs: Myd88 [KO]
    *** reqs: Myd88 and/or Tradd [DKO]
    *** source: 18641654-Fig-5d
  *** P38s[phosAb] phos(TPY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30+ min
    *** reqs: Myd88 [KO]
    *** source: 19898473-Fig-1b

not Nfkb1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15++ 30+ min
    *** does not req: Nfkb1 [KO]
    *** source: 17709378-Fig-1b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs<Nfkb1~null><xNfkb> in BMS
    *** does not req: xNfkb1 [omission]
    *** unaffected by: xNfkb1(S927A/S932A) [substitution]
    *** source: 15485931-Fig-4e
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647<xNfkb1> in BMS
    *** times: 0 7+ 15++ 30++ min
    *** unaffected by: xNfkb1(S927A/S932A) [substitution]
    *** source: 15485931-Fig-4a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 15+ 30+ min
    *** does not req: Nfkb1 [KO]
    *** source: 12667451-Fig-1d

Pkce--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 5 15+ 30+ 45 60 min
    *** partially reqs: Pkce [KO]
    *** source: 16757566-Fig-5a

not Socs1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs<Ifng~null> in BMS
    *** times: 0 1+ 8++ hr
    *** does not req: Socs1 [KO]
    *** source: 12433365-Fig-3

not Tab1/2--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30++ 60++ 120+ 240+ min
    *** does not req: Tab1 [KO]
    *** does not req: Tab2 [KO]
    *** source: 16260493(D)

Tak1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 15+ 30++ 60++ 120+ 240+ min
    *** reqs: Tak1 [KO]
    *** source: 16260493(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mSpBCs in BMS
    *** times: 0 15+ 30++ 60+ min
    *** reqs: Tak1 [KO]
    *** source: 16186825(D)

not Tbk1--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS "immortalized"
    *** times: 0 20+ 40 min
    *** does not req: Tbk1 or Ikke [DKO]
    *** source: 15210742-Fig-6c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 20++ 40+ min
    *** does not req: Tbk1 [KO]
    *** source: 15210742-Fig-3b

not Trif--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mLFs in BMS
    *** times: 0 20+ 40++ min
    *** does not req: Trif [KO]
    *** source: 12855817-Fig-3d
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10++ 30++ 60+ min
    *** does not req: Trif [KO]
    *** source: 12872135-Fig-2a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 20+ 40++ 60+ min
    *** reqs: Trif and/or Myd88 [DKO]
    *** source: 12855817-Fig-3e
  *** P38s[phosAb] phos(TPY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30+ min
    *** unaffected by: Trif [fmut]
    *** source: 19898473-Fig-1b


Ticam2 ???

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 5 15+ 30+ 45 60 min
    *** partially reqs: Ticam2 [KO]
    *** source: 16757566-Fig-5a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10++ 20++ 30+ 40 min
    *** does not req: Ticam2 [KO]
    *** source: 14556004(D)

Tirap--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 20+ 60+ min
    *** comment: reqs Tirap [KO] at 10 min only
    *** source: 12447442(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 15+ 25+ 45+ min
    *** inhibited by: Tirap-Peptide-Inhibitor [addition]
    *** source: 11526399(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 20+ min
    *** comment: reqs Tirap [KO] at 10 min not 20 min
    *** source: 12447441-Fig-4b

not Tollip--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 20++ 40 75+ min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 10+ 30+ min
    *** does not req: Tollip [KO]
    *** source: 16428431(D)

not Tpl2--

  *** P38s[Ab]IP IVKA(Atf2)(sitenr)[phosAb] is increased irt Lps (30 min)
    *** cells: mPECs in BMLS
    *** does not req: Tpl2 [KO]
    *** source: 11163183-Fig-5b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (30 min)
    *** cells: mPECs in BMLS
    *** does not req: Tpl2 [KO]
    *** source: 11163183-Fig-5b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs<Nfkb1~null><xTpl2> in BMS
    *** times: 0 15+ 30+ min
    *** does not req: xTpl2 [omission]
    *** unaffected by: xTpl2(D207A) [substitution]
    *** source: 17709378-Fig-1b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs<Nfkb1~null><xTpl2> in BMS
    *** times: 0 15+ 30+ min
    *** does not req: xTpl2 [omission]
    *** unaffected by: xTpl2(S400A) [substitution]
    *** unaffected by: xTpl2(S413A) [substitution]
    *** source: 17709378-Fig-2b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs<Tpl2~null><xTpl2> in BMS
    *** times: 0 15+ 30+ min
    *** does not req: xTpl2 [omission]
    *** unaffected by: xTpl2(S400A) [substitution]
    *** unaffected by: xTpl2(S413A) [substitution]
    *** unaffected by: xTpl2(D270A)"KD" [substitution]
    *** source: 17709378-Fig-4a
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647<xTpl2> in BMS
    *** times: 0 7+ 15++ 30+ min
    *** unaffected by: xTpl2(mnr)"KD" [substitution]
    *** source: 15485931-Fig-3a

not Traf3--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30++ 60+ min
    *** does not req: Traf3 [KO]
    *** source: 16306937-Fig-S3a
  *** P38s[phosAb] phos(TPY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5+ 10+ 30+ min
    *** does not req: Traf3 [RNAi]
    *** source: 19898473-Fig-3a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647<Traf3~kd><xTraf3> in BMS
    *** times: 0 5 10+ min
    *** does not req: xTraf3 [omission]
    *** unaffected by: xTraf3(C68A/H70A) [substitution]
    *** source: 19898473-Fig-5b

not Traf6--

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 10+ 30++ 60++ min
    *** does not req: Traf6 [KO]
    *** source: 16306937-Fig-4a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mSMacs in BMS
    *** times: 0 10++ 20++ 30++ 60+ 90+ min
    *** partially reqs: Traf6 [KO]
    *** source: 15322147-Fig-3a
  *** P38s[phosAb] phos(TPY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5+ 10+ 30+ min
    *** reqs: Traf6 [RNAi]
    *** source: 19898473-Fig-3a

effect of preconditioning with Lps

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: hPBMonos in BMS
    *** times: 0 5+ 15++ 30+ 60 min
    *** inhibited by: Lps [preconditioning]
    *** source: 21220427-Fig-1d
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: hPBMonos in BMS
    *** times: 0 5+ 15++ 30++ 60+ min
    *** inhibited by: Lps [preconditioning]
    *** source: 21220427-Fig-1b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 5 15+ 30+ 60 min
    *** inhibited by: Lps [preconditioning]
    *** source: 21220427-Fig-3a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 5+ 15++ 30++ 60 min
    *** inhibited by: Lps [preconditioning]
    *** source: 21220427-Fig-1c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 5+ 30++ 60 min
    *** inhibited by: Lps [preconditioning]
    *** source: 21220427-Fig-2

chemicals

  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 20+ 40+ min
    *** inhibited by: Dynasore [addition]
    *** source: 18297073-Fig-1c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5 15+ 30++ 60+ 120+ min
    *** unaffected by: DMOG [pretreatment]
    *** source: 19762779-Fig-S6a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (7 min)
    *** cells: RAW2647<xTpl2> in BMS
    *** unaffected by: BMS345541 [pretreatment]
    *** unaffected by: IKK2InhibitorIV [pretreatment]
    *** source: 17709378-Fig-5c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** unaffected by: 15dPGJ2 [pretreatment]
    *** source: 15199157-Fig-2c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** unaffected by: MG132 [pretreatment]
    *** source: 15199157-Fig-8b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** unaffected by: PS1145 [pretreatment]
    *** source: 15199157-Fig-2a
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt Lps (15 min)
    *** cells: mBMMs in BMS
    *** unaffected by: Bay117082 [pretreatment]
    *** source: 15485931-Fig-5b
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 7+ 15+ 30+ min
    *** unaffected by: Bay117082 [pretreatment]
    *** source: 15485931-Fig-5a
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 7+ 15+ 30+ min
    *** unaffected by: MG132 [pretreatment]
    *** source: 15485931-Fig-2c
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 7+ 15+ 30+ min
    *** unaffected by: MG132 [pretreatment]
    *** source: 15485931-Fig-3b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (10 min)
    *** cells: RAW2647 in BMS
    *** inhibited by: SmacMimetic [pretreatment]
    *** unaffected by: Dynasore [pretreatment]
    *** source: 19898473-Fig-S7
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5 10+ min
    *** source: 19898473-Fig-5b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5+ 10++ 30++ min
    *** inhibited by: MG132 [pretreatment]
    *** source: 19898473-Fig-S2c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 30+ 60+ min
    *** partially inhibited by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S1
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647<Traf3~kd> in BMS
    *** times: 0 5+ 10++ 30++ min
    *** unaffected by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-S2d
  *** P38s[phosAb] phos(TPY)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 5 10 30+ 60++ min
    *** inhibited by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-1a



no extras

  *** P38s[phosAb] phos(S536)[phosAb] is increased irt Lps (times)
    *** cells: mBMMs<Ifng~null> in BMS
    *** times: 0 5++ 10++ 15++ 30++ 60+ min
    *** source: 16415872-Fig-6b
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (1 hr)
    *** cells: U373<xCd14> in BMS
    *** source: 12062447-Fig-4a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (10 min)
    *** cells: hPBMCs in BMLS
    *** source: 15040785(D)
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (30 min)
    *** cells: mPECs in BMS
    *** source: 11896392-Fig-2
  *** P38a[Ab]IP IVKA(Atf2)[32P-ATP] is increased irt Lps (times)
    *** cells: CHO<xCd14> in BMS
    *** times: 0 15+ 30++ 60++ 120+ min
    *** source: 7535770-Fig-8
  *** P38a[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 2 5 15+ 30++ 45+ 60 90 min
    *** source: 12881422-Fig-2c
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0+ 5 20++ min
    *** source: 21220427-Fig-1a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 5+ 10++ 20++ 30+ 60 90 120 min
    *** source: 18458086-Fig-1f
  *** P38s[phosAb] phos(TEY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 7+ 15+ 30+ min
    *** source: 15485931-Fig-3a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 7+ 15++ 30++ min
    *** source: 15485931-Fig-4a
  *** P38s[phosAb] phos(TGY)[phosAb] is increased irt Lps (20 min)
    *** cells: hMDDCs in BMS
    *** source: 16858407-Fig-2a






