=============
Transcription
=============

Ampka1--

  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: THP1 in BMS
    *** reqs: Ampka1 [RNAi]
    *** source: 22833096-Fig-4c

Ikke--

  *** IL1b-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: mEFs in BMS
    *** times: 0 1+ 2+ 5++ hr
    *** reqs: Ikke [KO]
    *** source: 12736252-Fig-4a

not Irak1--

  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: mSpCs in BMS
    *** does not req: Irak1 [KO]
    *** source: 15465816-Fig-1b

not Irf3--

  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 2++ 6+ 12 24 hr
    *** does not req: Irf3 [KO]
    *** source: 12821121(D)

Myd88--

  *** IL1b-gene mRNA[Northern] is increased irt Lps (90 min)
    *** cells: mPECs in BMS
    *** reqs: Myd88 [KO]
    *** source: 10435584-Fig-3c

not Pias4--

  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMDCs in BMS
    *** times: 0 60+ 180+ 360++ min
    *** repressed by: Pias4 [KO]
    *** source: 17606919-Fig-5b

TLR4--

  *** IL1b-gene mRNA[RPA] is increased irt Lps (5 hr)
    *** cells: HENC2 in BMS
    *** reqs: TLR4 [KO]
    *** source: 16895974(D)
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (24 hr)
    *** cells: mPECs in BMS
    *** reqs: TLR4 [null-mut]
    *** source: 11179315-Fig-3

Chemicals

  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-5b
  *** IL6-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-5b
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: RAW2647 in BMS
    *** partially inhibited by: H89 [pretreatment]
    *** source: 10706690-Fig-6d
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: RAW2647 in BMS
    *** partially inhibited by: SB203580 [pretreatment]
    *** unaffected by: PD98059 [pretreatment]
    *** inhibited by: SB203580 + PD98059 [pretreatment]
    *** inhibited by: Ro318220 [pretreatment]
    *** source: 10706690-Fig-5b

no extras

  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 2+ 4+ 6+ 8+ hr
    *** source: 10706690-Fig-5a
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0 30 60+ 120+ 180+ 360+ min
    *** source: 10706690-Fig-7c
  *** IL1b-gene mRNA[Northern] is increased irt Lps (4 hr)
    *** cells: mPECs in BMS
    *** source: 12096038-Fig-1a
  *** IL1b-gene mRNA[RPA] is increased irt Lps (5 hr)
    *** cells: hMDDCs in BMS
    *** source: 16895974(D)
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: mPECs in BMS
    *** source: 16709849(D)
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: mPECs in BMS
    *** source: 11896392-Fig-1
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** source: 18297073-Fig-5e
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (24 hr)
    *** cells: mPECs in BMS
    *** source: 16709849(D)
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: J774A1 in BMS
    *** times: 0 1+ 2+ 5+ 24+ hr
    *** source: 12542469(D)
  *** IL1b-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 2+ 4+ 6+ 8+ 10+ hr
    *** source: 11179315-Fig-4
  *** IL1b-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 1 2 4+ 6++ 8++ 24 hr
    *** source: 11051551-Fig-6a
  *** IL1b-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: hPBMCs in BMS
    *** times: 0 2+ 4++ 6+ 24+ hr
    *** source: 11051551-Fig-6a
  *** IL1b-gene mRNA[Northern] is increased irt Lps (tnr)
    *** cells: hUVECs in BMS
    *** source: 11051551-Fig-6a

=========
Secretion
=========

Ampka1--

  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (9 hr)
    *** cells: THP1 in BMS
    *** enhanced by: xAmpka1 [addition]
    *** partially inhibited by: xAmpka1(D159A)"DN" [addition]
    *** enhanced by: xAmpka1(T174D)"CA" [addition]
    *** source: 22833096-Fig-1k
  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (9 hr)
    *** cells: THP1 in BMS
    *** reqs: Ampka1 [RNAi]
    *** source: 22833096-Fig-2h

Pycard--  for secretion only???

  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: mKupfferCells in BMS
    *** reqs: Pycard [KO]
    *** source: 15507117-Fig-2a
  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: mPECs in BMS
    *** reqs: Pycard [KO]
    *** source: 15507117-Fig-2a
  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 30+ 60++ 120+++ min
    *** reqs: Pycard [RNAi]
    *** source: 16585594-Fig-6d
  *** IL1b[Ab] secretion[WB] is increased irt Lps (times)
    *** cells: THP1 in BMLS "treated with PMS for 3 hr"
    *** times: 0 1 3+ 6+ hr
    *** comment: only the cleaved IL1b is secreted
    *** inhibited by: xPycard(1-94) [addition]
    *** source: 12191486(D)

Iceberg--  ???

  *** IL1b[Ab] secretion[ELISA] is detectable
    *** cells: THP1 in BMS
    *** inhibited by: xIceberg [addition]
    *** source: 11051551-Fig-5
  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (6 hr)
    *** cells: THP1 in BMS
    *** bkg inhibited by: xIceberg [addition]
    *** source: 11051551-Fig-5

Chemicals

  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: mPECs in BMS
    *** partially inhibited by: Z-YVAD-FMK [addition]
    *** partially inhibited by: Ac-YVAD-CHO [addition]
    *** source: 15507117-Fig-2a
  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (9 hr)
    *** cells: THP1 in BMS
    *** inhibited by: Compound-C [cotreatment]
    *** source: 22833096-Fig-1e

no extras

  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: J774A1 in BMS
    *** source: 12542469(D)
  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 3++ 6+ 12 18 24 hr
    *** comment: secretion is measured in 3 hr increments
    *** source: 11051551-Fig-6b
  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: hPBMCs in BMS
    *** times: 0 3++ 6++ 12++ 18+ 24+ hr
    *** comment: secretion is measured in 3 hr increments
    *** source: 11051551-Fig-6b
  *** IL1b[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: THP1<xPycard> in BMS "primed with PMA (3 hr) + Lps (1 hr)"
    *** times: 0 1+ 2++ 3++ hr
    *** source: 17599095(D)
  *** IL1b-gene mRNA[MicroArray] is increased irt Lps (3 hr)
    *** cells: THP1 in BMS
    *** source: 22833096-Table-S1a
