Ikk2--

  *** Rela[Ab] boundto(Ikba-gene)[ChIP] is increased irt Tnf (2 hr)
    *** cells: mEFs in BMS "immortalized"
    *** reqs: Ikk2 [KO]
    *** source: 12736252-Fig-6e

Msk1/2---

  *** xRela(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: mEFs in BMS
    *** reqs: Msk1 and/or Msk2 [DKO]
    *** source: 12628924-Fig-8b

repressed by Pias1--

  *** Rela[Ab] boundto(Ikba-gene)[ChIP] is increased irt Tnf (times)
    *** cells: U2OS in BMS
    *** times: 0 20+ 60++ min
    *** inhibited by: xPias1 [addition]
    *** source: 15657437-Fig-8b
  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: MCF7 in BMS
    *** comment: binding is inhibited by addition of rPias1 to lysates
    *** source: 15657437-Fig-7a

repressed by Pias4--

  *** Rela[Ab] boundto(CxcL1-gene)[ChIP] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** repressed by: Pias4 [KO]
    *** source: 17606919-Fig-5c

not Rsk2--

  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: HELA in BMLS "nuclear fraction"
    *** times: 0 10+ 30+ min
    *** does not req: Rsk2 [RNAi]
    *** source: 20385620-Fig-4b

Tank--

  *** xRela(TAD)[Gal4-DBD] Gal4-reporter[Luc] is detectable
    *** cells: HEK293 in BMS
    *** partially reqs: Tank [RNAi]
    *** source: 16336209-Fig-7d

not Traf2--

  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** does not req: Traf2 [KO]
    *** source: 9390694-Fig-6b

repressed by Stat1--

  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (tnr)
    *** cells: mEFs in BMS
    *** repressed by: Stat1 [KO]
    *** source: 10848577-Fig-5b

=========
chemicals
=========

  *** xRela(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: L929SA in BMS
    *** inhibited by: SB203580 + PD98059 [addition]
    *** inhibited by: H89 [addition]
    *** source: 12628924-Fig-2b
  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (tnr)
    *** cells: HEK293T in BMS
    *** enhanced by: TrichostatinA [addition]
    *** source: 11533489-Fig-1b
  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (10 min)
    *** cells: HELA in BMS
    *** unaffected by: PD144795 [addition]
    *** source: 10938077-Fig-3a


=====================================
Rela features required for activation
=====================================

acetyl(K310)

  *** Rela[Ab] boundto(IL8-gene)[ChIP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 30+ 60++ min
    *** comment: bound Rela is acetylated on K310 [AcAb]
    *** source: 16135789-Fig-2b

phos(S276)

  *** xRela(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: L929SA in BMS
    *** inhibited by: xRela(S276C) [substitution]
    *** source: 12628924-Fig-2b
  *** Rela[Ab] boundto(IL8-gene)[ChIP] is increased irt Tnf (times)
    *** cells: HELA in BMS
    *** times: 0 30+ 60++ min
    *** comment: bound Rela is phosed on S276 [phosAb]
    *** source: 16135789-Fig-2b

phos(S311)  ???

  *** Rela[Ab] boundto(IL6-gene)[ChIP] is increased irt Tnf (90 min)
    *** cells: mEFs in BMS
    *** inhibited by: xRela(S311A) [substitution]
    *** source: 12881425-Fig-9b

not phos(S529)

  *** xRela(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: L929SA in BMS
    *** unaffected by: xRela(S529A) [substitution]
    *** source: 12628924-Fig-2b

not phos(S536)  ???

  *** xRela(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tnf (6 hr)
    *** cells: L929SA in BMS
    *** unaffected by: xRela(S536A) [substitution]
    *** source: 12628924-Fig-2b

no extras

  *** Rela[Ab] boundto(Bcl10-gene)[ChIP] is increased irt Tnf (times)
    *** cells: MCF7 in BMS
    *** times: 0 15++ 30+ 60 min
    *** source: 16280327-Fig-3a
  *** Rela[Ab] boundto(Ikba-gene)[ChIP] is increased irt Tnf (times)
    *** cells: MCF7 in BMS
    *** times: 0+ 15++ 30++ 60+ min
    *** source: 16280327-Fig-3a
  *** Rela[Ab] boundto(Ikba-gene)[ChIP] is increased irt Tnf (30 min)
    *** cells: mEFs in BMS
    *** unaffected by: Pias4 [KO]
    *** source: 17606919-Fig-5c
  *** Rela[Ab] boundto(IL6-gene)[ChIP] is increased irt Tnf (3 hr)
    *** cells: mEFs in BMS
    *** source: 15241416-Fig-3d
  *** Rela[Ab] boundto(IL12a-gene)[ChIP] is increased irt Tnf (times)
    *** cells: RAW2647 in BMS "treated with Ifng (4 hr)"
    *** times: 0 10 30+ 60+ 120 min
    *** source: 17018642-Fig-7a
  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (times)
    *** cells: MCF7 in BMS
    *** times: 0 15+ 30+ min
    *** source: 16280327-Fig-1
  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (30 min)
    *** cells: C2 in BMS
    *** source: 16806820-Fig-4a
  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: NIH3T3 in BMS
    *** source: 14585990-Fig-4b
  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (15 min)
    *** cells: HEK293 in BMS "nuclear-extracts"
    *** source: 10581243-Fig-5a
  *** xRela(TAD)[Gal4-DBD] Gal4-reporter[Luc] is increased irt Tnf (tnr)
    *** cells: HEK293 in BMS
    *** source: 16336209-Fig-7d
  *** Rela[Ab] snaggedby[WB] oligo[biotin] is increased irt Tnf (times)
    *** cells: A549 in BMS
    *** times: 0 15+ 30+ 60+ min
    *** source: 15677444-Fig-4a
  *** Rela[Ab] oligo-binding[EMSA] is increased irt Tnf (20 min)
    *** cells: mEFs in BMLS "nuclear-extracts"
    *** source: 11113181-Fig-5
