===========================
Phosphorylation on Tyrosine
===========================

  *** Pik3rs[Ab] Yphos[pYAb-ppt] is increased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0 1++ 5+ 15 min
    *** source: 8550620-Fig-3a
  *** Pik3rs[Ab] Yphos[pYAb-ppt] is increased irt Egf (1 min)
    *** cells: PC12 in BMLS
    *** times: 0 1++ 5+ 15 min
    *** source: 8550620-Fig-4

contradiction

  *** Pik3rs[Ab]IP Yphos[pYAb] is unchanged irt Egf (times)
    *** cells: MKN74 in BMS
    *** times: 0 3+ 10+ min
    *** source: 11352916-Fig-4c

=====================
Lipid Kinase Activity
=====================

  *** Pik3rs[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Egf (10 min)
    *** cells: hSVKs in BMS
    *** source: 11716761-Fig-5

=================
EgfR-Pi3krS coppt
=================

  *** Pik3rs[Ab] copptby[WB] EgfR[Ab] is increased irt Egf (10 min)
    *** cells: 16E6P in BMS "Egf deprived"
    *** source: 8662998-Fig-4
  *** Pik3rs[Ab] copptby[WB] xEgfR[Ab] is increased irt Egf (times)
    *** cells: NIH3T3<xErbb4> in BMLS
    *** times: 0+ 1++ 5+ 10+ 15+ 30+ 60+ 120+ min
    *** source: 9710588-Fig-8a
  *** Pik3rs[Ab] copptby[WB] EgfR[Ab] is increased irt Egf (10 min)
    *** cells: DLD1 in BMS
    *** source: 7797556-Fig-6
  *** Pik3rs[Ab] copptby[WB] EgfR[Ab] is increased irt Egf (10 min)
    *** cells: LS174T in BMS
    *** source: 7797556-Fig-6
  *** Pik3rs[Ab] copptby[WB] EgfR[Ab] is increased irt Egf (10 min)
    *** cells: MCF7 in BMS
    *** source: 7797556-Fig-6
  *** Pik3rs[Ab] copptby[WB] EgfR[Ab] is increased irt Egf (10 min)
    *** cells: NIH3T3 in BMS
    *** source: 7797556-Fig-6
  *** Pik3rs[Ab] copptby[WB] EgfR[Ab] is increased irt Egf (10 min)
    *** cells: WIDR in BMS
    *** source: 7797556-Fig-6
  *** Pi3k[Ab] copptby[WB] EgfR[Ab] is increased irt Egf (5 min)
    *** cells: HELA in BMLS
    *** source: 12783862-Fig-1a
  *** xPik3r?[Ab] copptby[WB] xEgfR[Ab] is increased irt Egf (5 min)
    *** cells: CHO<xEgfR><xRin1><xPik3r?> in BMLS
    *** source: 12783862-Fig-1b



contradictions

  *** Pik3rs[Ab] copptby[WB] EgfR[Ab] is unchanged irt Egf (10 min)
    *** cells: A431 in BMS
    *** source: 7797556-Fig-6
  *** Pik3rs[Ab] copptby[WB] EgfR[Ab] is unchanged irt Egf (2 min)
    *** cells: MDAMB361 in BMLS
    *** source: 11297548-Fig-1a
  *** Pik3rs[Ab] copptby[WB] EgfR[Ab] is detectable-but unchanged irt Egf (10 min)
    *** cells: MDCK in BMS
    *** source: 11716761-Fig-1b

=================
EgfR-Pi3kcS coppt
=================

  *** EgfR[Ab] copptby[WB] xPik3c2b[tAb] is increased irt Egf (times)
    *** cells: A431 in BMLS "Triton-Soluble fraction"
    *** times: 0 1+ 5+ 10+ 15++ 20+ 25+ 30+ 60+ 120+ min
    *** source: 16775008-Fig-1a

=================================================
coprecipitation with other EgfR binding proteins
=================================================

Gab1--

  *** Pik3rs[Ab] copptby[WB] Gab1[Ab] is increased irt Egf (10 min)
    *** cells: MIMCD3 in BMLS
    *** inhibited by: U0126 [addition]
    *** source: 11896055(D)
  *** Pik3rs[Ab] copptby[WB] xGab1[tAb] is increased irt Egf (10 min)
    *** cells: mEFs<xGab1> in BMLS
    *** unaffected by: xGab1(Y627F/Y659F) [substitution]
    *** inhibited by: xGab1(Y447F/Y472F/Y589F) [substitution]
    *** source: 12629518(D)
  *** Pi3k[Ab] copptby[WB] xGab1[tAb] is increased irt Egf (5 min)
    *** cells: VERO in BMLS
    *** enhanced by: xGab1(Y627F) [substitution]
    *** source: 11134009-Fig-6e

Gab2--

  *** Pik3rs[Ab] copptby[WB] xGab2[Ab] is increased irt Egf (1 min)
    *** cells: rHepatocytes in BMLS
    *** partially inhibited by: xGab2(del(348-355)) [substitution]
    *** source: 12464621-Fig-6a


Grb2--

  *** Pik3rs[Ab] copptby[WB] Grb2[Ab] is increased irt Egf (10 min)
    *** cells: 16E6P in BMS "Egf deprived"
    *** source: 8662998-Fig-4

Cbl--

  *** Pik3rs[Ab] copptby[WB] Cbl[Ab] is increased irt Egf (10 min)
    *** cells: 16E6P in BMS "Egf deprived"
    *** source: 8662998-Fig-4
  *** Pik3rs[Ab] copptby[WB] Cbl[Ab] is increased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0 1++ 5+ 15 min
    *** source: 8550620-Fig-3a,4
  *** Pik3rs[Ab] copptby[WB] Cbl[Ab] is increased irt Egf (times)
    *** cells: T47D in BMLS
    *** times: 0 2++ 5++ 10+ 20+ 30 60 120 min
    *** source: 11994282(D)
  *** Cbl[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Egf (times)
    *** cells: T47D in BMLS
    *** times: 0 1++ 2++ 5+ 10+ 20+ min
    *** source: 11994282(D)
  *** Cbl[Ab]IP IVLKA(PtdIns)[TLC] is increased irt Egf (times)
    *** cells: PC12 in BMLS
    *** times: 0 1++ 5+ 15 min
    *** source: 8550620-Fig-1a

Shc1--

  *** Pik3rs[Ab] copptby[WB] Shc1[Ab] is increased irt Egf (10 min)
    *** cells: 16E6P in BMS "Egf deprived"
    *** source: 8662998-Fig-4
  *** xPik3c2b[Ab] copptby[WB] Shc1[Ab] is increased irt Egf (times)
    *** cells: A431 in BMLS
    *** times: 0 5+ 30++ 60++ 120+ 240+ 360+ 480+ min
    *** source: 16775008-Fig-1g

