========================================
Ikk1 can autophosphorylate on S176/S180
========================================

  *** rIkk1[32P] phos[32P-ATP] is detectable
    *** cells: none
    *** inhibited by: rIkk1(K44M) [substitution]
    *** partially inhibited by: xIkk1(S176A/S180A) [substitution]
    *** source: 10779355-Fig-7a

================
Kinase Activity
================

auto--

  *** rIkk1[32P] IVKA(auto)[32P-ATP] is detectable
    *** cells: none
    *** source: 11520989-Fig-4b
  *** xIkk1[tAb]IP IVKA(auto)[32P-ATP] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xIkk1(K44A)"KD" [substitution]
    *** source: 16612387-Fig-4a

on Ikba--

  *** xIkk1[tAb]IP IVKA(Ikba)[32P-ATP] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xIkk1(K44A)"KD" [substitution]
    *** source: 16612387-Fig-4a

on Irf7--

  *** xIkk1[tAb]IP IVKA(Irf7)[32P-ATP] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xIkk1(K44A)"KD" [substitution]
    *** source: 16612387-Fig-4a

=================
Coprecipitations
=================

Ikbkap--
  *** Ikk1[Ab] copptby[WB] xIkbkap[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10094049-Fig-4c
Irf1--
  *** Ikk1[Ab] copptby[WB] Irf7[Ab] is detectable
    *** cells: mBMfDCs in BMS
    *** source: 16612387-Fig-3d
Irf7--
  *** Ikk1[Ab] copptby[WB] xIrf7[tAb] is detectable
    *** cells: mBMDCs in BMS
    *** source: 16612387-Fig-S5a
  *** xIkk1[tAb] copptby[WB] xIrf7[tAb] is detectable
    *** cells: HEK293T in BMS
    *** enhanced by: xTraf6 [addition]
    *** enhanced by: xMyd88 [addition]
    *** source: 16612387-Fig-3c
Mavs--
  *** xIkk1[tAb] copptby[WB] xMavs[tAb] is detectable
    *** cells: HEK293T in BMS
    *** source: 16177806-Fig-3a
Nfkb2--
  *** xIkk1[tAb] copptby[WB] xNfkb2[Ab] is increased itpo xNik
    *** cells: HEK293 in BMS
    *** inhibited by: xNfkb2(S866A/S870A) [substitution]
    *** inhibited by: xNfkb2(S866D/S870D) [substitution]
    *** unaffected by: xNfkb2(S872A) [substitution]
    *** unaffected by: xNfkb2(S99A/S108A/S115A/S123A/S872A) [substitution]
    *** unaffected by: xIkk1(mnr)"KD" [substitution]
    *** unaffected by: xIkk1(mnr)"CA" [substitution]
    *** source: 15140882-Fig-1a,2a,6a
Nod1--
  *** xIkk1[tAb] copptby[WB] xNod1[tAb] is undetectable
    *** cells: HEK293 in BMS
    *** source: 10329646(D)
Pkca--
  *** xIkk1[tAb] copptby[WB] xPkca[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10022904-Fig-1c
Pkci--
  *** xIkk1[tAb] copptby[WB] xPkci[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10022904-Fig-1b
Pkcz--
  *** xIkk1[tAb] copptby[WB] xPkcz[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 10022904-Fig-1c
Ppp2cb--
  *** Ikk1[Ab] copptby[WB] Ppp2cb[Ab] is detectable
    *** cells: HELA in BMS
    *** source: 14585847-Fig-1d
  *** Ikk1[Ab] copptby[WB] xPpp2cb[tAb] is detectable
    *** cells: HEK293 in BMS
    *** source: 14585847-Fig-1b
TnfR1--
  *** Ikk1[Ab] copptby[WB] xTnfR1[Ab] is detectable
    *** cells: HEK293T in BMS
    *** inhibited by: xNemo [addition]
    *** source: 10755617-Fig-5c
Trpc4ap--
  *** xIkk1[tAb] copptby[WB] xTrpc4ap[tAb] is detectable
    *** cells: COS7 in BMS
    *** source: 14585990-Fig-7a


