===============
Kinase activity
===============

requires Cdc42--

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (10 min)
    *** cells: MDCK in BMLS
    *** inhibited by: xCdc42(T17N) [addition]
    *** source: 11948414-Fig-5a

requires Crk--

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (15 min)
    *** cells: HELA<xJnk1> in BMLS
    *** partially inhibited by: xCrk(R38V) [addition]
    *** source: 10618718-Fig-1a

requires Gab1--

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (15 min)
    *** cells: HELA<xJnk1> in BMLS
    *** enhanced by: xGab1 [addition]
    *** inhibited by: xGab1(mnr)"Met-binding-domain" [addition]
    *** source: 10618718-Fig-6b

does not require Hras--

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (10 min)
    *** cells: MDCK in BMLS
    *** unaffected by: xHras(S17N) [addition]
    *** source: 11948414-Fig-5a

Chemicals

  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (10 min)
    *** cells: MDCK in BMLS
    *** unaffected by: U0126 [pretreatment] no-bkg-control
    *** source: 11948414-Fig-6a
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (30 min)
    *** cells: hBMECs in BMS
    *** inhibited by: SP600125 [pretreatment]
    *** source: 17055484-Fig-3b
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (30 min)
    *** cells: hBMECs in BMS
    *** partially inhibited by: PP2 [pretreatment]
    *** source: 17055484-Fig-4b

No extras

  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (times)
    *** cells: MDCK in BMS
    *** times: 0 5+ 15++ 30+ 60 min
    *** source: 10793146-Fig-3b
  *** xJnk1[tAb]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (10 min)
    *** cells: MDCK in BMLS
    *** source: 11948414-Fig-2b
  *** Jnks[Ab]IP IVKA(Jun)[32P-ATP] is increased irt Hgf (times)
    *** cells: hBMECs in BMS
    *** times: 0+ 5++ 15++ 30+++ 60+++ 120+++ min
    *** comment: no total protein controls
    *** source: 17055484-Fig-3a
  -------- Ets1 is not a substrate? ----------------------------------
  *** xJnk1[tAb]IP IVKA(Ets1)[32P-ATP] is detectable-but unchanged irt Hgf (10 min)
    *** cells: MDCK in BMLS
    *** source: 11948414-Fig-2b

============================
Phosphorylation on TPY site
============================

  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt Hgf (15 min)
    *** cells: RGM1 in BMLS
    *** enhanced by: Tgfb1 [cotreatment]
    *** source: 15326485-Fig-2g
  *** Jnks[phosAb] phos(TPY)[phosAb] is increased irt Hgf (times)
    *** cells: RGM1 in BMLS
    *** times: 0 5++ 15++ 30+ 60 120 min
    *** source: 15326485-Fig-2d

Contradictions

  *** Jnks[phosAb] phos(TPY)[phosAb] is detectable-but unchanged irt Hgf (times)
    *** cells: MDCK in BMLS
    *** times: 0+ 5+ 30+ 60+ 180+ min
    *** unaffected by: xGab1 [addition]
    *** unaffected by: xGab2 [addition]
    *** source: 12058075-Fig-2d
