ArhGef7-- ???

  *** xEgfR[125I] surface-exp[125I-ligand] is decreased irt Egf (times)
    *** cells: CHO<xEgfR> in BMLS
    *** times: 0+++ 10++ 30+ 90+ min
    *** unaffected by: xArhGef7 [addition]
    *** source: 16407834-Fig-4f
  *** EgfR[125I] surface-exp[125I-ligand] is decreased irt Egf (times)
    *** cells: mEFs in BMLS
    *** times: 0++++ 20+++ 40++ 60+ min
    *** repressed by: ArhGef7 [RNAi]
    *** source: 16407834-Fig-4f
  *** xEgfR[125I] surface-exp[125I-ligand] is decreased irt Egf (times)
    *** cells: CHO<xEgfR><xCbl> in BMLS
    *** times: 0+++ 10++ 30+ 90+ min
    *** unaffected by: xArhGef7 + xCdc42 [addition]
    *** partially reversed by: xArhGef7 [addition]
    *** source: 16407834-Fig-4f

not Becn1--

  *** EgfR[Ab] internalization[IHC] is increased irt Egf (times)
    *** cells: U251 in BMLS "on Laminin"
    *** times: 0 30+ 70+ min
    *** does not req: Becn1 [RNAi]
    *** source: 16390869(D)

Cbl-- ???

  *** Egf[125I] internalization[Surface-strip] is increased irt Egf (times)
    *** cells: CHO<xEgfR> in BMLS
    *** times: 0 5+ 10++ 20++ min
    *** enhanced by: xCbl [addition]
    *** source: 12177062(D)
  *** xEgfR[125I] surface-exp[125I-ligand] is decreased irt Egf (times)
    *** cells: CHO<xEgfR> in BMLS
    *** times: 0+++ 10++ 30+ 90+ min
    *** enhanced by: xCbl [addition]
    *** unaffected by: xCbl(R829A) [addition]
    *** source: 16407834-Fig-4f
  *** EgfR[125I] surface-exp[125I-ligand] is decreased irt Egf (times)
    *** cells: mEFs in BMLS
    *** times: 0++++ 20+++ 40++ 60+ min
    *** enhanced by: xCbl [addition]
    *** source: 16407834-Fig-4f
  *** xEgfR[125I] surface-exp[125I-ligand] is decreased irt Egf (times)
    *** cells: COS7 in BMS
    *** times: 0++ 10+ 20+ 40+ 60+ min
    *** enhanced by: xCbl [addition]
    *** source: 12815057-Fig-4a

Cblb-- ???

  *** Egf[125I] internalization[Surface-strip] is increased irt Egf (times)
    *** cells: CHO<xEgfR> in BMLS
    *** times: 0 5+ 10++ 20++ min
    *** enhanced by: xCblb [addition]
    *** source: 12177062(D)

Cblc-- ???

  *** Egf[125I] internalization[Surface-strip] is increased irt Egf (times)
    *** cells: CHO<xEgfR> in BMLS
    *** times: 0 5+ 10++ 20++ min
    *** enhanced by: xCblc [addition]
    *** source: 12177062(D)

not Cdc42--

  *** xEgfR[125I] surface-exp[125I-ligand] is decreased irt Egf (times)
    *** cells: CHO<xEgfR> in BMLS
    *** times: 0+++ 10++ 30+ 90+ min
    *** unaffected by: xCdc42 [addition]
    *** source: 16407834-Fig-4f

Cin85--

  *** Egf[125I] internalization[Surface-strip] is increased irt Egf (times)
    *** cells: CHO<xEgfR> in BMLS
    *** times: 0 5+ 10++ 20++ min
    *** inhibited by: xCin85(mnr)"DN" [addition]
    *** source: 12177062(D)

not Hras--

  *** Egf[125I] internalization[Surface-strip] is increased irt Egf (times)
    *** cells: HELA in BMS
    *** times: 0 2 5+ 10++ 15++ min
    *** unaffected by: xHras(S17N)"DN" [addition]
    *** source: 15194809-Fig-3c

  *** xEgfR[Ab] internalization[IHC] is increased irt Egf (times)
    *** cells: COS7 in BMLS
    *** times: 0 5+ 30++ min
    *** source: 17182860(D)
  *** EgfR[Ab] internalization[IHC] is increased irt Egf (times)
    *** cells: KB in BMLS
    *** times: 0 5+ 15+ 30++ 60+ 180+ min
    *** source: 12009895(D)

Tnk2 internalizes with EgfR

  *** xTnk2[XFP] colocwith[IHC] Eea1[Ab] is increased irt Egf (times)
    *** cells: COS7 in BMLS
    *** times: 0+ 5++ 30+++ min
    *** source: 17182860(D)


  *** xEgfR[125I] surface-exp[125I-ligand] is decreased irt Egf (times)
    *** cells: COS7<xCbl> in BMS
    *** times: 0++ 10+ 20+ 40+ 60+ min
    *** reversed by: xSpry2 [addition]
    *** unaffected by: xSpry2(Y55F) [addition]
    *** source: 12815057-Fig-4a


chemicals

  *** xEgfR[XFP] locatedin(vesicles)[IHC] is increased irt Egf (15 min) 
    *** cells: HELA<xEgfR> in BMS
    *** unaffected by: 5Z7Oxozeaenol [pretreatment]
    *** inhibited by: PD153035 [pretreatment]
    *** source: 19687304-Fig-1f
  *** xEgfR[XFP] locatedin(vesicles)[IHC] is increased irt Egf (15 min) 
    *** cells: HELA<xEgfR> in BMS
    *** unaffected by: SB203580 [pretreatment]
    *** unaffected by: U0126 [pretreatment]
    *** source: 19687304-Fig-5b
  *** EgfR[Ab]IP surface-exp[FACS] is decreased irt Egf (15 min)
    *** cells: HELA in BMS
    *** partially reversed by: SB203580 [pretreatment]
    *** source: 19687304-Fig-5c


=====================
Relocation to Nucleus
=====================

  *** EgfR[Ab] infraction(nuclear)[WB] is increased irt Egf (30 min)
    *** cells: A431 in BMLS
    *** source: 15950906-Fig-1a
  *** EgfR[Ab] infraction(nuclear)[WB] is increased irt Egf (30 min)
    *** cells: A431 in BMLS
    *** source: 15950906-Fig-4b


  *** Egf[125I] internalization[Surface-strip] is decreased itpo xHras(T17N)
    *** cells: NR6 in BMS
    *** source: 11703925-Fig-5c
  *** Egf[125I] internalization[Surface-strip] is increased itpo xHras(G12V)
    *** cells: NR6 in BMS
    *** source: 11703925-Fig-5c
  *** Egf[125I] internalization[Surface-strip] is increased itpo xRab5a
    *** cells: NR6 in BMS
    *** inhibited by: xRab5a(S34N) [substitution]
    *** source: 11703925-Fig-5c
  *** Egf[125I] internalization[Surface-strip] is increased itpo xRin1
    *** cells: NR6 in BMS
    *** inhibited by: xHras(T17N) [addition]
    *** enhanced by: xHras(G12V) [addition]
    *** inhibited by: xRab5a(S34N) [addition]
    *** enhanced by: xRab5a [addition]
    *** source: 11703925-Fig-5c
  *** Egf[125I] internalization[Surface-strip] is increased itpo xRin1
    *** cells: NR6 in BMS
    *** source: 11703925-Fig-5a

????

  *** xEgfR[Ab] infraction(membrane)[WB] is decreased irt Egf (2 hr)
    *** cells: 3Y1<xEgfR> in BMS
    *** reversed by: Go6976 [pretreatment]
    *** source: 11134345-Fig-5c
  *** xEgfR[Ab] infraction(membrane)[WB] is decreased irt Egf (2 hr)
    *** cells: 3Y1<xEgfR> in BMS
    *** unaffected by: Rottlerin [pretreatment]
    *** source: 11134345-Fig-5d
  *** xEgfR[Ab] infraction(membrane)[WB] is decreased irt Egf (30 min)
    *** cells: 3Y1<xEgfR> in BMS
    *** reversed by: 1Butanol [pretreatment]
    *** unaffected by: isoButanol [pretreatment]
    *** source: 11134345-Fig-3
  *** xEgfR[Ab] infraction(membrane)[WB] is decreased irt Egf (30 min)
    *** cells: 3Y1<xEgfR> in BMS
    *** enhanced by: xRala [addition]
    *** reversed by: xRala(S28N) [addition]
    *** source: 11134345-Fig-4b
  *** xEgfR[Ab] infraction(membrane)[WB] is decreased irt Egf (30 min)
    *** cells: 3Y1<xEgfR> in BMS
    *** partially reversed by: Go6976 [pretreatment]
    *** unaffected by: Rottlerin [pretreatment]
    *** source: 11134345-Fig-5b




