===========================
Recruitment to IL2R complex
===========================

  *** Pik3rs[Ab] copptby[WB] IL2Rb[Ab] is increased irt IL2 (times) 
    *** cells: hPHAblasts in BMLS "IL2 deprived"
    *** times: 0 1 2+ min
    *** source: 7509794-Fig-1

=======================================
Coppt with other IL2R complex Proteins
=======================================

Gab2--

  *** Pi3k[Ab] copptby[WB] xGab2[tAb] is increased irt IL2 (10 min)
    *** cells: KIT225 in BMS "IL2-deprived"
    *** unaffected by: xGab2(Y614F) [substitution]
    *** source: 15170389-Fig-2a

Irs1--

  *** Pik3rs[Ab] copptby[WB] Irs1[Ab] is increased irt IL2 (times)
    *** cells: hPBMCs in BMLS
    *** times: 0 5+ 15+ min
    *** source: 7499365-Fig-3

Lck--

  *** Pik3rs[Ab] copptby[WB] Lck[Ab] is increased irt IL2 (10 min)
    *** cells: HT2 in BMS "IL2-deprived"
    *** source: 8397196-Fig-6

Shp2--

  *** Pik3rs[Ab] copptby[WB] Shp2[Ab] is increased irt IL2 (10 min)
    *** cells: NK33 in BMS
    *** source: 9590209-Fig-1e

=====
Yphos
=====

Lck--

  *** Pik3rs[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: CTLL2 in BMS "IL2-deprived"
    *** unaffected by: xLck [addition]
    *** source: 8397196-Fig-4
  *** Pik3rs[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: HT2 in BMS "IL2-deprived"
    *** unaffected by: xLck [addition]
    *** source: 8397196-Fig-4

IL2Rg--

  *** Pik3rs[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: ED40515<xIL2Rg(1-290)"M1"> in BMS
    *** inhibited by: xIL2Rg((1-312)/P266A/P269A)"PA2" [substitution]
    *** source: 10421845-Fig-5c
  *** Pik3rs[Ab]IP Yphos[pYAb] is increased irt IL2 (10 min)
    *** cells: ED40515<xIL2Rg> in BMS
    *** inhibited by: xIL2Rg(1-290)"M1" [substitution]
    *** partially inhibited by: xIL2Rg(1-321)"M2" [substitution]
    *** source: 10421845-Fig-3a

  *** Pik3rs[Ab]IP Yphos[pYAb] is increased irt IL2 (times)
    *** cells: hPBTCs in BMLS
    *** times: 0 1+ 5+ min
    *** source: 9973481-Fig-2a

=====================
Lipid Kinase Activity
=====================

ToxinB--

  *** Pik3rs[Ab] IVLKA(PtdIns)[TLC] is increased irt IL2 (30 min)
    *** cells: TS1<xIL2Ra><xIL2Rb> in BMS "IL2-deprived"
    *** partially inhibited by: ToxinB [pretreatment]
    *** source: 9029085-Fig-5

Piceatannol

  *** Pik3rs[Ab]IP IVLKA(PI45P2)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: Piceatannol [pretreatment] no-bkg-control
    *** source: 12393431-Fig-3

Syk--

  *** Pik3rs[Ab]IP IVLKA(PI45P2)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** inhibited by: xSyk(mnr)"KD" [addition] no-bkg-control
    *** source: 12393431-Fig-3

Cd56--

  *** Pik3rs[Ab]IP IVLKA(PI45P2)[32P-ATP] is increased irt IL2 (5 min)
    *** cells: NK92 in BMS "IL2 deprived"
    *** unaffected by: xCd56 [addition]
    *** source: 12393431-Fig-3






