===============
Kinase Activity
===============

  *** Erks[Ab]IP IVKA(MBP)[32P-ATP] is increased irt UV (times)
    *** cells: HELA in BMLS
    *** times: 0 5 10+ 15+ 30+ 45+ 60 min
    *** comment: this is a much weaker response than Jnks-IVKA
    *** source: 8846788-Fig-1
  *** Erks[Ab]IP IVKA(Elk1)[32P-ATP] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** source: 11777913-Fig-4b

===============
Phosphorylation
===============

not Mnk1-- or Mnk2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (20 min)
    *** cells: mEFs in BMLS
    *** does not req: Mnk1 and/or Mnk2 [DKO]
    *** source: 15254222-Fig-3a

not Msk1-- or Msk2--

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (15 min)
    *** cells: mEFs in BMLS
    *** does not req: Msk2 [KO]
    *** does not req: Msk1 [KO]
    *** does not req: Msk1 or Msk2 [DKO]
    *** source: 11909979-Fig-4a

chemicals

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (15 min)
    *** cells: mEFs in BMLS
    *** inhibited by: PD184352 [addition] no-bkg-control
    *** unaffected by: SB203580 [addition] no-bkg-control
    *** source: 11909979-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 11896587-Fig-3a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: LY294002 [pretreatment]
    *** inhibited by: xPik3c?(mnr)"DN" [addition]
    *** source: 11350959-Fig-4
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMS
    *** enhanced by: H89 [pretreatment]
    *** inhibited by: PD98059 [pretreatment]
    *** unaffected by: SB202190 [pretreatment]
    *** source: 11441012-Fig-5b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (times)
    *** cells: JB6CL41 in BMS
    *** times: 0 15++ 30+ 60 120 min
    *** unaffected by: H89 [pretreatment]
    *** source: 11441012-Fig-4a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** source: 11777913-Fig-2c
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: U0126 [pretreatment]
    *** source: 11777913-Fig-2d
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: PD169316 [pretreatment]
    *** source: 11777913-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 11777913-Fig-8a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (1 hr)
    *** cells: JB6CL41 in BMLS
    *** unaffected by: SB202190 [pretreatment]
    *** source: 11777913-Fig-2b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: PD98059 [pretreatment]
    *** unaffected by: SB202190 [pretreatment]
    *** source: 11983683-Fig-2a

no extras

  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (30 min)
    *** cells: JB6CL41 in BMLS
    *** inhibited by: xErk2(mnr)"DN" [addition]
    *** source: 11896587-Fig-2a
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** comment: increase is significantly less than that seen for Serum or PMA
    *** source: 20188673-Fig-1b
  *** Erks[phosAb] phos(TEY)[phosAb] is increased irt UV (times)
    *** cells: JB6CL41 in BMS
    *** times: 0 15++ 30+ 60 min
    *** source: 11441012-Fig-3a

contradictions

  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt UV (2 min)
    *** cells: MCF7 in BMLS
    *** source: 17693255-Fig-S1b
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt UV (2 hr)
    *** cells: mEFs in BMS
    *** source: 17237771-Fig-S3f
  *** Erks[phosAb] phos(TEY)[phosAb] is unchanged irt UV (60 min)
    *** cells: CHO<xProTgfa> in BMLS
    *** unaffected by: U0126 [pretreatment]
    *** unaffected by: SB203580 [pretreatment]
    *** unaffected by: JNK-Inhibitor-II [pretreatment]
    *** unaffected by: Bisindolylmaleimide-I [pretreatment]
    *** source: 20188673-Fig-1d
