Location

  *** Hras[Ab] copptby[WB] Raf1[Ab] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0+ 1++ 3++ 5+ 15+ 30+ min
    *** source: 9564038-Fig-1b

InsR attributes

  *** Hras[Ab]IP GTP-association[TLC] is increased irt Ins (5 min)
    *** cells: CHO<xInsR> in BMLS
    *** partially inhibited by: xInsR(Y1158F) [substitution]
    *** partially inhibited by: xInsR(Y1162F/T1163F) [substitution]
    *** inhibited by: xInsR(Y1158F/T1162F) [substitution]
    *** source: 7806540-Fig-6

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No Extras
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  *** Hras[Ab]IP GTP-association[TLC] is increased irt Ins (times)
    *** cells: RAT1<xInsR> in BMLS
    *** times: 0 2+++ 7+++ 15++ 30+ 60 120 min
    *** source: 7592690-Fig-1e
  *** Hras[Ab]IP GTP-association[TLC] is increased irt Ins (times)
    *** cells: CHO<xInsR><xEgfR> in BMLS
    *** times: 0 1++ 3+ 5 30 min
    *** source: 8663461-Fig-2

not Dok1

  *** xHras[tAb] GTP-association[BDPD] is increased irt Ins (10 min)
    *** cells: CHO<xInsR> in BMLS
    *** inhibited by: xDok1 [addition]
    *** source: 11551902-Fig-6a

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Chemicals
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  *** Hras[Ab]IP GTP-association[TLC] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 1+++ 3++ 5++ 10+ 30+ min
    *** comment: decrease after 3 min is inhibited by PD98059
    *** source: 7673108-Fig-3
  *** Hras[Ab]IP GTP-association[TLC] is increased irt Ins (30 min)
    *** cells: NIH3T3<xInsR> in BMLS
    *** unaffected by: Wortmannin [addition]
    *** unaffected by: Rapamycin [addition]
    *** source: 12820960-Fig-2a


Mek1????

  *** Hras[Ab]IP GTP-association[TLC] is increased irt Ins (times)
    *** cells: CHO<xInsR> in BMS
    *** times: 0 5++ 30+ min
    *** comment: inhibited by xMek1(K97R)"DN" at 30 min only
    *** source: 7673108-Fig-4d
