=============
Transcription
=============

Ampk1a--

  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: THP1 in BMS
    *** reqs: Ampka1 [RNAi]
    *** source: 22833096-Fig-4c

Ciap1-- Ciap2--

  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: KMS28BM in BMS
    *** reqs: Ciap1 and/or Ciap2 [fmut]
    *** source: 19898473-Fig-S9c
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (tnr)
    *** cells: RAW2647 in BMS
    *** reqs: Ciap1 and/or Ciap2 [RNAi]
    *** source: 19898473-Fig-S9b

Hif1a--

  *** ProTnf-gene promo-reporter[Luc] is increased irt Lps (12 hr)
    *** cells: CHANG in BMS
    *** partially reqs: Hif1a [RNAi] no-bkg-control
    *** source: 17451682-Fig-5b
  *** ProTnf-gene mRNA[Northern] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** partially reqs: Hif1a [RNAi]
    *** source: 19762779-Fig-S5
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** partially reqs: Hif1a [RNAi]
    *** source: 19762779-Fig-4c

not Hmgb1--

  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mFLcDCs in BMS
    *** times: 0 3++ 6+ hr
    *** does not req: Hmgb1 [KO]
    *** source: 19890330-Fig-3a

Myd88--  ???

  *** ProTnf-gene mRNA[Northern] is increased irt Lps (90 min)
    *** cells: mPECs in BMS
    *** does not req: Myd88 [KO]
    *** source: 10435584-Fig-3c
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS
    *** reqs: Myd88 [KO]
    *** source: 19898473-Fig-6b


Phd1--
Phd2--

  *** ProTnf-gene mRNA[Northern] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** partially reqs: Phd1 [RNAi]
    *** partially reqs: Phd2 [RNAi]
    *** source: 19762779-Fig-S4
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** reqs: Phd1 [RNAi]
    *** partially reqs: Phd2 [RNAi]
    *** source: 19762779-Fig-2c

not Tpl2--

  *** ProTnf-gene mRNA[RPA] is increased irt Lps (1 hr)
    *** cells: mPECs in BMLS
    *** does not req: Tpl2 [KO]
    *** source: 11163183-Fig-4b
  *** ProTnf-gene mRNA[RPA] is increased irt Lps (1 hr)
    *** cells: mBMMs in BMLS
    *** does not req: Tpl2 [KO]
    *** source: 11163183-Fig-4b
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 3++ 6+ hr
    *** does not req: Tpl2 [KO]
    *** comment: inhibited at 3 hr only itao Tpl2
    *** source: 18187448-Fig-2b

not Trif--

  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS "immortalized"
    *** does not req: Trif [KO]
    *** source: 22065573-Fig-1b
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS
    *** does not req: Trif [fmut]
    *** source: 19898473-Fig-6b

chemicals

  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS
    *** inhibited by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-6a
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS
    *** inhibited by: SmacMimetic [pretreatment]
    *** source: 19898473-Fig-6b
  *** ProTnf-gene mRNA[RPA] is increased irt Lps (1 hr)
    *** cells: J774 in BMS
    *** partially inhibited by: PD98059 [pretreatment]
    *** unaffected by: CsA [pretreatment]
    *** unaffected by: SB203580 [pretreatment]
    *** source: 10913190-Fig-5a
  *** ProTnf-gene mRNA[Northern] is increased irt Lps (1 hr)
    *** cells: rNCMs in BMS
    *** inhibited by: WY14643 [pretreatment]
    *** inhibited by: Rosiglitazone [pretreatment]
    *** source: 11009565-Fig-3b
  *** ProTnf-gene mRNA[Northern] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-S1b
  *** ProTnf-gene mRNA[Northern] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-S5
  *** ProTnf-gene mRNA[Northern] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0+ 1++ 2++ 4+++ 6++ 24+ hr
    *** comment: inhibited by DMOG [pretreatment] at 4-24 hr
    *** source: 19762779-Fig-S1a
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-1b
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (1 hr)
    *** cells: THP1 in BMS
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-6b
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-4c
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0+ 1++ 2++ 3+++ 6+++ 24+ hr
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-1a
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (times)
    *** cells: THP1 in BMS
    *** times: 0 1+++ 3++ 6+ hr
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-6c
  *** ProTnf-gene promo-reporter[Luc] is increased irt Lps (1 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-1d
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS "immortalized"
    *** partially inhibited by: JSH23 [pretreatment]
    *** partially inhibited by: CHX [pretreatment]
    *** source: 22065573-Fig-2b
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: mBMMs in BMS "immortalized"
    *** partially inhibited by: JSH23 [pretreatment]
    *** source: 22065573-Fig-1b
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: THP1 in BMS "differentiated with Csf1"
    *** partially inhibited by: JSH23 [pretreatment]
    *** source: 22065573-Fig-1c


no extras

  *** ProTnf-gene mRNA[RPA] is increased irt Lps (times)
    *** cells: J774 in BMS
    *** times: 0 1+ 4++ hr
    *** source: 10913190-Fig-1
  *** ProTnf-gene mRNA[RPA] is increased irt Lps (times)
    *** cells: MONOMAC6 in BMS
    *** times: 0 1++ 4+ hr
    *** source: 10913190-Fig-1
  *** ProTnf-gene mRNA[RPA] is increased irt Lps (times)
    *** cells: P388D1 in BMS
    *** times: 0 1++ 4+ hr
    *** source: 10913190-Fig-1
  *** ProTnf-gene mRNA[Northern] is increased irt Lps (4 hr)
    *** cells: mPECs in BMS
    *** source: 12096038-Fig-1a
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (2 hr)
    *** cells: RAW2647 in BMS
    *** source: 11896392-Fig-5b
  *** ProTnf-gene mRNA[RTPCR] is increased irt Lps (3 hr)
    *** cells: mPECs in BMS
    *** source: 11896392-Fig-1  
  *** ProTnf-gene promo-reporter[Luc] is increased irt Lps (12 hr)
    *** cells: CHANG in BMS
    *** source: 17451682-Fig-5a
  *** ProTnf-gene promo-reporter[Luc] is increased irt Lps (12 hr)
    *** cells: HEPG2 in BMS
    *** source: 17451682-Fig-5a
  *** ProTnf-gene mRNA[MicroArray] is increased irt Lps (3 hr)
    *** cells: THP1 in BMS
    *** source: 22833096-Table-S1a


===========
Translation
===========

not Tpl2--

  *** ProTnf[Ab] prot-exp[WB] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 60+ 120+ 240+ min
    *** does not req: Tpl2 [KO]
    *** source: 18187448-Fig-2b

not Unc93bp1--

  *** xTnf[Ab] prot-exp[FACS] is increased irt Lps (tnr)
    *** cells: mBMDCs in BMS
    *** unaffected by: xUnc93b1 [addition]
    *** unaffected by: xUnc93b1(H412R) [addition]
    *** source: 16415873-Fig-4a

chemicals

  *** ProTnf[Ab] prot-exp[IHC] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS "pretreated with TAPI1"
    *** unaffected by: PD184352 [pretreatment]
    *** source: 18187448-Fig-5
  *** ProTnf[Ab] prot-exp[WB] is increased irt Lps (4 hr)
    *** cells: hPBMonos in BMS
    *** unaffected by: PD184352 [pretreatment]
    *** unaffected by: U0126 [pretreatment]
    *** source: 18187448-Fig-1c
  *** ProTnf[Ab] prot-exp[WB] is increased irt Lps (4 hr)
    *** cells: mBMMs in BMS
    *** unaffected by: PD184352 [pretreatment]
    *** source: 18187448-Fig-1b
  *** ProTnf[Ab] prot-exp[WB] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** unaffected by: PD184352 [pretreatment]
    *** source: 18187448-Fig-1a


==================
Surface Expression
==================

Tpl2--

  *** ProTnf[Ab] surface-exp[FACS] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 90++ 180+ min
    *** reqs: Tpl2 [KO]
    *** source: 18187448-Fig-4

chemicals

  *** ProTnf[Ab] surface-exp[IHC] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS "pretreated with TAPI1"
    *** inhibited by: PD184352 [pretreatment]
    *** source: 18187448-Fig-5

=========
Secretion
=========

Ampka1--

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (9 hr)
    *** cells: THP1 in BMS
    *** enhanced by: xAmpka1 [addition]
    *** partially inhibited by: xAmpka1(D159A)"DN" [addition]
    *** enhanced by: xAmpka1(T174D)"CA" [addition]
    *** source: 22833096-Fig-1i
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (9 hr)
    *** cells: THP1 in BMS
    *** reqs: Ampka1 [RNAi]
    *** source: 22833096-Fig-2h

not IL10--

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (5 hr)
    *** cells: mBMMs in BMS
    *** partially inhibited by: IL10 [cotreatment]
    *** source: 12754506-Fig-1b
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (9 hr)
    *** cells: mPECs in BMS
    *** inhibited by: IL10 [cotreatment]
    *** source: 12754507-Fig-2b
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: hPBMonos in BMS
    *** inhibited by: IL10 [cotreatment]
    *** source: 10875937-Fig-5

not IL6--

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (9 hr)
    *** cells: mPECs in BMS
    *** unaffected by: IL6 [cotreatment]
    *** comment: inhibited by IL6 in Socs3-null cells
    *** source: 12754507-Fig-2b
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 6+ 12++ 24+ hr
    *** unaffected by: IL6 [cotreatment]
    *** comment: inhibited by IL6 in Socs3-null cells
    *** source: 12754507-Fig-2a

not IL22--

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: hPBMonos in BMS
    *** unaffected by: IL22 [cotreatment]
    *** source: 10875937-Fig-5

Phd1-- Phd2--

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: RAW2647 in BMS
    *** reqs: Phd1 [RNAi]
    *** partially reqs: Phd2 [RNAi]
    *** source: 19762779-Fig-2d

not Socs3--

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (5 hr)
    *** cells: mBMMs in BMS
    *** does not req: Socs3 [KO]
    *** source: 12754506-Fig-1b
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 6+ 12++ 24+ hr
    *** does not req: Socs3 [KO]
    *** source: 12754507-Fig-2a

Tpl2--

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 2+ 4++ hr
    *** reqs: Tpl2 [KO]
    *** source: 17709378-Fig-4b
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: mBMMs<Tpl2~null><xTpl2> in BMS
    *** times: 0 2+ 4+ hr
    *** reqs: xTpl2 [omission]
    *** inhibited by: xTpl2(S400A) [substitution]
    *** unaffected by: xTpl2(S413A) [substitution]
    *** inhibited by: xTpl2(D270A)"KD" [substitution]
    *** source: 17709378-Fig-4b
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: mBMMs in BMS
    *** times: 0 3+ 6+ 20++ hr
    *** reqs: Tpl2 [KO]
    *** source: 18187448-Fig-2a

not Unc93bp1--

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (4 hr)
    *** cells: mPECs in BMS
    *** unaffected by: Unc93b1(H412R) [fmut]
    *** source: 16415873-Fig-1a

chemicals

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (18 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: SB203580 [pretreatment]
    *** source: 18255061-Fig-1a
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 1+ 2+ 4+ 6++ 8++ hr
    *** inhibited by: SB203580 [pretreatment]
    *** source: 18255061-Fig-2
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: TM6008 [pretreatment]
    *** source: 19762779-Fig-S2
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: mPECs in BMS
    *** times: 0 3+ 6+ 12++ 24++ hr
    *** partially inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-6a
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: RAW2647 in BMS
    *** times: 0+ 1++ 2+++ 3++++ 6++++ 24++++++ hr
    *** partially inhibited by: DMOG [pretreatment]
    *** source: 19762779-Fig-1c
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (6 hr)
    *** cells: mBMMs in BMS
    *** inhibited by: PS1145 [pretreatment]
    *** source: 15199157-Fig-1d
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (9 hr)
    *** cells: THP1 in BMS
    *** inhibited by: Compound-C [cotreatment]
    *** source: 22833096-Fig-1d
  *** Tnf[Ab] secretion[ELISA] is increased irt FSL1 (4 hr)
    *** cells: hPBMonos in BMS
    *** inhibited by: PD184352 [pretreatment]
    *** source: 18187448-Fig-1d
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (4 hr)
    *** cells: hPBMonos in BMS
    *** inhibited by: PD184352 [pretreatment]
    *** inhibited by: U0126 [pretreatment]
    *** source: 18187448-Fig-1c
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (4 hr)
    *** cells: mBMMs in BMS
    *** inhibited by: PD184352 [pretreatment]
    *** source: 18187448-Fig-1b
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (4 hr)
    *** cells: RAW2647 in BMS
    *** inhibited by: PD184352 [pretreatment]
    *** source: 18187448-Fig-1a

other

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: THP1 in BMS
    *** inhibited by: Lps [preconditioning]
    *** source: 21220427-Fig-9c
  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (24 hr)
    *** cells: THP1<Tnfaip3~null> in BMS
    *** unaffected by: Lps [preconditioning]
    *** source: 21220427-Fig-9c

no extras--

  *** Tnf[Ab] secretion[ELISA] is increased irt Lps (times)
    *** cells: hPBMCs in BMS
    *** times: 0 1+ 3++ 6+++ 24++ 48+ 72+ hr
    *** source: 15308104-Fig-2a
