Recruitment to Trka based on similarity to EgfR

=====================
Requirement for Trka
=====================

  *** Shc1[Ab]IP Yphos[pYAb] is unchanged irt Ngf (5 min)
    *** cells: PC12NNR5<xTrka(K544N)"KD"> in BMS
    *** source: 8155326-Fig-1
  *** Shc1[Ab]IP Yphos[pYAb] is increased irt Ngf (5 min)
    *** cells: PC12NNR5<xTrka> in BMS
    *** inhibited by: xTrka(Y496F) [substitution]
    *** inhibited by: xTrka(Y496F/Y791F) [substitution]
    *** source: 8155326-Fig-7a

  *** Shc1p66[Ab] snaggedby[WB] xTrka{phos}[Ab]IP is detectable
    *** cells: none
    *** comment: detergent extracts of mouse brain were used as a source of Shc1p66
    *** IPfrom: SF9<xTrka> in BMS
    *** comment: xTrka[Ab]IP was autophosed in phos-buffer containing ATP
    *** unaffected by: xTrka(Y791F) [substitution]
    *** inhibited by: xTrka(Y496F) [substitution]
    *** inhibited by: xTrka(K544N)"KD" [substitution]
    *** unaffected by: xTrka(Y676F) [substitution]
    *** unaffected by: xTrka(Y751F) [substitution]
    *** partially inhibited by: xTrka(Y670F/Y671F) [substitution]
    *** source: 8155326-Fig-5

==========================
Phosphorylaton on Tyrosine
==========================

  *** Shc1[Ab]IP Yphos[pYAb] is increased irt Ngf (1 min)
    *** cells: PC12 in BMS
    *** source: 8288573-Fig-1
  *** Shc1[Ab]IP Yphos[pYAb] is increased irt Ngf (5 min)
    *** cells: PC12 in BMS
    *** source: 8155326-Fig-1
  *** Shc1[Ab]IP Yphos[pYAb] is increased irt Ngf (5 min)
    *** cells: PC12<xTrka> in BMS
    *** source: 8155326-Fig-3a
  *** Shc1[Ab]IP Yphos[pYAb] is increased irt Ngf (times)
    *** cells: PC12 in BMS
    *** times: 0 5+++ 120+ 300+ 960 min
    *** source: 8155326-Fig-2a
  *** Shc1[Ab]IP Yphos[pYAb] is increased irt Ngf (times)
    *** cells: PC12<xTrka> in BMS
    *** times: 0 5+ 120+ 300+ 960 min
    *** source: 8155326-Fig-2b
  *** Shc1[Ab]IP Yphos[pYAb] is increased irt Ngf (5 min)
    *** cells: PC12<xTrka> in BMS
    *** unaffected by: xRgs19ip1 [addition]
    *** source: 11251075-Fig-8c
  *** Shc1[Ab]IP Yphos[pYAb] is increased irt Ngf (times)
    *** cells: PC12 in BMS
    *** times: 0 1+ 3++ 10+ min
    *** source: 15167895-Fig-1a

==============================================
Association with other Trka binding proteins
==============================================

Grb2--

  *** Shc1[Ab] snaggedby[WB] Grb2[GST] is increased irt Ngf (1 min)
    *** cells: PC12 in BMS
    *** source: 8155326-Fig-1







