=================
Response via NgfR
=================

  *** Akt1[phosAb] phos(S473)[phosAb] is increased itpo xNgfR
    *** cells: hFibros in BMS
    *** source: 11312266-Fig-4
  *** Akt1[phosAb] phos(S473)[phosAb] is increased itpo xNgfR
    *** cells: MG873T3 in BMS
    *** source: 11312266-Fig-3c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased itpo xNgfR
    *** cells: MG873T3 in BMS
    *** source: 11312266-Fig-3d
  *** Akt1[phosAb] phos(S473)[phosAb] is increased itpo xNgfR
    *** cells: PC12NNR5 in BMS
    *** source: 11312266-Fig-2

===============
Phosphorylation
===============

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC6 in BMLS
    *** source: 15632082-Fig-1c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ngf (15 min)
    *** cells: PC12 in BMS
    *** source: 11312266-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ngf (times)
    *** cells: PC63 in BMHIS
    *** times: 0 5+++ 20++ 45++ 90++ 240+ min
    *** comment: sustained signal (20-240 min) reqs Ppp2r1a [RNAi]
    *** source: 16129692-Fig-3a
  *** Akt1[phosAb] phos(S473)[phosAb] is unchanged irt Ngf (15 min)
    *** cells: PC12NNR5 in BMS
    *** source: 11312266-Fig-3a
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC12 in BMS
    *** source: 11953455-Fig-10a
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ngf (times)
    *** cells: PC12 in BMS
    *** times: 0 2++ 5++ 10++ 20+ 40+ min
    *** source: 11953455-Fig-1a
  *** Akt1[phosAb] phos(sitenr)[phosAb] is unchanged irt Ngf (10 min)
    *** cells: rECNs in BMS
    *** source: 11953455-Fig-10b
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ngf (15 min)
    *** cells: PC12 in BMLS
    *** source: 11733534-Fig-2c
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ngf (times)
    *** cells: PC12<xGab1> in BMLS
    *** times: 0+ 1++ 5++ 10++ 20++ min
    *** source: 10601297-Fig-4b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ngf (times)
    *** cells: PC12 in BMLS
    *** times: 0+ 1+ 5++ 10+ 20+ min
    *** source: 10601297-Fig-4b
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ngf (tnr)
    *** cells: PC12<xGab1> in BMLS
    *** source: 10601297-Fig-4a
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ngf (tnr)
    *** cells: PC6 in BMLS
    *** source: 16157584-Fig-1d
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ngf (times)   
    *** cells: PC12 in BMS
    *** times: 0 1 3++ 10+ min
    *** source: 15167895-Fig-1a

not Arms--

  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ngf (times)   
    *** cells: PC12 in BMS
    *** times: 0 5++ 40+ min
    *** does not req: Arms [RNAi]
    *** source: 15167895-Fig-7b
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ngf (times)   
    *** cells: PC12 in BMS
    *** times: 0 5++ 40+ min
    *** unaffected by: xArms [addition]
    *** partially inhibited by: xArms(del(1110-1131))"PPRPP" [addition]
    *** source: 15167895-Fig-6e



Chemicals

  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ngf (15 min)
    *** cells: PC12 in BMS
    *** inhibited by: Wortmannin [pretreatment]
    *** inhibited by: LY294002 [pretreatment]
    *** source: 11312266-Fig-6a
  *** Akt1[phosAb] phos(S473/T308)[phosAb] is increased irt Ngf (5 min)
    *** cells: PC12 in BMS
    *** unaffected by: U0126 [addition] no-bkg-control
    *** inhibited by: LY294002 [addition] no-bkg-control
    *** source: 11340168-Fig-5b
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC12 in BMS
    *** inhibited by: Wortmannin [pretreatment]
    *** inhibited by: LY294002 [pretreatment]
    *** unaffected by: PD98059 [pretreatment]
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 11953455-Fig-5
  *** Akt1[phosAb] phos(sitenr)[phosAb] is increased irt Ngf (10 min)
    *** cells: PC12 in BMS
    *** inhibited by: Wortmannin [pretreatment]
    *** unaffected by: PD98059 [pretreatment]
    *** unaffected by: Rapamycin [pretreatment]
    *** source: 11953455-Fig-6
  *** Akt1[phosAb] phos(S473)[phosAb] is increased irt Ngf (15 min)
    *** cells: PC6 in BMLS
    *** inhibited by: LY294002 [pretreatment]
    *** source: 16157584-Fig-S1a
