|
|
 | used in 10608883 with no explanation except that they are fibroblasts
|
|
|
|
| NIH3T3 expressing InsR 12606547(C)
|
|
|
|
| TIB-208 mouse lymphoblast suspension B lymphocyte; reticulum cell sarcoma
|
|
|
|
| A-375 CRL-1619 human skin; malignant melanoma adherent
|
|
|
|
| contains Braf(V600E) 19274086(C)
|
|
|
|
| A427 HTB-53 human epithelial adherent lung; carcinoma
|
|
|
|
| contains a Kras-CA-mutation 16630891(C)
|
|
|
|
| breast carcinoma cell line
|
|
|
|
| A431 CRL-1555 human epithelial adherent epidermis; epidermoid carcinoma
|
|
|
|
| expresses moderate levels of Pten mRNA 9187108(D)
|
|
|
|
 | Egf resistant clone of A431 17646046(C)
|
|
|
|
| number of EgfR: WT > 11a > 1a > 8a
|
|
|
|
| human alveolar type II (ATII) epithelial cell-derived cell line 17088343(C)
|
|
|
|
| A549 CCL-185 human lung; carcinoma epithelial adherent
|
|
|
|
| CDKN2A p.M1_*157del c.1_471del471 Homozygous
KRAS p.G12S c.34G>A Homozygous
STK11 p.Q37* c.109C>T Homozygous
|
|
|
|
| Samples from same individual: A549SF
|
|
|
|
| A-673 CRL-1598 human fibroblast adherent muscle; rhabdomyosarcoma
|
|
|
|
| A7r5 CRL-1444 rat fibroblast adherent thoracic aorta; smooth muscle
|
|
|
|
| murine macrophage cell line 17277110
|
|
|
|
| myeloma cell line 9020138(C)
|
|
|
|
| human thyroid cancer cells from GF Juillard (University of California at Los Angeles) 14729949(C)
|
|
|
|
| express high level of Rela protein but low levels of Pten 14729949(D)
|
|
|
|
| human thyroid tumor from anaplastic carcinoma 15231710(C)
|
|
|
|
| 20. Russo D, Arturi F, Bulotta S, Pellizzari L, Filetti S, Manzini G, Damante G, Tell G 2001 ApeI/Ref-I expression and cellular localization in human thyroid carcinoma cell lines. J Endocrinol Invest 24:C10–C12.
|
|
|
|
| ARPE-19 CRL-2302 human epithelial adherent eye (retina), pigmented epithelium
|
|
|
|
| AsPC-1 CRL-1682 human ascites (metastasis); adenocarcinoma adherent (pancreas primary)
|
|
|
|
| Chondrogenic cell line derivied by mouse teratocarcinoma
|
|
|
|
| In culture, these cells mimic the multistep process of chondrocyte differentiation. After plating, they proliferate until confluency, at which point they undergo growth arrest following contact inhibition. After 4 days, these cells undergo a phenotypic change characterized by the secretion of a variety of ECM molecules, such as type II collagen, aggrecan, and link protein, and by the formation of cartilaginous nodules on the culture plate (12, 18, 19).
|
|
|
|
| 12. Shukunami, C., Ohta, Y., Sakuda, M., and Hiraki, Y. (1998) Exp. Cell Res. 241, 1–11
|
|
|
|
| 18. Atsumi, T., Miwa, Y., Kimata, K., and Ikawa, Y. (1990) Cell Differ. Dev. 30, 109 –116
|
|
|
|
| 19. Shukunami, C., Shigeno, C., Atsumi, T., Ishizeki, K., Suzuki, F., and Hiraki, Y. (1996) J. Cell Biol. 133, 457– 468
|
|
|
|
| B16-F1 CRL-6323* mouse adherent skin; melanoma
|
|
|
|
| contains WT Braf 19274086(C)
|
|
|
|
| used without explanation in 99950686(C)
|
|
|
|
| used without explanation in 15039778(C)
|
|
|
|
| derived from SV40-transformed mature splenic macrophages 10799548(C)
|
|
|
|
| 31. Morgan, C., Pollard, J. W., and Stanley, E. R. (1987) J. Cell. Physiol. 130, 420 – 427
32. Buscher, D., Sbarba, P. D., Hipskind, R. A., Rapp, U. R., Stanley, E. R., and Baccarini, M. (1993) Oncogene 8, 3323–3332
|
|
|
|
| BAC1.2F5 is a simian virus 40 large-T-antigen-immortalized cell line that retains CSF-1 dependence and many other properties of primary murine BMM. 9632768(C)
|
|
|
|
| BA/F3 mouse pro B cells DSMZ#ACC-300
|
|
|
|
| IL-3 dependent murine pro B cell line established from peripheral blood; apparently derived from BALB/c mouse
|
|
|
|
| BALB/3T3 cloneA31 CCL-163 mouse fibroblast adherent skeletal muscle; lysyl oxidase deficiency
|
|
|
|
| murine keratinocytes from Harold L Moses [13] 14993291(C)
|
|
|
|
| 13. Coffey, R. J., Jr., C. C. Bascom, N. J. Sipes, R. Graves-Deal, B. E. Weissman and H. L. Moses. 1988. Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta. Mol. Cell Biol. 8:3088–3093.
|
|
|
|
| human thyroid tumor from papillary carcinoma 15231710(C)
|
|
|
|
| 20. Russo D, Arturi F, Bulotta S, Pellizzari L, Filetti S, Manzini G, Damante G, Tell G 2001 ApeI/Ref-I expression and cellular localization in human thyroid carcinoma cell lines. J Endocrinol Invest 24:C10–C12.
|
|
|
|
| BRAF p.V600E c.1799T>A Homozygous
TP53 p.D259Y c.775G>T Homozygous
|
|
|
|
| BEAS2B CRL-9609 human epithelial adherent lung (bronchus); virus transformed
|
|
|
|
| betaHC-9: a tissue culture model of pancreatic beta-cell 15192046(C)
|
|
|
|
| expressed EgfR and ErbB4 15192046(C)
|
|
|
|
| used without explanation in: 8653792 12972531
|
|
|
|
| BHK21 CCL-10 hamster fibroblast adherent hamster, Syrian golden kidney, clone-13
|
|
|
|
| from 19276070(M): MRE-beta-Geo reporter cell line, BHK3038, was kindly provided by Dr. R. D. Palmiter (University of Washington, Seattle, WA).
|
|
|
|
| Burkitt lymphoma, human 10692572(C)
|
|
|
|
| B-cell lymphoma 12150925(C)
|
|
|
|
| human cell line derived from Hek293 [28] 9020886(C)
|
|
|
|
| 28 Pear, W. S., Nolan, G. P., Scott, M. L. and Baltimore, D. (1993) Proc. Natl. Acad.
Sci. U.S.A. 90, 8392–8396
|
|
|
|
| "buffalo rat liver cells" 11598209(C)
|
|
|
|
| maybe BRL 3A CRL-1442 rat liver adherent
|
|
|
|
| derived from BHK cells and constitutively express the T7 polymerase
|
|
|
|
| provided by Karl-Klaus Conzelmann, Max Pettenkofer Institut
|
|
|
|
| BT-549 HTB-122 human epithelial adherent mammary gland; ductal carcinoma
|
|
|
|
| BxPC-3 CRL-1687 human pancreas; adenocarcinoma adherent
|
|
|
|
| Smad4-null 17638924(D) [WB]
|
|
|
|
| CDKN2A p.M1_*157del c.1_471del471 Homozygous
MAP2K4 p.? c.1041_1200del160 Homozygous
SMAD4 p.? c.1_1659del1659 Homozygous
TP53 p.Y220C c.659A>G Homozygous
|
|
|
|
| mouse Ink4a/Arf null melanocyte C140 cells 19187764(C)
|
|
|
|
| murine myoblast 16806820(C)
|
|
|
|
| C2C12 CRL-1772 mouse fibroblast adherent muscle
|
|
|
|
| used in 11265759 without explanation
|
|
|
|
| "mouse mygenic cells", "skeletal muscle cells" 14525954(C)
|
|
|
|
| can be differentiated into "myotubes" by culturing confluent cells for 4 days in DMEM in 2% horse serum
|
|
|
|
| endogenously express PpaRd(C)
|
|
|
|
| 16945942(C) mouse C2C12 satellite cells
|
|
|
|
| differentiated by switching cells from 10% FBS to 1% HS for 7 days
|
|
|
|
| C3H/10T1/2 CCL-226 mouse fibroblast adherent embryo Clone 8
|
|
|
|
| C3H10T12 cells transfected with Hras(G12V) are called 11A cells in 11358964
|
|
|
|
| C3H10T12 cells express Pkca, Pkcd, Pkce, Pkch but not Pkcb or Pkcg 11358964(D)
|
|
|
|
| Caco2 HTB-37 human epithelial adherent colon; colorectal adenocarcinoma
|
|
|
|
| Calu3 HTB-55 human pleural effusion (metastasis); adenocarcinoma (lung primary) epithelial adherent
|
|
|
|
| Capan-1 HTB-79 human liver (metastasis); adenocarcinoma (pancreas primary) epithelial adherent
|
|
|
|
| Smad4-null 17638924(D) [WB]
|
|
|
|
| BRCA2 p.S1982fs*22 c.5946delT Homozygous
CDKN2A p.M1_*157del c.1_471del471 Homozygous
KRAS p.G12V c.35G>T Homozygous
SMAD4 p.S343* c.1028C>G Homozygous
TP53 p.A159V c.476C>T Homozygous
|
|
|
|
| used in 15258589 with out explanation
|
|
|
|
| CCD-18Co CRL-1459 human colon fibroblast adherent
|
|
|
|
| ChangLiver CCL-13 human epithelial adherent HeLa contaminant
|
|
|
|
| used without explanation in 9774335
|
|
|
|
| possibly: Dede CCL-39 hamster fibroblast adherent lung
|
|
|
|
| ChangLiver CCL-13 human epithelial adherent HeLa contaminant
|
|
|
|
| This line was originally thought to be derived from normal liver tissue, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via HeLa cell contamination.
|
|
|
|
| Chinese Hamster Ovary Cells - see CHO-K1
|
|
|
|
| used without explanation in 11598209
|
|
|
|
| CHO-K1 CCL-61 hamster epithelial adherent ovary
CHO-K1 CRL-9618 hamster epithelial adherent ovary
|
|
|
|
| used without explanation in 10567225
|
|
|
|
| COLO 205 CCL-222 human ascites (metastasis); colorectal adenocarcinoma epithelial mixed (colon primary)
|
|
|
|
| colon carcinoma 10197981(C)
|
|
|
|
| APC p.T1556fs*3 c.4666_4667insA Homozygous
BRAF p.V600E c.1799T>A Heterozygous
SMAD4 p.? c.1_904del904 Homozygous
TP53 p.Y103_L111>L c.308_333>TA Homozygous
|
|
|
|
| used in many refs without explanation - possibly Cos1 or Cos7
|
|
|
|
| COS-1 CRL-1650 African green moneky kidney fibroblast adherent
|
|
|
|
| also used when cells are only described as "COS" cells, as in 9416833(C)
|
|
|
|
| COS-1 cells do not contain sufficient amounts of endogenous isoprenoid precursors to farnesylate overexpressed Ras proteins, so medium was supplemented with mevalonolactone to augment available precursors. 10358073(C)
|
|
|
|
| 11686307(D) COS cells produce only MHC-B [Myh10] not MHC-A [Myh9]
|
|
|
|
| COS-7 CRL-1651 African green moneky kidney fibroblast adherent
|
|
|
|
| 10620507 uses Cos7-M6 without explanation
|
|
|
|
| used in 10652228 without explanation
|
|
|
|
| CMT-93 CCL-223 mouse epithelial adherent rectum; polyploid carcinoma
|
|
|
|
| CTLL-2 TIB-214 mouse lymphoblast suspension T lymphocyte; cytotoxic
|
|
|
|
| hematopoietic cell line established from a patient with acute myeloblastic leukemia 10753828(C)
|
|
|
|
| 8069916(C): murine IL2 dependent cytotoxic T cell line
|
|
|
|
| 8692855(C): murine IL2 dependent cell line
|
|
|
|
| CV-1 CCL-70 monkey fibroblast adherent African Green monkey kidney
|
|
|
|
| "nonmuscle cells" "African green monkey cells" 14525954(C)
|
|
|
|
| T cells used in 11073940(C)
|
|
|
|
| Tp53-null mouse fibroblasts 10806474(C)
|
|
|
|
| Daudi CCL-213 human lymphoblast suspension peripheral blood, B lymphoblast; Burkitt’s lymphoma
|
|
|
|
| lymphoblastoid cell line 9374471(C)
|
|
|
|
| dermatofibrosarcoma protuberans cell line
|
|
|
|
| contains constitutively active PdgfR 12177062(C)
|
|
|
|
| DLD-1 CCL-221 human colon; colorectal adenocarcinoma epithelial adherent
|
|
|
|
| mutations: Kras(G13D)"CA" Tp53-null Apc-null 10197981(C)
|
|
|
|
| 16. M. van de Wetering, M. Oosterwegel, K. van Norren, H. Clevers, EMBO J. 12, 3847 (1993); V. Korinek and N. Barker, unpublished data.
|
|
|
|
| used without explanation in 12771962
|
|
|
|
| used without explanation in 15268862
|
|
|
|
| A Tgfb1-resistant mutant of MV1LU which lacks TgfbR2 1333888(C)
|
|
|
|
| The mkT6R-II receptor expressed in DR-26 cells contains a single base mutation (C to T) that transforms the seventh codon of the transmembrane region into a stop codon predicting a truncated receptor II protein that, if stable, is likely to be released into the medium. 1333888(D)
|
|
|
|
| A Tgfb1-resistant mutant of MV1LU which lacks TgfbR2 1333888(C)
|
|
|
|
| In DR-27 cells, receptor II contains a single base mutation (G to A) that converts the third cysteine in the extracellular domain to tyrosine (Figure 3) a change that may prevent TGFf3
binding owing to incorrect folding of the binding site. 1333888(D)
|
|
|
|
| DT40 CRL-2111 chicken lymphoblast suspension bursa; lymphoma
|
|
|
|
| DU 145 HTB-81 human epithelial adherent brain (metastasis); carcinoma (prostate primary)
|
|
|
|
| CDKN2A p.D84Y c.250G>T Homozygous
MLH1 p.? c.117-2A>T Homozygous
RB1 p.K715* c.2143A>T Homozygous
STK11 p.K178fs*86 c.532_536delAAGCC Homozygous
TP53 p.V274F c.820G>T Heterozygous
TP53 p.P223L c.668C>T Heterozygous
|
|
|
|
| EA.hy926 used in 15793306:
|
|
|
|
| the EA.hy926 cell line, formed by fusion of HUVECs with the human lung carcinoma cell line A549, which retains EC-like responses to TNF, and, as
reported here, displays an extensive caveolar system.
|
|
|
|
| The human-derived EA.hy926 EC line [24] (provided by Dr. W. Sessa, Yale University, New Haven, CT)
|
|
|
|
| 24. Edgell CJ, McDonald CC, Graham JB: Permanent cell line expressing
human factor VIII-related antigen established by hybridization. Proc
Natl Acad Sci USA 1983, 80:3734 –3737
|
|
|
|
| human, used without more explanation 14657239(C)
|
|
|
|
| A derivative of T24 human bladder line
|
|
|
|
| T24 HTB-4 human epithelial adherent urinary bladder; transitional cell carcinoma
|
|
|
|
| fibroblasts, used without more explanaation in 14651849
|
|
|
|
| also called EEF126-8 (EEF8, TSC2 -/-)
|
|
|
|
| human epithelial bladder derived cell line 9020886(C) 16260598(C)
|
|
|
|
| EJ bladder carcinoma cells were obtained from the European Collection of Cell Cultures (Porton Down, U.K.).
|
|
|
|
| EL4 TIB-39 mouse lymphoblast suspension T lymphocyte; lymphoma
|
|
|
|
| mouse mammary epithelial cell line 10197981(C)
|
|
|
|
| The parental cell line EpH4 is nontumorigenic and responds to TGFb1 with growth inhibition, whereas its v-Ha-Ras-transformed derivative, EpRas, responds with a transition into a fibroblastoid phenotype that is not growth inhibited and is highly invasive in vivo (Oft et al. 1996).
|
|
|
|
| Oft, M., J. Peli, C. Rudaz, H. Schwarz, H. Beug, and E. Reichmann. 1996. TGF-beta-1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tu-
mor cells. Genes & Dev. 10: 2462–2477.
|
|
|
|
| CCL39 cells expressing EgfR 9733714
|
|
|
|
| 17. Sardet, C., Fafournoux, P., and Pouyssegur, J. (1991) J. Biol. Chem. 266,
19166 –19171
|
|
|
|
| NF2(Merlin)-pos, p53-null osteosarcoma cells 16535381(C)
|
|
|
|
| 23. McClatchey, A. I., Saotome, I., Mercer, K., Crowley, D., Gusella, J. F., Bronson, R. T. & Jacks, T. (1998) Genes Dev. 12, 1121–1133.
|
|
|
|
| F9 CRL-1720 mouse epithelial adherent testis; embryonic carcinoma; testicular teratoma
|
|
|
|
| lack Jun and Fos [15,16] 9732876 (C)
|
|
|
|
| 5. Chiu, R. etal. The c-Fos protein interacts with c-Jun/AP-1to stimulate transcription of AP-1 responsive genes. Cell 54, 541–552(1988).
6. Yang-Yen, H.F., Chiu, R. &Karin,M. Elevation of AP-1activity during F9 cell differentiation is due to increased c-Jun transcription. NewBiol. 2, 351–361(1990).
|
|
|
|
| lack detectable levels of Jun 16511568
|
|
|
|
| Yang-Yen HF, Chiu R, Karin M (1990) Elevation of AP1 activity during F9 cell differentiation is due to increased c-jun transcription. New Biologist 2: 351–361
|
|
|
|
| van Dam H, Wilhelm D, Herr I, Steffen A, Herrlich P, Angel P (1995) ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J 14: 1798–1811
|
|
|
|
| rat hepatoma 10688912(C) 15069087(C)
|
|
|
|
| murine myeloid cell line 8995447(C)
|
|
|
|
| IL-4-dependent myeloid cell
|
|
|
|
| 14. Welham, M. J., Learmonth, L., Bone, H., and Schrader, J. W. (1995) J. Biol. Chem. 270, 12286 –12296
|
|
|
|
| A multipotent factor-dependent cell line, FDCP-mix. These cells possess a nonleukemic phenotype, have a normal karyotype, are factor dependent, and can be directed to undergo multilineage development in response to cytokines (77). By changing growth conditions (serum and cytokines), it is possible to grow this cell line under self-renewing conditions, such that they retain their multipotent state; alternatively, they may be directed to differentiate to form erythroid or myeloid cells. 16648489(C)
|
|
|
|
| FDC-P1 CRL-12103 mouse lymphoblast suspension bone marrow
|
|
|
|
| 10910062(C): murine IL-3-dependent myelomonocytic progenitor cell line
|
|
|
|
| a subclone of FDCP1 produced by continuous culturing in Csf1 which expresses the endogenous Csf1R and can grow in Csf1 as the sole hematopeietic growth factor 1710692(D)
|
|
|
|
| FRTL CRL-1468 rat thyroid adherent
|
|
|
|
| SV40-transformed human skin fibroblasts 7737130(C)
|
|
|
|
| SV40-immortalized human fibroblast cell line, normal human 18990686(C)
|
|
|
|
| insulin responsive Chinese hamster ovary-derived cell line 16049009(C)
|
|
|
|
| used in heterkaryon assay in 12191473 without explanation
|
|
|
|
| human lung cancer cells from John Yannelli (Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY). 17974977(C)
|
|
|
|
| mutant Kras status 17974977(C)
|
|
|
|
| lung cancer cell line 16676006(C)
|
|
|
|
| p53-negatvie [RTPCR] 16676006(D)
|
|
|
|
| Rat hepatoma cells (clone T-7-18 [4]) 10409724(C)
|
|
|
|
| 4. Baumann, H., K. R. Prowse, S. Marinokovic, K.-A. Won, and G. P. Jahreis. 1989. Stimulation of hepatic acute phase response by cytokines and glucocorticoids. Ann. N. Y. Acad. Sci. 557:280–295.
|
|
|
|
| NCI-H358 CRL-5807 human epithelial adherent lung (bronchiole; alveolus); bronchioalveolar carcinoma; non-small cell lung cancer
|
|
|
|
| nonsmall cell lung cancer
|
|
|
|
| KRAS p.G12C c.34G>T Heterozygous
|
|
|
|
| NCI-H838 CRL-5844 human lymph node (metastasis); adenocarcinoma; non-adherent small cell lung cancer (lung primary)
|
|
|
|
| CDKN2A p.M1_*157del c.1_471del471 Homozygous
STK11 p.T212fs*75 c.633delG Homozygous
TP53 p.E62* c.184G>T Homozygous
|
|
|
|
| human non-small lung cancer cells 16940186(C)
|
|
|
|
| NCI-H460 HTB-177 human epithelial adherent pleural effusion (metastasis); large cell carcinoma (lung primary)
|
|
|
|
| HaCat cells are a spontaneously immortalized, nontumorigenic keratinocyte cell line widely utilized as a model system for the study of structural and regulatory aspects of epithelial cell physiology and pathology (12, 13). 10969083(C)
|
|
|
|
| 12. Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., and Fusenig, N. E. (1988) J. Cell Biol. 106, 761–771
13. Breitkreutz, D., Schoop, V. M., Mirancea, N., Baur, M., Stark, H. J., and Fusenig, N. E. (1998) Eur. J. Cell Biol. 75, 273–286
|
|
|
|
| expresses high levels of Pten mRNA 9187108(D)
|
|
|
|
| used without explanation in 16630891
|
|
|
|
| mouse mammary epithelial cells
|
|
|
|
| HC11 mouse mammary epithelial cells have been widely used as an in vitro model of mammary gland epithelial cell differentiation. The HC11 cell line preserves important features of mammary epithelial cell lactogenic differentia- tion; it was clonally derived from the COMMA-1D cells, a line immortalized from mammary tissue of a pregnant BALB/c mouse [1,2]. The HC11 cells are non-tumorigenic, display a normal epithelial phenotype, and the injection of HC11 cells into the cleared fat pad of BALB/c mice exhibited normal ductal and alveolar-like structures [1,3]. HC11 mammary epithelial cell lactogenic differentiation can be initiated in culture following the growth to conflu- ence and deposition of extracellular matrix in the presence of epidermal growth factor (EGF), subsequent removal of EGF from the culture and the addition of lactogenic hormone mix, DIP (dexamethasone, insulin, and prolactin); upon differentiation HC11 cells express specific milk pro- teins including β-casein [1]. Moreover, during lactogenic differentiation in culture the HC11 cells undergo pheno- typic transformation to "mammospheres", enlarged domed structures with a lumen [4-6].
|
|
|
|
| 74. Taverna D, Groner B, Hynes NE: Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation. Cell Growth Differ 1991, 2(3):145-154.
|
|
|
|
| 9. Hynes NE, Taverna D, Harwerth IM, Ciardiello F, Salomon DS, Yamamoto T, Groner B: Epidermal growth factor receptor, but not c-erbB-2, activation prevents lactogenic hormone induction of the beta-casein gene in mouse mammary epithelial cells. Mol Cell Biol 1990, 10(8):4027-4034.
|
|
|
|
| HCT 116 CCL-247 human colon; colorectal carcinoma epithelial adherent on feeder cells
|
|
|
|
| CDKN2A p.R24fs*20 c.68_69insG Homozygous
|
|
|
|
| CTNNB1 p.S45del c.133_135delTCT Heterozygous
|
|
|
|
| KRAS p.G13D c.38G>A Heterozygous
|
|
|
|
| MLH1 p.S252* c.755C>A Homozygous
|
|
|
|
| PIK3CA p.H1047R c.3140A>G Heterozygous
|
|
|
|
| HEI 193 is a human schwannoma cell line established from a patient bearing a loss-of-function splice-site mutation in NF2 (20, 21). 16537831(C)
|
|
|
|
| 20. Fraenzer, J. T., Pan, H., Minimo, L., Jr., Smith, G. M., Knauer, D. & Hung, G.
(2003) Int . J. Oncol . 23, 1493–1500.
21. Hung, G., Li, X., Faudoa, R., Xeu, Z., Kluwe, L., Rhim, J. S., Slatter y, W. &
Lim, D. (2002) Int . J. Oncol . 20, 475– 482.
|
|
|
|
| 293 CRL-1573 human epithelial adherent kidney, fetal
|
|
|
|
| contains adenovirus EIA gene 9187108(C)
|
|
|
|
| does not express Pten mRNA 9187108(D) ???
|
|
|
|
| expresses Pten protein 14561749(C) with SCAb
|
|
|
|
| transfection of HEK293 with Pten does not inhibit growth 10698713(D) indicating that it already expresses Pten
|
|
|
|
| used without explanation in 16286006 17360704 12906785
|
|
|
|
| obtained from Invitrogen but Invitrogen doesn't carry them 11116146(C)
|
|
|
|
| 293-H Cells, SFM Adapted Invitrogen SKU# 11631-017
|
|
|
|
| Adapted to CD 293 Medium (Cat. No. 11913-019).293-F and 293-H Cells are clonal isolates, derived from transformed embryonal human kidney cells (1,2). The 293-F strain is a fast-growing variant of the 293 cell line. The 293-H strain is a variant of the 293 cell line that demonstrates better adherence in monolayer culture and ease of use for plaque assays and other anchorage dependent applications. The 293 parental cell line was selected for growth and transfection efficiency (2). Both 293-F and 293-H cell lines can beadapted to serum-free suspension culture in 293 SFM II or CD 293 Medium supplemented with L-glutamine for recombinant protein production and adenovirus propagation.
|
|
|
|
| 293-TK/Zeo cells were expanded to pools of 107 cells each, subjected to five rounds of mutagenesis with ICR191 (an intercalating agent that induces frameshift mutations), and selected in gancyclovir plus IL-1.
|
|
|
|
| turns on Nfkb-reporter or CBS binding irt Tnf but not IL1b
|
|
|
|
| secretes IL8 irt Tnf but not IL1b
|
|
|
|
| lacks Irak1 protein expression
|
|
|
|
| 293-TK/Zeo cells were expanded to pools of 107 cells each, subjected to five rounds of mutagenesis with ICR191 (an intercalating agent that induces frameshift mutations), and selected in gancyclovir plus IL-1.
|
|
|
|
| turns on Nfkb-reporter or CBS binding irt Tnf but not IL1b
|
|
|
|
| secretes IL8 irt Tnf but not IL1b
|
|
|
|
| 293-TK/Zeo cells were expanded to pools of 107 cells each, subjected to five rounds of mutagenesis with ICR191 (an intercalating agent that induces frameshift mutations), and selected in gancyclovir plus IL-1.
|
|
|
|
| turns on Nfkb-reporter or CBS binding irt Tnf but not IL1b
|
|
|
|
| secretes IL8 irt IL1b but not Tnf
|
|
|
|
| lacks Myd88 protein expression
|
|
|
|
| used without explanation in 14690596 11533489 16135789 10755617 14560022
|
|
|
|
| possibly: 293T/17 CRL-11268 human epithelial adherent kidney; highly transfective
|
|
|
|
| HeLa CCL-2 human cervix; adenocarcinoma epithelial adherent
|
|
|
|
| STK11 p.? c.1_464del464 Homozygous
|
|
|
|
| D98-AH2-CloneB, GLC-82, KB, MR1-3, AKI, J-111, MR10-1, Hep2, Hep-2C
|
|
|
|
| expresses moderate levels of Pten mRNA 9187108(D)
|
|
|
|
| HeLa S3 CCL-2.2 human cervix; adenocarcinoma epithelial adherent
|
|
|
|
| immortalized mouse PECs 16895974
|
|
|
|
| Hep 3B2.1-7 HB-8064 human epithelial adherent liver; hepatocellular carcinoma
|
|
|
|
| might be: HEPA1C1C7 or HEPA16
|
|
|
|
| Hepa 1-6 CRL-1830 mouse epithelial adherent liver; hepatoma
|
|
|
|
| Hepa-1c1c7 CRL-2026 mouse epithelial adherent liver; hepatoma
|
|
|
|
| Hep G2 HB-8065† human epithelial adherent liver; hepatocellular carcinoma
|
|
|
|
| used without explanation in 8524316
|
|
|
|
| HoxB8-immortalized myeloid progenitors 163606937(C)
|
|
|
|
| Fetal liver myeloid progenitors were immortalized using an oestrogen-responsive ER-HoxB8 oncogene in the presence of 1mM oestrogen and GM-CSF [21].
|
|
|
|
| 21. Knloepfler, P. S., Sykes, D. B., Pasillas, M. &Kamps, M. P. HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. Oncogene20, 5440-5448(2001).
|
|
|
|
| HK-2 CRL-2190 human epithelial adherent kidney (cortex, proximal tubule); HPV-16 transformed
|
|
|
|
| human renal proximal tubular epithelial cells immortalized by transduction with human papilloma virus 16 E6/E7 genes (21) 15084590(C)
|
|
|
|
| 21. Ryan, M. J., Johnson, G., Kirk, J., Fuerstenberg, S. M., Zager, R. A., and
Torok-Storb, B. (1994) Kidney Int. 45, 48 –57
|
|
|
|
| HL-60 CCL-240 human peripheral blood; promyeloblast; acute myeloblastic suspension promyelocytic leukemia
|
|
|
|
| TP53 p.M1_*394del c.1_1182del1182 Confirmed somatic variant Homozygous
|
|
|
|
| CDKN2A p.R80* c.238C>T Confirmed somatic variant Homozygous
|
|
|
|
| NRAS p.Q61L c.182A>T Confirmed somatic variant Heterozygous
|
|
|
|
| human hepatocellular carcinoma cells 12872134(C)
|
|
|
|
| used without explanation in 12621041
|
|
|
|
| mastocytoma aka mast cell leukemia cell line 12177062(C)
|
|
|
|
| HMC1.1 expresseds Kit V560C mutation
|
|
|
|
| HMC1.2 expresses Kit V560C and D816V mutation
|
|
|
|
| Human microvascular endothelial cell-1
|
|
|
|
| First published by PMID:1361507
|
|
|
|
| Human dermal microvascular endothelial cells (HMEC) immortalized through transfection with SV40 T antigen
|
|
|
|
| human squamous cell carcinoma 11716761(C)
|
|
|
|
| used without explanation in 16630891
|
|
|
|
| possibly: HPAF-II CRL-1997 human epithelial adherent pancreas; adenocarcinoma
|
|
|
|
| 11278283(C) human thymoma derived
|
|
|
|
| HS-24, a tumor cell line with properties of human bronchial EC (1,32), was generously provided by Dr. E. Spiess (Heidelberg, Germany). 15557085(C)
|
|
|
|
| 1. Abe T, Kobayashi N, Yoshimura K, Trapnell BC, Kim H, Hubbard
RC, Brewer MT, Thompson RC, and Crystal RG. Expression of the
secretory leukoprotease inhibitor gene in epithelial cells. J Clin Invest 87:
2207–2215, 1991.
|
|
|
|
| 32. Maruyama MJ, Hay G, Yoshimura K, Chu CS, and Crystal RG.
Modulation of secretory leukoprotease inhibitor gene expression in human
bronchial epithelial cells by phorbol ester. J Clin Invest 94: 368 –375,
1994.
|
|
|
|
| Hs24Fs CRL-7016 human fibroblast adherent skin (foreskin)
|
|
|
|
| human oral squamous cell carcinoma cells 9311995(C)
|
|
|
|
| HT-1080 CCL-121 human epithelial adherent connective tissue; fibrosarcoma
|
|
|
|
| CDKN2A p.M1_*157del c.1_471del471 Homozygous
NRAS p.Q61K c.181C>A Heterozygous
|
|
|
|
| do not express Egr1 11781575(C)
|
|
|
|
| HT-29 HTB-38 human epithelial adherent colon; colorectal adenocarcinoma
|
|
|
|
| colon carcinoma 10197981(C)
|
|
|
|
| APC p.T1556fs*3 c.4666_4667insA Heterozygous
APC p.E853* c.2557G>T Heterozygous
BRAF p.V600E c.1799T>A Heterozygous
PIK3CA p.P449T c.1345C>A Heterozygous
SMAD4 p.Q311* c.931C>T Homozygous
TP53 p.R273H c.818G>A Homozygous
|
|
|
|
| do not express Lef1 or Tcf7 9065401(D)
|
|
|
|
| cervical cancer cells 16005186(C) [15]
|
|
|
|
| [15] S.L. Huang, R.Y. Shyu, M.Y. Yeh, S.Y. Jiang, Anticancer Res. 22
(2002) 799.
|
|
|
|
| a human hepatoma cell line (gift from Michael Gale) 16301520(C)
|
|
|
|
| a hepatoma cell line (gift from CM Rice) 16177806(C)
|
|
|
|
| Huh7 cells expressing the HCV-replicon 16731946(C)
|
|
|
|
| 5. Blight, K. J., A. A. Kolykhalov, and C. M. Rice. 2000. Eficient initiation of HCV RNA replication in cell culture. Science 290:1972–1974.
|
|
|
|
| IEC18 CRL-1589 rat epithelial adherent ileum
|
|
|
|
| a previously characterized, clonal intestinal epithelial cell line which is hypersensitive to TGFP, relative to the parental cells from which it was derived.[ref below] The clonal 4-1 cell line was developed4-1 cells were derived by chemical mutagenesis of untransformed rat intestinal epithelial (IEC-18) cells, selection in the presence of TGFP, and limiting dilution cloning, as described previously. 1544886(C)
|
|
|
|
| K. M. Mulder, P. R. Segarini, S. L. Morris, J. M. Ziman, and H. G. Choi (1993) J Cell Physiol 154,162-174.
|
|
|
|
| a clone of IEC18 that is resistant to Tgfb effects 7706248(C)
|
|
|
|
| K. M. Mulder, P. R. Segarini, S. L. Morris, J. M. Ziman, and H. G. Choi (1993) J Cell Physiol 154,162-174.
|
|
|
|
| IIA1.6 a murine B cell line that does not express any of the Tcf genes 9065401(C)
|
|
|
|
| M. Molenaar et al., Cell 86, 396 (1996)
|
|
|
|
| J. Behrens et al., Nature 382, 638 (1996)
|
|
|
|
| O. Huber et al., Mech. Dev. 59, 3 (1996).
|
|
|
|
| a mouse BALB/c monocyte/macrophage cell line 15820149(C)
|
|
|
|
| J774A.1 TIB-67 mouse macrophage adherent macrophage; monocyte; reticulum cell sarcoma
|
|
|
|
| mouse macrophage-like cell line
|
|
|
|
| JAR HTB-144 human epithelial adherent placenta; choriocarcinoma
|
|
|
|
| a Jurkat clone that does not express Lck or Syk 15240695(D)
|
|
|
|
| Nemo-null, no other info 14695475(C)
|
|
|
|
| JM4.5.2 cells, a T cell line that lacks expression of NEMO (46). 12867425(C)
|
|
|
|
| 46. Harhaj, E. W., Good, L., Xiao, G., Uhlik, M., Cvijic, M. E., Rivera-Walsh, I., and Sun, S. C. (2000) Oncogene 19, 1448 –1456
|
|
|
|
| human T lymphocyte; acute T cell leukemia lymphoblast suspension
|
|
|
|
| Jurkat, Clone E6-1 TIB-152 human lymphoblast suspension T lymphocyte; acute T cell leukemia
|
|
|
|
| lacks expression of Syk as a result of a single nucleotide insertion in the Syk open reading frame, leading to premature translational termination (40).
|
|
|
|
| 40. Fargnoli, J., Burkhardt, A. L., Laverty, M., Kut, S. A., van Oers, N. S., Weiss, A., and
Bolen, J. B. (1995) J. Biol. Chem. 270, 26533–26537
|
|
|
|
| European Collection of Animal Cell Culture (HPACC)
|
|
|
|
| General Cell Collection: H33HJ-JA1
Catalogue No.: 90112119
Cell Line Name: H33HJ-JA1
Keywords: Human lymphoma
Cell Line Description: Derivative of the Jurkat cell line and secretes Interleukin 2. The cells should be handled under laboratory containment level 2.
Species: Human
Tissue: blood
Morphology: Lymphoblast
Growth Mode: Suspension
Subculture Routine: Maintain cultures between 2-9x10,000 cells/ml; 5% CO2; 37°C.
Culture Medium: RPMI 1640 + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
Karyotype: Not specified
Products: Interleukin 2 (IL-2)
Depositor: Obtained from ATCC
Originator: No
Country: USA
References: None specified by depositor
Additional Bibliography: Not specified
Patents: This material is cited in a US and/or other Patent and may not be used to infringe patent claims.
Research Council Deposit: No
Release Conditions: No
|
|
|
|
| Fadd "deficient" Jurkat cells 12107169(C)[23]
|
|
|
|
| 23. Juo, P., Kuo, C. J., Yuan, J., and Blenis, J. (1998) Curr. Biol. 8, 1001–1008
|
|
|
|
| used without description in 10725328
|
|
|
|
| a Jurkat cell line that allows the episomal amplification of the transfected plasmids 10669745(C)
|
|
|
|
| a T-antigen-expressing Jurkat cell line 10669745(C)
|
|
|
|
| Jurkat transfected with SV40 T-antigen
|
|
|
|
| Huh7 cells expressing the HCV-replicon (gift from Michael Gale) 16301520(C)
|
|
|
|
| 19. Sumpter, R., Jr., Wang, C., Foy, E., Loo, Y. M. & Gale, M., Jr. (2004) J. Virol. 78, 11591–11604.
|
|
|
|
| CCL-243, human, lymphoblast, suspension
pleural effusion (metastatic); chronic myelogenous leukemia (bone marrow primary)
|
|
|
|
| K562 lack the entire locus for type I IFN genes and results in the absence of autocrine IFN expression 15208624(C)
|
|
|
|
| "express a mutant EgfR lacking intrinsic protein tryosine kinase activity" 8524316(C)
|
|
|
|
| human oral epithelial carcinoma
|
|
|
|
| KB CCL-17 human epithelial adherent HeLa contaminant
|
|
|
|
| human myeloid cell 15240695(C)
|
|
|
|
| human myelogenous leukemia cell line
|
|
|
|
| TP53 p.? c.672+1G>A Confirmed somatic variant Homozygous
|
|
|
|
| KG1 grown in RPMI/HI-FCS + Csf1 + IL4 for 5 days
|
|
|
|
| KGI grown in RPMI + Csf2 + Tnf + Ionomycin for 1-3 days
|
|
|
|
| KIT225/K6, an IL-Zdependent subclone derived from the human T cell line KIT225 (18), was obtained from Dr. T. Uchiyama (Kyoto, Japan) and previously had been demonstrated to express IL-12Rs (19). 7527811(C)
|
|
|
|
| 19. Desai, B. B., T. Truitt, S. Honasoge, R. Warrier, R. Chizzonite, and
M. Gately. 1993. Expression of functional IL-12 receptor on a hu-
man IL-2-dependent T cell line. J. Immunol. 150t207A.
|
|
|
|
| KMS-28BM (WT) and KMS-28PE (c-IAP-/-) multiple myeloma cells, were
a generous gift from Rafael Fonseca, Mayo Clinic (3) 18635759(C)
|
|
|
|
| J. J. Keats et al., Cancer Cell 12, 131 (2007). 17692805
|
|
|
|
| L6 CRL-1458 rat adherent skeletal muscle myoblast
|
|
|
|
| used without explanation in 12034739
|
|
|
|
| "a derivative of MV1LU [24] obtained from J Massague" 12193595(C)
|
|
|
|
| 24. Attisano, L., Carcamo, J., Ventura, F., Weis, F. M. B., Massague´ , J., and Wrana, J. L. (1993) Cell 75, 671– 680
|
|
|
|
| used in 12628924 with no explanation about the "SA"
|
|
|
|
| Tsc2-null LExF2 cells (LEF) were maintained in DMEM/F12 (Invitrogen)
containing 10% FBS and 50 mg/mL P/S (Inoki et al., 2003). 16959574(C)
|
|
|
|
| Inoki, K., Zhu, T., and Guan, K.L. (2003). TSC2 mediates cellular energy
response to control cell growth and survival. Cell 115, 577–590.
|
|
|
|
| L Cells CRL-2648 mouse fibroblast adherent subcutaneous connective tissue, areolar and adipose; control for L Wnt-3A cells
|
|
|
|
| LLC-MK2 CCL-7.1 monkey, Rhesus kidney epithelial adherent
|
|
|
|
| LLC-PK1 CL-101 pig kidney epithelial adherent
|
|
|
|
| LN-229 CRL-2611 human epithelial adherent brain; glioblastoma; apoptosis studies; p53+, p16–, p14ARF–
|
|
|
|
| LNCaP cl.FGC CRL-1740 human lymph node (metastasis); carcinoma (prostate epithelial loosely adherent primary) clusters
|
|
|
|
| colon carcinoma 10197981(C)
|
|
|
|
| Kras-G12D Tp53-null Apc-null 10197981(C)
|
|
|
|
| LoVo CCL-229 human lymph node, left supraclavicular region (metastasis); colorectal adenocarcinoma (colon primary) epithelial adherent
|
|
|
|
| M059J CRL-2366 human fibroblast adherent brain, glial cell; malignant glioblastoma; glioma
|
|
|
|
| null for DNA-PKcs 15718470(C)
|
|
|
|
| M1 TIB-192 mouse myeloblast; myeloid leukemia suspension
|
|
|
|
| contains Lkb1 protein 19187764-Fig-6d
|
|
|
|
| Cosmic id 905975 same donor as MDAMB435
|
|
|
|
| BRAF p.V600E c.1799T>A Heterozygous
CDKN2A p.? c.150+2T>C Heterozygous
CDKN2A p.? c.456_457+25AGGTGAGGACTGATGATC TGAGAATTT>C Heterozygous
TP53 p.G266E c.797G>A Heterozygous
|
|
|
|
| M12.4.1 a B cell line 15084608(C)[31]
|
|
|
|
| 31. Hamano, T., Kim, K. J., Leiserson, W. M., and Asofsky, R. (1982) J. Immunol.
129, 1403–1406
|
|
|
|
| testiculare cell line derived from a mouse leydig cell tumor 10854429(C)
|
|
|
|
| 21. Ascoli, M. (1981) Endocrinology 108, 88 –95
|
|
|
|
| a murine bone marrow macrophage cell line established by infection with retroviruses carying v-raf and v-myc oncogenes 17618271(C)
|
|
|
|
| Blasi, E. et al. Selective immortalization of murine macrophages from fresh bone
marrow by a raf/myc recombinant murine retrovirus. Nature 318, 667-670 (1985).
|
|
|
|
| Malme-3M HTB-64 human skin; malignant melanoma mixed adherent
|
|
|
|
| contains Lkb1 protein 19187764-Fig-6d
|
|
|
|
| MC3T3-E1 CRL-2594 mouse bone (calvaria); osteoblast differentiation model fibroblast adherent Subclone 14
MC3T3-E1 CRL-2595 mouse bone (calvaria); osteoblast differentiation model fibroblast adherent Subclone 24
MC3T3-E1 CRL-2596 mouse bone (calvaria); osteoblast differentiation model fibroblast adherent Subclone 30
MC3T3-E1 CRL-2593 mouse bone (calvaria); osteoblast differentiation model fibroblast adherent Subclone 4
|
|
|
|
| mouse calvarial cell line
|
|
|
|
| the only major BMP7 type I receptor expressed on this cell line is ALK2 - 9748228(C)
|
|
|
|
| ten Dijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C.-H., and Miyazono, K. (1994) J. Biol. Chem. 269, 16985–6988
|
|
|
|
| derived by Sudo et al. (44) - 9748228(C)
|
|
|
|
| 44. Sudo, H., Kodama, H., Amagi, Y., Yamamoto, S., and Kasai, S. (1983) J. Cell Biol. 96, 191–198
|
|
|
|
| MC/9 CRL-8306 mouse lymphoblast suspension liver, mast cell
|
|
|
|
| Mast cells line 9525930(C)
|
|
|
|
| MCF7 HTB-22 human pleural effusion (metastasis); adenocarcinoma epithelial adherent (mammary gland primary)
|
|
|
|
| p53-positive [RTPCR] 16676006(D)
|
|
|
|
| synonyms: MCF-7S1 MCF7-S1
|
|
|
|
| used without explanation in 17244528 12058026
|
|
|
|
| MCF 10A CRL-10317 human epithelial adherent mammary gland; fibrocystic disease
|
|
|
|
| MCF-12A CRL-10782 human epithelial adherent mammary gland
|
|
|
|
| used without explanation in 11894095
|
|
|
|
| human fibroblast line 14560022(C)
|
|
|
|
| MDA-MB-231 HTB-26 human epithelial adherent pleural effusion (metastasis); adenocarcinoma (mammary gland primary)
|
|
|
|
| BRAF p.G464V c.1391G>T Heterozygous
CDKN2A p.M1_*157del c.1_471del471 Homozygous
KRAS p.G13D c.38G>A Heterozygous
NF2 p.E231* c.691G>T Homozygous
TP53 p.R280K c.839G>A Homozygous
|
|
|
|
| MDA-MB-361 HTB-27 human brain (metastasis); adenocarcinoma (mammary epithelial loosely adherent gland primary)
|
|
|
|
| MDA-MB-361 HTB-27 human brain (metastasis); adenocarcinoma (mammary epithelial loosely adherent gland primary)
|
|
|
|
| Cosmic id 905975 same donor as M14
|
|
|
|
| BRAF p.V600E c.1799T>A Heterozygous
CDKN2A p.? c.150+2T>C Heterozygous
CDKN2A p.? c.456_457+25AGGTGAGGACTGATGATC TGAGAATTT>C Heterozygous
TP53 p.G266E c.797G>A Heterozygous
|
|
|
|
| MDA-MB-453 HTB-131 human epithelial adherent pleural effusion (metastasis); carcinoma (mammary gland primary)
|
|
|
|
| CDH1 p.W638* c.1913G>A Homozygous
PIK3CA p.H1047R c.3140A>G Heterozygous
|
|
|
|
| MDA-MB-468 HTB-132 human epithelial adherent pleural effusion (metastasis); adenocarcinoma (mammary gland primary)
|
|
|
|
| PTEN p.? c.253+1G>T Homozygous
RB1 p.? c.265_2787del2523 Homozygous
SMAD4 p.? c.1_1659del1659 Homozygous
TP53 p.R273H c.818G>A Homozygous
|
|
|
|
| MDCK (NBL-2) CCL-34 dog epithelial adherent kidney
|
|
|
|
| MEG-01 CRL-2021 human lymphoblast mixed bone marrow; megakaryoblast; chronic myelogenous leukemia
|
|
|
|
| MeWo HTB-65 human fibroblast adherent lymph node (metastasis); malignant melanoma (skin primary)
|
|
|
|
| contains Lkb1 protein 19187764-Fig-1a
|
|
|
|
| MIA PaCa-2 CRL-1420 human epithelial adherent pancreas; carcinoma
|
|
|
|
| mIMCD-3 CRL-2123 mouse epithelial adherent (transgenic) kidney (medulla, collecting duct)
|
|
|
|
| used without explanation in 17287212
|
|
|
|
| human myeloblastic leukemia 9187108(C)
|
|
|
|
| expresses high levels of Pten mRNA 9187108(D)
|
|
|
|
| mouse ATII cell-derived cell line
|
|
|
|
| Primary fibroblast cells from a classical Menkes disease patient were immortalized by the SV40 gene transfer to derive Me32aT22/2L (43) and designated MNK(Del). The 4.6-kb cDNA encoding the human MNK protein was cloned into a mammalian expression vector and transfected into Me32aT22/2L, and MNK-expressing clone A12-H9 was designated MNK(++) (43). The empty mammalian expression vector, pCMB77, was transfected alone into Me32aT22/2L to derive Me32aT22/2L(pCMB77) and designated MNK(v/o) (43).
|
|
|
|
| 43. La Fontaine, S. L., Firth, S. D., Camakaris, J., Englezou, A., Theophilos, M. B., Petris, M. J., Howie, M., Lockhart, P. J., Greenough, M., Brooks, H., Reddel, R. R., and Mercer, J. F. (1998) J. Biol. Chem. 273, 31375–31380
|
|
|
|
| acute T-cell lymphoblastic leukemia 9374471(C)
|
|
|
|
| ATCC: MOLT-4 CRL-1582 human T lymphoblast; acute lymphoblastic leukemia lymphoblast, suspension
|
|
|
|
| MRC5 CCL-171 human fibroblast adherent lung
|
|
|
|
| human thyroid cancer cells from GF Juillard (University of California at Los Angeles) 14729949(C)
|
|
|
|
| express high level of Rela protein but low levels of Pten 14729949(D)
|
|
|
|
| MTLn3 rat mammary adenocarcinoma cell line 15337778(C)
|
|
|
|
| Mv1Lu (NBL-7) CCL-64 mink lung epithelial adherent
|
|
|
|
| mink lung epithelial cells 9311995(C)
|
|
|
|
| express: Smad2 Smad3 Smad4 (Smad1 and/or Smad5)
|
|
|
|
| used without explanation in 14750902 12904571 15241417
|
|
|
|
| MV-4-11 CRL-9591 human lymphoblast suspension peripheral blood; biphenotypic B myelomonocytic leukemia
|
|
|
|
| pre-B cell line 9020138(C)
|
|
|
|
| NBT-II CRL-1655 rat epithelial adherent lymphoma urinary bladder; tumor
|
|
|
|
| CRL-5844 human lymph node (metastasis); adenocarcinoma; non-adherent small cell lung cancer (lung primary)
|
|
|
|
| express high levels of endogenous Rela protein 14729949(D)
|
|
|
|
| Neuro-2a CCL-131 mouse brain, neuroblast; neuroblastoma neuronal and adherent amoeboid stem cells
|
|
|
|
| NIH3T3 CRL-1658 mouse fibroblast adherent embryo
|
|
|
|
| differentiated into adipocytes: 7739560(M):
|
|
|
|
| 3T3-L1 fibroblasts were maintained in DMEM containing penicillin-streptomycin plus 10% calf serum and incubated at 37oC in an 8% CO2/air gas mixture.
3T3-L1 fibroblasts (2 days postconfluent) were differentiated into adipocytes by replacing the medium with DMEM containing penicillin-streptomycin, 10% fetal bovine serum, 0.25 uM dexamethasone, 500 uM isobutylmethylxanthine, and 1 ug/ml insulin for 3 days. The 3T3-L1 cells were then incubated with DMEM containing 100 U of penicillin per ml, 100 ug of streptomycin per ml, and 10% fetal bovine serum for 8 to 40 days to maintain the adipocyte phenotype.
|
|
|
|
| NMuMG CRL-1636 mouse epithelial adherent mammary gland
|
|
|
|
| murine fibroblast cell line 8621573(C)
|
|
|
|
| used without explanation in 14747473(C)
|
|
|
|
| used in 11231577 without explanation
|
|
|
|
| OsA-CL osteosarcoma cells 17085434(C)
|
|
|
|
| 10. Knockaert, M., Sapkota, G., Alarcon, C., Massague´, J., and Brivanlou, A. H. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 11940 –11945
|
|
|
|
| P19 CRL-1825 mouse epithelial adherent embryo; teratocarcinoma; embryonic carcinoma
|
|
|
|
| used in 16630891 without explanation
|
|
|
|
| PANC-1 CRL-1469 human epithelial adherent pancreas (duct); epithelioid carcinoma
|
|
|
|
| PC-12 CRL-1721 rat adrenal gland; pheochromocytoma polygonal loosely adherent clusters
|
|
|
|
| express mRNA for Mlk1 Mlk2 Mlk3 Dlk Lzk GAPDH cyclophilin 11494869(D)
|
|
|
|
| expresses high levels of Pten mRNA 9187108(D)
|
|
|
|
| PC-3 CRL-1435 human epithelial adherent bone (metastasis); adenocarcinoma (prostate primary)
|
|
|
|
| a subline originating from PC3 cells [4] 10801443
|
|
|
|
| 4. Franzén P, Ichijo H, Miyazono K: Different signals mediate transforming growth factor-β1-induced growth inhibition and extracellular matrix production in prostatic carcinoma cells. Exp Cell Res1993, 207:1-7.
|
|
|
|
| PC6 is a subline of PC12 cells that produces neurites in response to NGF but also grows isolated cells, rather than clumps of cells (42) (generous gift of T. Vanaman, University of Kentucky,
Lexington). 15632082(C)
|
|
|
|
| 42. Pittman, R. N., S. Wang, A. J. DiBenedetto, and J. C. Mills. 1993. A system
for characterizing cellular and molecular events in programmed neuronal
cell death. J. Neurosci. 13:3669–3680.
|
|
|
|
| a subline of neuronal PC12 pheochromocytoma cells 16129692(C)
|
|
|
|
| PT67 CRL-12284 mouse fibroblast adherent embryo; amphotropic retroviral packaging line
|
|
|
|
| Py-4-1 mouse endothelial cells (a generous gift of Victoria Bautch, University of
North Carolina, Chapel Hill, NC) 11029289(C)
|
|
|
|
| a TGF-beta type I receptor expressing clone of highly transfectable MV1LU-L17 cells 12621041
|
|
|
|
| A Tgfb1-resistant mutant of MV1LU which lacks TgfbR1 1333888(C)
|
|
|
|
| Mv1Lu / R1B-L17 is a derivative cell line defective in the TgfbR1 receptor that has a high
transfection efficiency and responds to TGFb on transfection of TgfbR1. 10197981(C)
|
|
|
|
| Wrana, J.L., L. Attisano, R. Wieser, F. Ventura, and J. Massague´. 1994. Mechanism of activation of the TGF-beta receptor. Nature 370: 341–347.
|
|
|
|
| derived from Mv1Lu - defective in TgfbR1 10197981(C)
|
|
|
|
| mink lung epithelial cells 7791754(C)
|
|
|
|
| R-l B cell line was derived from Mvl Lu by chemical mutagenesis and is resistant to TGFB owing to a deficiency in the type I receptor (Boyd and Massagub, 1989; Wrana et al., 1992).
|
|
|
|
| a mutant of Mv1Lu cells used in 11094085 without explanation
|
|
|
|
| Raji CCL-86 human lymphoblast suspension B lymphocyte; Burkitt’s lymphoma
|
|
|
|
| Ramos (RA 1) CRL-1596 human lymphoblast suspension B lymphocyte; Burkitt’s lymphoma (American)
|
|
|
|
| Burkitt lymphoma cell line
|
|
|
|
| Katz, P., G. Whalen, and J. H. Kehrl. 1994. Differential expression of a novel
protein kinase in human B lymphocytes: preferential localization in the
germinal center. J. Biol. Chem. 269:16802–16809.
|
|
|
|
| Rat1-R12 CRL-2210 rat epithelial adherent connective tissue
|
|
|
|
| Rat1-5R: defective in Nemo
|
|
|
|
| Yamaoka, S., Courtois, G., Bessia, C., Whiteside, S. T., Weil, R., Agou, F., Kirk, H. E., Kay, R. J., and Israel, A. (1998) Cell 93, 1231–1240
|
|
|
|
| used without explanation in 10835426 (as Rat-1a) and 16027121 (as Rat1A)
|
|
|
|
| Rat2 CRL-1764 rat fibroblast adherent fetus
|
|
|
|
| RAW264.7 TIB-71 mouse adherent monocyte; macrophage; AMLV-induced tumor
|
|
|
|
| mouse macrophage line 11323673(C)
|
|
|
|
| used in 16630891 as a "neuroblastoma" no other info given
|
|
|
|
| RBL-2H3 CRL-2256 rat fibroblast adherent peripheral blood; basophil; leukemia
|
|
|
|
| 11686307(D): RBL-2H3 cells produce only MHC-A (Choi et al., 1996)
|
|
|
|
| Choi, O. H., Park, C.-S., Itoh, K., Adelstein, R. S. and Beaven, M. A. (1996). Cloning of the cDNA encoding rat myosin heavy chain-A and evidence for the absence of myosin heavy chain-B in cultured rat mast (RBL-2H3) cells. J. Muscle Res. Cell Motil. 17, 69-77.
|
|
|
|
| "normal rat fibroblasts" 10480934(C)
|
|
|
|
| A rat cell line (RGM-1) was established from normal gastric mucosa 15326485(C)
|
|
|
|
| Kobayashi I, Kawano S, Tsuji S, Matsui H, Nakama A, Sawaoka H, Masuda E, Takei Y, Nagano K, Fusamoto H, Ohno T, Fukutomi H and Kamada T. (1996). In Vitro Cell
Dev. Biol. Anim., 32, 259–261.
|
|
|
|
| "epithelial cells" 16959574(C)
|
|
|
|
| "rabbit kidney cells" 7512734(C)
|
|
|
|
| CRL-2577 human epithelial adherent colon; carcinoma; control for RKO-E6 and RKO-AS45-1 cells
|
|
|
|
| 909698 BRAF p.V600E c.1799T>A Heterozygous
|
|
|
|
| 909698 NF1 p.N2341fs*5 c.7022delA Heterozygous
|
|
|
|
| 909698 PIK3CA p.H1047R c.3140A>G Heterozygous
|
|
|
|
| RK13 CCL-37 rabbit kidney epithelial adherent
|
|
|
|
| human B-cell follicular lymphoma cell line 15670770(C)
|
|
|
|
| RT4-D6P2T CRL-2768 rat neuronal adherent Schwann cell; schwannoma
|
|
|
|
| a rat schwannoma cell line in which merlin can be expressed from a stably transfected ectopic, doxycycline-inducible (TetON) construct (22). 16537381(C)
|
|
|
|
| 24. Shaw, R. J., McClatchey, A. I. & Jacks, T. (1998) J. Biol . Chem. 273, 7757–7764.
|
|
|
|
| used in 12640114 without explanation
|
|
|
|
| "have a deletion of the type I IFN locus" 9660935(C)
|
|
|
|
| Miyakoshi, J., Dobler, K.D., Allalunis-Turner, J., McKean, J.D., Petruk, K., Allen, P.B., Aronyk, K.N., Weir, B., Huyser-Wierenga, D., Fulton, D., Urtasum, R.C., and Day, R.S., III (1990). Absence of IFNA and IFNB genes from human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferons. Cancer Res. 50, 278–283.
|
|
|
|
| Saos-2 HTB-85 human epithelial adherent bone; osteosarcoma
|
|
|
|
| do not express endogenous p53 15073170(C)
|
|
|
|
| p53-negative [RTPCR] 16676006(D)
|
|
|
|
| does not express Pten mRNA 9187108(D)
|
|
|
|
| human keratinocytes, epithelial cell line 11716761(C)
|
|
|
|
| Sf9 CRL-1711 armyworm, epithelial adherent fall ovary
|
|
|
|
| Sf21 (officially called IPLB-Sf21AE) is a continuous cell line developed from ovaries of the Fall Army worm, Spodoptera frugiperda, a moth species that is an agricultural pest on corn and other grass species. It was originally developed in the United States at the Henry A. Wallace Beltsville Agricultural Research Center. Sf9 is a substrain (clone) of these cells that was isolated from Sf21 by researchers at Texas A&M University. [Wikipedia]
|
|
|
|
| used without explanation in 16919458(C)
|
|
|
|
| SH-SY5Y CRL-2266 human bone marrow (metastasis); neur(brain primary) oblastoma epithelial sadherent
|
|
|
|
| SK-BR-3 HTB-30 human epithelial adherent pleural effusion (metastasis); adenocarcinoma (colon primary)
|
|
|
|
| SK-MEL-2 HTB-68 human skin (metastasis); malignant melanoma (skin polygonal adherent primary)
|
|
|
|
| NRAS p.Q61R c.182A>G Homozygous
TP53 p.G245S c.733G>A Heterozygous
|
|
|
|
| SK-MEL-28 HTB-72 human skin; malignant melanoma polygonal adherent
|
|
|
|
| BRAF p.V600E c.1799T>A Homozygous
EGFR p.P753S c.2257C>T Homozygous
TP53 p.L145R c.434_435TG>GT Homozygous
|
|
|
|
| contains Braf(V600E) 19274086(C)
|
|
|
|
| contains Lkb1 protein 19187764-Fig-1a,3b
|
|
|
|
| SK-MEL-31 HTB-73 human epithelial adherent skin; malignant melanoma
|
|
|
|
| not in Casmic database but listed as being from the same individual as SKMEL2
|
|
|
|
| contains LKb1 protein 19187764(C)
|
|
|
|
| contains Lkb1 protein 19187764-Fig-1a
|
|
|
|
| SK-N-DZ CRL-2149 human epithelial adherent bone marrow (metastasis); embryonal neuro-blastoma (brain/neuroblast primary)
|
|
|
|
| SK-N-MC HTB-10 human epithelial adherent supraorbital area (metastasis); neuroepithelioma (brain primary)
|
|
|
|
| SK-OV-3 HTB-77 human epithelial adherent ascites (metastasis); adenocarcinoma (ovaryprimary)
|
|
|
|
| CDKN2A p.? c.1_457del457 Homozygous
PIK3CA p.H1047R c.3140A>G Heterozygous
TP53 p.S90fs*33 c.267delC Homozygous
|
|
|
|
| SL29 CRL-1590 chicken fibroblast adherent embryo
|
|
|
|
| Trypsinization of a decapitated 11-day leghorn embryo. The cells have a doubling potential of 35 population doublings.
|
|
|
|
| 10202139(C): 3Y1 Rat Fibroblasts transformed with vSrc
|
|
|
|
| from Japanese Cancer Research Resources Bank
|
|
|
|
| 16959574(C): bone marrow stroma cells
|
|
|
|
| testicular cell line derived from immature Sertoli cells by targeted oncogenesis (20) 10854429(C)
|
|
|
|
| 20. Dutertre, M., Rey, R., Porteu, A., Josso, N., and Picard, J. Y. (1997) Mol. Cell.
Endocrinol. 136, 57– 65
|
|
|
|
| SW48 CCL-231 human colon; colorectal adenocarcinoma epithelial adherent
|
|
|
|
| SW480 CCL-228 human colon; colorectal adenocarcinoma epithelial adherent
|
|
|
|
| 16. M. van de Wetering, M. Oosterwegel, K. van Norren, H. Clevers, EMBO J. 12, 3847 (1993); V. Korinek and N. Barker, unpublished data.
|
|
|
|
| a Smad4 deficient cell line 11265759(C)
|
|
|
|
| colon carcinoma 10197981(C)
|
|
|
|
| 16. M. van de Wetering, M. Oosterwegel, K. van Norren, H. Clevers, EMBO J. 12, 3847 (1993); V. Korinek and N. Barker, unpublished data.
|
|
|
|
| APC p.Q1338* c.4012C>T Homozygous
KRAS p.G12V c.35G>T Homozygous
MAP2K4 p.? c.219_891del673 Homozygous
SMAD4 p.? c.955+5G>C Homozygous
TP53 p.P309S c.925C>T Homozygous
TP53 p.R273H c.818G>A Homozygous
|
|
|
|
| human anaplastic thyroid carcinoma cells 9335507(C)
|
|
|
|
| 3T3-Swiss-albino CCL-92 mouse fibroblast adherent embryo; feeder layer cell
|
|
|
|
| T24 HTB-4 human epithelial adherent urinary bladder; transitional cell carcinoma
|
|
|
|
| HRAS p.G12V c.35G>T Homozygous
TP53 p.Y126* c.378C>G Homozygous
|
|
|
|
| T24 and T24T human bladder cancer cell lines with nonmetastatic and metastatic phenotypes, respectively, and their growth conditions and doubling time of 30 h have been described previously (3, 4). 11861368(C)
|
|
|
|
| 3. Seraj, M. J., Harding, M. A., Gildea, J. J., Gulding, K. M., and Theodorescu, D. The
relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in
lineage related human bladder cancer cell lines. Clin. Exp. Metastasis, 18: 519 –525,
2000.
4. Gildea, J. J., Golden, W. L., Harding, M. A., and Theodorescu, D. Genetic and
phenotypic changes associated with the acquisition of tumorigenicity in human
bladder cancer. Genes Chromosomes Cancer, 27: 252–263, 2000.
|
|
|
|
| T-47D HTB-133 human epithelial adherent pleural effusion (metastasis); ductal carcinoma (mammary gland primary)
|
|
|
|
| PIK3CA p.H1047R c.3140A>G Heterozygous
TP53 p.L194F c.580C>T Homozygous
|
|
|
|
| mouse lung epithelial cell-derived cell line
|
|
|
|
| "TE671 is a human rhabdomyosarcoma cell line from American Type Culture Collection" 9020886(C)
|
|
|
|
| possibly: RD CCL-136 human spindle and large adherent muscle; rhabdomyosarcoma
|
|
|
|
| THLE-2 CRL-2706 human epithelial adherent liver, left lobe; SV40 transformed
|
|
|
|
| human macrophage-like cell line
|
|
|
|
| THP-1 TIB-202 human monocyte; acute monocytic leukemia monocyte suspension
|
|
|
|
| CR3; complement (C3) receptor
|
|
|
|
| HLA A2, A9, B5, DRw1, DRw2 antigens
|
|
|
|
| Amelogenin: X,Y
CSF1PO: 11,13
D13S317: 13
D16S539: 11,12
D5S818: 11,12
D7S820: 10
THO1: 8,9.3
TPOX: 8,11
vWA: 16
|
|
|
|
| CAMR Centre for Applied Microbiology & Research (ECACC, Salisbury, Wiltshire)
|
|
|
|
| Derived from the peripheral blood of a 1 year old male with acute monocytic leukaemia. THP-1 cells have Fc and C3b receptors and lack surface and cytoplasmic immunoglobulins. These cells also stain positive for alpha-naphthyl butyrate esterase produce lysozymes and are phagocytic (both latex beads and sensitised erythrocytes). THP-1 cells can also restore the response of purified T lymphocytes to Con A, show increased CO2 production on phagocytosis and can be differentiated into macrophage-like cells using for example DMSO.
|
|
|
|
| Refs: Int J Cancer 1980;26:171; Cancer Res 1982;42:1530; J Immunol 1983;131:1882
|
|
|
|
| Availability in cell line catalogues: ATCC TIB 202; DSMZ ACC 16; ICLC HTL97014
|
|
|
|
| Genomic Mutations: [COSMIC/Cosmic]
|
|
|
|
| CDKN2A p.M1_*157del c.1_471del471 Confirmed somatic variant Homozygous
|
|
|
|
| Cdkn2a (p16-Ink4): OFF mutation AAa 1-21 deletion (inhibitor of proliferation)
|
|
|
|
| NRAS p.G12D c.35G>A Confirmed somatic variant Heterozygous
|
|
|
|
| Nras: G12D Activiating mutation (activator of proliferation)
|
|
|
|
| TP53 p.R174fs*3 c.520_545del26 Confirmed somatic variant Homozygous
|
|
|
|
| OFF mutation R174 deletion causing frameshift (inhibitor of proliferation)
|
|
|
|
| Genes with no mutations detected so far:
|
|
|
|
| APC, BRAF, CBFB, CDH1, CTNNB1, CYLD, EGFR, FBXW7, FGFR3, FLCN, FLT3, GNAS, HRAS, JAK2, KIT, KRAS, MAP2K4, MLH1, MSH2, MSH6, MYC, NF1, NF2, NOTCH1, NPM1, NTRK3, PALB2, PIK3C2A, PIK3CA, PTCH, PTEN, RB1, RET, RUNX1, SMAD4, SMO, SOCS1, STK11, SUFU, TSC1, TSC2, VHL, WT1
|
|
|
|
| Other characteristics [10223614]
|
|
|
|
| Positive for nonspecific esterase (alpha-naphtyl-butyrate) 10223614(C)
|
|
|
|
| Normal human LDH isozyme patterns 10223614(C)
|
|
|
|
| does not form rosettes with neuraminidase SRBC (assay for T cells) 10223614(C)
|
|
|
|
| FcgR1a (Cd64) positive 10223614(C)
|
|
|
|
| FcgR2b (Cd32) positive 10223614(C)
|
|
|
|
| FcgR3a and FcgR3b (Cd16) negative 10223614(C)
|
|
|
|
| Positive for HLA-DR surface expression 10223614(C)
|
|
|
|
| Negative for Cd1a 10223614(C)
|
|
|
|
| Positive for CR3 (Mac1) surface expression 10223614(C)
|
|
|
|
| Positive for CR4 (Cd11c) surface expression 10223614(C)
|
|
|
|
| Capable of reducing Nitroblue terazolium 10223614(C)
|
|
|
|
| Phagocytizes Latex but not SRBC in HI-FBS 10223614(C)
|
|
|
|
| TnfR1-positive [RTPCR] 19854138(D)
|
|
|
|
| TnfR2-negative [RTPCR] 19854138(D)
|
|
|
|
| THP1 grown in RPMI/HI-FCS + Csf2 + IL4 for 5 days
|
|
|
|
| THP1 grown in RPMI + IL4 + Csf2 + Tnf + Ionomycin for 1-3 days
|
|
|
|
| used in 12438239 TRKE-2 rat kidney epithelial cell; Ref. 37
|
|
|
|
| 37. Walker, C., and Ginsler, J. Development of a quantitative in vitro transformation
assay for kidney epithelial cells. Carcinogenesis (Lond.), 13: 25–32, 1992.
|
|
|
|
| dog kidney epithelial cells 8264620(C)
|
|
|
|
| a clone of HEK293 cells stably expressing SV40 TAg 11022047(C)
|
|
|
|
| The cell line used in this study is the prostate carcinoma cell line TSU-pr1 (Iizumi et al., 1987). This cell line was derived from human prostatic adenocarcinoma metastatic to lymph node (kindly provided by A. Passaniti, University of Maryland National Institute of Health, Baltimore).
|
|
|
|
| Iizumi, T., Yazaki, T., Kanoh, S., Kondo, I. and Koiso, K. (1987). Establishment of a new prostatic carcinoma cell line (TSU-pr1). J. Urol. 137, 1304-1306.
|
|
|
|
| "U-251 human glioblastoma cells were obtained from the National Cancer Institute
Frederick Cancer DCT Tumor Repository" 16390869(C)
|
|
|
|
| multiple myeloma 9374471(C)
|
|
|
|
| U266B1 TIB-196 human B lymphoblast; plasmacytoma; myeloma lymphoblast, suspension
|
|
|
|
| U2OS HTB-96 human epithelial adherent bone; osteosarcoma
|
|
|
|
| p53-positive [RTPCR] 16676006(D)
|
|
|
|
| TnfR1-positive [RTPCR] 19854138(D)
|
|
|
|
| TnfR2-negative [RTPCR] 19854138(D)
|
|
|
|
| "human astrocytoma" 11179315(C)
|
|
|
|
| Irf9-null cells cells received from G Stark 17923090(C)
|
|
|
|
| a Stat1-deficient human cell line 1048577(C) derived from 2fTGH cells
|
|
|
|
| used in 11163210 without description
|
|
|
|
| we used U4A/Jak1 cells, which express endogenous Smurf2 and in which SnoN concentration decreases in a proteasome-dependent manner in response to TGF-β signalling.
|
|
|
|
| IfnaR2-null cells received from G Stark 17923090(C)
|
|
|
|
| Stat2-null cells received from G Stark 17923090(C)
|
|
|
|
| U87MG HTB-14 human epithelial adherent brain; glioblastoma; astrocytoma
|
|
|
|
| human astrocytoma 11179315(C)
|
|
|
|
| 687590 CDKN2A p.M1_*157del c.1_471del471 Homozygous
|
|
|
|
| 687590 PTEN p.? c.209+1G>T Homozygous
|
|
|
|
| U937 CRL-1593.2 human monocyte suspension macrophage; histiocytic lymphoma
|
|
|
|
| macrophage-like 15953029(C)
|
|
|
|
| BRAF p.V600E c.1799T>A Homozygous
CDKN2A p.M1_*157del c.1_471del471 Homozygous
PTEN p.P248fs*5 c.741_742insA Homozygous
|
|
|
|
| contains Lkb1 protein 19187764-Fig-1a,6d
|
|
|
|
| BRAF p.V600E c.1799T>A Heterozygous
|
|
|
|
| contains Lkb1 protein 19187764-Fig-1a,6d
|
|
|
|
| contains Braf(V600E) 19274086(C)
|
|
|
|
| African green monkey kidney cell line
|
|
|
|
| Vero CCL-81 African green monkey kidney epithelial adherent
|
|
|
|
| comment: negative for Ifna2 and Ifnb1 by Southern blot 3134658(D)
|
|
|
|
| "Primary human fibroblasts" 12110590(C)
|
|
|
|
| WEHI-231 CRL-1702 mouse lymphoblast suspension B lymphocyte; lymphoma
|
|
|
|
| B-cell lymphoma cell line 9535930(C)
|
|
|
|
| WM35 CRL-2807 human spindle-shaped adherent skin, melanocyte; primary superficial spreading melanoma in radial growth phase/vertical growth phase
|
|
|
|
| contains Lkb1 protein 19187764-Fig-6d
|
|
|
|
| contains Lkb1 protein 19187764-Fig-6d
|
|
|
|
| contains Lkb1 protein 19187764-Fig-6d
|
|
|
|
| WI 38 CCL-75 human fibroblast adherent lung
|
|
|
|
| breast cancer 18037881(C)
|
|
|
|
| ZR-75-1 CRL-1500 human ascites (metastasis); ductal carcinoma epithelial adherent (mammary gland epithelium primary)
|
|
|
|
| used in 7816602 without explanation
|
|
|
|
| used with explanation in 8524316 (C)
|
|
|
|
| a human cell line used without more info in 10848577
|
|
|
|
| a human fibrosarcoma 8798467(C)
|
|
|
|
| parent to mutant cell lines: U1A,U2A,U3A,U4A,U5A,U6A 8798467(22,27-30)
|
|
|
|
| parent to mutant cell lines: U1A,U2A,U3A,U4A,U5A,U6A 8798467(29, 35, 42, 44, 45, 48)
|
|
|
|
| 29. John, J., R. McKendry, S. Pellegrini, D. Flavell, I. M. Kerr, and G. R. Stark.
1991. Isolation and characterization of a new mutant human cell line unre-
sponsive to alpha and beta interferons. Mol. Cell. Biol. 11:4189–4195.
|
|
|
|
| 35. Leung, S., S. A. Qureshi, I. M. Kerr, J. E. Darnell, Jr., and G. R. Stark. 1995.
Role of STAT2 in the alpha interferon signaling pathway. Mol. Cell. Biol. 15:
1312–1317.
|
|
|
|
| 42. McKendry, R., J. John, D. Flavell, M. Mu¨ller, I. M. Kerr, and G. R. Stark.
1991. High-frequency mutagenesis of human cells and characterization of a
mutant unresponsive to both alpha- and beta-interferons. Proc. Natl. Acad. Sci. USA
88:11455–11459.
|
|
|
|
| 44. Muller, M., J. Briscoe, C. Laxton, D. Guschin, A. Ziemiecki, O. Silvennoinen, A. G. Harpur, G. Barbieri, B. A. Witthuhn, C. Schindler, S. Pellegrini, A. F. Wilks, J. N. Ihle, G. R. Stark, and I. M. Kerr. 1993. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature (London) 366:129–135.
|
|
|
|
| 48. Pellegrini, S., J. John, M. Shearer, I. M. Kerr, and G. R. Stark. 1989. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol. Cell. Biol. 9:4605–4612.
|
|
|
|
| differentiation: 2173694(M)
|
|
|
|
| to adipocytes was induced by incubating the cells for 2 days in the
same volumes of high glucose DMEM containing 10% fetal bovine
serum, 5 fig/ml insulin, 0.25 pM dexamethasone, 0.5 mM 3-isobutyl-
l-methylxanthine, 50 units/ml penicillin, and 50 fig/ml streptomycin
sulfate. The cells were then incubated for an additional 2 days in the
same media without 0.25 ELM dexamethasone and 0.5 mM 3-isobutyl-
1-methylxanthine. The cells were then maintained for an additional
6 to 10 days in high glucose DMEM containing 10% fetal bovine
serum prior to measuring sugar uptake or harvesting cell membranes.
At this time, greater than 95% of the cells appeared to express the
|
|
|
|
| 3T3 subclone transformed with a temperature-sensitive mutant v-Abl (24). The v-Abl kinase in D5 cells is inactive at 39°C, but kinase activity is restored upon shifting cells to 32°C. 11003655(C)
|
|
|
|
| 24. Renshaw, M. W., E. T. Kipreos, M. R. Albrecht, and J. Y. Wang. 1992. Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context. EMBO J. 11:3941–3951.
|
|
|
|
| Rat fibroblast 12049732(C) 9038154(C)(calls it 3YI)
|
|
|
|
| used without explanation in 16129686
|
|
|
|
| 0734, Japan Cell Resource Bank (JCRB) rat fibroblast 10318861(M)
|
|
|
|
| from 11907583: 4E3 cells were generated by stable transfection of Jurkat cells with human TNF-RII cDNA16, provided by M. Lenardo. [16]
|
|
|
|
| 16. Chan, F. K. & Lenardo, M. J. A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes. Eur. J. Immunol. 30, 652 – 660 (2000).
|
|
|
|
| 1.3E2, a Nemo-deficient murine pre-B cell line 19675659(C)
|
|
|
|
| derived from 70Z3 cells 18635759(C)
|
|
|
|
| G. Courtois, S. T. Whiteside, C. H. Sibley, A. Israel, Mol Cell Biol 17, 1441 (1997).
|
|
|
|
| human mammary epithelial cell strain immortalized with human appilloma virus E6
|
|
|
|
| 22. Band, V., De Caprio, J. A., Delmolino, L., Kulesa, V., and Sager, R. (1991)
J. Virol. 65, 6671– 6676
|
|
|
|
| IL3 dependent mouse lymphoblast from bone marrow
|
|
|
|
| 32D Clone 3 CRL-11346† mouse lymphoblast mixed bone marrow
|
|
|
|
| 12417588(C) 32D cells are murine myeloid progenitors that express few endogenous insulin receptors and no Irs proteins and require intrleukin-3 for growth (48)
|
|
|
|
| 48. Myers, M. G., Jr., Zhang, Y., Aldaz, G. A. I., Grammer, T. C., Glasheen, E. M., Yenush, L., Wang, L. M., Sun, X. J., Blenis, J., Pierce, J. H., and White, M. F. (1996) Mol. Cell. Biol. 16, 4147– 4155
|
|
|
|
| mouse melanoma cell line isolated from neoplasitic lesions raised in HGF-transgenic-UV irradiated mice 19274086(C)
|
|
|
|
| 33: Leshem Y, Gitelman I, Ponzetto C, Halevy O. Preferential binding of Grb2 or
phosphatidylinositol 3-kinase to the met receptor has opposite effects on
HGF-induced myoblast proliferation. Exp Cell Res. 2002 Apr 1;274(2):288-98.
PubMed PMID: 11900489.
|
|
|
|
| contains WT Braf 19274086(C)
|
|
|
|
| used without explaination in 19274086
|
|
|
|
| 33: Leshem Y, Gitelman I, Ponzetto C, Halevy O. Preferential binding of Grb2 or
phosphatidylinositol 3-kinase to the met receptor has opposite effects on
HGF-induced myoblast proliferation. Exp Cell Res. 2002 Apr 1;274(2):288-98.
PubMed PMID: 11900489.
|
|
|
|
| contains WT Braf 19274086(C)
|
|
|
|
| 11460167(C) used without explanation
|
|
|
|
| 12566447(C) mouse pre-B cells
|
|
|
|
| 70Z/3 TIB-158 mouse lymphoblast suspension
pre-B lymphoblast; methylnitrosourea-induced lymphoma
|
|
|
|
| parental cells of 13E2 Nemo-null cells 18635759(C)
|
|
|
|
| mammoplasty-derivied normal human mammary epithelial cell
|
|
|
|
| 21. Band, V., and Sager, R. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 1249 –1253
|
|
|
|
| 786-O CRL-1932 human epithelial adherent kidney; renal cell adenocarcinoma
|
|
|
|
| CDKN2A p.? c.1_150del150 Homozygous
PTEN p.Q149* c.445C>T Homozygous
TP53 p.P278A c.832C>G Heterozygous
TP53 p.? c.560-2A>G Heterozygous
VHL p.G104fs*55 c.311delG Homozygous
|
|
|
|
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}
;){kind=small}